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peptide synthase [Pseudomonas aeruginosa PAO1].


LOCUS       NP_251114               4342 aa            linear   CON 24-JAN-2019
ACCESSION   NP_251114
VERSION     NP_251114.1
DBLINK      BioProject: PRJNA57945
            Assembly: GCF_000006765.1
DBSOURCE    REFSEQ: accession NC_002516.2
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa PAO1
  ORGANISM  Pseudomonas aeruginosa PAO1
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 4342)
  AUTHORS   Winsor,G.L., Van Rossum,T., Lo,R., Khaira,B., Whiteside,M.D.,
            Hancock,R.E. and Brinkman,F.S.
  TITLE     Pseudomonas Genome Database: facilitating user-friendly,
            comprehensive comparisons of microbial genomes
  JOURNAL   Nucleic acids Res. 37 (DATABASE ISSUE), D483-D488 (2009)
   PUBMED   18978025
REFERENCE   2  (residues 1 to 4342)
  AUTHORS   Cirz,R.T., O'Neill,B.M., Hammond,J.A., Head,S.R. and Romesberg,F.E.
  TITLE     Defining the Pseudomonas aeruginosa SOS response and its role in
            the global response to the antibiotic ciprofloxacin
  JOURNAL   J. Bacteriol. 188 (20), 7101-7110 (2006)
   PUBMED   17015649
REFERENCE   3  (residues 1 to 4342)
  AUTHORS   Palmer,K.L., Mashburn,L.M., Singh,P.K. and Whiteley,M.
  TITLE     Cystic fibrosis sputum supports growth and cues key aspects of
            Pseudomonas aeruginosa physiology
  JOURNAL   J. Bacteriol. 187 (15), 5267-5277 (2005)
   PUBMED   16030221
REFERENCE   4  (residues 1 to 4342)
  AUTHORS   Salunkhe,P., Smart,C.H., Morgan,J.A., Panagea,S., Walshaw,M.J.,
            Hart,C.A., Geffers,R., Tummler,B. and Winstanley,C.
  TITLE     A cystic fibrosis epidemic strain of Pseudomonas aeruginosa
            displays enhanced virulence and antimicrobial resistance
  JOURNAL   J. Bacteriol. 187 (14), 4908-4920 (2005)
   PUBMED   15995206
REFERENCE   5  (residues 1 to 4342)
  AUTHORS   Filiatrault,M.J., Wagner,V.E., Bushnell,D., Haidaris,C.G.,
            Iglewski,B.H. and Passador,L.
  TITLE     Effect of anaerobiosis and nitrate on gene expression in
            Pseudomonas aeruginosa
  JOURNAL   Infect. Immun. 73 (6), 3764-3772 (2005)
   PUBMED   15908409
REFERENCE   6  (residues 1 to 4342)
  AUTHORS   Rasmussen,T.B., Bjarnsholt,T., Skindersoe,M.E., Hentzer,M.,
            Kristoffersen,P., Kote,M., Nielsen,J., Eberl,L. and Givskov,M.
  TITLE     Screening for quorum-sensing inhibitors (QSI) by use of a novel
            genetic system, the QSI selector
  JOURNAL   J. Bacteriol. 187 (5), 1799-1814 (2005)
   PUBMED   15716452
REFERENCE   7  (residues 1 to 4342)
  AUTHORS   Winsor,G.L., Lo,R., Sui,S.J., Ung,K.S., Huang,S., Cheng,D.,
            Ching,W.K., Hancock,R.E. and Brinkman,F.S.
  TITLE     Pseudomonas aeruginosa Genome Database and PseudoCap: facilitating
            community-based, continually updated, genome annotation
  JOURNAL   Nucleic acids Res. 33 (DATABASE ISSUE), D338-D343 (2005)
   PUBMED   15608211
REFERENCE   8  (residues 1 to 4342)
  AUTHORS   Wagner,V.E., Bushnell,D., Passador,L., Brooks,A.I. and
            Iglewski,B.H.
  TITLE     Microarray analysis of Pseudomonas aeruginosa quorum-sensing
            regulons: effects of growth phase and environment
  JOURNAL   J. Bacteriol. 185 (7), 2080-2095 (2003)
   PUBMED   12644477
REFERENCE   9  (residues 1 to 4342)
  AUTHORS   Schuster,M., Lostroh,C.P., Ogi,T. and Greenberg,E.P.
  TITLE     Identification, timing, and signal specificity of Pseudomonas
            aeruginosa quorum-controlled genes: a transcriptome analysis
  JOURNAL   J. Bacteriol. 185 (7), 2066-2079 (2003)
   PUBMED   12644476
REFERENCE   10 (residues 1 to 4342)
  AUTHORS   Stover,C.K., Pham,X.Q., Erwin,A.L., Mizoguchi,S.D., Warrener,P.,
            Hickey,M.J., Brinkman,F.S., Hufnagle,W.O., Kowalik,D.J., Lagrou,M.,
            Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y.,
            Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R.,
            Smith,K., Spencer,D., Wong,G.K., Wu,Z., Paulsen,I.T., Reizer,J.,
            Saier,M.H., Hancock,R.E., Lory,S. and Olson,M.V.
  TITLE     Complete genome sequence of Pseudomonas aeruginosa PA01, an
            opportunistic pathogen
  JOURNAL   Nature 406 (6799), 959-964 (2000)
   PUBMED   10984043
REFERENCE   11 (residues 1 to 4342)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-OCT-2010) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   12 (residues 1 to 4342)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (08-SEP-2010) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    protein update by submitter
REFERENCE   13 (residues 1 to 4342)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (02-OCT-2008) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    protein update by submitter
REFERENCE   14 (residues 1 to 4342)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JUL-2006) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    Sequence update by submitter
REFERENCE   15 (residues 1 to 4342)
  AUTHORS   Ung,K.S., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (04-FEB-2003) Department of Molecular Biology and
            Biochemistry, Simon Fraser University, 8888 University Dr.,
            Burnaby, British Columbia V5A 1S6, Canada
REFERENCE   16 (residues 1 to 4342)
  AUTHORS   Stover,C.K., Pham,X.-Q.T., Erwin,A.L., Mizoguchi,S.D., Warrener,P.,
            Hickey,M.J., Brinkman,F.S.L., Hufnagle,W.O., Kowalik,D.J.,
            Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E.,
            Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N.,
            Folger,K.R., Kas,A., Larbig,K., Lim,R.M., Smith,K.A., Spencer,D.H.,
            Wong,G.K.-S., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H.,
            Hancock,R.E.W., Lory,S. and Olson,M.V.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAY-2000) Department of Medicine and Genetics,
            University of Washington Genome Center, University Of Washington,
            Box 352145, Seattle, WA 98195, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AAG05812.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..4342
                     /organism="Pseudomonas aeruginosa PAO1"
                     /strain="PAO1"
                     /db_xref="taxon:208964"
     Protein         1..4342
                     /product="peptide synthase"
                     /calculated_mol_wt=480168
     Region          1..4342
                     /region_name="PRK05691"
                     /note="peptide synthase; Validated"
                     /db_xref="CDD:235564"
     CDS             1..4342
                     /gene="pvdL"
                     /locus_tag="PA2424"
                     /coded_by="complement(NC_002516.2:2707666..2720694)"
                     /note="Product name confidence: class 1 (Function
                     experimentally demonstrated in P. aeruginosa)"
                     /transl_table=11
                     /db_xref="GeneID:882838"
CONTIG      join(WP_003115540.1:1..4342)
ORIGIN      
        1 mmdafelptt lvqalrrrav qeperlalrf laeddgegvv lsyrdldlra rsiaaalqah
       61 aqlgdravll fpsgpdyvaa ffgclyagvi avpayppesa rrhhqerlls iiadaeprlv
      121 lttadlrepl lqmnaqlsaa napqllcvdq ldpavaeawd epqvrpehia flqytsgsta
      181 lpkgvqvshg nlvanevlir rgfgigaddv ivswlplyhd mgliggllqp ifsgvpcvlm
      241 spryflerpv rwleaisqyg gtvsggpdfa yrlcservae salqrldlsg wrvafsgsep
      301 irqdslerfa ekfaasrfda ssffacygla eatlfvtggq rgqgipalav dgealarnri
      361 aegegsvlmc cgrsqpehav livdaasgev lgddnvgeiw aagpsiahgy wrnpeasaka
      421 fverdgrtwl rtgdlgflrd gelfvtgrlk dmlivrghnl ypqdiertve sevpsarkgr
      481 vaafavtvdg eegigiaaei grgvqksvpa qelidsirqa vaeayqeapk vvallnpgal
      541 pktssgklqr sacrlrledg sldsyalfpg lqavqeaqpp agddellari geiwkarlgv
      601 aqvaprdhff llggnsigaa qvvaqvrdsl gvaldlrqlf eaptlqafsa tvarqlaagl
      661 paeapmahlp rgvdlpqsaa qqrlwltwqi dpqsaaynip gglrlrgeld eaalrasfqr
      721 lverhealrt rflerdgaal qridergefa wqfvdlaala eheraaaaaq rreaeaqqpf
      781 dlekgpllrv slvrldeqeh qlwvtlhhiv adgwslnlll defsrlyaea cggqpadlap
      841 lelhyaefaa wqrqwldage garqlaywre rlgdtapvle latdhprtar qaspaarysl
      901 rvdealarai reaaldheas vfmwllaafq allhrhsgqg eirigvpsan rqrletqglv
      961 gffintlvlr gtprarqpfa allgeareat lgaqanqdlp fdqvlaacgq ggqlfqvlfn
     1021 hqqrdlsalr rlpglladel pwhsreakfd lqlqseedar grltlnfdya adlfdeasir
     1081 rfaaqylell rqvaedpqrc lgdialvdae qaahlaewgs apceparawl pellerqlaq
     1141 saervalewd ggslgyaelh aranrlahyl rdkgvgpdvr vaicaerspq llvgllaivk
     1201 aggayvpldp dypserlaym ladsgvelll tqahlferlp gaegvtpicl dslkldnwps
     1261 qapglhlhgd nlayviytsg stgqpkgvgn thaalaerlq wmqatytldg ddvlmqkapv
     1321 sfdvsvwecf wplvtgcrlv laapgehrdp arlvelvrqf gvttlhfvpp llqlfidepg
     1381 vaacgslrrl fsggealpae lrnrvlqrlp avalhnrygp tetainvthw qcraedgers
     1441 pigrplgnvv crvldaefnl lpagvagelc igglglargy lgrpalsaer fvadpfsaag
     1501 erlyrtgdra rwnadgvley lgrldqqvkl rgfriepeei qarllaqpgv aqavvvireg
     1561 vagsqlvgyy tgavgaeaea eqnqrlraal qaelpeymvp tqlmrlaqmp lgpsgkldtr
     1621 alpepvwqqr ehveprtelq rriaaiwsev lglprvglrd dffelgghsl latrivsrtr
     1681 qacdvelplr alfeaselea fceqvraaqa agrtdshgai rridreqpvp lsysqqrmwf
     1741 lwqlepdspa ynvgglarls gpldvarfea alqalvqrhe tlrttfpsvd gvpvqrvhgd
     1801 gglhmdwqdf saldrdsrqq hlqtladsea hrpfdlesgp llrvcmvkma erehylvvtl
     1861 hhivtegwam difarelgal yeaflddres pleplpvqyl dysvwqrewl esgerqrqld
     1921 ywkaqlgneh pllelpgdrp rppvqshqgd lyrfdlspel aervrrfnaa rgltmfmtmt
     1981 atlaallyry sgqqdlriga pvanrirpes egligaflnt qvlrcrldgq msvgelleqv
     2041 rqtvidgqsh qdlpfdhlve alqpprsaay nplfqvmcnv qrwefqqtrq lagmtveyia
     2101 ndaratkfdl nlevtdldqr lgccltysrd lfdepriarm aghwqnllea llgdpqrria
     2161 elplfaaeer kqlllagtag eaglqdtlhg lfaarvaasp qapaltfagq tlsyaeldar
     2221 snrlarvlrs hgvgpevrvg lalerslemv vgllailkag gayvpldpey plerlqymie
     2281 dsgvrlllsh aalfealgel pagvarwcle edgpaldaed paplaalsgp qhqayliyts
     2341 gstgkpkgva vshgeiamhc aaviecfgmr aedcelhfys infdaaserl lapllcgarv
     2401 vlraqgqwga eeicelirae gvsilgftps ygsqlaqwle sqgrqlpvrm citggealtg
     2461 ehlqrirqaf apasffnayg ptetvvmpla claperleeg aasvpigsvv garvayilda
     2521 dlalvpqgat gelyvggagl argyherpal saerfvpdpf aaeggrlyrt gdlvrlcdng
     2581 qveyvgridh qvkirgfrie lgeiearlle hpqvrealvl aldspsgkql agyvasavae
     2641 qdedaqaalr ealkthlkqq lpdymvpahl lllaslplta ngkldrralp apdpalnrqa
     2701 yeaprsvleq qlagvwrevl nvervglgdn ffelggdsil siqvvsrarq lgihfsprdl
     2761 fqhqtvqsla avarhsqasq aeqgpvqgds altpiqhwff dlplarrehw nqalllqprq
     2821 aidlgllrks lqrlveqhda lrlafrqvdg ewlaqhrplr eqellwhvpv qsfdecaelf
     2881 akaqrsldle qgpllravlv dgpageqrll laihhlvvdg vswrvlledl qqvyrqfaeg
     2941 aepalpakts afrdwagrlq ayagseslre elgwwqarlg gqpvewpcdr pqgdnreala
     3001 esvslrldpq rtrqllqqap aayrtqvndl lltalarvlc rwsgqpstlv qleghgreal
     3061 fddidltrsv gwftsayplr ltpaqspges ikaikeqlra vphkglgygv lryladpavr
     3121 qamaalptap itfnylgqfd qsfadalfqp ldqptgpihd eqaplpnels vdgqvyggel
     3181 vlrwtysrer ydartvnela qaylaelqal iehcledgag gltpsdfpla qlsqaqldal
     3241 avpageiedv ypltpmqegl llhtllepgt giyymqdryr idspldperf aaawqavvar
     3301 healrasfvw nagetmlqvi hkpgrtrief ldwselpedg heerlqalhk rereagfdll
     3361 eqppfhlrli rlgearywfm msnhhilida wcrgllmndf feiysalges rpanlptppr
     3421 yrdyiawlqr qdleqsrrww seslrgferp tlvpsdrpfl rehagesggm ivgdrytrld
     3481 aadgarlrel aqryqltvnt faqaawaltl rrfsgerdvl fgvtvagrpv gmpemqrtvg
     3541 lfinsiplrv qmpaagqrct vrewlnrlfe rnlelreheh lplvaiqess elpkgqplfd
     3601 slfvfenapv evsvldraqs lnassdsgrt htnfpltvvc ypgddlglhl sydqryfeap
     3661 tverllgefk rlllaladgf hgelealpll gederdflld gcnrsardyp leqgyvrlfe
     3721 aqvaahpqri aascleqrws yaelnrranr lghalraagv gidqpvalla ergldllgmi
     3781 vgsfkagagy lpldpghptq rltrivelsr tlvlvctqac reqalalfde lgcvdrprll
     3841 vwdeiqqgeg aehdpqvysg pqnlayviyt sgstglpkgv mveqagmlnn qlskvpylel
     3901 dendviaqta sqsfdisvwq flaaplfgar vaivpnavah dpqgllahvg eqgitvlesv
     3961 psliqgmlae erqaldglrw mlptgeampp elarqwlkry priglvnayg paecsddvaf
     4021 frvdlastes tylpigsptd nnrlyllgag addafelvpl gavgelcvag tgvgrgyvgd
     4081 plrtaqafvp hpfgapgerl yrtgdlarrr adgvleyvgr idhqvkirgf rielgeiear
     4141 lheradvrea avavqegang kylvgylvpg etprssadsp aglmveqgaw ferikqqlra
     4201 dlpdymvplh wlvldrmpln angkldrkal paldigqmqn qayqaprnel eetlariwae
     4261 vlkvervgvf dnffelgghs llatqiasrv qkalqrnvpl ramfecttve elasyiesla
     4321 pseiseqkae rlndlmskle ml