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LOCUS NP_253501 681 aa linear CON 24-JAN-2019 ACCESSION NP_253501 VERSION NP_253501.1 DBLINK BioProject: PRJNA57945 Assembly: GCF_000006765.1 DBSOURCE REFSEQ: accession NC_002516.2 KEYWORDS RefSeq. SOURCE Pseudomonas aeruginosa PAO1 ORGANISM Pseudomonas aeruginosa PAO1 Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. REFERENCE 1 (residues 1 to 681) AUTHORS Winsor,G.L., Van Rossum,T., Lo,R., Khaira,B., Whiteside,M.D., Hancock,R.E. and Brinkman,F.S. TITLE Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes JOURNAL Nucleic acids Res. 37 (DATABASE ISSUE), D483-D488 (2009) PUBMED 18978025 REFERENCE 2 (residues 1 to 681) AUTHORS Cirz,R.T., O'Neill,B.M., Hammond,J.A., Head,S.R. and Romesberg,F.E. TITLE Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin JOURNAL J. Bacteriol. 188 (20), 7101-7110 (2006) PUBMED 17015649 REFERENCE 3 (residues 1 to 681) AUTHORS Palmer,K.L., Mashburn,L.M., Singh,P.K. and Whiteley,M. TITLE Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology JOURNAL J. Bacteriol. 187 (15), 5267-5277 (2005) PUBMED 16030221 REFERENCE 4 (residues 1 to 681) AUTHORS Salunkhe,P., Smart,C.H., Morgan,J.A., Panagea,S., Walshaw,M.J., Hart,C.A., Geffers,R., Tummler,B. and Winstanley,C. TITLE A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance JOURNAL J. Bacteriol. 187 (14), 4908-4920 (2005) PUBMED 15995206 REFERENCE 5 (residues 1 to 681) AUTHORS Filiatrault,M.J., Wagner,V.E., Bushnell,D., Haidaris,C.G., Iglewski,B.H. and Passador,L. TITLE Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa JOURNAL Infect. Immun. 73 (6), 3764-3772 (2005) PUBMED 15908409 REFERENCE 6 (residues 1 to 681) AUTHORS Rasmussen,T.B., Bjarnsholt,T., Skindersoe,M.E., Hentzer,M., Kristoffersen,P., Kote,M., Nielsen,J., Eberl,L. and Givskov,M. TITLE Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector JOURNAL J. Bacteriol. 187 (5), 1799-1814 (2005) PUBMED 15716452 REFERENCE 7 (residues 1 to 681) AUTHORS Winsor,G.L., Lo,R., Sui,S.J., Ung,K.S., Huang,S., Cheng,D., Ching,W.K., Hancock,R.E. and Brinkman,F.S. TITLE Pseudomonas aeruginosa Genome Database and PseudoCap: facilitating community-based, continually updated, genome annotation JOURNAL Nucleic acids Res. 33 (DATABASE ISSUE), D338-D343 (2005) PUBMED 15608211 REFERENCE 8 (residues 1 to 681) AUTHORS Wagner,V.E., Bushnell,D., Passador,L., Brooks,A.I. and Iglewski,B.H. TITLE Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment JOURNAL J. Bacteriol. 185 (7), 2080-2095 (2003) PUBMED 12644477 REFERENCE 9 (residues 1 to 681) AUTHORS Schuster,M., Lostroh,C.P., Ogi,T. and Greenberg,E.P. TITLE Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis JOURNAL J. Bacteriol. 185 (7), 2066-2079 (2003) PUBMED 12644476 REFERENCE 10 (residues 1 to 681) AUTHORS Stover,C.K., Pham,X.Q., Erwin,A.L., Mizoguchi,S.D., Warrener,P., Hickey,M.J., Brinkman,F.S., Hufnagle,W.O., Kowalik,D.J., Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R., Smith,K., Spencer,D., Wong,G.K., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H., Hancock,R.E., Lory,S. and Olson,M.V. TITLE Complete genome sequence of Pseudomonas aeruginosa PA01, an opportunistic pathogen JOURNAL Nature 406 (6799), 959-964 (2000) PUBMED 10984043 REFERENCE 11 (residues 1 to 681) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (06-OCT-2010) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 12 (residues 1 to 681) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (08-SEP-2010) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK protein update by submitter REFERENCE 13 (residues 1 to 681) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (02-OCT-2008) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK protein update by submitter REFERENCE 14 (residues 1 to 681) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (05-JUL-2006) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK Sequence update by submitter REFERENCE 15 (residues 1 to 681) AUTHORS Ung,K.S., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (04-FEB-2003) Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REFERENCE 16 (residues 1 to 681) AUTHORS Stover,C.K., Pham,X.-Q.T., Erwin,A.L., Mizoguchi,S.D., Warrener,P., Hickey,M.J., Brinkman,F.S.L., Hufnagle,W.O., Kowalik,D.J., Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R.M., Smith,K.A., Spencer,D.H., Wong,G.K.-S., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H., Hancock,R.E.W., Lory,S. and Olson,M.V. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (16-MAY-2000) Department of Medicine and Genetics, University of Washington Genome Center, University Of Washington, Box 352145, Seattle, WA 98195, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to AAG08199. Method: conceptual translation. FEATURES Location/Qualifiers source 1..681 /organism="Pseudomonas aeruginosa PAO1" /strain="PAO1" /db_xref="taxon:208964" Protein 1..681 /product="2,4-dienoyl-CoA reductase" /calculated_mol_wt=74501 Region 16..368 /region_name="DCR_FMN" /note="2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; cd02930" /db_xref="CDD:239240" Site order(35,37,69,111,175,177,186,225,263,266,321..322,345, 348,352,364) /site_type="active" /db_xref="CDD:239240" Site order(35,37,69,111,225,321..322) /site_type="other" /note="FMN binding site [chemical binding]" /db_xref="CDD:239240" Site order(175,177,186,263,266) /site_type="other" /note="2,4-decadienoyl-CoA binding site" /db_xref="CDD:239240" Site 177 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:239240" Site order(345,348,352,364) /site_type="other" /note="4Fe-4S cluster binding site [ion binding]" /db_xref="CDD:239240" Region <371..>521 /region_name="GltD" /note="NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; COG0493" /db_xref="CDD:440259" Region 409..>638 /region_name="FadH2" /note="NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]; COG0446" /db_xref="CDD:440215" CDS 1..681 /gene="fadH2" /locus_tag="PA4814" /coded_by="NC_002516.2:5403305..5405350" /note="Product name confidence: class 2 (High similarity to functionally studied protein)" /transl_table=11 /db_xref="GeneID:880156" CONTIG join(WP_003112345.1:1..681) ORIGIN 1 mrtpypplaa apyphllapl dlgftrlrnr vvmgsmhtgl edrlwdfgkl aayyrerarg 61 gvglivtggf apcregwllp fgssltsale vpahrrltqa vhaeggkill qilhagrygy 121 hpmavsaspl kspiswftpr elsergirkt irafvrcarl akaaaydgve vmgsegylln 181 qflcprtnrr ddqwggplen rmrlaleivr girrivgqrf ilcyrlslld lveggntwde 241 vrrialalee agitllntgi gwhesrvpti vtsvpraafa evsarlrhel kvpviasnri 301 ntpevaesll atdkadlvsm arplladpqf vakagagrae eintciacnq acldhafanr 361 ratclvnpra afetelryrk artqkriavi gagpaglsaa cvaaerghrv slfeasgeig 421 gqfnlakrip gkeefretlr yfrvrlerlg vdlrlghrvr qgeldgqfdd vvvatgiqpr 481 rpridgiggp tvlsyvdvlr gapvgarvai vgaggigfdv aaflvaapsd gqpralgewl 541 aewgvdldns qpgglrepap trparqvwll qrkpgapgaq lgktsgwvhr ahlrhnavrm 601 lggveylkid ergllirvdg verwlevdnv vicagqeplr elqirqates lrfhliggar 661 vageldakra iregamlaar l