Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]

protein AmbE [Pseudomonas aeruginosa PAO1].


LOCUS       NP_250992               2124 aa            linear   CON 24-JAN-2019
ACCESSION   NP_250992
VERSION     NP_250992.1
DBLINK      BioProject: PRJNA57945
            Assembly: GCF_000006765.1
DBSOURCE    REFSEQ: accession NC_002516.2
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa PAO1
  ORGANISM  Pseudomonas aeruginosa PAO1
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 2124)
  AUTHORS   Winsor,G.L., Van Rossum,T., Lo,R., Khaira,B., Whiteside,M.D.,
            Hancock,R.E. and Brinkman,F.S.
  TITLE     Pseudomonas Genome Database: facilitating user-friendly,
            comprehensive comparisons of microbial genomes
  JOURNAL   Nucleic acids Res. 37 (DATABASE ISSUE), D483-D488 (2009)
   PUBMED   18978025
REFERENCE   2  (residues 1 to 2124)
  AUTHORS   Cirz,R.T., O'Neill,B.M., Hammond,J.A., Head,S.R. and Romesberg,F.E.
  TITLE     Defining the Pseudomonas aeruginosa SOS response and its role in
            the global response to the antibiotic ciprofloxacin
  JOURNAL   J. Bacteriol. 188 (20), 7101-7110 (2006)
   PUBMED   17015649
REFERENCE   3  (residues 1 to 2124)
  AUTHORS   Palmer,K.L., Mashburn,L.M., Singh,P.K. and Whiteley,M.
  TITLE     Cystic fibrosis sputum supports growth and cues key aspects of
            Pseudomonas aeruginosa physiology
  JOURNAL   J. Bacteriol. 187 (15), 5267-5277 (2005)
   PUBMED   16030221
REFERENCE   4  (residues 1 to 2124)
  AUTHORS   Salunkhe,P., Smart,C.H., Morgan,J.A., Panagea,S., Walshaw,M.J.,
            Hart,C.A., Geffers,R., Tummler,B. and Winstanley,C.
  TITLE     A cystic fibrosis epidemic strain of Pseudomonas aeruginosa
            displays enhanced virulence and antimicrobial resistance
  JOURNAL   J. Bacteriol. 187 (14), 4908-4920 (2005)
   PUBMED   15995206
REFERENCE   5  (residues 1 to 2124)
  AUTHORS   Filiatrault,M.J., Wagner,V.E., Bushnell,D., Haidaris,C.G.,
            Iglewski,B.H. and Passador,L.
  TITLE     Effect of anaerobiosis and nitrate on gene expression in
            Pseudomonas aeruginosa
  JOURNAL   Infect. Immun. 73 (6), 3764-3772 (2005)
   PUBMED   15908409
REFERENCE   6  (residues 1 to 2124)
  AUTHORS   Rasmussen,T.B., Bjarnsholt,T., Skindersoe,M.E., Hentzer,M.,
            Kristoffersen,P., Kote,M., Nielsen,J., Eberl,L. and Givskov,M.
  TITLE     Screening for quorum-sensing inhibitors (QSI) by use of a novel
            genetic system, the QSI selector
  JOURNAL   J. Bacteriol. 187 (5), 1799-1814 (2005)
   PUBMED   15716452
REFERENCE   7  (residues 1 to 2124)
  AUTHORS   Winsor,G.L., Lo,R., Sui,S.J., Ung,K.S., Huang,S., Cheng,D.,
            Ching,W.K., Hancock,R.E. and Brinkman,F.S.
  TITLE     Pseudomonas aeruginosa Genome Database and PseudoCap: facilitating
            community-based, continually updated, genome annotation
  JOURNAL   Nucleic acids Res. 33 (DATABASE ISSUE), D338-D343 (2005)
   PUBMED   15608211
REFERENCE   8  (residues 1 to 2124)
  AUTHORS   Wagner,V.E., Bushnell,D., Passador,L., Brooks,A.I. and
            Iglewski,B.H.
  TITLE     Microarray analysis of Pseudomonas aeruginosa quorum-sensing
            regulons: effects of growth phase and environment
  JOURNAL   J. Bacteriol. 185 (7), 2080-2095 (2003)
   PUBMED   12644477
REFERENCE   9  (residues 1 to 2124)
  AUTHORS   Schuster,M., Lostroh,C.P., Ogi,T. and Greenberg,E.P.
  TITLE     Identification, timing, and signal specificity of Pseudomonas
            aeruginosa quorum-controlled genes: a transcriptome analysis
  JOURNAL   J. Bacteriol. 185 (7), 2066-2079 (2003)
   PUBMED   12644476
REFERENCE   10 (residues 1 to 2124)
  AUTHORS   Stover,C.K., Pham,X.Q., Erwin,A.L., Mizoguchi,S.D., Warrener,P.,
            Hickey,M.J., Brinkman,F.S., Hufnagle,W.O., Kowalik,D.J., Lagrou,M.,
            Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y.,
            Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R.,
            Smith,K., Spencer,D., Wong,G.K., Wu,Z., Paulsen,I.T., Reizer,J.,
            Saier,M.H., Hancock,R.E., Lory,S. and Olson,M.V.
  TITLE     Complete genome sequence of Pseudomonas aeruginosa PA01, an
            opportunistic pathogen
  JOURNAL   Nature 406 (6799), 959-964 (2000)
   PUBMED   10984043
REFERENCE   11 (residues 1 to 2124)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-OCT-2010) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   12 (residues 1 to 2124)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (08-SEP-2010) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    protein update by submitter
REFERENCE   13 (residues 1 to 2124)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (02-OCT-2008) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    protein update by submitter
REFERENCE   14 (residues 1 to 2124)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JUL-2006) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    Sequence update by submitter
REFERENCE   15 (residues 1 to 2124)
  AUTHORS   Ung,K.S., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (04-FEB-2003) Department of Molecular Biology and
            Biochemistry, Simon Fraser University, 8888 University Dr.,
            Burnaby, British Columbia V5A 1S6, Canada
REFERENCE   16 (residues 1 to 2124)
  AUTHORS   Stover,C.K., Pham,X.-Q.T., Erwin,A.L., Mizoguchi,S.D., Warrener,P.,
            Hickey,M.J., Brinkman,F.S.L., Hufnagle,W.O., Kowalik,D.J.,
            Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E.,
            Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N.,
            Folger,K.R., Kas,A., Larbig,K., Lim,R.M., Smith,K.A., Spencer,D.H.,
            Wong,G.K.-S., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H.,
            Hancock,R.E.W., Lory,S. and Olson,M.V.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAY-2000) Department of Medicine and Genetics,
            University of Washington Genome Center, University Of Washington,
            Box 352145, Seattle, WA 98195, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AAG05690.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..2124
                     /organism="Pseudomonas aeruginosa PAO1"
                     /strain="PAO1"
                     /db_xref="taxon:208964"
     Protein         1..2124
                     /product="protein AmbE"
                     /calculated_mol_wt=228914
     Region          3..1261
                     /region_name="EntF"
                     /note="seryl-AMP synthase component of non-ribosomal
                     peptide synthetase [Secondary metabolites biosynthesis,
                     transport and catabolism]; COG1020"
                     /db_xref="CDD:440643"
     Region          462..910
                     /region_name="A_NRPS"
                     /note="The adenylation domain of nonribosomal peptide
                     synthetases (NRPS); cd05930"
                     /db_xref="CDD:341253"
     Site            order(593,596..601,603..604)
                     /site_type="other"
                     /note="acyl-activating enzyme (AAE) consensus motif"
                     /db_xref="CDD:341253"
     Site            order(596..597,715..716,736..741,760,825,837,840)
                     /site_type="other"
                     /note="AMP binding site [chemical binding]"
                     /db_xref="CDD:341253"
     Region          <1198..1372
                     /region_name="PRK12467"
                     /note="peptide synthase; Provisional"
                     /db_xref="CDD:237108"
     Region          1360..1776
                     /region_name="DCL_NRPS-like"
                     /note="DCL-type Condensation domains of nonribosomal
                     peptide synthetases (NRPSs), such as terminal fungal CT
                     domains and Dual Epimerization/Condensation (E/C) domains;
                     cd19536"
                     /db_xref="CDD:380459"
     Region          1792..1850
                     /region_name="PP-binding"
                     /note="Phosphopantetheine attachment site; pfam00550"
                     /db_xref="CDD:425746"
     Region          1880..2114
                     /region_name="GrsT"
                     /note="Surfactin synthase thioesterase subunit [Secondary
                     metabolites biosynthesis, transport and catabolism];
                     COG3208"
                     /db_xref="CDD:442441"
     CDS             1..2124
                     /gene="ambE"
                     /locus_tag="PA2302"
                     /coded_by="complement(NC_002516.2:2532669..2539043)"
                     /note="Product name confidence: class 1: Function
                     experimentally demonstrated in P. aeruginosa"
                     /transl_table=11
                     /db_xref="GeneID:878274"
CONTIG      join(WP_010895606.1:1..2124)
ORIGIN      
        1 msasedlqsa vqpaaseale gfplsplqtr awrrhaerpe ntvvgvrlha padpvatler
       61 lrraldgeaq lrvayrtmpg mslpvqvldg raadllverl pgdgdwagrf aresarlaas
      121 plggegqpvl algllldaag etlqglllaa pafvvdaasl vallrrglgp agqasadegd
      181 eallfqhfse wanealaged gesasgywre qaavaaespl aladdlgege wtarrllpra
      241 llerlaangl peaaallawt qvagqfqgde glplemarlv sgrlfnefae lagpfagvap
      301 lclenvrags vgerldalqa ailaqeeaaa lrdpfapdwp laelgfawla geldgagvae
      361 ldcrqpplgg flelqvlphg egrlaslrvr rdhdgtlagr lldawvecle siaadrqlpl
      421 aglpligaae reryqawqge rvepapvesl vaafdlraal qpqapallda hgsldfatlr
      481 arseavaeal laagvrpgqa vavmtgrnre aivallgvmr aaavytpvnp efpaarverm
      541 reaggivfal adaecagrar eafagacldl stlplagsgm slpapggrda aymiftsgts
      601 gqpkgvvveh asalnlsqal artvyanvvg eglrvtvnap fsfdssikqi lqllsghclv
      661 lvpqevrsdp qrmlgfleer ridvldctps lfrlllqagl ddahpalpgr ilvggerfde
      721 aswevaagwr rcqvfnlygp teatvnasla rvaeharpti gralanvdlh vvdglgrrkt
      781 rgasgelwig gagvargyag dageaagrfv eegwpgsgrl yrsgdlvrwr adgcleflgr
      841 ideqvkingy rielgeirsa llehpavgea avltdeadaa epgadrriva fvtaaeetad
      901 eswlevdlps ghrvaglnln eteyvyqeif vdevysrdgi vlppdavvld vganiglfsl
      961 yiasraprar vvafeplapi rrrleanlgr yapqvevfgi glsdaereet ftyypgystf
     1021 sgiaeyadas gerdvirryl snqgeeggan llldnideil ddrlraeahr crlrrldqvi
     1081 gelgleridl lkidvqraem dvllglddaa lakvrqivle vhdkrdgata gradalsdll
     1141 rrhgfevsir qdallegtdr yncyavrpgy aeslaeridw ralaprpaaa lggelseqal
     1201 rgflearlpa ymlpsriarv erlpltaegk ldrrallaal aaeaaaqtle apanateaal
     1261 leiwksvlkr paigvsdnff qvggdsirli qmqvmareag laftlrdvfn hqsirelarl
     1321 laapaspada lgtsapqsle pfallsaaer krlpegldda ypmtslqqgm llqseasgdp
     1381 rllhnvvlhe vhgrldgell arawailigr hailrtgfdl hggqvplqwv hpatavaaev
     1441 pvhdlcgldg etrrlrlraw ieeeqatpfd wsrpplvrla alalderrfa lgvaehhsvl
     1501 dgwslqslvd ellavyadll agvvareaea pavgfrdyva lereaeanaa salfwldyla
     1561 garyrplpgl aeegprrmaa vrvdvpadsl srlralaers glplrsllla ahgralcrfs
     1621 dadevvtgfv shgrpeepga drllglflnt lpcrlsasvd lldsarrafd yeraslehrr
     1681 hplaairrrn relrldslfn fvdfhqddaa pagvrhggil dqvvvdvdvp lavdfevage
     1741 rlevgfqyaa grfpaeraea lagayreall allgdpvqpp aaaqaedsve lrrvlkvlsr
     1801 vlgrplaadq gfasagghsl lgvqaiaelr rltgrqlslg llqgdpdare vvrrchaada
     1861 pplppatera ralwlqrsgs aqprlrlial ppaggnagtf rgwdarlpad vellaiqypg
     1921 rqerqdepfv tdveamlcai ddallplldr pfaligaslg gmlayelaar leslhglrar
     1981 qlfvissrap gpdleyprfh amgdaellrt lreydvlple vlddpelrei slatlradsr
     2041 laadyryrpr eplaipitai lgeqdpgvsr vaidgwrrha sryeletlag ghglvvtaae
     2101 evcailrqrl apdvpggvpa nlat