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chloride channel protein [Shigella flexneri 2a str. 301].


LOCUS       NP_706103                473 aa            linear   CON 24-AUG-2016
ACCESSION   NP_706103
VERSION     NP_706103.1
DBLINK      BioProject: PRJNA62907
            Assembly: GCF_000006925.2
DBSOURCE    REFSEQ: accession NC_004337.2
KEYWORDS    RefSeq.
SOURCE      Shigella flexneri 2a str. 301
  ORGANISM  Shigella flexneri 2a str. 301
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Shigella.
REFERENCE   1  (residues 1 to 473)
  AUTHORS   Jin,Q., Yuan,Z., Xu,J., Wang,Y., Shen,Y., Lu,W., Wang,J., Liu,H.,
            Yang,J., Yang,F., Zhang,X., Zhang,J., Yang,G., Wu,H., Qu,D.,
            Dong,J., Sun,L., Xue,Y., Zhao,A., Gao,Y., Zhu,J., Kan,B., Ding,K.,
            Chen,S., Cheng,H., Yao,Z., He,B., Chen,R., Ma,D., Qiang,B., Wen,Y.,
            Hou,Y. and Yu,J.
  TITLE     Genome sequence of Shigella flexneri 2a: insights into
            pathogenicity through comparison with genomes of Escherichia coli
            K12 and O157
  JOURNAL   Nucleic Acids Res. 30 (20), 4432-4441 (2002)
   PUBMED   12384590
REFERENCE   2  (residues 1 to 473)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (26-AUG-2011) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (residues 1 to 473)
  AUTHORS   Jin,Q., Shen,Y., Wang,J.H., Liu,H., Yang,J., Yang,F., Zhang,X.B.,
            Zhang,J.Y., Yang,G.W., Wu,H.T., Dong,J., Sun,L.L., Xue,Y.,
            Zhao,A.L., Gao,Y.S., Zhu,J.P., Chen,S.X., Yao,Z.J., Wang,Y.,
            Lu,W.C., Qiang,B.Q., Wen,Y.M. and Hou,Y.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-AUG-2011) State Key Laboratory for Moleclular
            Virology and Genetic Engineering, Microbial Genome Center of
            Chinese Ministry of Public Health, 6 Rongjing Eastern Street, BDA,
            Beijing 100176, P.R.China
  REMARK    Sequence update by submitter
REFERENCE   4  (residues 1 to 473)
  AUTHORS   Jin,Q., Shen,Y., Wang,J.H., Liu,H., Yang,J., Yang,F., Zhang,X.B.,
            Zhang,J.Y., Yang,G.W., Wu,H.T., Dong,J., Sun,L.L., Xue,Y.,
            Zhao,A.L., Gao,Y.S., Zhu,J.P., Chen,S.X., Yao,Z.J., Wang,Y.,
            Lu,W.C., Qiang,B.Q., Wen,Y.M. and Hou,Y.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-DEC-2004) State Key Laboratory for Moleclular
            Virology and Genetic Engineering, Microbial Genome Center of
            Chinese Ministry of Public Health, 6 Rongjing Eastern Street, BDA,
            Beijing 100176, P.R.China
  REMARK    Sequence update by submitter
REFERENCE   5  (residues 1 to 473)
  AUTHORS   Jin,Q., Shen,Y., Wang,J.H., Liu,H., Yang,J., Yang,F., Zhang,X.B.,
            Zhang,J.Y., Yang,G.W., Wu,H.T., Dong,J., Sun,L.L., Xue,Y.,
            Zhao,A.L., Gao,Y.S., Zhu,J.P., Chen,S.X., Yao,Z.J., Wang,Y.,
            Lu,W.C., Qiang,B.Q., Wen,Y.M. and Hou,Y.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAY-2001) State Key Laboratory for Moleclular
            Virology and Genetic Engineering, Microbial Genome Center of
            Chinese Ministry of Public Health, 6 Rongjing Eastern Street, BDA,
            Beijing 100176, P.R.China
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence is identical to AAN41810.
            RefSeq Category: Reference Genome
                        CLI: Clinical Isolate
                        FGS: First Genome sequenced
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Shigella flexneri 2a str. 301"
                     /strain="301"
                     /serotype="2a"
                     /db_xref="taxon:198214"
     Protein         1..473
                     /product="chloride channel protein"
                     /calculated_mol_wt=50206
     Region          36..473
                     /region_name="PRK05277"
                     /note="H(+)/Cl(-) exchange transporter ClcA"
                     /db_xref="CDD:235385"
     Site            order(106..110,146..150,355..359,445)
                     /site_type="active"
                     /note="Cl- selectivity filter [active]"
                     /db_xref="CDD:238504"
     Site            order(107,109,148..149,355..357,445)
                     /site_type="other"
                     /note="Cl- binding residues [ion binding]"
                     /db_xref="CDD:238504"
     Site            148
                     /site_type="active"
                     /note="pore gating glutamate residue [active]"
                     /db_xref="CDD:238504"
     Site            order(194,203,216,223,403,406,414,426,433..434,437)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238504"
     Site            203
                     /site_type="active"
                     /note="H+/Cl- coupling transport residue [active]"
                     /db_xref="CDD:238504"
     CDS             1..473
                     /gene="yadQ"
                     /locus_tag="SF0147"
                     /coded_by="NC_004337.2:166762..168183"
                     /note="Code: P; COG: COG0038"
                     /transl_table=11
                     /db_xref="GeneID:1024457"
CONTIG      join(WP_000845386.1:1..473)
ORIGIN      
        1 mktdtpslet pqaarlrrrq lirqllerdk tplailfmaa vvgtlvglaa vafdkgvawl
       61 qnqrmgalvh tadnyplllt vaflcsavla mfgyflvrky apeaggsgip eiegaledqr
      121 pvrwwrvlpv kffgglgtlg ggmglgregp tvqiggnisr mvldifrlkg dearhtllat
      181 gaaaglaaaf naplagilfi ieemrpqfry tlisikavfi gvimstimyr ifnhevalid
      241 vgklsdapln tlwlylilgi ifgifgpifn kwvlgmqdll hrvhggnitk wvlmggaigg
      301 lcgllgfvap atsgggfnli piatagnfsm gmlvfifvar vittllcfss gapggifapm
      361 lalgtvlgta fgmvavelfp qyhleagtfa iagmgallaa sirapltgii lvlemtdnyq
      421 lilpmiitgl gatllaqftg gkplysaila rtlakqeaeq larskaasas ent