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peptide synthase [Pseudomonas aeruginosa PAO1].


LOCUS       NP_251092               5149 aa            linear   CON 24-JAN-2019
ACCESSION   NP_251092
VERSION     NP_251092.1
DBLINK      BioProject: PRJNA57945
            Assembly: GCF_000006765.1
DBSOURCE    REFSEQ: accession NC_002516.2
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa PAO1
  ORGANISM  Pseudomonas aeruginosa PAO1
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 5149)
  AUTHORS   Winsor,G.L., Van Rossum,T., Lo,R., Khaira,B., Whiteside,M.D.,
            Hancock,R.E. and Brinkman,F.S.
  TITLE     Pseudomonas Genome Database: facilitating user-friendly,
            comprehensive comparisons of microbial genomes
  JOURNAL   Nucleic acids Res. 37 (DATABASE ISSUE), D483-D488 (2009)
   PUBMED   18978025
REFERENCE   2  (residues 1 to 5149)
  AUTHORS   Cirz,R.T., O'Neill,B.M., Hammond,J.A., Head,S.R. and Romesberg,F.E.
  TITLE     Defining the Pseudomonas aeruginosa SOS response and its role in
            the global response to the antibiotic ciprofloxacin
  JOURNAL   J. Bacteriol. 188 (20), 7101-7110 (2006)
   PUBMED   17015649
REFERENCE   3  (residues 1 to 5149)
  AUTHORS   Palmer,K.L., Mashburn,L.M., Singh,P.K. and Whiteley,M.
  TITLE     Cystic fibrosis sputum supports growth and cues key aspects of
            Pseudomonas aeruginosa physiology
  JOURNAL   J. Bacteriol. 187 (15), 5267-5277 (2005)
   PUBMED   16030221
REFERENCE   4  (residues 1 to 5149)
  AUTHORS   Salunkhe,P., Smart,C.H., Morgan,J.A., Panagea,S., Walshaw,M.J.,
            Hart,C.A., Geffers,R., Tummler,B. and Winstanley,C.
  TITLE     A cystic fibrosis epidemic strain of Pseudomonas aeruginosa
            displays enhanced virulence and antimicrobial resistance
  JOURNAL   J. Bacteriol. 187 (14), 4908-4920 (2005)
   PUBMED   15995206
REFERENCE   5  (residues 1 to 5149)
  AUTHORS   Filiatrault,M.J., Wagner,V.E., Bushnell,D., Haidaris,C.G.,
            Iglewski,B.H. and Passador,L.
  TITLE     Effect of anaerobiosis and nitrate on gene expression in
            Pseudomonas aeruginosa
  JOURNAL   Infect. Immun. 73 (6), 3764-3772 (2005)
   PUBMED   15908409
REFERENCE   6  (residues 1 to 5149)
  AUTHORS   Rasmussen,T.B., Bjarnsholt,T., Skindersoe,M.E., Hentzer,M.,
            Kristoffersen,P., Kote,M., Nielsen,J., Eberl,L. and Givskov,M.
  TITLE     Screening for quorum-sensing inhibitors (QSI) by use of a novel
            genetic system, the QSI selector
  JOURNAL   J. Bacteriol. 187 (5), 1799-1814 (2005)
   PUBMED   15716452
REFERENCE   7  (residues 1 to 5149)
  AUTHORS   Winsor,G.L., Lo,R., Sui,S.J., Ung,K.S., Huang,S., Cheng,D.,
            Ching,W.K., Hancock,R.E. and Brinkman,F.S.
  TITLE     Pseudomonas aeruginosa Genome Database and PseudoCap: facilitating
            community-based, continually updated, genome annotation
  JOURNAL   Nucleic acids Res. 33 (DATABASE ISSUE), D338-D343 (2005)
   PUBMED   15608211
REFERENCE   8  (residues 1 to 5149)
  AUTHORS   Wagner,V.E., Bushnell,D., Passador,L., Brooks,A.I. and
            Iglewski,B.H.
  TITLE     Microarray analysis of Pseudomonas aeruginosa quorum-sensing
            regulons: effects of growth phase and environment
  JOURNAL   J. Bacteriol. 185 (7), 2080-2095 (2003)
   PUBMED   12644477
REFERENCE   9  (residues 1 to 5149)
  AUTHORS   Schuster,M., Lostroh,C.P., Ogi,T. and Greenberg,E.P.
  TITLE     Identification, timing, and signal specificity of Pseudomonas
            aeruginosa quorum-controlled genes: a transcriptome analysis
  JOURNAL   J. Bacteriol. 185 (7), 2066-2079 (2003)
   PUBMED   12644476
REFERENCE   10 (residues 1 to 5149)
  AUTHORS   Stover,C.K., Pham,X.Q., Erwin,A.L., Mizoguchi,S.D., Warrener,P.,
            Hickey,M.J., Brinkman,F.S., Hufnagle,W.O., Kowalik,D.J., Lagrou,M.,
            Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y.,
            Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R.,
            Smith,K., Spencer,D., Wong,G.K., Wu,Z., Paulsen,I.T., Reizer,J.,
            Saier,M.H., Hancock,R.E., Lory,S. and Olson,M.V.
  TITLE     Complete genome sequence of Pseudomonas aeruginosa PA01, an
            opportunistic pathogen
  JOURNAL   Nature 406 (6799), 959-964 (2000)
   PUBMED   10984043
REFERENCE   11 (residues 1 to 5149)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-OCT-2010) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   12 (residues 1 to 5149)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (08-SEP-2010) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    protein update by submitter
REFERENCE   13 (residues 1 to 5149)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (02-OCT-2008) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    protein update by submitter
REFERENCE   14 (residues 1 to 5149)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JUL-2006) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    Sequence update by submitter
REFERENCE   15 (residues 1 to 5149)
  AUTHORS   Ung,K.S., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (04-FEB-2003) Department of Molecular Biology and
            Biochemistry, Simon Fraser University, 8888 University Dr.,
            Burnaby, British Columbia V5A 1S6, Canada
REFERENCE   16 (residues 1 to 5149)
  AUTHORS   Stover,C.K., Pham,X.-Q.T., Erwin,A.L., Mizoguchi,S.D., Warrener,P.,
            Hickey,M.J., Brinkman,F.S.L., Hufnagle,W.O., Kowalik,D.J.,
            Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E.,
            Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N.,
            Folger,K.R., Kas,A., Larbig,K., Lim,R.M., Smith,K.A., Spencer,D.H.,
            Wong,G.K.-S., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H.,
            Hancock,R.E.W., Lory,S. and Olson,M.V.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAY-2000) Department of Medicine and Genetics,
            University of Washington Genome Center, University Of Washington,
            Box 352145, Seattle, WA 98195, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AAG05790.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..5149
                     /organism="Pseudomonas aeruginosa PAO1"
                     /strain="PAO1"
                     /db_xref="taxon:208964"
     Protein         1..5149
                     /product="peptide synthase"
                     /calculated_mol_wt=569057
     Region          1..5149
                     /region_name="PRK12316"
                     /note="peptide synthase; Provisional"
                     /db_xref="CDD:237054"
     CDS             1..5149
                     /locus_tag="PA2402"
                     /coded_by="complement(NC_002516.2:2671729..2687178)"
                     /note="'Product name confidence: class 3 (Function
                     proposed based on presence of conserved amino acid motif,
                     structural feature or limited sequence similarity to an
                     experimentally studied gene)'"
                     /transl_table=11
                     /db_xref="GeneID:878257"
CONTIG      join(WP_010895613.1:1..5149)
ORIGIN      
        1 mnaedslkla rrfielpvek rrvfletlrg egidfslfpi pagvssaerd rlsyaqqrmw
       61 flwhlepqsg aynlpsavrl ngpldrqale rafaslvqrh etlrtvfprg addslaqapl
      121 qrplevafed csglpedeqe arlreeaqre slqpfdlceg pllrvrlirl geerhvlllt
      181 lhhivsdgws mnvlieefsr fysayatgae pglpalpiqy adyalwqrsw leageqerql
      241 eywrgklger hpvlelptdh prpavpsyrg sryefsiepa laealrgtar rqgltlfmll
      301 lggfnillqr ysgqtdlrvg vpianrnrae vegliglfvn tqvlrsvfdg rtsvatllag
      361 lkdtvlgaqa hqdlpferlv eafkversls hsplfqvmyn hqplvadiea ldsvaglsfg
      421 qldwksrttq fdlsldtyek ggrlyaalty atdlfeartv ermarhwqnl lrgmlenpqa
      481 svdslpmlda eergqllegw nataaeyplq rgvhrlfeeq vertptapal afgeerldya
      541 elnrranrla haliergvga drlvgvamer siemvvalma ilkaggayvp vdpeypeerq
      601 aymledsgvq lllsqshlkl plaqgvqrid ldqadawlen haennpgvel ngenlayviy
      661 tsgstgkpkg agnrhsalsn rlcwmqqayg lgvgdtvlqk tpfsfdvsvw effwplmsga
      721 rlvvaapgdh rdpaklveli nregvdtlhf vpsmlqaflq dedvasctsl krivcsgeal
      781 padaqqqvfa klpqaglynl ygpteaaidv thwtcveegk davpigrpia nlacyildgn
      841 lepvpvgvlg elylagrgla rgyhqrpglt aerfvaspfv agermyrtgd laryradgvi
      901 eyagridhqv klrglrielg eiearllehp wvreaavlav dgkqlvgyvv leseggdwre
      961 alaahlatsl peymvpaqwl alermplspn gkldrkalpa pevsvaqagy saprnavert
     1021 laeiwqdllg veqvglddnf fslggdsivs iqvvsrarqa glqlsprdlf qhqnirslal
     1081 aakagaatae qgpasgeval apvqrwffeq sipnrqhwnq slllqarqpl dgdrlgrale
     1141 rlqaqhdalr lrfreergaw hqayaeqage plwrrqagse evllalceea qrsldleqgp
     1201 llrallvdma dgsqrlllvi hhlavdgvsw rilledlqrl yadldadlgp rsssyqawsr
     1261 hlheqagarl deldywqaql hdaphalpce nphgalenrh erklvltlda ertrqllqea
     1321 paayrtqvnd llltalarat crwsgdasvl vqleghgred lgeaidlsrt vgwftslfpl
     1381 rltpaadlge slkaikeqlr gvpdkgvgyg llrylageea atrlaalpqp ritfnylgrf
     1441 drqfdgaall vpatesagaa qdpcaplanw lsiegqvygg elslhwsfsr emfaeatvqr
     1501 lvddyarelh aliehcldpr hrgvtpsdfp laglsqtqld elsldpdsvr diyplspmqq
     1561 gmlfhslhgt egdyvnqlrm diggldpdrf raawqatlda heilrsgflw kdgwpqplqv
     1621 vfeqatlelr lappgsdpqr qaeaereagf dparaplqrl vlvplangrm hliytyhhil
     1681 mdgwsnaqll aevlqryagq evaatvgryr dyigwlqsrd akatesfwrd rlaslemptr
     1741 larqarteqp gqgehlreld pqttrqlasf aqgqkvtlnt lvqaawalll qrhcgqetva
     1801 fgatvagrpa elpgieaqig lfintlpvia apqpqqsvad ylqgmqalnl alrehehtpl
     1861 ydiqrwaghg gealfdsilv fenfpvaeal rqapadlefs tpsnheqtny pltlgvtlge
     1921 rlslqyvyar rdfdaadiae ldrhllhllq rmaetpqaal gelalldage rqealrdwqa
     1981 plealprggv aaafahqaas apeaialvcg deylsyaeld mraerlargl rargvaaeal
     2041 vaiaaersfd lvvgllgilk agagylpldp nypaerlaym lrdsgarwli cqetlaerlp
     2101 cpaeverlpl etaawpasad trplpevage tlayviytsg stgqpkgvav sqaalvahcq
     2161 aaartygvgp gdcqlqfasi sfdaaaeqlf vpllagarvl lgdagqwsaq hladeverha
     2221 vtildlppay lqqqaeelrh agrriavrac ilggeawdas lltqqavqae awfnaygpte
     2281 avitplawhc rtqeggapai gralgarrac ildaalqpca pgmigelyig gqclargylg
     2341 rpgqtaerfv adpfsgsger lyrtgdlary rvdgqveylg radqqikirg frieigeies
     2401 qllahpyvae aavvaldgvg gpllaaylvg rdamrgedll aelrtwlagr lpaymqptaw
     2461 qvlsslplna ngkldrkalp kvdaaarrqa geppregler svaaiweall gvegiardeh
     2521 ffelgghsls atrvvsrlrq dleldvplri lferpvladf aaslesqaas aapvlqilpr
     2581 vaelplshaq qrmwflwkle pesaayhlps vlhvrgvldq aalqqafdwl vlrhetlrtr
     2641 feevdgqarq tilanmplri vledcagase atlrqrvaee irqpfdlarg pllrvrllal
     2701 agqehvlvit qhhivsdgws mqvmvdellq ayaaarrgeq ptlapltlqy adyaawhraw
     2761 ldsgegarql dywrerlgae qpvlelpadr vrpaqasgrg qrldmalpvs lseellacar
     2821 regvtpfmll lasfqvllkr ysgqsdirvg vpianrnrae verligffvn tqvlrcqvda
     2881 glafrdllgr vreaalgaqa hqdlpfeqlv dalqpernls hsplfqvmyn hqsgerqdaq
     2941 vdglhiesfa wdgaaaqfdl aldtwetpdg lgaaltyatd lfeartverm arhwqnllrg
     3001 mlenpqasvd slpmldaeer gqllegwnat aaeyplqrgv hrlfeeqver tptapalafg
     3061 eerldyaeln rranrlahal iergvgadrl vgvamersie mvvalmailk aggayvpvdp
     3121 eypeerqaym ledsgvqlll sqshlklpla qgvqridldq adawlenhae nnpgielnge
     3181 nlayviytsg stgkpkgagn rhsalsnrlc wmqqayglgv gdtvlqktpf sfdvsvweff
     3241 wplmsgarlv vaapgdhrdp aklvalinre gvdtlhfvps mlqaflqded vvsctslkri
     3301 vcsgealsad aqqqvfaklp qaglynlygp teaaidvthw scveegkdav pigrpianlg
     3361 cyildgdlep vpvgvlgely lagrglargy hqrpgltaer fvaspfvage rmyrtgdlar
     3421 yradgvieya gridhqvklr glrielgeie arllehpwvr eaavlavdsr qlvgyvvles
     3481 eggdwreala ahlatslpey mvpaqwlale rmplspngkl drkalprpqa aagqthvapq
     3541 nemerriaav wadvlkleev gatdnffalg gdsivsiqvv srcraagiqf tpkdlfqqqt
     3601 vqglarvarv gaavqmeqgp vsgetvllpf qrlffeqpip nrqhwnqsll lkprealnak
     3661 aleaalqalv ehhdalrlrf hetdgtwhae haeatlggal lwraeavdrq aleslceesq
     3721 rsldladgpl lrsllvdmad ggqrlllvih hlvvdgvswr illedlqray qqslrgeapr
     3781 lpgktspfka wagrvsehar gesmkaqlqf wrellegapa elpcehpqga leqrfatsvq
     3841 srfdrslter llkqapaayr tqvndlllta larvvcrwsg assslvqleg hgreelfadi
     3901 dlsrtvgwft slfpvrlspv adlgeslkai keqlraipdk glgygllryl ageesarvla
     3961 glpqaritfn ylgqfdaqfd emalldpage sagaemdpga pldnwlslng rvfdgelsid
     4021 wsfssqmfge dqvrrladdy vaeltalvdf ccdsprhgat psdfplagld qarldalpva
     4081 leevediypl spmqqgmlfh slyeqassdy inqmrvdvsg ldlprfraaw qsaldrhail
     4141 rsgfawqgel qqplqivyrq rqlpfaeedl sqaanrdaal lalaaaerer gfelqrapll
     4201 rlllvktaeg ehhliythhh illdgwsnaq llsevlesya grspeqlrdg rysdyiawlq
     4261 rqdaaateaf wreqmaalde ptrlvealaq pgltsangvg ehlrevdata tarlrdfarr
     4321 hqvtlntlvq agwalllqry tgqhtvvfga tvsgrpadlp gvenqvglfi ntlpvvvtla
     4381 pqmtldellq glqrqnlalr eqehtplfel qrwagfggea vfdnllvfen ypvdevlers
     4441 saggvrfgav amheqtnypl alalgggdsl slqfsydrgl fpaatierlg rhlttlleaf
     4501 aehpqrrlvd lqmlekaels aigaiwnrsd sgypatplvh qrvaerarma pdavavifde
     4561 ekltyaelds ranrlahali argvgpevrv aiamqrsaei mvaflavlka ggayvpldie
     4621 yprerllymm qdsrahlllt hshllerlpi peglsclsvd reeewagfpa hdpevalhgd
     4681 nlayviytsg stgmpkgvav shgpliahiv atgeryemtp edcelhfmsf afdgshegwm
     4741 hplingarvl irddslwlpe rtyaemhrhg vtvgvfppvy lqqlaehaer dgnpppvrvy
     4801 cfggdavaqa sydlawralk pkylfngygp tetvvtpllw karagdacga aympigtllg
     4861 nrsgyildgq lnllpvgvag elylggegva rgylerpalt aerfvpdpfg apgsrlyrsg
     4921 dltrgradgv vdylgrvdhq vkirgfriel geiearlreh psvreavvva qpgavgqqlv
     4981 gyvvaqapav adspeaqaec raqlktalre rlpeymvpsh llflarmplt pngkldrkgl
     5041 pqpdasllqq vyvaprsdle qqvagiwaev lqlqqvgldd nffelgghsl laiqvtarmq
     5101 sevgvelpla alfqteslqa yaelaaaqts sndtdfddlr efmseleai