Sap5p [Candida albicans SC5314].

LOCUS       XP_719147                418 aa            linear   PLN 18-APR-2022
ACCESSION   XP_719147
VERSION     XP_719147.1
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
DBSOURCE    REFSEQ: accession XM_714054.1
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (residues 1 to 418)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (residues 1 to 418)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (residues 1 to 418)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (residues 1 to 418)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 418)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (residues 1 to 418)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AOW30234.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Candida albicans SC5314"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     Protein         1..418
                     /product="Sap5p"
                     /calculated_mol_wt=45518
     Region          90..406
                     /region_name="SAP_like"
                     /note="SAPs, pepsin-like proteinases secreted from
                     pathogens to degrade host proteins; cd05474"
                     /db_xref="CDD:133141"
     Site            order(108..111,294..297)
                     /site_type="active"
                     /note="catalytic motif [active]"
                     /db_xref="CDD:133141"
     Site            order(108,294)
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:133141"
     Site            order(157..162,164..168)
                     /site_type="active"
                     /note="Active site flap [active]"
                     /db_xref="CDD:133141"
     CDS             1..418
                     /gene="SAP5"
                     /locus_tag="CAALFM_C603030WA"
                     /coded_by="XM_714054.1:1..1257"
                     /note="Secreted aspartyl proteinase; sap4,5,6 triple null
                     defective in utilization of protein as N source; virulence
                     role effected by URA3; expressed during infection; mRNA
                     localized to hyphal tip via She3; rat catheter and Spider
                     biofilm induced"
                     /transl_table=12
                     /db_xref="CGD:CAL0000193807"
                     /db_xref="GeneID:3639268"
ORIGIN      
        1 mflknilsvl afallidaap vkrspgfvtl dfnvkrslvd pddptveakr splfleftps
       61 efpvdetgrd gdvdkrgpva vtlhneaity taditvgsdn qklnvivdtg ssdlwipdsn
      121 vicipkwrgd kgdfcksags yspassrtsq nlntrfdiky gdgsyakgkl ykdtvgiggv
      181 svrdqlfanv wstsarkgil gigfqsgeat efdydnlpis lrnqgiigka ayslylnsae
      241 astgqiifgg idkakysgsl vdlpitsekk ltvglrsvnv rgrnvdantn vlldsgttis
      301 yftrsivrni lyaigaqmkf dsagnkvyva dcktsgtidf qfgnnlkisv pvseflfqty
      361 ytsgkpfpkc evriresedn ilgdnflrsa yvvynlddkk ismapvkyts esdivain