Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]
LOCUS NP_252767 991 aa linear CON 24-JAN-2019 ACCESSION NP_252767 VERSION NP_252767.1 DBLINK BioProject: PRJNA57945 Assembly: GCF_000006765.1 DBSOURCE REFSEQ: accession NC_002516.2 KEYWORDS RefSeq. SOURCE Pseudomonas aeruginosa PAO1 ORGANISM Pseudomonas aeruginosa PAO1 Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. REFERENCE 1 (residues 1 to 991) AUTHORS Winsor,G.L., Van Rossum,T., Lo,R., Khaira,B., Whiteside,M.D., Hancock,R.E. and Brinkman,F.S. TITLE Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes JOURNAL Nucleic acids Res. 37 (DATABASE ISSUE), D483-D488 (2009) PUBMED 18978025 REFERENCE 2 (residues 1 to 991) AUTHORS Cirz,R.T., O'Neill,B.M., Hammond,J.A., Head,S.R. and Romesberg,F.E. TITLE Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin JOURNAL J. Bacteriol. 188 (20), 7101-7110 (2006) PUBMED 17015649 REFERENCE 3 (residues 1 to 991) AUTHORS Palmer,K.L., Mashburn,L.M., Singh,P.K. and Whiteley,M. TITLE Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology JOURNAL J. Bacteriol. 187 (15), 5267-5277 (2005) PUBMED 16030221 REFERENCE 4 (residues 1 to 991) AUTHORS Salunkhe,P., Smart,C.H., Morgan,J.A., Panagea,S., Walshaw,M.J., Hart,C.A., Geffers,R., Tummler,B. and Winstanley,C. TITLE A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance JOURNAL J. Bacteriol. 187 (14), 4908-4920 (2005) PUBMED 15995206 REFERENCE 5 (residues 1 to 991) AUTHORS Filiatrault,M.J., Wagner,V.E., Bushnell,D., Haidaris,C.G., Iglewski,B.H. and Passador,L. TITLE Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa JOURNAL Infect. Immun. 73 (6), 3764-3772 (2005) PUBMED 15908409 REFERENCE 6 (residues 1 to 991) AUTHORS Rasmussen,T.B., Bjarnsholt,T., Skindersoe,M.E., Hentzer,M., Kristoffersen,P., Kote,M., Nielsen,J., Eberl,L. and Givskov,M. TITLE Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector JOURNAL J. Bacteriol. 187 (5), 1799-1814 (2005) PUBMED 15716452 REFERENCE 7 (residues 1 to 991) AUTHORS Winsor,G.L., Lo,R., Sui,S.J., Ung,K.S., Huang,S., Cheng,D., Ching,W.K., Hancock,R.E. and Brinkman,F.S. TITLE Pseudomonas aeruginosa Genome Database and PseudoCap: facilitating community-based, continually updated, genome annotation JOURNAL Nucleic acids Res. 33 (DATABASE ISSUE), D338-D343 (2005) PUBMED 15608211 REFERENCE 8 (residues 1 to 991) AUTHORS Wagner,V.E., Bushnell,D., Passador,L., Brooks,A.I. and Iglewski,B.H. TITLE Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment JOURNAL J. Bacteriol. 185 (7), 2080-2095 (2003) PUBMED 12644477 REFERENCE 9 (residues 1 to 991) AUTHORS Schuster,M., Lostroh,C.P., Ogi,T. and Greenberg,E.P. TITLE Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis JOURNAL J. Bacteriol. 185 (7), 2066-2079 (2003) PUBMED 12644476 REFERENCE 10 (residues 1 to 991) AUTHORS Stover,C.K., Pham,X.Q., Erwin,A.L., Mizoguchi,S.D., Warrener,P., Hickey,M.J., Brinkman,F.S., Hufnagle,W.O., Kowalik,D.J., Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R., Smith,K., Spencer,D., Wong,G.K., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H., Hancock,R.E., Lory,S. and Olson,M.V. TITLE Complete genome sequence of Pseudomonas aeruginosa PA01, an opportunistic pathogen JOURNAL Nature 406 (6799), 959-964 (2000) PUBMED 10984043 REFERENCE 11 (residues 1 to 991) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (06-OCT-2010) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 12 (residues 1 to 991) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (08-SEP-2010) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK protein update by submitter REFERENCE 13 (residues 1 to 991) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (02-OCT-2008) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK protein update by submitter REFERENCE 14 (residues 1 to 991) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (05-JUL-2006) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK Sequence update by submitter REFERENCE 15 (residues 1 to 991) AUTHORS Ung,K.S., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (04-FEB-2003) Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REFERENCE 16 (residues 1 to 991) AUTHORS Stover,C.K., Pham,X.-Q.T., Erwin,A.L., Mizoguchi,S.D., Warrener,P., Hickey,M.J., Brinkman,F.S.L., Hufnagle,W.O., Kowalik,D.J., Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R.M., Smith,K.A., Spencer,D.H., Wong,G.K.-S., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H., Hancock,R.E.W., Lory,S. and Olson,M.V. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (16-MAY-2000) Department of Medicine and Genetics, University of Washington Genome Center, University Of Washington, Box 352145, Seattle, WA 98195, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to AAG07465. Method: conceptual translation. FEATURES Location/Qualifiers source 1..991 /organism="Pseudomonas aeruginosa PAO1" /strain="PAO1" /db_xref="taxon:208964" Protein 1..991 /product="nonribosomal peptide synthetase" /calculated_mol_wt=110225 Region 10..489 /region_name="A_NRPS_VisG_like" /note="similar to adenylation domain of virginiamycin S synthetase; cd17651" /db_xref="CDD:341306" Site order(146,149..154,156..157) /site_type="other" /note="acyl-activating enzyme (AAE) consensus motif" /db_xref="CDD:341306" Site order(149..150,264..265,281..286,308,372,384,387,482) /site_type="other" /note="AMP binding site [chemical binding]" /db_xref="CDD:341306" Region 517..570 /region_name="PP-binding" /note="Phosphopantetheine attachment site; pfam00550" /db_xref="CDD:425746" Region 620..990 /region_name="Thioester-redct" /note="thioester reductase domain; TIGR01746" /db_xref="CDD:273787" CDS 1..991 /locus_tag="PA4078" /coded_by="NC_002516.2:4555254..4558229" /note="'Product name confidence: class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene)'" /transl_table=11 /db_xref="GeneID:878689" CONTIG join(WP_003113040.1:1..991) ORIGIN 1 mskdsvlglf rqhadthper palvdrersf syreldrlsd rlaahlarrg vargellpll 61 aersaelvia ilaaakcaaa yvpvdrrqpd rrkrevlrqc qaplalatha edlpgqpvev 121 iaqalatsaa gaaprpaldg sealyvifts gttgepkgvv iesrslanlv gwhnrrfnmd 181 qrsrttlmag vgfdvsqwei wstlcagacl hlvpdevrpd paallaffae qrishafapt 241 vmvpalaeqp appslalryl fcageklppv atgglpytvv dyygpteatv fatcrivdae 301 ahrrpasigt pidgceafil daddrpchgd rpgelnlagv clareylrdp dmtarrfhys 361 qalrrrlyrt gdkarwladg slqflgrldd qvkirghrve lgdveaallr qpaihgavvl 421 ahadprsgsq qlsafvvprq qdgdaravla aiktalrqel pdymlpsryl sldslpttvn 481 gkidrqalrr hldeqcqerl deqrfgtpge lqvalswqev lghtdfgldd sffevgghsl 541 laaalvrels rrfgnrayih diyrtpsvrq laaslarrag eappaldsep aqelqrdvrl 601 padvdfsrpt dtaqllaprh illtgasglm gahllaella sreadlhcpv raqndahale 661 rlrqaarqhr ielaetdwrr vrayaadlae pgfglpaety relagsvdqv fhsasavnfi 721 qpysymkrdn veglgqvlrf casgrckplm llssisvysw ghlhtgkrlm redddidqnl 781 pavvtdmgyv rskwvmekia dlaaerglpl mtfrlgyatc hsrtgayady qwwsrlartc 841 leyravpllr elreglttvd ymveaisvia rqpsalgkkf nlvpsiprcl tldeffgrlg 901 rragrplrqm pfddwvslwe dnrdaplypl lsmfrdnmya grstvelyqd tylwdctnve 961 ehlrgsavre pefddrlldl ylaglggsam r