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basement membrane-specific heparan sulfate proteoglycan core


LOCUS       XP_070074535            4275 aa            linear   INV 09-DEC-2024
            protein isoform X17 [Drosophila takahashii].
ACCESSION   XP_070074535
VERSION     XP_070074535.1
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_070218434.1
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4275
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..4275
                     /product="basement membrane-specific heparan sulfate
                     proteoglycan core protein isoform X17"
                     /calculated_mol_wt=473185
     Region          84..>169
                     /region_name="CCDC66"
                     /note="Coiled-coil domain-containing protein 66;
                     pfam15236"
                     /db_xref="CDD:434558"
     Region          418..451
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(423,430,441..442)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(434,437,441,447..448)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            444..448
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          504..536
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(510,518,529..530)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(522,525,529,535..536)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            532..536
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          544..579
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(549,558,569..570)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(562,565,569,575..576)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            572..576
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          589..623
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(594,602,613..614)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(606,609,613,619..620)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            616..620
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          675..710
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(680,689,700..701)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(693,696,700,706..707)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            703..707
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          794..827
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(799,806,817..818)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(810,813,817,823..824)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            820..824
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          848..880
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(854,862,873..874)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(866,869,873,879..880)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            876..880
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          898..931
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(903,910,921..922)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(914,917,921,927..928)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            924..928
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          941..971
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(942,950,961..962)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(954,957,961,967..968)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            964..968
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          972..1006
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(977,985,996..997)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(989,992,996,1002..1003)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            999..1003
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1012..1046
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1017,1025,1036..1037)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1029,1032,1036,1042..1043)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1039..1043
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1061..1129
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          1161..1195
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1166,1174,1185..1186)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1178,1181,1185,1191..1192)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1188..1192
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1201..1235
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1206,1214,1225..1226)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1218,1221,1225,1231..1232)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1228..1232
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1244..1278
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1249,1257,1268..1269)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1261,1264,1268,1274..1275)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1271..1275
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1296..1371
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1299..1303
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1312..1316
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1335..1339
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1349..1354
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1363..1366
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1470..1600
                     /region_name="Laminin_B"
                     /note="Laminin B (Domain IV); pfam00052"
                     /db_xref="CDD:459652"
     Region          1657..1710
                     /region_name="Laminin_EGF"
                     /note="Laminin EGF domain; pfam00053"
                     /db_xref="CDD:395007"
     Site            order(1657,1659,1671,1681,1683,1692)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Region          1835..1971
                     /region_name="Laminin_B"
                     /note="Laminin B (Domain IV); pfam00052"
                     /db_xref="CDD:459652"
     Region          <1972..1998
                     /region_name="EGF_Lam"
                     /note="Laminin-type epidermal growth factor-like domain;
                     laminins are the major noncollagenous components of
                     basement membranes that mediate cell adhesion, growth
                     migration, and differentiation; the laminin-type epidermal
                     growth factor-like module occurs in...; cd00055"
                     /db_xref="CDD:238012"
     Region          2006..2055
                     /region_name="EGF_Lam"
                     /note="Laminin-type epidermal growth factor-like domain;
                     laminins are the major noncollagenous components of
                     basement membranes that mediate cell adhesion, growth
                     migration, and differentiation; the laminin-type epidermal
                     growth factor-like module occurs in...; cd00055"
                     /db_xref="CDD:238012"
     Site            order(2007,2009,2016,2023,2026,2035)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Region          <2092..2122
                     /region_name="Laminin_EGF"
                     /note="Laminin EGF domain; pfam00053"
                     /db_xref="CDD:395007"
     Region          2188..2322
                     /region_name="Laminin_B"
                     /note="Laminin B (Domain IV); pfam00052"
                     /db_xref="CDD:459652"
     Region          2477..2559
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          2488..2492
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          2504..2508
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          2523..2527
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          2537..2542
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          2552..2555
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          <2586..2639
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          2670..2753
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          2681..2685
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          2694..2698
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          2717..2721
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          2731..2736
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          2766..2846
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          2783..2787
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409570"
     Region          2796..2800
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409570"
     Region          2815..2819
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409570"
     Region          2829..2834
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409570"
     Region          2842..2845
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409570"
     Region          2864..2940
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          2872..2876
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          2885..2889
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          2906..2910
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          2920..2925
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          2933..2936
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          2953..3040
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          2963..2967
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          2976..2980
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          3020..3025
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          3165..3241
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          3174..3178
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          3187..3191
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          3207..3211
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          3221..3226
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          3253..>3320
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          3264..3268
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          3280..3287
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          3303..3307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          3403..3471
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          3427..3431
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          3448..3451
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          3461..3466
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          3495..3561
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          3503..3507
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          3516..3520
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          3535..3539
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          3549..3554
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          3583..3730
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          3753..3785
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          3833..3986
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          4040..4072
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          4081..4234
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     CDS             1..4275
                     /gene="trol"
                     /coded_by="XM_070218434.1:209..13036"
                     /db_xref="GeneID:108055788"
ORIGIN      
        1 mgspgsqapa iaigisngrr ghtgslllrl llvafvlnac hvpptnakqi tkskvddqdf
       61 iladtqslqg svdldddeaf lippdseekl dkkftpegnw wsqglhrvrr slnsffgsdd
      121 ddqekererq rqrqnnrdaa nrqkelrrqq kesqnrekql rlerqerqrl akrnnhvvfn
      181 rvtdprkras dlydeneasg lneeetttyr tyfvvnepys ddykerdslq fqnlqkllde
      241 dlrnffnrnf ennddeeqei hstlervdqt kdhfkirvql rvdlpssind fgskleqqln
      301 vykridrlga stdgvftfte ssvykyehqy divtprvivs gqpitekpve apqefdedpi
      361 evalptdeve gsgqdsgscr gdatfqcrrs gkticdemrc dgsrdcpdae deegcevcne
      421 lqfkcdnkcl plnkrcdnry dcedqtdeag cqryeveesq pqpqpqpqpe pepepepepe
      481 pepepepepe epitdneqpe qnsecratef rcnngdcidi rkrcdhisdc segedeneec
      541 paacsgmeyq crdgtrcisl sqqcdghsdc sdaddeehcd gsgndgedcr fdefrcgtge
      601 cipmrqvcdn iydcndysde vscaeeeeds vgipigrppq rpapkhdwld eldaneyhvy
      661 hpsnvyelan sknpcasnqf rcattnvcip lhlrcdnfyh cndmsdekdc eqyqrrtttt
      721 trrpstsarp sftftfttqg pgllerrnst tsrttagstt rateapqwpw atrptetttt
      781 npittvgvat riycppnrla cngrcvsrri rcdgkrdcld gydemycpvv nttetnyhyp
      841 thnpkpktcr thewqctnle ciemrlkcdd vpdcsdgsde dlsicfgtat trlkpsdcgp
      901 dqffcddlcy nrsircnghm dcsdgsdeia csslsvlpcp qhqcpsgrcy sesercdrhr
      961 hcedgsdean ccyadqfrcn ngdciaesah cdgnidcsdq sdeldcggds qclpnqfrck
     1021 ngqcvsstar cnkrsdcldg sdeqncanep nnsgrgtnql klktypdnqi ikesrevifr
     1081 crdegpnrak vkwsrpggrp lppgftdrng rleipnirve dagayvceav gyanyipgqh
     1141 vtvnlnverl nereirpdsa cteyqatcmn gecidksgic dghpdcsdgs dehscslglk
     1201 cqpnqfmcsn skcvdrtwrc dgendcgdns detscdpeps dapcrydefq crsghcipks
     1261 fqcdymndct dgtdeigcsv pspmtlpaps ivvmeyevle ltcvgtgvpt ptivwrlnwg
     1321 hvpekcesks yggtgtlrcp nmrpqdsgay scefintrgt fypktnsivt vtpvrsdvck
     1381 agffnmlark seecvqcfcf gvstncdsan lftyaiqppi lshrvvsvel spfrqivine
     1441 aspgqdlltl hhgvqfrasn vhyngretpf lalpaeymgn qlksyggnlr yevryngngr
     1501 pvsgpdviit gnsftlthrv rthpgqnnrv tipflpggwt kpdgrkgtre dimmilanvd
     1561 nilirlgyld starevdlin ialdsagsad qglgsaslve kctcppgyvg dscescasgy
     1621 vrqargpwlg hcvpftpepc pagtygnprl gvpcqecpcp hagannfasg cqqspdgdvi
     1681 crcnegyagk rcehcaqgyq gnplapggvc rkipdsscnv dgtyniysng tcqckdsvig
     1741 eqcdtcapks fhlnsftytg ciecfcsgvg ldcdssswyr nqvtstfgrt rvnhgfalis
     1801 dymrntpvtv pvsmstqana lsfvgsaeqa gntlywslpa aflgnkltsy ggklsytlsy
     1861 splpsgimsr nsapdvviks gedlrlihyr ksqvspsvan tyaveikesa wqrgdelvpn
     1921 rehvlmalsn itaiyikaty ttstkeaslr svtldtatat nlgtaravev eqcrcpegyl
     1981 glsceqcapg ytrdpeagiy lglcrpcecn ghskycnset gecescsdnt egfncdrcaa
     2041 gyvgdatrgt sydcqyddgg yptsrppapg nqtaeclvnc qqegtagcrg yqceckrnva
     2101 gdrcdqcrpg tyglsaqnpd gckecycsgl tnqcrsasly rqlipvdfis tpplitdefg
     2161 dimdrdnlvp dvprnvytyk htsytpkyws lrgsvlgnql lsyggrleys livesvgrdh
     2221 rgkdvvlign glkliwsrpd ghdneqeyhv rlhedeqwtv edrgsarqat radfmtvlsd
     2281 lqhililatp kvptvstsis nvilessitt rapgathasd ielcqcpsgy tgtscescap
     2341 lhyrdasgrc sqcpcdasnt escglvsggn vecqcrprwr gdrcreidts piieeppqic
     2401 dlsrgfccsg fqfdiapnet isfndtlqiy kgnriignmt klrygcpsre tneptpepdt
     2461 stddpvrtqi ivsiarpeit ilpvggsltl sctgrmrwtn spvfvnwykq gshlpegvev
     2521 qggnlqlfnl qisdsgiyic qavsnetghs ftdhvsitvs qedqrspahi vdlpndvtfe
     2581 eyvsneivce vegnppptvt wtrvdghada qstrtdnnrl vfdsprksde gryrcqaens
     2641 lsreekyvvv yvrsnppqpp pqqdrlyitp qevngvagds fqlscqftsa aslrydwshd
     2701 grslsasspr nvvvrgnvle vrdanvrdsg tytcvafdlr trrnftesar vyieqpnepg
     2761 ilgdkphilt leqniiivqg edlsitceas gtpypsikwt kvqenlaenv risgnvltiy
     2821 ggrsenrgly sciaenshgs dqsstsidie prerpsltid tatqkvsvgs qaslycaaqg
     2881 ipeptvewvr tdgqplsprh kvqapgyvvi ddivlddsgt yecrasniag qvsglatinv
     2941 qeptlvriep drqhhivtqg delslscvgs gvptpsvfws fegrdvdrmg vpegavfaqp
     3001 frtntadvki frvskenegi yvchgsndag edqqyirvev qprrgdvgag gddngdvdtr
     3061 qppnrpqiqp nplsnerltt elgnnvtlic nvdnvntewe rvdgtplphn aytvrntlvi
     3121 vfvepqnlgq yrcngigrdg rveahvvrel vllplpritf ypnipltvel gqnldvycqv
     3181 envrpedvhw ttdnnrplps svriegnvlr fasitqaaag eyrcsatnqy gsrsknarvv
     3241 vkqpsgfqpv phsqvqqrqv gdsiqlrcrl ttqygdevrg niqfnwyred gsplprgvrp
     3301 dsqvlqlvkl qpedegryic nsydlgsgqq lppvsidlqv lrtttqypfn rfkggvslkd
     3361 tpcmvlyica avpaapqnpi ylppvapprs perilepqls lsvqssnlpa gdgttvecfs
     3421 sddsypdvvw eradgaplse nvqqvgnnlv isnvastdag nyvckcktde gdlyttsykl
     3481 eveeqphelk sskivyakvg gnadlqcgad edrqpsyrws rqygqlqagr slqneklsld
     3541 rvqandagty vcsaqysdge tvdfpnilvv tgaipqfrqe prsymsfptl snssfkfnfe
     3601 ltfrpenadg lllfngqtrg sgdyialslk dryaefrfdf ggkpllvrae eplaldewht
     3661 vrvsrfkrdg yiqvddqhpv afptsqhqqi pqleliedly iggvpnwefl paeavgqqsg
     3721 fvgcisrltl qgrtvelire akfkegitdc rpcaqgpcqn kgvclesqte qaytcvcqpg
     3781 wtgrdcaieg tqctagvcgs grcentendm eclcplnrag drcqyneiln eqslnfksns
     3841 faaygtpkvt kvnitlsvrp asledsvily taestlpsgd ylalvlrggh aellintaar
     3901 ldpvvvrsae plplnrwtri eirrrlgegi lkvgdgperk akapgsdril slkthlfvgg
     3961 vdrstvkinr dvnitkgfdg cisklynsqk svnllgdird aanvqncgea neidddeyem
     4021 pvalpspkva enerqlmapc asdpcenggs cseqedmaic scpfgfsgkh cqnhlqlsfn
     4081 asfrgdgyve lnrshfqpal eqtyshigiv fttnkpngll fwwgqeagee ytgqdfiaaa
     4141 vvdgyveysm rldgeeavir nsdirvdnge rhiviakrde ntamleldqi ldtgdtrpti
     4201 nkamklpgnv fvggapdvaa ftgfrykdnf ngcivvvege tvgqinlssa aingvnanvc
     4261 pandeplggt eppvv