bifunctional ornithine acetyltransferase/N-acetylglutamate synthase

LOCUS       NP_465115                398 aa            linear   CON 28-AUG-2016
            [Listeria monocytogenes EGD-e].
ACCESSION   NP_465115
VERSION     NP_465115.1
DBLINK      BioProject: PRJNA61583
            Assembly: GCF_000196035.1
DBSOURCE    REFSEQ: accession NC_003210.1
KEYWORDS    RefSeq.
SOURCE      Listeria monocytogenes EGD-e
  ORGANISM  Listeria monocytogenes EGD-e
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Listeriaceae;
            Listeria.
REFERENCE   1  (residues 1 to 398)
  AUTHORS   Toledo-Arana,A., Dussurget,O., Nikitas,G., Sesto,N.,
            Guet-Revillet,H., Balestrino,D., Loh,E., Gripenland,J., Tiensuu,T.,
            Vaitkevicius,K., Barthelemy,M., Vergassola,M., Nahori,M.A.,
            Soubigou,G., Regnault,B., Coppee,J.Y., Lecuit,M., Johansson,J. and
            Cossart,P.
  TITLE     The Listeria transcriptional landscape from saprophytism to
            virulence
  JOURNAL   Nature 459 (7249), 950-956 (2009)
   PUBMED   19448609
REFERENCE   2  (residues 1 to 398)
  AUTHORS   Chatterjee,S.S., Hossain,H., Otten,S., Kuenne,C., Kuchmina,K.,
            Machata,S., Domann,E., Chakraborty,T. and Hain,T.
  TITLE     Intracellular gene expression profile of Listeria monocytogenes
  JOURNAL   Infect. Immun. 74 (2), 1323-1338 (2006)
   PUBMED   16428782
REFERENCE   3  (residues 1 to 398)
  AUTHORS   Glaser,P., Frangeul,L., Buchrieser,C., Amend,A., Baquero,F.,
            Berche,P., Bloecker,H., Brandt,P., Chakraborty,T., Charbit,A.,
            Chetouani,F., Couve,E., de Daruvar,A., Dehoux,P., Domann,E.,
            Dominguez-Bernal,G., Duchaud,E., Durand,L., Dussurget,O.,
            Entian,K.-D., Fsihi,H., Garcia-Del Portillo,F., Garrido,P.,
            Gautier,L., Goebel,W., Gomez-Lopez,N., Hain,T., Hauf,J.,
            Jackson,D., Jones,L.-M., Karst,U., Kreft,J., Kuhn,M., Kunst,F.,
            Kurapkat,G., Madueno,E., Maitournam,A., Mata Vicente,J., Ng,E.,
            Nordsiek,G., Novella,S., de Pablos,B., Perez-Diaz,J.-C., Remmel,B.,
            Rose,M., Rusniok,C., Schlueter,T., Simoes,N., Tierrez,A.,
            Vazquez-Boland,J.-A., Voss,H., Wehland,J. and Cossart,P.
  TITLE     Comparative genomics of Listeria species
  JOURNAL   Science 294 (5543), 849-852 (2001)
   PUBMED   11679669
REFERENCE   4  (residues 1 to 398)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (08-NOV-2001) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 398)
  AUTHORS   Glaser,P., Frangeul,L. and Rusniok,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUN-2001) Glaser P., Institut Pasteur, Genomique des
            Microorganismes Pathogenes, 25 rue du Docteur Roux, 75724 Paris
            Cedex 15, FRANCE
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CAC99668.
            RefSeq Category: Reference Genome
                        FGS: First Genome sequenced
                        MOD: Model Organism
                        UPR: UniProt Genome
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..398
                     /organism="Listeria monocytogenes EGD-e"
                     /strain="EGD-e"
                     /db_xref="taxon:169963"
     Protein         1..398
                     /product="bifunctional ornithine
                     acetyltransferase/N-acetylglutamate synthase"
                     /EC_number="2.3.1.1"
                     /EC_number="2.3.1.35"
                     /calculated_mol_wt=42606
     Region          11..398
                     /region_name="OAT"
                     /note="Ornithine acetyltransferase (OAT) family; also
                     referred to as ArgJ. OAT catalyzes the first and fifth
                     steps in arginine biosynthesis, coupling acetylation of
                     glutamate with deacetylation of N-acetylornithine, which
                     allows recycling of the acetyl group in...; cd02152"
                     /db_xref="CDD:239065"
     Site            order(47..51,81,116..117,178,182,219..222,300..302,
                     305..306,308..309,311,313..316,318..319,322..325,343,
                     385..387)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:239065"
     Site            order(113..114,148..149,174,177,185,393,397..398)
                     /site_type="active"
                     /note="active site pocket [active]"
                     /db_xref="CDD:239065"
     Site            184..185
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:239065"
     CDS             1..398
                     /gene="argJ"
                     /locus_tag="lmo1590"
                     /coded_by="complement(NC_003210.1:1631516..1632712)"
                     /experiment="EXISTENCE:[PMID:19448609]"
                     /note="bifunctional arginine biosynthesis protein ArgJ;
                     functions at the 1st and 5th steps in arginine
                     biosynthesis; involved in synthesis of acetylglutamate
                     from glutamate and acetyl-CoA and ornithine by
                     transacetylation between acetylornithine and glutmate"
                     /transl_table=11
                     /db_xref="GeneID:984450"
CONTIG      join(WP_010989754.1:1..398)
ORIGIN      
        1 melikgnias pkgfyadgkh aglkrkrndi gwiysevpan aaavytmnqm qaapifvtkd
       61 sfqsnaklqa iivnsgnana ctgnqgmlda lamraqtaek leipldsvav astgiigdml
      121 pmdkinagie mlekqtgnaa dfeeailttd tfqkqisfqt eiggrkvtms gvakgsgmih
      181 pnmatmlafi ttdaaipael lqkllkikvd ktfnqitvdg dtstndmvvv mangcaenpm
      241 lqegtadfak fadmfqavte hlaksiardg egatklievq vngatkteda rmiakkivss
      301 slvktaafgg dgnwgriica igysggrfap dnitikiggi eilnhssqti ynqqaldayl
      361 eeehiiievd lhiglesgta wgcdlsyeyv kinacyrt