Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]

hypothetical protein PA4735 [Pseudomonas aeruginosa PAO1].


LOCUS       NP_253423               1088 aa            linear   CON 24-JAN-2019
ACCESSION   NP_253423
VERSION     NP_253423.1
DBLINK      BioProject: PRJNA57945
            Assembly: GCF_000006765.1
DBSOURCE    REFSEQ: accession NC_002516.2
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa PAO1
  ORGANISM  Pseudomonas aeruginosa PAO1
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 1088)
  AUTHORS   Winsor,G.L., Van Rossum,T., Lo,R., Khaira,B., Whiteside,M.D.,
            Hancock,R.E. and Brinkman,F.S.
  TITLE     Pseudomonas Genome Database: facilitating user-friendly,
            comprehensive comparisons of microbial genomes
  JOURNAL   Nucleic acids Res. 37 (DATABASE ISSUE), D483-D488 (2009)
   PUBMED   18978025
REFERENCE   2  (residues 1 to 1088)
  AUTHORS   Cirz,R.T., O'Neill,B.M., Hammond,J.A., Head,S.R. and Romesberg,F.E.
  TITLE     Defining the Pseudomonas aeruginosa SOS response and its role in
            the global response to the antibiotic ciprofloxacin
  JOURNAL   J. Bacteriol. 188 (20), 7101-7110 (2006)
   PUBMED   17015649
REFERENCE   3  (residues 1 to 1088)
  AUTHORS   Palmer,K.L., Mashburn,L.M., Singh,P.K. and Whiteley,M.
  TITLE     Cystic fibrosis sputum supports growth and cues key aspects of
            Pseudomonas aeruginosa physiology
  JOURNAL   J. Bacteriol. 187 (15), 5267-5277 (2005)
   PUBMED   16030221
REFERENCE   4  (residues 1 to 1088)
  AUTHORS   Salunkhe,P., Smart,C.H., Morgan,J.A., Panagea,S., Walshaw,M.J.,
            Hart,C.A., Geffers,R., Tummler,B. and Winstanley,C.
  TITLE     A cystic fibrosis epidemic strain of Pseudomonas aeruginosa
            displays enhanced virulence and antimicrobial resistance
  JOURNAL   J. Bacteriol. 187 (14), 4908-4920 (2005)
   PUBMED   15995206
REFERENCE   5  (residues 1 to 1088)
  AUTHORS   Filiatrault,M.J., Wagner,V.E., Bushnell,D., Haidaris,C.G.,
            Iglewski,B.H. and Passador,L.
  TITLE     Effect of anaerobiosis and nitrate on gene expression in
            Pseudomonas aeruginosa
  JOURNAL   Infect. Immun. 73 (6), 3764-3772 (2005)
   PUBMED   15908409
REFERENCE   6  (residues 1 to 1088)
  AUTHORS   Rasmussen,T.B., Bjarnsholt,T., Skindersoe,M.E., Hentzer,M.,
            Kristoffersen,P., Kote,M., Nielsen,J., Eberl,L. and Givskov,M.
  TITLE     Screening for quorum-sensing inhibitors (QSI) by use of a novel
            genetic system, the QSI selector
  JOURNAL   J. Bacteriol. 187 (5), 1799-1814 (2005)
   PUBMED   15716452
REFERENCE   7  (residues 1 to 1088)
  AUTHORS   Winsor,G.L., Lo,R., Sui,S.J., Ung,K.S., Huang,S., Cheng,D.,
            Ching,W.K., Hancock,R.E. and Brinkman,F.S.
  TITLE     Pseudomonas aeruginosa Genome Database and PseudoCap: facilitating
            community-based, continually updated, genome annotation
  JOURNAL   Nucleic acids Res. 33 (DATABASE ISSUE), D338-D343 (2005)
   PUBMED   15608211
REFERENCE   8  (residues 1 to 1088)
  AUTHORS   Wagner,V.E., Bushnell,D., Passador,L., Brooks,A.I. and
            Iglewski,B.H.
  TITLE     Microarray analysis of Pseudomonas aeruginosa quorum-sensing
            regulons: effects of growth phase and environment
  JOURNAL   J. Bacteriol. 185 (7), 2080-2095 (2003)
   PUBMED   12644477
REFERENCE   9  (residues 1 to 1088)
  AUTHORS   Schuster,M., Lostroh,C.P., Ogi,T. and Greenberg,E.P.
  TITLE     Identification, timing, and signal specificity of Pseudomonas
            aeruginosa quorum-controlled genes: a transcriptome analysis
  JOURNAL   J. Bacteriol. 185 (7), 2066-2079 (2003)
   PUBMED   12644476
REFERENCE   10 (residues 1 to 1088)
  AUTHORS   Stover,C.K., Pham,X.Q., Erwin,A.L., Mizoguchi,S.D., Warrener,P.,
            Hickey,M.J., Brinkman,F.S., Hufnagle,W.O., Kowalik,D.J., Lagrou,M.,
            Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y.,
            Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R.,
            Smith,K., Spencer,D., Wong,G.K., Wu,Z., Paulsen,I.T., Reizer,J.,
            Saier,M.H., Hancock,R.E., Lory,S. and Olson,M.V.
  TITLE     Complete genome sequence of Pseudomonas aeruginosa PA01, an
            opportunistic pathogen
  JOURNAL   Nature 406 (6799), 959-964 (2000)
   PUBMED   10984043
REFERENCE   11 (residues 1 to 1088)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-OCT-2010) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   12 (residues 1 to 1088)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (08-SEP-2010) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    protein update by submitter
REFERENCE   13 (residues 1 to 1088)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (02-OCT-2008) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    protein update by submitter
REFERENCE   14 (residues 1 to 1088)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JUL-2006) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    Sequence update by submitter
REFERENCE   15 (residues 1 to 1088)
  AUTHORS   Ung,K.S., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (04-FEB-2003) Department of Molecular Biology and
            Biochemistry, Simon Fraser University, 8888 University Dr.,
            Burnaby, British Columbia V5A 1S6, Canada
REFERENCE   16 (residues 1 to 1088)
  AUTHORS   Stover,C.K., Pham,X.-Q.T., Erwin,A.L., Mizoguchi,S.D., Warrener,P.,
            Hickey,M.J., Brinkman,F.S.L., Hufnagle,W.O., Kowalik,D.J.,
            Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E.,
            Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N.,
            Folger,K.R., Kas,A., Larbig,K., Lim,R.M., Smith,K.A., Spencer,D.H.,
            Wong,G.K.-S., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H.,
            Hancock,R.E.W., Lory,S. and Olson,M.V.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAY-2000) Department of Medicine and Genetics,
            University of Washington Genome Center, University Of Washington,
            Box 352145, Seattle, WA 98195, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AAG08121.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..1088
                     /organism="Pseudomonas aeruginosa PAO1"
                     /strain="PAO1"
                     /db_xref="taxon:208964"
     Protein         1..1088
                     /product="hypothetical protein"
                     /calculated_mol_wt=118460
     Region          2..>330
                     /region_name="YhdR"
                     /note="Uncharacterized conserved protein YhdP, contains
                     DUF3971 and AsmA2 domains [Function unknown]; COG3164"
                     /db_xref="CDD:442397"
     Region          140..>253
                     /region_name="DUF748"
                     /note="Domain of Unknown Function (DUF748); pfam05359"
                     /db_xref="CDD:461629"
     Region          <366..474
                     /region_name="PRK13808"
                     /note="adenylate kinase; Provisional"
                     /db_xref="CDD:172341"
     Region          476..627
                     /region_name="DUF748"
                     /note="Domain of Unknown Function (DUF748); pfam05359"
                     /db_xref="CDD:461629"
     Region          692..841
                     /region_name="DUF748"
                     /note="Domain of Unknown Function (DUF748); pfam05359"
                     /db_xref="CDD:461629"
     Region          749..>941
                     /region_name="OmpA"
                     /note="Outer membrane protein OmpA and related
                     peptidoglycan-associated (lipo)proteins [Cell
                     wall/membrane/envelope biogenesis]; COG2885"
                     /db_xref="CDD:442131"
     CDS             1..1088
                     /locus_tag="PA4735"
                     /coded_by="NC_002516.2:5318575..5321841"
                     /note="'Product name confidence: class 4 (Homologs of
                     previously reported genes of unknown function, or no
                     similarity to any previously reported sequences)'"
                     /transl_table=11
                     /db_xref="GeneID:881654"
CONTIG      join(WP_003113909.1:1..1088)
ORIGIN      
        1 mpkglkravs allitflvyc llgfllipgi glrvanqqla qyatvparle riefnpfsle
       61 ltlwglrlge eknpqlafrr lyanlqldsl wkrqlhladv elegphtell fgekgqlnla
      121 slfrippses pepeqpsdpf plridriqla egslhfqdlr psepvdfsfd plgfelhnls
      181 tlpddgakmt lvatgpnggr ldwegdltlv pitsrghlsv kdiqlkawwp yvrdnaplvl
      241 engvvslssd yrldlskdtq llldkaalkl adfsinspqg kplaklasld vaattldlak
      301 qevvlgevrs qgleawaare kdgqldwqkl fadftppprk apapkpaent dpaaaptdaa
      361 kttsepatdg aakaaaiasg easkdrpaek dasvaetera tddkesakaa egaadkvakq
      421 etskapktgk atgqetakta eidkaasdsp qqladtaktp ppestkasae tpakpwnivl
      481 rdaqlrgyka hlvdrqpate vplevgpldl dlqnvdslgk tpfdlklktg lgnrgqvqas
      541 gqvvldpvsa rlkvstrdid lrvaqayisp firlelrsgf lgselavdlk sveplafsvd
      601 gsaevsqlht ldtikdrdfv kwtkltlngl ayrhedslsi qsvsfeepya rfiinedrst
      661 nvseliipqp asssgktaae sknapaskpl gihiggvrin ngsanfadlt lmppfgtaiq
      721 qlsgevgtld trnsqpakvd ikgkvdkyap vtiageldpf dplkklditt sfkrvelttl
      781 tpysgkfagy rirkgrlnld lhyqiersql kaenkvlleg lqlgekvdsp davdlpvkla
      841 vallkdtkgn idiqlpvagd lnnpefsvmp ivwqtlrnlv lravqapfkf iaglaaggne
      901 dlgtvpfaag sdeltpeaqa nldkladalk erpalrleve gvasaaadgp sigakrlele
      961 yqntyyrmlq rrgdkvpsda kqlevpenmq apllegiyrt rlkqqppaew keldsderta
     1021 kmreaviasw aksqvllrqi gqaratrikd ylvekgqlpd driylidvsf aegedkgnvd
     1081 tqlhldse