bifunctional glutamate--cysteine ligase/glutathione synthetase

LOCUS       NP_466292                776 aa            linear   CON 28-AUG-2016
            [Listeria monocytogenes EGD-e].
ACCESSION   NP_466292
VERSION     NP_466292.1
DBLINK      BioProject: PRJNA61583
            Assembly: GCF_000196035.1
DBSOURCE    REFSEQ: accession NC_003210.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes EGD-e
  ORGANISM  Listeria monocytogenes EGD-e
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 776)
  AUTHORS   Toledo-Arana,A., Dussurget,O., Nikitas,G., Sesto,N.,
            Guet-Revillet,H., Balestrino,D., Loh,E., Gripenland,J., Tiensuu,T.,
            Vaitkevicius,K., Barthelemy,M., Vergassola,M., Nahori,M.A.,
            Soubigou,G., Regnault,B., Coppee,J.Y., Lecuit,M., Johansson,J. and
            Cossart,P.
  TITLE     The Listeria transcriptional landscape from saprophytism to
            virulence
  JOURNAL   Nature 459 (7249), 950-956 (2009)
   PUBMED   19448609
REFERENCE   2  (residues 1 to 776)
  AUTHORS   Chatterjee,S.S., Hossain,H., Otten,S., Kuenne,C., Kuchmina,K.,
            Machata,S., Domann,E., Chakraborty,T. and Hain,T.
  TITLE     Intracellular gene expression profile of Listeria monocytogenes
  JOURNAL   Infect. Immun. 74 (2), 1323-1338 (2006)
   PUBMED   16428782
REFERENCE   3  (residues 1 to 776)
  AUTHORS   Glaser,P., Frangeul,L., Buchrieser,C., Amend,A., Baquero,F.,
            Berche,P., Bloecker,H., Brandt,P., Chakraborty,T., Charbit,A.,
            Chetouani,F., Couve,E., de Daruvar,A., Dehoux,P., Domann,E.,
            Dominguez-Bernal,G., Duchaud,E., Durand,L., Dussurget,O.,
            Entian,K.-D., Fsihi,H., Garcia-Del Portillo,F., Garrido,P.,
            Gautier,L., Goebel,W., Gomez-Lopez,N., Hain,T., Hauf,J.,
            Jackson,D., Jones,L.-M., Karst,U., Kreft,J., Kuhn,M., Kunst,F.,
            Kurapkat,G., Madueno,E., Maitournam,A., Mata Vicente,J., Ng,E.,
            Nordsiek,G., Novella,S., de Pablos,B., Perez-Diaz,J.-C., Remmel,B.,
            Rose,M., Rusniok,C., Schlueter,T., Simoes,N., Tierrez,A.,
            Vazquez-Boland,J.-A., Voss,H., Wehland,J. and Cossart,P.
  TITLE     Comparative genomics of Listeria species
  JOURNAL   Science 294 (5543), 849-852 (2001)
   PUBMED   11679669
REFERENCE   4  (residues 1 to 776)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (08-NOV-2001) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 776)
  AUTHORS   Glaser,P., Frangeul,L. and Rusniok,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUN-2001) Glaser P., Institut Pasteur, Genomique des
            Microorganismes Pathogenes, 25 rue du Docteur Roux, 75724 Paris
            Cedex 15, FRANCE
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CAD00983.
            RefSeq Category: Reference Genome
                        FGS: First Genome sequenced
                        MOD: Model Organism
                        UPR: UniProt Genome
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..776
                     /organism="Listeria monocytogenes EGD-e"
                     /strain="EGD-e"
                     /db_xref="taxon:169963"
     Protein         1..776
                     /product="bifunctional glutamate--cysteine
                     ligase/glutathione synthetase"
                     /EC_number="6.3.2.2"
                     /EC_number="6.3.2.3"
                     /calculated_mol_wt=88431
     Region          7..776
                     /region_name="PRK02471"
                     /note="bifunctional glutamate--cysteine ligase
                     GshA/glutathione synthetase GshB"
                     /db_xref="CDD:179427"
     CDS             1..776
                     /locus_tag="lmo2770"
                     /coded_by="NC_003210.1:2850620..2852950"
                     /experiment="EXISTENCE:[PMID:19448609]"
                     /note="Synthesizes glutathione from L-glutamate and
                     L-cysteine via gamma-L-glutamyl-L-cysteine"
                     /transl_table=11
                     /db_xref="GeneID:986798"
CONTIG      join(WP_010990064.1:1..776)
ORIGIN      
        1 mikldmtmld sfkedpnlrk llfsghfgle kenirvtsdg klaltphpai fgpkednpyi
       61 ktdfsesqie mitpvtdsid svyewlenlh nivslrsene llwpssnppi lpaeedipia
      121 eyktpdspdr kyrehlakgy gkkiqllsgi hynfsfpeal idglyanisl peeskqdfkn
      181 rlylkvakyf mknrwlliyl tgaspvylad fsktkheesl pdgssalrdg islrnsnagy
      241 knkealfvdy nsfdayissi snyieagkie smrefynpir lknahtdqtv eslaehgvey
      301 leirsidlnp lepngiskde ldfihlflik gllsedrelc annqqladen ennialngla
      361 qpsikncdne dipladagll eldkmsdfik slrpedtklr aiiekqkerl lhpektiaaq
      421 vkqqvtkegy vdfhlnqakt ymeetealay kligaedmel stqiiwkdai argikvdvld
      481 raenflrfqk gdhieyvkqa sktskdnyvs vlmmenkvvt klvlaehdir vpfgdsfsdq
      541 alaleafslf edkqivvkpk stnygwgisi fknkftledy qealniafsy dssviieefi
      601 pgdefrflvi ndkveavlkr vpanvtgdgi htvrelveek ntdplrgtdh lkplekirtg
      661 peetlmlsmq nlswdsipka eeiiylrens nvstggdsid yteemddyfk eiairatqvl
      721 dakicgvdii vpretidrdk haiielnfnp amhmhcfpyq geqkkigdki ldflfd