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putative cation efflux system protein [Salmonella enterica subsp.


LOCUS       NP_459346               1055 aa            linear   CON 08-SEP-2022
            enterica serovar Typhimurium str. LT2].
ACCESSION   NP_459346
VERSION     NP_459346.1
DBLINK      BioProject: PRJNA57799
            BioSample: SAMN02604315
DBSOURCE    REFSEQ: accession NC_003197.2
KEYWORDS    RefSeq.
SOURCE      Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
  ORGANISM  Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Salmonella.
REFERENCE   1  (residues 1 to 1055)
  AUTHORS   McClelland,M., Sanderson,K.E., Spieth,J., Clifton,S.W.,
            Latreille,P., Courtney,L., Porwollik,S., Ali,J., Dante,M., Du,F.,
            Hou,S., Layman,D., Leonard,S., Nguyen,C., Scott,K., Holmes,A.,
            Grewal,N., Mulvaney,E., Ryan,E., Sun,H., Florea,L., Miller,W.,
            Stoneking,T., Nhan,M., Waterston,R. and Wilson,R.K.
  TITLE     Complete genome sequence of Salmonella enterica serovar Typhimurium
            LT2
  JOURNAL   Nature 413 (6858), 852-856 (2001)
   PUBMED   11677609
REFERENCE   2  (residues 1 to 1055)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (08-SEP-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (residues 1 to 1055)
  AUTHORS   McClelland,M., Jain,A., Saraogi,P., Mendelson,R., Westerman,R.,
            SanMiguel,P. and Csonka,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JAN-2016) Department of Microbiology and Molecular
            Genetics, University of California, Irvine, CA 92697, USA
  REMARK    Sequence update by submitter
REFERENCE   4  (residues 1 to 1055)
  CONSRTM   The Salmonella typhimurium Genome Sequencing Project
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2001) Genome Sequencing Center, Department of
            Genetics, Washington University School of Medicine, 4444 Forest
            Park Boulevard, St. Louis, MO 63108, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AAL19305.
            Supported by NIH grant 5U 01 AI43283
            
            Coding sequences below are predicted from manually evaluated
            computer analysis, using similarity information and the programs;
            GLIMMER; http://www.tigr.org/softlab/glimmer/glimmer.html and
            GeneMark; http://opal.biology.gatech.edu/GeneMark/
            
            EC numbers were kindly provided by Junko Yabuzaki and the Kyoto
            Encyclopedia of Genes and Genomes; http://www.genome.ad.jp/kegg/,
            and Pedro Romero and Peter Karp at EcoCyc;
            http://ecocyc.PangeaSystems.com/ecocyc/
            
            The analyses of ribosome binding sites and promoter binding sites
            were kindly provided by Heladia Salgado, Julio Collado-Vides and
            ReguonDB;
            http://kinich.cifn.unam.mx:8850/db/regulondb_intro.frameset
            
            This sequence was finished as follows unless otherwise noted: all
            regions were double stranded, sequenced with an alternate
            chemistries or covered by high quality data (i.e., phred quality >=
            30); an attempt was made to resolve all sequencing problems, such
            as compressions and repeats; all regions were covered by sequence
            from more than one m13 subclone.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..1055
                     /organism="Salmonella enterica subsp. enterica serovar
                     Typhimurium str. LT2"
                     /strain="LT2"
                     /serovar="Typhimurium"
                     /sub_species="enterica"
                     /culture_collection="ATCC:700720"
                     /culture_collection="SGSC:1412"
                     /type_material="type strain of Salmonella enterica"
                     /db_xref="taxon:99287"
                     /focus
     Protein         1..1055
                     /product="putative cation efflux system protein"
                     /calculated_mol_wt=113783
     Region          1..1044
                     /region_name="AcrB"
                     /note="Multidrug efflux pump subunit AcrB [Defense
                     mechanisms]; COG0841"
                     /db_xref="CDD:440603"
     CDS             1..1055
                     /locus_tag="STM0351"
                     /coded_by="complement(NC_003197.2:393894..397061)"
                     /note="similar to E. coli integral transmembrane protein;
                     acridine resistance (AAC76298.1); Blastp hit to AAC76298.1
                     (1034 aa), 42% identity in aa 3 - 1030"
                     /transl_table=11
                     /db_xref="GeneID:1251870"
CONTIG      join(WP_000673160.1:1..1055)
ORIGIN      
        1 mkfthffiar pifaivlsll mllagaiafl klplseypav tpptvqvsas ypganpqvia
       61 dtvaapleqv ingvdgmlym ntqmaidgrm visiafeqgt dpdmaqiqvq nrvsralprl
      121 peevqrigvv tektspdmlm vvhlvspqkr ydslylsnfa irqvrdelar lpgvgdvlvw
      181 gageyamrvw ldpakianrg ltasdivtal reqnvqvaag svgqqpeasa afqmtvntlg
      241 rltseeqfge ivvkigadge vtrlrdvarv tlgadaytlr sllngeaapa lqiiqspgan
      301 aidvsnairg kmdelqqnfp qdieyriayd ptvfvraslq svaitlleal vlvvlvvvmf
      361 lqtwrasiip lvavpvslvg tfalmhlfgf slntlslfgl vlsigivvdd aivvvenver
      421 hisqgkspge aakkamdevt gpilsitsvl tavfipsafl aglqgefyrq faltiaisti
      481 lsainsltls palaaillrp hhdtakadwl trlmgtvtgg ffhrfnrffd sasnryvsav
      541 rravrgsviv mvlyagfvgl twlgfhqvpn gfvpaqdkyy lvgiaqlpsg asldrteavv
      601 kqmsaialae pgvesvvvfp glsvngpvnv pnsalmfaml kpfderedps lsanaiagkl
      661 mhkfshipdg figifppppv pglgatggfk lqiedraelg feamtkvqse imskamqtpe
      721 lanmlasfqt napqlqvdid rvkaksmgvs ltdifetlqi nlgslyvndf nrfgrawrvm
      781 aqadapfrmq qedigllkvr nakgemipls afvtimrqsg pdriihyngf psvdisggpa
      841 pgfssgqatd aiekivretl pegmvfewtd lvyqekqagn salaifalav llaflilaaq
      901 ynswslpfav lliapmslls aivgvwvsgg dnniftqigf vvlvglaakn ailivefara
      961 kehdgadplt avleasrlrl rpilmtsfaf iagvvplvla tgagaemrha mgiavfagml
     1021 gvtlfglllt pvfyvvvrrm alkrenrvds hdqqa