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LOCUS NP_248866 679 aa linear CON 24-JAN-2019 ACCESSION NP_248866 VERSION NP_248866.1 DBLINK BioProject: PRJNA57945 Assembly: GCF_000006765.1 DBSOURCE REFSEQ: accession NC_002516.2 KEYWORDS RefSeq. SOURCE Pseudomonas aeruginosa PAO1 ORGANISM Pseudomonas aeruginosa PAO1 Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. REFERENCE 1 (residues 1 to 679) AUTHORS Winsor,G.L., Van Rossum,T., Lo,R., Khaira,B., Whiteside,M.D., Hancock,R.E. and Brinkman,F.S. TITLE Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes JOURNAL Nucleic acids Res. 37 (DATABASE ISSUE), D483-D488 (2009) PUBMED 18978025 REFERENCE 2 (residues 1 to 679) AUTHORS Cirz,R.T., O'Neill,B.M., Hammond,J.A., Head,S.R. and Romesberg,F.E. TITLE Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin JOURNAL J. Bacteriol. 188 (20), 7101-7110 (2006) PUBMED 17015649 REFERENCE 3 (residues 1 to 679) AUTHORS Palmer,K.L., Mashburn,L.M., Singh,P.K. and Whiteley,M. TITLE Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology JOURNAL J. Bacteriol. 187 (15), 5267-5277 (2005) PUBMED 16030221 REFERENCE 4 (residues 1 to 679) AUTHORS Salunkhe,P., Smart,C.H., Morgan,J.A., Panagea,S., Walshaw,M.J., Hart,C.A., Geffers,R., Tummler,B. and Winstanley,C. TITLE A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance JOURNAL J. Bacteriol. 187 (14), 4908-4920 (2005) PUBMED 15995206 REFERENCE 5 (residues 1 to 679) AUTHORS Filiatrault,M.J., Wagner,V.E., Bushnell,D., Haidaris,C.G., Iglewski,B.H. and Passador,L. TITLE Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa JOURNAL Infect. Immun. 73 (6), 3764-3772 (2005) PUBMED 15908409 REFERENCE 6 (residues 1 to 679) AUTHORS Rasmussen,T.B., Bjarnsholt,T., Skindersoe,M.E., Hentzer,M., Kristoffersen,P., Kote,M., Nielsen,J., Eberl,L. and Givskov,M. TITLE Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector JOURNAL J. Bacteriol. 187 (5), 1799-1814 (2005) PUBMED 15716452 REFERENCE 7 (residues 1 to 679) AUTHORS Winsor,G.L., Lo,R., Sui,S.J., Ung,K.S., Huang,S., Cheng,D., Ching,W.K., Hancock,R.E. and Brinkman,F.S. TITLE Pseudomonas aeruginosa Genome Database and PseudoCap: facilitating community-based, continually updated, genome annotation JOURNAL Nucleic acids Res. 33 (DATABASE ISSUE), D338-D343 (2005) PUBMED 15608211 REFERENCE 8 (residues 1 to 679) AUTHORS Wagner,V.E., Bushnell,D., Passador,L., Brooks,A.I. and Iglewski,B.H. TITLE Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment JOURNAL J. Bacteriol. 185 (7), 2080-2095 (2003) PUBMED 12644477 REFERENCE 9 (residues 1 to 679) AUTHORS Schuster,M., Lostroh,C.P., Ogi,T. and Greenberg,E.P. TITLE Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis JOURNAL J. Bacteriol. 185 (7), 2066-2079 (2003) PUBMED 12644476 REFERENCE 10 (residues 1 to 679) AUTHORS Stover,C.K., Pham,X.Q., Erwin,A.L., Mizoguchi,S.D., Warrener,P., Hickey,M.J., Brinkman,F.S., Hufnagle,W.O., Kowalik,D.J., Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R., Smith,K., Spencer,D., Wong,G.K., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H., Hancock,R.E., Lory,S. and Olson,M.V. TITLE Complete genome sequence of Pseudomonas aeruginosa PA01, an opportunistic pathogen JOURNAL Nature 406 (6799), 959-964 (2000) PUBMED 10984043 REFERENCE 11 (residues 1 to 679) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (06-OCT-2010) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 12 (residues 1 to 679) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (08-SEP-2010) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK protein update by submitter REFERENCE 13 (residues 1 to 679) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (02-OCT-2008) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK protein update by submitter REFERENCE 14 (residues 1 to 679) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (05-JUL-2006) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK Sequence update by submitter REFERENCE 15 (residues 1 to 679) AUTHORS Ung,K.S., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (04-FEB-2003) Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REFERENCE 16 (residues 1 to 679) AUTHORS Stover,C.K., Pham,X.-Q.T., Erwin,A.L., Mizoguchi,S.D., Warrener,P., Hickey,M.J., Brinkman,F.S.L., Hufnagle,W.O., Kowalik,D.J., Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R.M., Smith,K.A., Spencer,D.H., Wong,G.K.-S., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H., Hancock,R.E.W., Lory,S. and Olson,M.V. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (16-MAY-2000) Department of Medicine and Genetics, University of Washington Genome Center, University Of Washington, Box 352145, Seattle, WA 98195, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to AAG03566. Method: conceptual translation. FEATURES Location/Qualifiers source 1..679 /organism="Pseudomonas aeruginosa PAO1" /strain="PAO1" /db_xref="taxon:208964" Protein 1..679 /product="aerotaxis transducer Aer2" /calculated_mol_wt=72460 Region 11..55 /region_name="HAMP_I" /note="first HAMP domain of aerotaxis transducer Aer2 and similar domains; cd17529" /db_xref="CDD:381746" Site order(14..15,17..19,21..22,24,27,43..44,47..48,50..51, 54..55) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:381746" Region 66..111 /region_name="HAMP" /note="Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; cl01054" /db_xref="CDD:470050" Region 114..156 /region_name="HAMP_N3" /note="HAMP N-terminal domain 3; pfam18575" /db_xref="CDD:465808" Region 172..>306 /region_name="NtrB" /note="Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; COG3852" /db_xref="CDD:443061" Region 306..374 /region_name="HAMP_2" /note="HAMP domain; pfam18947" /db_xref="CDD:465927" Region <349..679 /region_name="MCP_signal" /note="Methyl-accepting chemotaxis protein (MCP), signaling domain; cl46910" /db_xref="CDD:481250" Site order(421..422,425..426,429,432..433,435..436,439, 442..443,446,449..450,453..454,457,460..461,463..464,468, 470..471,474,477..478,481..482,485,488,491..492,495,499, 502,509,513,516,519..520,523,526..527,530..531,533..534, 537..538,551..552,555,558..559,562,565..566,568..569, 572..573,576,579..580,583,586..587,589..590,593..594, 596..597,600,603..604) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:206779" Site 491..524 /site_type="other" /note="putative CheW interface [polypeptide binding]" /db_xref="CDD:206779" CDS 1..679 /gene="aer2" /locus_tag="PA0176" /coded_by="complement(NC_002516.2:199600..201639)" /note="Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)" /transl_table=11 /db_xref="GeneID:882219" CONTIG join(WP_003112650.1:1..679) ORIGIN 1 mglfnahava qqradriatl lqsfadgqld tavgeapapg yerlydslra lqrqlreqra 61 elqqveslea glaemsrqhe agwidqtipa erlegraari akgvnelvaa hiavkmkvvs 121 vvtaygqgnf eplmdrlpgk kaqiteaidg vrerlrgaae atsaqlataa ynariksald 181 nvsanvmiad ndlniiymnr tvsemlgrae adirkqlpnf dagrlmgani dvfhknpahq 241 rhllanltgv hkaelnlggr rfsldvvpvf ndanerlgsa vqwtdrteeh raeqevsqlv 301 qaaaagdfsk rveeagkegf flrlakdlns lvdtadrglr dvsrmlgala qgdltqriea 361 dyqgtfgqlk dfsndtaqsl srmlgqirea adtintaase iasgnaelsa rteqqassle 421 etassmeelt stvklnaena rqanslaana sevatqggtv vqkvvstmss inesarkiad 481 iigvidgiaf qtnilalnaa veaarageqg rgfavvagev rtlaqrsaaa akeiktlisd 541 svdkvengnt lvaqagqtms divvairrvt dimseiaaas aeqstgieev nsavsqmddm 601 tqqnaalvee aaaaaeamqe qagllnqsva vfrldtppsv vqlasarpsa prpsapapla 661 rsgmaraska rkedgweef