Sap6p [Candida albicans SC5314].

LOCUS       XP_719105                418 aa            linear   PLN 18-APR-2022
ACCESSION   XP_719105
VERSION     XP_719105.1
DBLINK      BioProject: PRJNA14005
            BioSample: SAMN02953594
DBSOURCE    REFSEQ: accession XM_714012.1
KEYWORDS    RefSeq.
SOURCE      Candida albicans SC5314
  ORGANISM  Candida albicans SC5314
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade;
            Candida.
REFERENCE   1  (residues 1 to 418)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Assembly of a phased diploid Candida albicans genome facilitates
            allele-specific measurements and provides a simple model for repeat
            and indel structure
  JOURNAL   Genome Biol. 14 (9), R97 (2013)
   PUBMED   24025428
REFERENCE   2  (residues 1 to 418)
  AUTHORS   van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D.,
            Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B.,
            Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T.
  TITLE     Assembly of the Candida albicans genome into sixteen supercontigs
            aligned on the eight chromosomes
  JOURNAL   Genome Biol. 8 (4), R52 (2007)
   PUBMED   17419877
REFERENCE   3  (residues 1 to 418)
  AUTHORS   Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S.,
            Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T.,
            Davis,R.W. and Scherer,S.
  TITLE     The diploid genome sequence of Candida albicans
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004)
   PUBMED   15123810
REFERENCE   4  (residues 1 to 418)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (15-APR-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 418)
  AUTHORS   Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
REFERENCE   6  (residues 1 to 418)
  CONSRTM   Candida Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (30-SEP-2016) Department of Genetics, Candida Genome
            Database, Stanford University, Mail Stop-5120, Stanford, CA 94305,
            USA
  REMARK    Sequence and annotation update by submitter
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to AOW30203.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: CGD
            Annotation Status   :: Full annotation
            Annotation Version  :: A22-s07-m01-r01
            URL                 :: http://www.candidagenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Candida albicans SC5314"
                     /strain="SC5314"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:MYA-2876"
                     /db_xref="taxon:237561"
                     /chromosome="6"
                     /haplotype="A"
                     /geo_loc_name="USA: New York"
                     /collected_by="Margarita Silva-Hutner"
     Protein         1..418
                     /product="Sap6p"
                     /calculated_mol_wt=45301
     Region          90..406
                     /region_name="SAP_like"
                     /note="SAPs, pepsin-like proteinases secreted from
                     pathogens to degrade host proteins; cd05474"
                     /db_xref="CDD:133141"
     Site            order(108..111,294..297)
                     /site_type="active"
                     /note="catalytic motif [active]"
                     /db_xref="CDD:133141"
     Site            order(108,294)
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:133141"
     Site            order(157..162,164..168)
                     /site_type="active"
                     /note="Active site flap [active]"
                     /db_xref="CDD:133141"
     CDS             1..418
                     /gene="SAP6"
                     /locus_tag="CAALFM_C602710CA"
                     /coded_by="XM_714012.1:1..1257"
                     /note="Secreted aspartyl protease; expressed during hyphal
                     growth, oral carriage, infection; sap4,5,6 triple mutant
                     defective in protein utilization as N source; virulence
                     role affecte by URA3; N-glycosylated; rat catheter biofilm
                     induced"
                     /transl_table=12
                     /db_xref="CGD:CAL0000179762"
                     /db_xref="GeneID:3639229"
ORIGIN      
        1 mllknilsvl afallidaap vkrspgfvtl dfnvkrslvd pddptveskr splfldldpt
       61 kipvddtgrn dgvdkrgpva vkldneiity saditvgsnn qklsvivdtg ssdlwipdsk
      121 aicipkwrgd rgdfcknngs yspaasstsk nlntrfeiky adgsyakgnl yqdtvgigga
      181 svknqlfanv wstsahkgil gigfqaneat rtpydnlpis lkkqgiiakn ayslflnspe
      241 assgqiifgg idkakysgsl velpitsdrt lsvglrsvnv mgrnvnvnag vlldsgttis
      301 yftpsiarsi iyalggqvhf dsagnkayva dcktsgtvdf qfdknlkisv paseflyqly
      361 ytngkpypkc eirvresedn ilgdnfmrsa yivydlddkk ismaqvkyts esnivain