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chemotactic signal transduction system protein [Pseudomonas


LOCUS       NP_249104               2472 aa            linear   CON 24-JAN-2019
            aeruginosa PAO1].
ACCESSION   NP_249104
VERSION     NP_249104.1
DBLINK      BioProject: PRJNA57945
            Assembly: GCF_000006765.1
DBSOURCE    REFSEQ: accession NC_002516.2
KEYWORDS    RefSeq.
SOURCE      Pseudomonas aeruginosa PAO1
  ORGANISM  Pseudomonas aeruginosa PAO1
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Pseudomonadales; Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (residues 1 to 2472)
  AUTHORS   Winsor,G.L., Van Rossum,T., Lo,R., Khaira,B., Whiteside,M.D.,
            Hancock,R.E. and Brinkman,F.S.
  TITLE     Pseudomonas Genome Database: facilitating user-friendly,
            comprehensive comparisons of microbial genomes
  JOURNAL   Nucleic acids Res. 37 (DATABASE ISSUE), D483-D488 (2009)
   PUBMED   18978025
REFERENCE   2  (residues 1 to 2472)
  AUTHORS   Cirz,R.T., O'Neill,B.M., Hammond,J.A., Head,S.R. and Romesberg,F.E.
  TITLE     Defining the Pseudomonas aeruginosa SOS response and its role in
            the global response to the antibiotic ciprofloxacin
  JOURNAL   J. Bacteriol. 188 (20), 7101-7110 (2006)
   PUBMED   17015649
REFERENCE   3  (residues 1 to 2472)
  AUTHORS   Palmer,K.L., Mashburn,L.M., Singh,P.K. and Whiteley,M.
  TITLE     Cystic fibrosis sputum supports growth and cues key aspects of
            Pseudomonas aeruginosa physiology
  JOURNAL   J. Bacteriol. 187 (15), 5267-5277 (2005)
   PUBMED   16030221
REFERENCE   4  (residues 1 to 2472)
  AUTHORS   Salunkhe,P., Smart,C.H., Morgan,J.A., Panagea,S., Walshaw,M.J.,
            Hart,C.A., Geffers,R., Tummler,B. and Winstanley,C.
  TITLE     A cystic fibrosis epidemic strain of Pseudomonas aeruginosa
            displays enhanced virulence and antimicrobial resistance
  JOURNAL   J. Bacteriol. 187 (14), 4908-4920 (2005)
   PUBMED   15995206
REFERENCE   5  (residues 1 to 2472)
  AUTHORS   Filiatrault,M.J., Wagner,V.E., Bushnell,D., Haidaris,C.G.,
            Iglewski,B.H. and Passador,L.
  TITLE     Effect of anaerobiosis and nitrate on gene expression in
            Pseudomonas aeruginosa
  JOURNAL   Infect. Immun. 73 (6), 3764-3772 (2005)
   PUBMED   15908409
REFERENCE   6  (residues 1 to 2472)
  AUTHORS   Rasmussen,T.B., Bjarnsholt,T., Skindersoe,M.E., Hentzer,M.,
            Kristoffersen,P., Kote,M., Nielsen,J., Eberl,L. and Givskov,M.
  TITLE     Screening for quorum-sensing inhibitors (QSI) by use of a novel
            genetic system, the QSI selector
  JOURNAL   J. Bacteriol. 187 (5), 1799-1814 (2005)
   PUBMED   15716452
REFERENCE   7  (residues 1 to 2472)
  AUTHORS   Winsor,G.L., Lo,R., Sui,S.J., Ung,K.S., Huang,S., Cheng,D.,
            Ching,W.K., Hancock,R.E. and Brinkman,F.S.
  TITLE     Pseudomonas aeruginosa Genome Database and PseudoCap: facilitating
            community-based, continually updated, genome annotation
  JOURNAL   Nucleic acids Res. 33 (DATABASE ISSUE), D338-D343 (2005)
   PUBMED   15608211
REFERENCE   8  (residues 1 to 2472)
  AUTHORS   Wagner,V.E., Bushnell,D., Passador,L., Brooks,A.I. and
            Iglewski,B.H.
  TITLE     Microarray analysis of Pseudomonas aeruginosa quorum-sensing
            regulons: effects of growth phase and environment
  JOURNAL   J. Bacteriol. 185 (7), 2080-2095 (2003)
   PUBMED   12644477
REFERENCE   9  (residues 1 to 2472)
  AUTHORS   Schuster,M., Lostroh,C.P., Ogi,T. and Greenberg,E.P.
  TITLE     Identification, timing, and signal specificity of Pseudomonas
            aeruginosa quorum-controlled genes: a transcriptome analysis
  JOURNAL   J. Bacteriol. 185 (7), 2066-2079 (2003)
   PUBMED   12644476
REFERENCE   10 (residues 1 to 2472)
  AUTHORS   Stover,C.K., Pham,X.Q., Erwin,A.L., Mizoguchi,S.D., Warrener,P.,
            Hickey,M.J., Brinkman,F.S., Hufnagle,W.O., Kowalik,D.J., Lagrou,M.,
            Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y.,
            Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R.,
            Smith,K., Spencer,D., Wong,G.K., Wu,Z., Paulsen,I.T., Reizer,J.,
            Saier,M.H., Hancock,R.E., Lory,S. and Olson,M.V.
  TITLE     Complete genome sequence of Pseudomonas aeruginosa PA01, an
            opportunistic pathogen
  JOURNAL   Nature 406 (6799), 959-964 (2000)
   PUBMED   10984043
REFERENCE   11 (residues 1 to 2472)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-OCT-2010) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   12 (residues 1 to 2472)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (08-SEP-2010) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    protein update by submitter
REFERENCE   13 (residues 1 to 2472)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (02-OCT-2008) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    protein update by submitter
REFERENCE   14 (residues 1 to 2472)
  AUTHORS   Winsor,G.L., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JUL-2006) Department of Molecular Biology and
            Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby,
            British Columbia V5A 1S6, Canada
  REMARK    Sequence update by submitter
REFERENCE   15 (residues 1 to 2472)
  AUTHORS   Ung,K.S., Hancock,R.E. and Brinkman,F.S.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (04-FEB-2003) Department of Molecular Biology and
            Biochemistry, Simon Fraser University, 8888 University Dr.,
            Burnaby, British Columbia V5A 1S6, Canada
REFERENCE   16 (residues 1 to 2472)
  AUTHORS   Stover,C.K., Pham,X.-Q.T., Erwin,A.L., Mizoguchi,S.D., Warrener,P.,
            Hickey,M.J., Brinkman,F.S.L., Hufnagle,W.O., Kowalik,D.J.,
            Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E.,
            Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N.,
            Folger,K.R., Kas,A., Larbig,K., Lim,R.M., Smith,K.A., Spencer,D.H.,
            Wong,G.K.-S., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H.,
            Hancock,R.E.W., Lory,S. and Olson,M.V.
  CONSRTM   Pseudomonas aeruginosa Community Annotation Project (PseudoCap)
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAY-2000) Department of Medicine and Genetics,
            University of Washington Genome Center, University Of Washington,
            Box 352145, Seattle, WA 98195, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AAG03802.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..2472
                     /organism="Pseudomonas aeruginosa PAO1"
                     /strain="PAO1"
                     /db_xref="taxon:208964"
     Protein         1..2472
                     /product="chemotactic signal transduction system protein"
                     /calculated_mol_wt=268446
     Region          <562..>703
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          864..>1085
                     /region_name="CheA"
                     /note="Chemotaxis protein histidine kinase CheA [Signal
                     transduction mechanisms]; COG0643"
                     /db_xref="CDD:440408"
     Region          1041..>1165
                     /region_name="CheA"
                     /note="Chemotaxis protein histidine kinase CheA [Signal
                     transduction mechanisms]; COG0643"
                     /db_xref="CDD:440408"
     Region          1186..>1349
                     /region_name="CheA"
                     /note="Chemotaxis protein histidine kinase CheA [Signal
                     transduction mechanisms]; COG0643"
                     /db_xref="CDD:440408"
     Region          1362..>1479
                     /region_name="CheA"
                     /note="Chemotaxis protein histidine kinase CheA [Signal
                     transduction mechanisms]; COG0643"
                     /db_xref="CDD:440408"
     Region          1522..1620
                     /region_name="HPT"
                     /note="Histidine Phosphotransfer domain, involved in
                     signalling through a two part component systems in which
                     an autophosphorylating histidine protein kinase serves as
                     a phosphoryl donor to a response regulator protein; the
                     response regulator protein is...; cd00088"
                     /db_xref="CDD:238041"
     Site            order(1565,1568..1569,1584,1587)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238041"
     Site            1565
                     /site_type="active"
                     /db_xref="CDD:238041"
     Region          1668..2330
                     /region_name="CheA"
                     /note="Chemotaxis protein histidine kinase CheA [Signal
                     transduction mechanisms]; COG0643"
                     /db_xref="CDD:440408"
     Region          2347..2472
                     /region_name="CheY"
                     /note="CheY-like REC (receiver) domain, includes
                     chemotaxis protein CheY and sporulation regulator Spo0F
                     [Signal transduction mechanisms]; COG0784"
                     /db_xref="CDD:440547"
     CDS             1..2472
                     /gene="chpA"
                     /locus_tag="PA0413"
                     /coded_by="NC_002516.2:454126..461544"
                     /note="Product name confidence: class 1: Function
                     experimentally demonstrated in P. aeruginosa."
                     /transl_table=11
                     /db_xref="GeneID:878176"
                     /db_xref="PseudoCap:PA0413"
CONTIG      join(WP_003114893.1:1..2472)
ORIGIN      
        1 mgdrhdyval ewvkgeiaet lkqarqalea fvenpqdptr mrfcltyvhq vqgtlqmvef
       61 ygaallaeem eqlvqalldg rvpnqgeale vlmqailqlp vyldriqtar rdlpmvvlpl
      121 lndlraarge kllsetslfa pdlsqrqpql dgeaiaqlrt delggllrkl rqtqqmalvg
      181 llrnqdvats lgylarvyar leglcreapl gplwsiasgl veglangsvv nsasvrtllr
      241 qldrelkrlv eqgadglnqa apdelvknll fyvakapsqs priralkeqy rldealpdhe
      301 tvdaerarla gpdrdamrsv vgalceelvr ikdsldlfvr sdrghpseld allaplkqia
      361 dtlavlgfgq prkvildqld vihalaqgrr epsdailmdv agallyveat lagmagpgde
      421 rnseesrlpt tdvaqihqlv ikearngleq akdaiiefia sqwnhehlar vpelltqvrg
      481 glamiplera atlletcnry iqeqllarka vpdwqsldtl adaitsveyy lerlsedhas
      541 qsdlildvae dslanlgytl kpnssapaep glsgpaaies paaeperpea vvevaetaeq
      601 ppadtapaea aredapqlas ddnwtlgeva pdagepsldl aldlplddsa evppalpevv
      661 eesgqpqsts aparslddfs ldeidlsgld lpadaapasg paaladwslp eqwglgddla
      721 qpaqagetld lsleepalsf dapleslepl palepfdgsa eqelvldald plpldvalpe
      781 aegevsaweg ssleeldlsd ldlpevqlpe aeaeappaae alaseapals laevmaapvq
      841 pinppaqnvp vsllpppade epvdeelrev fieeagevle tigrylpawk adhddrealt
      901 evrrafhtlk gsgrmvralv igelawsien lfnrvldrsi aasepvqrvv dqvvallpel
      961 veefaanaqr qrddvdllaa tahalakgep lpeppapddg gvppeagaeq pssldngvqa
     1021 ppladapqaa aeaqsdvell dpqlleiftn eaethlealv gfladcarel pqpvtdalqr
     1081 alhtlkgsah magilpiaei atpleklvke yksnllafdl reaellhdae qlfrigleqv
     1141 gaqrplnpip gsdallerie alhqeriasl eaerysdage rrdpllieaf lvegmdilld
     1201 aedllerwhe hpqerqelsa lreelstldr garhaelpqv eelcqallal ydaveegrla
     1261 vspaffeear qahealigmm dqvaaglqvt prpervaalq elleapaaea vpfidpeslg
     1321 addfppedee palpeavyee agapaeetvp aapapapgre ldeemvsifl eeavdilesa
     1381 gqalaqwqae pgalsslsal qrdlhtlkgg armaeiaeig dlahelealy eglvdrryqh
     1441 spqlagllqa chdrlaeqld qlsagqplad phdliqsirr frqgpvaeaa tpgeaespve
     1501 elvapaveep aapaaeafee rdpelveifl eegfdildsa aaalqrwmdd vdntieleal
     1561 qrdlhtlkgg armaeigeig dlahelefly eglcggrlra spalfgllqr chdelaemle
     1621 avrghrtlpd gqaliaeirr lrsdpdeqls vptsvslkpl aakgaaades eildifleea
     1681 ddllenlela lgrwdggngd aqplddllri lhtlkggarl agqtelgnla hdleqhltda
     1741 qqqgapwpds llldaqsgle glqrqvdllr erlaeddeag erpepaqalv qaddtdrava
     1801 salaeltrla paagaimaae aappaapatt lpfvrkaqea aqeaasrrap qelvkvpael
     1861 lenlvnlage tsifrgrveq qvsdvgftlg emestiervr dqlrrldtet qaqilsrhqa
     1921 daeragyeef dplemdrysq lqqlsralfe sasdlldlke tlaaknrdae tlllqqarvn
     1981 telqeglmrt rmvpfdrlvp rlrrivrqva gelgkqvefv vgnadgemdr tvlerivapl
     2041 ehmlrnavdh giesgetrra agkpehgtir lnigreggdi lltlsddgag irldavrrka
     2101 ierglmsads dlsdhevlqf vlesgfstae kvtqisgrgv gldvansevk qlggsvsiqt
     2161 epgqgtrfnv rlpftvsvnr almvlsgedl yavplntieg ivrvspyele alydqrgeag
     2221 ldtpsfeyag qsyelkylge llnngqepkl vgqslplpvi lvrssehava vqvdslagsr
     2281 eivvkslgpq fagvagisga tllgdgrvvv ildllatirs rhallgqesr rerlalrqem
     2341 aaseseqqrp plvmvvddsv tvrkvttrll erngmnvlta kdgvdaiaql qehrpdilll
     2401 diemprmdgf evatlvrhde rlgnlpiimi tsrtgekhre ralgigvnqy lgkpyqetel
     2461 leaiqslvgq he