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LOCUS NP_248796 530 aa linear CON 24-JAN-2019 ACCESSION NP_248796 VERSION NP_248796.1 DBLINK BioProject: PRJNA57945 Assembly: GCF_000006765.1 DBSOURCE REFSEQ: accession NC_002516.2 KEYWORDS RefSeq. SOURCE Pseudomonas aeruginosa PAO1 ORGANISM Pseudomonas aeruginosa PAO1 Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. REFERENCE 1 (residues 1 to 530) AUTHORS Winsor,G.L., Van Rossum,T., Lo,R., Khaira,B., Whiteside,M.D., Hancock,R.E. and Brinkman,F.S. TITLE Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes JOURNAL Nucleic acids Res. 37 (DATABASE ISSUE), D483-D488 (2009) PUBMED 18978025 REFERENCE 2 (residues 1 to 530) AUTHORS Cirz,R.T., O'Neill,B.M., Hammond,J.A., Head,S.R. and Romesberg,F.E. TITLE Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin JOURNAL J. Bacteriol. 188 (20), 7101-7110 (2006) PUBMED 17015649 REFERENCE 3 (residues 1 to 530) AUTHORS Palmer,K.L., Mashburn,L.M., Singh,P.K. and Whiteley,M. TITLE Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology JOURNAL J. Bacteriol. 187 (15), 5267-5277 (2005) PUBMED 16030221 REFERENCE 4 (residues 1 to 530) AUTHORS Salunkhe,P., Smart,C.H., Morgan,J.A., Panagea,S., Walshaw,M.J., Hart,C.A., Geffers,R., Tummler,B. and Winstanley,C. TITLE A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance JOURNAL J. Bacteriol. 187 (14), 4908-4920 (2005) PUBMED 15995206 REFERENCE 5 (residues 1 to 530) AUTHORS Filiatrault,M.J., Wagner,V.E., Bushnell,D., Haidaris,C.G., Iglewski,B.H. and Passador,L. TITLE Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa JOURNAL Infect. Immun. 73 (6), 3764-3772 (2005) PUBMED 15908409 REFERENCE 6 (residues 1 to 530) AUTHORS Rasmussen,T.B., Bjarnsholt,T., Skindersoe,M.E., Hentzer,M., Kristoffersen,P., Kote,M., Nielsen,J., Eberl,L. and Givskov,M. TITLE Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector JOURNAL J. Bacteriol. 187 (5), 1799-1814 (2005) PUBMED 15716452 REFERENCE 7 (residues 1 to 530) AUTHORS Winsor,G.L., Lo,R., Sui,S.J., Ung,K.S., Huang,S., Cheng,D., Ching,W.K., Hancock,R.E. and Brinkman,F.S. TITLE Pseudomonas aeruginosa Genome Database and PseudoCap: facilitating community-based, continually updated, genome annotation JOURNAL Nucleic acids Res. 33 (DATABASE ISSUE), D338-D343 (2005) PUBMED 15608211 REFERENCE 8 (residues 1 to 530) AUTHORS Wagner,V.E., Bushnell,D., Passador,L., Brooks,A.I. and Iglewski,B.H. TITLE Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment JOURNAL J. Bacteriol. 185 (7), 2080-2095 (2003) PUBMED 12644477 REFERENCE 9 (residues 1 to 530) AUTHORS Schuster,M., Lostroh,C.P., Ogi,T. and Greenberg,E.P. TITLE Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis JOURNAL J. Bacteriol. 185 (7), 2066-2079 (2003) PUBMED 12644476 REFERENCE 10 (residues 1 to 530) AUTHORS Stover,C.K., Pham,X.Q., Erwin,A.L., Mizoguchi,S.D., Warrener,P., Hickey,M.J., Brinkman,F.S., Hufnagle,W.O., Kowalik,D.J., Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R., Smith,K., Spencer,D., Wong,G.K., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H., Hancock,R.E., Lory,S. and Olson,M.V. TITLE Complete genome sequence of Pseudomonas aeruginosa PA01, an opportunistic pathogen JOURNAL Nature 406 (6799), 959-964 (2000) PUBMED 10984043 REFERENCE 11 (residues 1 to 530) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (06-OCT-2010) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 12 (residues 1 to 530) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (08-SEP-2010) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK protein update by submitter REFERENCE 13 (residues 1 to 530) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (02-OCT-2008) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK protein update by submitter REFERENCE 14 (residues 1 to 530) AUTHORS Winsor,G.L., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (05-JUL-2006) Department of Molecular Biology and Biochemisry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REMARK Sequence update by submitter REFERENCE 15 (residues 1 to 530) AUTHORS Ung,K.S., Hancock,R.E. and Brinkman,F.S. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (04-FEB-2003) Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A 1S6, Canada REFERENCE 16 (residues 1 to 530) AUTHORS Stover,C.K., Pham,X.-Q.T., Erwin,A.L., Mizoguchi,S.D., Warrener,P., Hickey,M.J., Brinkman,F.S.L., Hufnagle,W.O., Kowalik,D.J., Lagrou,M., Garber,R.L., Goltry,L., Tolentino,E., Westbrock-Wadman,S., Yuan,Y., Brody,L.L., Coulter,S.N., Folger,K.R., Kas,A., Larbig,K., Lim,R.M., Smith,K.A., Spencer,D.H., Wong,G.K.-S., Wu,Z., Paulsen,I.T., Reizer,J., Saier,M.H., Hancock,R.E.W., Lory,S. and Olson,M.V. CONSRTM Pseudomonas aeruginosa Community Annotation Project (PseudoCap) TITLE Direct Submission JOURNAL Submitted (16-MAY-2000) Department of Medicine and Genetics, University of Washington Genome Center, University Of Washington, Box 352145, Seattle, WA 98195, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to AAG03496. Method: conceptual translation. FEATURES Location/Qualifiers source 1..530 /organism="Pseudomonas aeruginosa PAO1" /strain="PAO1" /db_xref="taxon:208964" Protein 1..530 /product="cytochrome C oxidase subunit I" /calculated_mol_wt=58663 Region 30..514 /region_name="Cyt_c_Oxidase_I" /note="Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; cd01663" /db_xref="CDD:238833" Site order(30,109,113,115,122,162,166,184,188,208,215,218,226, 235..237,242..243,245,255,292,295,298..299,303) /site_type="other" /note="Subunit I/III interface [polypeptide binding]" /db_xref="CDD:238833" Site order(39,99,110,117,120,174..175,181,185) /site_type="active" /note="D-pathway [active]" /db_xref="CDD:238833" Site order(45,49,52,56,135..136,417,490,493) /site_type="other" /note="Subunit I/VIIc interface [polypeptide binding]" /db_xref="CDD:238833" Site order(59,62..63,425,428..429,462,480) /site_type="other" /note="Subunit I/IV interface [polypeptide binding]" /db_xref="CDD:238833" Site order(75,245,282,285..286,311..313,316,319,327,335,338, 345..347,359,377..378,380,382..386,450..451,455..457, 466..467) /site_type="other" /note="Subunit I/II interface [polypeptide binding]" /db_xref="CDD:238833" Site order(81,395,399,441,478) /site_type="other" /note="Low-spin heme (heme a) binding site [chemical binding]" /db_xref="CDD:238833" Site order(133,136) /site_type="other" /note="Subunit I/VIIa interface [polypeptide binding]" /db_xref="CDD:238833" Site order(155,231..234) /site_type="other" /note="Subunit I/VIa interface [polypeptide binding]" /db_xref="CDD:238833" Site order(208,215,255,292,295,298..299,303) /site_type="other" /note="Dimer interface" /db_xref="CDD:238833" Site order(245,250..251,381,385..386,455) /site_type="other" /note="Putative water exit pathway" /db_xref="CDD:238833" Site order(258,307..308,393) /site_type="other" /note="Binuclear center (heme a3/CuB) [ion binding]" /db_xref="CDD:238833" Site order(258,262,273,307..308,333,336) /site_type="active" /note="K-pathway [active]" /db_xref="CDD:238833" Site order(283,287,513) /site_type="other" /note="Subunit I/Vb interface [polypeptide binding]" /db_xref="CDD:238833" Site order(308,385..386,455..456) /site_type="other" /note="Putative proton exit pathway" /db_xref="CDD:238833" Site 313 /site_type="other" /note="Subunit I/VIb interface" /db_xref="CDD:238833" Site 346 /site_type="other" /note="Subunit I/VIc interface [polypeptide binding]" /db_xref="CDD:238833" Site order(394,455..456) /site_type="active" /note="Electron transfer pathway [active]" /db_xref="CDD:238833" Site order(426,483) /site_type="other" /note="Subunit I/VIIIb interface [polypeptide binding]" /db_xref="CDD:238833" Site order(462,466) /site_type="other" /note="Subunit I/VIIb interface [polypeptide binding]" /db_xref="CDD:238833" CDS 1..530 /gene="coxA" /locus_tag="PA0106" /coded_by="NC_002516.2:128512..130104" /note="Product name confidence: class 2 (High similarity to functionally studied protein)" /transl_table=11 /db_xref="GeneID:881877" CONTIG join(WP_003083723.1:1..530) ORIGIN 1 msavidtpdh hagdhhhgpa kglmrwvltt nhkdigtlyl wfsfmmfllg gsmamvirae 61 lfqpglqive paffnqmttm hglimvfgav mpafvglanw miplmigapd malprmnnfs 121 fwllpaafgl lvstlfmpgg gpnfgwtfya plsttfaphs vtffifaihl agissimgai 181 nviatilnlr apgmtlmkmp lfvwtwlita flliavmpvl agvvtmmlmd ihfgtsffsa 241 agggdpvlfq hvfwffghpe vyimilpafg avsaiiptfa rkplfgytsm vyatasiafl 301 sfvvwahhmf vvgipvtgel ffmyatmlia vptgvkvfnw vttmwegslt fetpmlfava 361 fvilftiggf sglmlaiapa dfqyhdtyfv vahfhyvlvp gaifgifasa yywlpkwtgh 421 mydetlgklh fwmsfigmnl affpmhfvgl agmprripdy nlqfadfnmv ssigafmfgt 481 tqllflfivi kcirggkpap akpwdgaegl ewsipspapy htfstppevk