thymidylate synthase [Listeria monocytogenes EGD-e].

LOCUS       NP_465399                314 aa            linear   CON 28-AUG-2016
ACCESSION   NP_465399
VERSION     NP_465399.1
DBLINK      BioProject: PRJNA61583
            Assembly: GCF_000196035.1
DBSOURCE    REFSEQ: accession NC_003210.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes EGD-e
  ORGANISM  Listeria monocytogenes EGD-e
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 314)
  AUTHORS   Toledo-Arana,A., Dussurget,O., Nikitas,G., Sesto,N.,
            Guet-Revillet,H., Balestrino,D., Loh,E., Gripenland,J., Tiensuu,T.,
            Vaitkevicius,K., Barthelemy,M., Vergassola,M., Nahori,M.A.,
            Soubigou,G., Regnault,B., Coppee,J.Y., Lecuit,M., Johansson,J. and
            Cossart,P.
  TITLE     The Listeria transcriptional landscape from saprophytism to
            virulence
  JOURNAL   Nature 459 (7249), 950-956 (2009)
   PUBMED   19448609
REFERENCE   2  (residues 1 to 314)
  AUTHORS   Chatterjee,S.S., Hossain,H., Otten,S., Kuenne,C., Kuchmina,K.,
            Machata,S., Domann,E., Chakraborty,T. and Hain,T.
  TITLE     Intracellular gene expression profile of Listeria monocytogenes
  JOURNAL   Infect. Immun. 74 (2), 1323-1338 (2006)
   PUBMED   16428782
REFERENCE   3  (residues 1 to 314)
  AUTHORS   Glaser,P., Frangeul,L., Buchrieser,C., Amend,A., Baquero,F.,
            Berche,P., Bloecker,H., Brandt,P., Chakraborty,T., Charbit,A.,
            Chetouani,F., Couve,E., de Daruvar,A., Dehoux,P., Domann,E.,
            Dominguez-Bernal,G., Duchaud,E., Durand,L., Dussurget,O.,
            Entian,K.-D., Fsihi,H., Garcia-Del Portillo,F., Garrido,P.,
            Gautier,L., Goebel,W., Gomez-Lopez,N., Hain,T., Hauf,J.,
            Jackson,D., Jones,L.-M., Karst,U., Kreft,J., Kuhn,M., Kunst,F.,
            Kurapkat,G., Madueno,E., Maitournam,A., Mata Vicente,J., Ng,E.,
            Nordsiek,G., Novella,S., de Pablos,B., Perez-Diaz,J.-C., Remmel,B.,
            Rose,M., Rusniok,C., Schlueter,T., Simoes,N., Tierrez,A.,
            Vazquez-Boland,J.-A., Voss,H., Wehland,J. and Cossart,P.
  TITLE     Comparative genomics of Listeria species
  JOURNAL   Science 294 (5543), 849-852 (2001)
   PUBMED   11679669
REFERENCE   4  (residues 1 to 314)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (08-NOV-2001) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 314)
  AUTHORS   Glaser,P., Frangeul,L. and Rusniok,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUN-2001) Glaser P., Institut Pasteur, Genomique des
            Microorganismes Pathogenes, 25 rue du Docteur Roux, 75724 Paris
            Cedex 15, FRANCE
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CAC99952.
            RefSeq Category: Reference Genome
                        FGS: First Genome sequenced
                        MOD: Model Organism
                        UPR: UniProt Genome
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..314
                     /organism="Listeria monocytogenes EGD-e"
                     /strain="EGD-e"
                     /db_xref="taxon:169963"
     Protein         1..314
                     /product="thymidylate synthase"
                     /EC_number="2.1.1.45"
                     /calculated_mol_wt=36032
     Region          3..314
                     /region_name="thym_sym"
                     /note="thymidylate synthase; TIGR03284"
                     /db_xref="CDD:213790"
     Site            order(16,20,28,30,176..177,184..185,199,201,205,214,
                     216..217,254..255)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238211"
     Site            order(21,58,80,83,144,196..197,215..217,219,226..227,257,
                     259)
                     /site_type="active"
                     /db_xref="CDD:238211"
     CDS             1..314
                     /gene="thyA"
                     /locus_tag="lmo1874"
                     /coded_by="complement(NC_003210.1:1947914..1948858)"
                     /experiment="EXISTENCE:[PMID:19448609]"
                     /note="ThyA; catalyzes formation of dTMP and
                     7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and
                     dUMP; involved in deoxyribonucleotide biosynthesis; there
                     are 2 copies in some Bacilli, one of which appears to be
                     phage-derived"
                     /transl_table=11
                     /db_xref="GeneID:985817"
CONTIG      join(WP_010989834.1:1..314)
ORIGIN      
        1 mkqyldleky vlengtqkgd rtgtgtistf gyqmrfdlqe gfpimttkrv pfklvvsell
       61 wflhgdtnir yllqhnnniw newaferfvk sddykgedmt dfglraerdp afkevyqaem
      121 ekfktriied eafatkygel gniygkqwre wktsqgetid qladliemik tnpnsrrliv
      181 sawnpedipn malppchslf qfyvadgkls cqlyqrsadi flgvpfnias yallthliar
      241 evgldvgefi htmgdahlyn nhieqvkeql srtphalpkl vlsdkpatif dfevadisld
      301 gynpdpsika pisv