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2,4-dieonyl-coa reductase [Salmonella enterica subsp. enterica


LOCUS       NP_462133                672 aa            linear   CON 08-SEP-2022
            serovar Typhimurium str. LT2].
ACCESSION   NP_462133
VERSION     NP_462133.1
DBLINK      BioProject: PRJNA57799
            BioSample: SAMN02604315
DBSOURCE    REFSEQ: accession NC_003197.2
KEYWORDS    RefSeq.
SOURCE      Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
  ORGANISM  Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Salmonella.
REFERENCE   1  (residues 1 to 672)
  AUTHORS   McClelland,M., Sanderson,K.E., Spieth,J., Clifton,S.W.,
            Latreille,P., Courtney,L., Porwollik,S., Ali,J., Dante,M., Du,F.,
            Hou,S., Layman,D., Leonard,S., Nguyen,C., Scott,K., Holmes,A.,
            Grewal,N., Mulvaney,E., Ryan,E., Sun,H., Florea,L., Miller,W.,
            Stoneking,T., Nhan,M., Waterston,R. and Wilson,R.K.
  TITLE     Complete genome sequence of Salmonella enterica serovar Typhimurium
            LT2
  JOURNAL   Nature 413 (6858), 852-856 (2001)
   PUBMED   11677609
REFERENCE   2  (residues 1 to 672)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (08-SEP-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (residues 1 to 672)
  AUTHORS   McClelland,M., Jain,A., Saraogi,P., Mendelson,R., Westerman,R.,
            SanMiguel,P. and Csonka,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JAN-2016) Department of Microbiology and Molecular
            Genetics, University of California, Irvine, CA 92697, USA
  REMARK    Sequence update by submitter
REFERENCE   4  (residues 1 to 672)
  CONSRTM   The Salmonella typhimurium Genome Sequencing Project
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2001) Genome Sequencing Center, Department of
            Genetics, Washington University School of Medicine, 4444 Forest
            Park Boulevard, St. Louis, MO 63108, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AAL22092.
            Supported by NIH grant 5U 01 AI43283
            
            Coding sequences below are predicted from manually evaluated
            computer analysis, using similarity information and the programs;
            GLIMMER; http://www.tigr.org/softlab/glimmer/glimmer.html and
            GeneMark; http://opal.biology.gatech.edu/GeneMark/
            
            EC numbers were kindly provided by Junko Yabuzaki and the Kyoto
            Encyclopedia of Genes and Genomes; http://www.genome.ad.jp/kegg/,
            and Pedro Romero and Peter Karp at EcoCyc;
            http://ecocyc.PangeaSystems.com/ecocyc/
            
            The analyses of ribosome binding sites and promoter binding sites
            were kindly provided by Heladia Salgado, Julio Collado-Vides and
            ReguonDB;
            http://kinich.cifn.unam.mx:8850/db/regulondb_intro.frameset
            
            This sequence was finished as follows unless otherwise noted: all
            regions were double stranded, sequenced with an alternate
            chemistries or covered by high quality data (i.e., phred quality >=
            30); an attempt was made to resolve all sequencing problems, such
            as compressions and repeats; all regions were covered by sequence
            from more than one m13 subclone.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..672
                     /organism="Salmonella enterica subsp. enterica serovar
                     Typhimurium str. LT2"
                     /strain="LT2"
                     /serovar="Typhimurium"
                     /sub_species="enterica"
                     /culture_collection="ATCC:700720"
                     /culture_collection="SGSC:1412"
                     /type_material="type strain of Salmonella enterica"
                     /db_xref="taxon:99287"
                     /focus
     Protein         1..672
                     /product="2,4-dieonyl-coa reductase"
                     /EC_number="1.3.1.34"
                     /calculated_mol_wt=72999
     Region          6..358
                     /region_name="DCR_FMN"
                     /note="2,4-dienoyl-CoA reductase (DCR) FMN-binding domain.
                     DCR in E. coli is an iron-sulfur flavoenzyme which
                     contains FMN, FAD, and a 4Fe-4S cluster. It is also a
                     monomer, unlike that of its eukaryotic counterparts which
                     form homotetramers and lack the...; cd02930"
                     /db_xref="CDD:239240"
     Site            order(25,27,59,101,165,167,176,215,253,256,311..312,335,
                     338,342,354)
                     /site_type="active"
                     /db_xref="CDD:239240"
     Site            order(25,27,59,101,215,311..312)
                     /site_type="other"
                     /note="FMN binding site [chemical binding]"
                     /db_xref="CDD:239240"
     Site            order(165,167,176,253,256)
                     /site_type="other"
                     /note="2,4-decadienoyl-CoA binding site"
                     /db_xref="CDD:239240"
     Site            167
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239240"
     Site            order(335,338,342,354)
                     /site_type="other"
                     /note="4Fe-4S cluster binding site [ion binding]"
                     /db_xref="CDD:239240"
     Region          <367..>512
                     /region_name="GltD"
                     /note="NADPH-dependent glutamate synthase beta chain or
                     related oxidoreductase [Amino acid transport and
                     metabolism, General function prediction only]; COG0493"
                     /db_xref="CDD:440259"
     Region          400..>652
                     /region_name="FadH2"
                     /note="NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur
                     reductase, or a related oxidoreductase [Lipid transport
                     and metabolism]; COG0446"
                     /db_xref="CDD:440215"
     CDS             1..672
                     /gene="fadH"
                     /locus_tag="STM3219"
                     /coded_by="NC_003197.2:3386262..3388280"
                     /note="similar to E. coli putative NADPH dehydrogenase
                     (AAC76116.1); Blastp hit to AAC76116.1 (672 aa), 85%
                     identity in aa 1 - 672"
                     /transl_table=11
                     /db_xref="GeneID:1254742"
CONTIG      join(WP_000121523.1:1..672)
ORIGIN      
        1 msypslfapl dlgfttlrnr vlmgsmhtgl eehpdgaerl aafyaerarh gvalivtggi
       61 apvpsgvvmt ggamlndasq ltphrvvtda vhaqggkial qilhtgrysy qphlvapsai
      121 qapinrfmph elthdeilql iddfahcaql areagydgve vmgsegylin efltrrtnhr
      181 ddewggdyas rmrfavevvr avrqrvgndf iiiyrlsmld lvenggtfde tvqlaqaiea
      241 agaslintgi gwhearipti atpvprgafs wvtrklkghv svpliatnri ndpqvaetil
      301 trgdadmvsm arpfladaef ltkaqsgrad eintcigcnq acldrifigk vtsclvnpra
      361 chethmpitp airkknlavv gagpaglafa inaasrghhv tlfdaqseig gqftiarqip
      421 gkeefyetlr yyrrmidvtg vtlklnqrvn aedlqpfdea ilacgivprr ppidgidhpk
      481 altylevlrd kapvgkrvai igcggigfdt amylsqhges tsqniaefct ewgidtslqq
      541 agglrpegpr larsprqivm lqrktskpge glgkttgwih ratllargvk mipavsyqki
      601 dddglhllig gepqllevdh vvicagqepr reladplraa gktvhliggc dvameldarr
      661 aiaqgtrlal ei