High-molecular-weight nonribosomal peptide/polyketide synthetase 1

LOCUS       YP_005227767            3163 aa            linear   CON 02-JUN-2020
            (HMWP1) [Klebsiella pneumoniae subsp. pneumoniae HS11286].
ACCESSION   YP_005227767
VERSION     YP_005227767.1
DBLINK      BioProject: PRJNA84387
            Assembly: GCF_000240185.1
DBSOURCE    REFSEQ: accession NC_016845.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae subsp. pneumoniae HS11286
  ORGANISM  Klebsiella pneumoniae subsp. pneumoniae HS11286
            Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
            Enterobacterales; Enterobacteriaceae; Klebsiella/Raoultella group;
            Klebsiella; Klebsiella pneumoniae complex.
REFERENCE   1  (residues 1 to 3163)
  AUTHORS   Liu,P., Li,P., Jiang,X., Bi,D., Xie,Y., Tai,C., Deng,Z.,
            Rajakumar,K. and Ou,H.Y.
  TITLE     Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae
            HS11286, a multidrug-resistant strain isolated from human sputum
  JOURNAL   J. Bacteriol. 194 (7), 1841-1842 (2012)
   PUBMED   22408243
REFERENCE   2  (residues 1 to 3163)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-FEB-2012) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (residues 1 to 3163)
  AUTHORS   Ou,H.-Y., Jiang,X., Liu,P. and Li,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2011) State Key Laboratory of Microbial
            Metabolism, Shanghai Jiaotong University, 1954 Huashan Road,
            Shanghai 200030, China
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence is identical to AEW62165.
            RefSeq Category: Reference Genome
                        CLI: Clinical Isolate
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..3163
                     /organism="Klebsiella pneumoniae subsp. pneumoniae
                     HS11286"
                     /strain="HS11286"
                     /sub_species="pneumoniae"
                     /db_xref="taxon:1125630"
     Protein         1..3163
                     /product="High-molecular-weight nonribosomal
                     peptide/polyketide synthetase 1 (HMWP1)"
                     /calculated_mol_wt=348667
     Region          27..1382
                     /region_name="PksD"
                     /note="Acyl transferase domain in polyketide synthase
                     (PKS) enzymes [Secondary metabolites biosynthesis,
                     transport and catabolism]; COG3321"
                     /db_xref="CDD:442550"
     Region          1435..1776
                     /region_name="KR_FAS_SDR_x"
                     /note="ketoreductase (KR) and fatty acid synthase (FAS),
                     complex (x) SDRs; cd05274"
                     /db_xref="CDD:187582"
     Site            order(1566..1567,1569,1589..1592,1610..1613,1637..1639,
                     1660..1661,1683..1684,1698,1726..1727)
                     /site_type="other"
                     /note="NADP binding site [chemical binding]"
                     /db_xref="CDD:187582"
     Site            order(1661,1685,1698,1702)
                     /site_type="active"
                     /db_xref="CDD:187582"
     Region          1816..1892
                     /region_name="AcpP"
                     /note="Acyl carrier protein [Lipid transport and
                     metabolism]; COG0236"
                     /db_xref="CDD:440006"
     Region          1915..2341
                     /region_name="Cyc_NRPS"
                     /note="Cyc (heterocyclization) domain of nonribosomal
                     peptide synthetases (NRPSs); belongs to the
                     Condensation-domain family; cd19535"
                     /db_xref="CDD:380458"
     Region          2317..3152
                     /region_name="EntF2"
                     /note="Thioesterase domain of type I polyketide synthase
                     or non-ribosomal peptide synthetase [Secondary metabolites
                     biosynthesis, transport and catabolism]; COG3319"
                     /db_xref="CDD:442548"
     CDS             1..3163
                     /locus_tag="KPHS_34670"
                     /coded_by="NC_016845.1:3448881..3458372"
                     /transl_table=11
                     /db_xref="GeneID:11848496"
CONTIG      join(WP_014343270.1:1..3163)
ORIGIN      
        1 mdnlrfssap tadsidasia qhypdcepva vigyachfpe spdgetfwqn llegrecsrr
       61 ftreellavg ldaaiiddph yvnigtvldn adcfdatlfg ysrqeaesmd pqqrlflqav
      121 whalehagya pgavphktgv fassrmstyp grealnvtev aqvkglqslm gndkdyiatr
      181 aayklnlhgp alsvqtacss slvavhlace slragesdma vaggvalsfp qqagyryqpg
      241 mifspdghcr pfdasaegtw agnglgcvvl rrlrdallsg dpiisvilss avnndgnrkv
      301 gytapsvagq qavieealml aaiddrqvgy iethgtgtpl gdaieiealr nvyaprpqdq
      361 rcalgsvksn mghldtaagi agllktvlav srgqipplln fhtpnpalkl eespftipvs
      421 aqawqdemry agvssfgigg tnchmivasl pdalnarlpd tdsgrksial llsaasdsal
      481 rrlatdyaga lredadassl aftalharrl dlpfrlaapl nretaealsa wageksgalv
      541 ysghgasgkq vwlftgqgsh wrtmgqtmyq hstafadtld rcfsacseml tpslreamfn
      601 pdsaqldnma waqpaivafe iamaahwrae glkpdfaigh svgefaaavv cghytieqvm
      661 plvcrrgalm qqcasgamva vfadedtlmp larqfeldla anngtqhtvf sgpearlavf
      721 catlsqhdin yrrlsvtgaa hsallepild rfqeacaglh aepgqipiis tltadvides
      781 tlnqadywrr hmrqpvrfiq siqvahqlga rvflemgpda qlvacgqrey rdnaywiasa
      841 rrnkeasdvl nqallqlyaa gvalpwadll agdgqriaap cypfdteryw kervspacep
      901 adaalsagle vasraatald lprlealkqc atrlhaiyvd qlvqrctgda iengvdamti
      961 mrrgrllpry qqllqrllnn cvvdgdyrct dgryvrarpi ehqqresllt elagycegfq
     1021 aipdtiarag drlyemmsga eepvaiifpq sasdgvevly qefsfgryfn qiaagvlrgi
     1081 vqtrqprqpl rilevgggtg gttawllpel ngvpaleyhf tdisalftrr aqqkfadydf
     1141 vkyseldlek eaqsqgfqaq sydlivaanv ihatrhigrt ldnlrpllkp ggrllmreit
     1201 qpmrlfdfvf gplvlplqdl daregelflt taqwqqqcrh agfskvawlp qdgsptagms
     1261 ehiilatlpg qavsavtfta psepvlgqal tdngdyladw sdcagqperf narwqeawrl
     1321 lsqrhgdalp vepppvaape wlgkvrlswq neafsrgqmr vearhpagew lplspaaplp
     1381 apqthyqwrw tplnvasidh pltfsfsagt larsdelaqy giihdphass rlmiveesed
     1441 tlalaekvia altasaagli vvtrrawrve enealsashh alwallrvaa neqperllaa
     1501 idlaentpwe tlhqglsavs lsqrwlaarg dtlwlpslap ntgcaaelpa nvftgdsrwh
     1561 lvtgafgglg rlavnwlrek garriallap rvdeswlrdv eggqtrvcrc dvgdagqlat
     1621 vlddlaangg iagaihaagv ladaplqeld dhqlaavfav kaqaasqllq tlrnhdgryl
     1681 ilyssaaatl gapgqsahal acgyldglaq qfstldapkt lsvawgawge sgraatpeml
     1741 atlasrgmga lsdaegcwhl eqavmrgapw rlamrvftdk mpplqqalfn isatekaatp
     1801 vippaddnaf ngslsdetav mawlkkriav qlrlsdpasl hpnqdllqlg mdsllflels
     1861 sdiqhylgvr inaerawqdl sphgltqlic skpeatpaas qpevlrhdad eryapfpltp
     1921 iqhaywlgrt hligyggvac hvlfewdkrh defnlailek awnqliarhd mlrmvvdadg
     1981 qqrilattpe yhiprddlra lspeeqrial ekrrhelsyr vlpadqwplf elvvseiddc
     2041 hyrlhmnldl lqfdvqsfkv mmddlaqvwr getlaplait frdyvmaeqa rrqtsawhda
     2101 wdywqeklpq lplapelpvv etppetphft tfkstigkte wqavkqrwqq qgvtpsaall
     2161 tlfaatlerw srtttftlnl tffnrqpihp qinqligdft svtlvdfnfs apvtlqeqmq
     2221 qtqqrlwqnm ahsemngvev irelgrlrgs qrqplmpvvf tsmlgmtleg mtidqamshl
     2281 fgepcyvftq tpqvwldhqv mesdgelmfs wycmdnvlep gaaeamfndy cailqaviaa
     2341 peslktlasg iaghiprrrw plnaqadydl rdieqatley pgirqaraei teqgaltldi
     2401 vmaddpspsa ampdeheltq lalplpeqaq ldeleatwrw learalqgia atlnrhglft
     2461 tpeiahrfsa ivqalsaqas hqrllrqwlq clterewlir egeswrcrip lceipepqea
     2521 cpqsqwsqal aqyletciar hdalfsgqcs plellfneqh rvtdalyrdn pasaclnryt
     2581 aqiaalcsae rilevgagta attapvlkat rntrqsyhft dvsaqflnda rarfhdesqv
     2641 syalfdinqp ldftahpeag ydlivavnvl hdashvvqtl rrlklllkag gllmiveate
     2701 rnsvfqlasv gfieglsgyr dfrrrdekpm ltrsawqevl vqagfanela wpaqessplr
     2761 qhllvarspg vnrpdkkavs rylqqrfgtg lpilqirqre alftplhaps daptepakpt
     2821 pvaggnpale kqvaelwqsl lsrpvarhhd ffelggdslm atrmvaqlnr rgiaranlqd
     2881 lfshstlsdf cahlqaatsg ednpiplcqg dgeetlfvfh asdgdisawl plasalnrrv
     2941 fglqakspqr fatldqmide yvgcirrqqp hgpyvlagws ygaflaagaa krlyakgeqv
     3001 rmvlidpvcr qdfccenraa llrllaegqt plalpehfdq qtpdsqladf islaktagmv
     3061 pqnltlqaae twldniahll rlltehtpge svpvpclmvy aagrparwtp aetewqgwin
     3121 naddavieas hwqimmeaph vqacaqhitr wlcatstqpe ntl