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LOCUS NP_001285053 4769 aa linear INV 26-DEC-2023 ACCESSION NP_001285053 VERSION NP_001285053.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 DBSOURCE REFSEQ: accession NM_001298124.1 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (residues 1 to 4769) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (residues 1 to 4769) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (residues 1 to 4769) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (residues 1 to 4769) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (residues 1 to 4769) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (residues 1 to 4769) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (residues 1 to 4769) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (residues 1 to 4769) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (residues 1 to 4769) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (residues 1 to 4769) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (residues 1 to 4769) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (residues 1 to 4769) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (residues 1 to 4769) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (residues 1 to 4769) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (residues 1 to 4769) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (residues 1 to 4769) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (residues 1 to 4769) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (residues 1 to 4769) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (residues 1 to 4769) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (residues 1 to 4769) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (residues 1 to 4769) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (residues 1 to 4769) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (residues 1 to 4769) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The reference sequence is identical to AHN59524. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## Method: conceptual translation. FEATURES Location/Qualifiers source 1..4769 /organism="Drosophila melanogaster" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" Protein 1..4769 /product="megalin, isoform C" /name="CG42611 gene product from transcript CG42611-RC" /note="CG42611-PC; mgl-PC; LDL receptor-related protein 2" /calculated_mol_wt=530038 Region 157..189 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(162,170,181..182) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(174,177,181,187..188) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 184..188 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 204..236 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(209,215,226..227) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(219,222,226,232..233) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 229..233 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 292..327 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(297,306,317..318) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(310,313,317,323..324) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 320..324 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 332..366 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(337,345,356..357) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(349,352,356,362..363) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 359..363 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 371..412 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(376,390,401..402) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(394,397,401,407..408) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 404..408 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region <447..488 /region_name="vWFA" /note="Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; cl00057" /db_xref="CDD:469594" Region <492..634 /region_name="YncE" /note="DNA-binding beta-propeller fold protein YncE [General function prediction only]; COG3391" /db_xref="CDD:442618" Region 573..>716 /region_name="NHL" /note="NHL repeat unit of beta-propeller proteins; cl18310" /db_xref="CDD:302697" Region 573..610 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 616..654 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 657..693 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 763..805 /region_name="FXa_inhibition" /note="Coagulation Factor Xa inhibitory site; pfam14670" /db_xref="CDD:464251" Region 854..>992 /region_name="YvrE" /note="Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; COG3386" /db_xref="CDD:442613" Region 922..964 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 973..1007 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 1188..1223 /region_name="Ldl_recept_a" /note="Low-density lipoprotein receptor domain class A; pfam00057" /db_xref="CDD:395011" Site order(1194,1202,1213..1214) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1206,1209,1213,1219..1220) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1216..1220 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1227..1259 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(1233,1241,1252..1253) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1245,1248,1252,1258..1259) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1255..1259 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1268..1303 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1273,1282,1293..1294) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1286,1289,1293,1299..1300) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1296..1300 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1308..1343 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1313,1322,1333..1334) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1326,1329,1333,1339..1340) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1336..1340 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1356..1387 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1357,1366,1377..1378) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1370,1373,1377,1383..1384) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1380..1384 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1391..1423 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(1397,1405,1416..1417) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1409,1412,1416,1422..1423) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1419..1423 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1435..1469 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(1441,1451,1462..1463) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1455,1458,1462,1468..1469) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1465..1469 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1522..1553 /region_name="FXa_inhibition" /note="Coagulation Factor Xa inhibitory site; pfam14670" /db_xref="CDD:464251" Region 1625..1665 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 1667..1711 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 1690..1729 /region_name="Ldl_recept_b" /note="Low-density lipoprotein receptor repeat class B; pfam00058" /db_xref="CDD:459654" Region 1712..1754 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 1986..2037 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 2151..>2179 /region_name="FXa_inhibition" /note="Coagulation Factor Xa inhibitory site; pfam14670" /db_xref="CDD:464251" Region 2259..2305 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 2326..2366 /region_name="Ldl_recept_b" /note="Low-density lipoprotein receptor repeat class B; pfam00058" /db_xref="CDD:459654" Region 2352..2392 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 2579..>2711 /region_name="NHL" /note="NHL repeat unit of beta-propeller proteins; cl18310" /db_xref="CDD:302697" Region 2593..2622 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 2634..2678 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 2671..2713 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 2867..2901 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(2872,2880,2891..2892) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(2884,2887,2891,2897..2898) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 2894..2898 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 2906..2941 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(2911,2919,2930..2931) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(2923,2926,2930,2938..2939) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site order(2933..2934,2937..2939) /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 2950..2983 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(2955,2964,2975..2976) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(2968,2971,2975,2981..2982) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 2978..2982 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3034..3066 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(3040,3048,3059..3060) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3052,3055,3059,3065..3066) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3062..3066 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3080..3115 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(3083,3097,3108..3109) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3101,3104,3108,3114..3115) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3111..3115 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3128..3159 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(3133,3141,3152..3153) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3145,3148,3152,3158..3159) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3155..3159 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3170..3204 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(3175,3183,3194..3195) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3187,3190,3194,3200..3201) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3197..3201 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3210..3242 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(3216,3224,3235..3236) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3228,3231,3235,3241..3242) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3238..3242 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3259..3287 /region_name="FXa_inhibition" /note="Coagulation Factor Xa inhibitory site; pfam14670" /db_xref="CDD:464251" Region 3293..3329 /region_name="FXa_inhibition" /note="Coagulation Factor Xa inhibitory site; pfam14670" /db_xref="CDD:464251" Region 3362..3394 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 3406..3448 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 3468..3511 /region_name="Ldl_recept_b" /note="Low-density lipoprotein receptor repeat class B; pfam00058" /db_xref="CDD:459654" Region 3498..3536 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 3536..3578 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 3607..3659 /region_name="FXa_inhibition" /note="Coagulation Factor Xa inhibitory site; pfam14670" /db_xref="CDD:464251" Region 3663..3696 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(3668,3678,3689..3690) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3682,3685,3689,3695..3696) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3692..3696 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3705..3739 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(3710,3718,3729..3730) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3722,3725,3729,3735..3736) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3732..3736 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3743..3775 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(3748,3757,3768..3769) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3761,3764,3768,3774..3775) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3771..3775 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3784..3817 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(3791,3799,3810..3811) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3803,3806,3810,3816..3817) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3813..3817 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3827..3861 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(3832,3843,3854..3855) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3847,3850,3854,3860..3861) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3857..3861 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3871..3901 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(3875,3883,3894..3895) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3887,3890,3894,3900..3901) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3897..3901 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3913..3947 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(3918,3926,3937..3938) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3930,3933,3937,3943..3944) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3940..3944 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3952..3986 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(3957,3965,3976..3977) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(3969,3972,3976,3982..3983) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 3979..3983 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 3996..4027 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(4001,4009,4020..4021) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(4013,4016,4020,4026..4027) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 4023..4027 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 4043..4071 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(4043,4051,4062..4063) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(4055,4058,4062,4068..4069) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 4065..4069 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 4086..4117 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(4088,4096,4107..4108) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(4100,4103,4107,4113..4114) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 4110..4114 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 4163..4194 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain; smart00179" /db_xref="CDD:214542" Site order(4163,4166,4180) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 4276..>4426 /region_name="NHL" /note="NHL repeat unit of beta-propeller proteins; cl18310" /db_xref="CDD:302697" Region 4291..4336 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 4350..4391 /region_name="Ldl_recept_b" /note="Low-density lipoprotein receptor repeat class B; pfam00058" /db_xref="CDD:459654" Region 4374..4417 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 4376..4422 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" CDS 1..4769 /gene="mgl" /locus_tag="Dmel_CG42611" /old_locus_tag="CG12139" /old_locus_tag="CG12654" /old_locus_tag="Dmel_CG12139" /old_locus_tag="Dmel_CG12654" /old_locus_tag="Dmel_CG34339" /old_locus_tag="Dmel_CG34352" /gene_synonym="anon-WO0140519.108; CG12139; CG12654; CG15316; CG34339; CG34352; CG42611; CT7830; Dm CG34352; Dmel\CG42611; LDLR; LRP-2; lrp2; megalin; Mgl; SOSIE" /coded_by="NM_001298124.1:498..14807" /db_xref="FLYBASE:FBpp0310026" /db_xref="GeneID:8674055" /db_xref="FLYBASE:FBgn0261260" ORIGIN 1 mnptpvgigf gfgrkppska rmrsrwrpps attllthdpa ngdshtaadp lqvtdaapsg 61 ppsssssspi gdrhsqhhss saidrrlqqq qhhqspqhhr qrgqlttlal lllalvaisn 121 letllavrte gprnrhgspg gslastggss sgintecptd sfrcnngkci shhwvcnyqk 181 dcddgedemq scpppecetp qlncgqytfn ktycipphyr cdmiedcedk sdeaqctyrk 241 cqhtdlfcnt ptgapaegar ltgpcvpkek rcdgyldcrt grdevgcsgv acrldqfrca 301 nglkcidaal kcnhrddcgd nsdeqgcnfp pchhaqfrct nalcipynfh cdgyhdcadk 361 sdeanctaia cpdnkhlcpr ggasgtpkci lksqlcdgkr dcedgsdeet ncsiascpal 421 scefkcgpsl tggvcyckpg qslapdnrtc vdldecaewg hcdqlctntl gsytcqcaqg 481 ytlindskci apdannlqli fahdraimrm lphgsepkil anataaagvt fhyarntlyw 541 sdiktrkvqs lpldaqnkav spfdqtlpgt wapvalavdw vgdkiyvadl vgqkidvfel 601 sgqwhavvlg snltspadla ldptaglmfv adggqvlrah mdgtharsiv seaaykasgv 661 tvdiiskrvf wcdslldyie svdyegahrv mvlrgqqvps psrlalfenr iywtdatkqg 721 imsvdkfegp tsiqvtykak direpkgiia vhalsqprvs npcgnnnggc nhmcivtavk 781 gaptglgfrc acstgyqlet dlklckpvse flmysqqrfi kgkvlepvie gfsdaimpvv 841 srrarfvgld fdardefiyy sdvlqdviyr vhrngtgrei vlasqnegve glavdwaskn 901 lyyidsrkgt lnvlstrnvt hrrtllknlk rpraivvhpn rgfiffsewd rpanitrant 961 dgsgllvfkn vtlgwpngls idfkedrvyw cdalldhvqh anldgtdikt vnsrlvrhpf 1021 sivihndwmy itdwrldaii rlhkltgeqe emmvrepqtn rlygvkvysh evqriadtqp 1081 chrnnggcqk icfavpigas ngtdgvttss psfgrlqsrc scpygerlad dqvscipdps 1141 aeppvqpcpn swdftcnnqr cipkswlcdg dddcldnsde eqnctkptcg snefqcrsgr 1201 cipqnfrcdq endcgdnsde qecgnvtcgt sqfacangrc ipnmwkcdse ndcgdssdeg 1261 dfcaektcay fqftcprtgh cipqswvcdg dddcfdkqde kdcppiscla nqfkcadlrq 1321 cveesykcdg ipdcndgsde vgcpsmgpnq cnlekhfrck stgfcipiaw hcdgsndcsd 1381 hsdeqdcgqi tcaqnffkcn ntncvfkayi cdgkddcgdn sdegaehacv pppfkcphgq 1441 wqcpgvserc vnitsvcddt pdcpngsdeg egcdlaeceh qagqcssfcq ktpngalcvc 1501 ppgseigedg ytcidsnecd ppglcsqqct ntkgsyfcsc tdgyvlepnk htckavnhta 1561 afliisnrhs ilvadlkeqg lervpiiven vvatasnmht gtifwsdmkl kkisrldrgm 1621 epqeiintgl dlveglaydw iaqnlywlds klntievsae ngsnrlvlvr enitqprgmc 1681 idpspgarwi fwtdwgenpr verigmdgtm rktiintkiy wpngltldia tkrvyfadsk 1741 ldfidfcyyn gtgrqqvlas shyllhphsl slfedtlywt drqlnrvlsa nkfrgknqtv 1801 vshlisqpls ihvhhaslqp mtpnpcagsr cqhlcllsps apegysckcr pgfkllsegr 1861 cieeenpflm vvkgtqivdl plnggdarag alapvigies stgldfdrkg etlywvqgre 1921 dddenctiyt tpygggnktl flgiengivg apytiafdwl grnlyignrv asnieavrvd 1981 gkqkyrtiil andgypnsvs rpkqialdpt egklfwideg vlevpikigr vdmngqnpiv 2041 vfqefahpes lavdtekkmv yysasnpavi gvmdyngddh tlilmkdshp makprslgil 2101 dhrlyyldpl yerivridlp hgdnpktivd nesdlrsmmi ykkralmqhp cqtnnggckh 2161 lcipgpgatr tcacgigyrk eneincvayk ifavvsqldm irgyslsdss eamvpisgpg 2221 hhilhvdvmy reqwiywaey nrgywngifr srpngtdlqh vvkdgigsng irgltidwva 2281 gnmyftnvyp henyvevcwl dgsnrkvlvk tttdaprela vnpikrllyw idygqhprig 2341 kalldgskwt plvtsgislp rdltidmqth diywvdskld tiqkisynga nrkiirrdlp 2401 npmgiavyln dvywvdrnlm tvfkaskhsa netatsvrtn leklrdiaiy ninnqpqddt 2461 npcahlgngg cdqlcfsfpp dggasgtsgg rnfrcecatg klsaderkce vvneylvfat 2521 rteiravnld phstevpftp ltnltnvvgl dfdfahnrml ytqirpwaki aytkankpgh 2581 dditvvlnkg inpegiaydw tqqkiywtds snnsiyamnl dgselvmiar verpraivld 2641 pcngtlfftd wgrfgtsgki frttmagslk raivdkdlsq psglaidyde rrlywtdavr 2701 ekiersdldg qnrellvaat iypfaitvfr nyiywtdlql rgvyraekht ganmvemvkr 2761 ledsprdiri yssdrqkcnv npcrinnggc aqschpapng kaeckcddst kvvnegrmca 2821 prnntceask fyckngrcis rmwscdgddd cgdnsdedpn ycayhscspn efrcnngrci 2881 fkswkcdhen dckdgsdelg cvyppcvdge ftcangrcip qaqvcngvnd ckdnatsdet 2941 hercpmnttc panhlkcekt nicvepywlc dgdndcgdns dedplhcgqr tcptnsfrcp 3001 nhrcipatwy cdgdddcgdg adeppdycks egrtcfgdlf tcdngncipr iyicdgdndc 3061 ldnsdednrh qcndrkcdee teftcvenks wqraqcipkk wicdgdpdcv dgadenttlh 3121 ncatqqpcge dmftcgngrc inkgwicdhd ndcgdgtdeg kfcnskyktc saqeftcqnf 3181 kcirnqsrcd geddcgdhsd evgcakenit cpqgqfactn gqcidynlvc nkypdcades 3241 depahcnvde cakveinqcg hkcvdtltgy ycdcnegykl ladgkacadv decleqpgac 3301 sqhcsntpgg fyckcdetyy erqndehtck rkdkippwli ftnkyyvrnm svdghqynlm 3361 hqdlmnvval dfdireeymy fcdvtaktif rakygeadde mppereavir hdshglegia 3421 idwvgrklyw ldrhsknldv seldgskrkt lrsgvvdpra ivvhpgigyl yftswhlqay 3481 iakmgmdgsn fsrilnwndg iawpnalsid yftdriywad ahldyiayad legrhrhtvl 3541 sgskvphvfa lslfddyiyw sdwnlkaivr ankfhganyt vlrntthrpy dlhinhplrq 3601 lpytnpcgtn nggcshlcli apppestyln iegyieegap ifkcacpnqf ylardmktcv 3661 anctagqhlc ggrdekcipw fwkcdgekdc kdgsdepatc aprhcragtf qckntnctps 3721 aticdgvddc gdrsdeqncd lpcplsdfkc kssgrcilds wrcdgdadck dgsdedpavc 3781 fkrtcdpkte fsckngrcip qlwmcdfdnd cgddsdepay mcrqrncttg wqrcpgqsny 3841 rcipkwlfcd gkddcrdnsd elpencpkcn petdfkcgnn rcipkqwmcd faddcgdasd 3901 eneavckgry recsesefrc gngkcissrw qcdheddcgd nsdemhcegy qckngtfqca 3961 sghciasyfr cdgdrdcrdm sdevgcpprf pggrycpesr fqcnnnlcvs lsdlcdgtdd 4021 cgdgsdedps vcsdfncdtl rrfqcsnerc varyqicdgv dncgdgsden nmtlcaskqk 4081 pcdlytqyqc ankhciersq vcdfsddcgd asdelgchht sscseanrgg cqqhchnltd 4141 ggyictcypg yiiaadnkkk csdvdecltr qhtcshqchn lngtyscscr egfhltdgas 4201 gvcraekedv illfvngqei rglnwhksee 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