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basement membrane-specific heparan sulfate proteoglycan core


LOCUS       XP_070074529            4364 aa            linear   INV 09-DEC-2024
            protein isoform X11 [Drosophila takahashii].
ACCESSION   XP_070074529
VERSION     XP_070074529.1
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_070218428.1
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4364
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..4364
                     /product="basement membrane-specific heparan sulfate
                     proteoglycan core protein isoform X11"
                     /calculated_mol_wt=482705
     Region          84..>169
                     /region_name="CCDC66"
                     /note="Coiled-coil domain-containing protein 66;
                     pfam15236"
                     /db_xref="CDD:434558"
     Region          418..451
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(423,430,441..442)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(434,437,441,447..448)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            444..448
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          504..536
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(510,518,529..530)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(522,525,529,535..536)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            532..536
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          544..579
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(549,558,569..570)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(562,565,569,575..576)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            572..576
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          589..623
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(594,602,613..614)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(606,609,613,619..620)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            616..620
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          675..710
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(680,689,700..701)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(693,696,700,706..707)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            703..707
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          797..831
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(803,811,822..823)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(815,818,822,828..829)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            825..829
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          836..871
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(841,850,861..862)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(854,857,861,867..868)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            864..868
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          886..920
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(891,899,910..911)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(903,906,910,916..917)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            913..917
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          939..973
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(944,952,963..964)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(956,959,963,969..970)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            966..970
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          987..1020
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(992,999,1010..1011)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1003,1006,1010,1016..1017)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1013..1017
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1030..1060
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1031,1039,1050..1051)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1043,1046,1050,1056..1057)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1053..1057
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1061..1095
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1066,1074,1085..1086)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1078,1081,1085,1091..1092)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1088..1092
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1101..1135
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1106,1114,1125..1126)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1118,1121,1125,1131..1132)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1128..1132
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1150..1218
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          1250..1284
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1255,1263,1274..1275)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1267,1270,1274,1280..1281)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1277..1281
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1290..1324
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1295,1303,1314..1315)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1307,1310,1314,1320..1321)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1317..1321
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1333..1367
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1338,1346,1357..1358)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1350,1353,1357,1363..1364)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1360..1364
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1385..1460
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1388..1392
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1401..1405
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1424..1428
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1438..1443
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1452..1455
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1559..1689
                     /region_name="Laminin_B"
                     /note="Laminin B (Domain IV); pfam00052"
                     /db_xref="CDD:459652"
     Region          1746..1799
                     /region_name="Laminin_EGF"
                     /note="Laminin EGF domain; pfam00053"
                     /db_xref="CDD:395007"
     Site            order(1746,1748,1760,1770,1772,1781)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Region          1924..2060
                     /region_name="Laminin_B"
                     /note="Laminin B (Domain IV); pfam00052"
                     /db_xref="CDD:459652"
     Region          <2061..2087
                     /region_name="EGF_Lam"
                     /note="Laminin-type epidermal growth factor-like domain;
                     laminins are the major noncollagenous components of
                     basement membranes that mediate cell adhesion, growth
                     migration, and differentiation; the laminin-type epidermal
                     growth factor-like module occurs in...; cd00055"
                     /db_xref="CDD:238012"
     Region          2095..2144
                     /region_name="EGF_Lam"
                     /note="Laminin-type epidermal growth factor-like domain;
                     laminins are the major noncollagenous components of
                     basement membranes that mediate cell adhesion, growth
                     migration, and differentiation; the laminin-type epidermal
                     growth factor-like module occurs in...; cd00055"
                     /db_xref="CDD:238012"
     Site            order(2096,2098,2105,2112,2115,2124)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Region          <2181..2211
                     /region_name="Laminin_EGF"
                     /note="Laminin EGF domain; pfam00053"
                     /db_xref="CDD:395007"
     Region          2277..2411
                     /region_name="Laminin_B"
                     /note="Laminin B (Domain IV); pfam00052"
                     /db_xref="CDD:459652"
     Region          2566..2648
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          2577..2581
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          2593..2597
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          2612..2616
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          2626..2631
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          2641..2644
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          <2675..2728
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          2759..2842
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          2770..2774
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          2783..2787
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          2806..2810
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          2820..2825
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          2855..2935
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          2872..2876
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409570"
     Region          2885..2889
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409570"
     Region          2904..2908
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409570"
     Region          2918..2923
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409570"
     Region          2931..2934
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409570"
     Region          2953..3029
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          2961..2965
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          2974..2978
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          2995..2999
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          3009..3014
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          3022..3025
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          3042..3129
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          3052..3056
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          3065..3069
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          3109..3114
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          3254..3330
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          3263..3267
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          3276..3280
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          3296..3300
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          3310..3315
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          3342..>3409
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          3353..3357
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          3369..3376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          3392..3396
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          3486..3554
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          3584..3650
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          3592..3596
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          3605..3609
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          3624..3628
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          3638..3643
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          3672..3819
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          3842..3874
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          3922..4075
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          4129..4161
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          4170..4323
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     CDS             1..4364
                     /gene="trol"
                     /coded_by="XM_070218428.1:209..13303"
                     /db_xref="GeneID:108055788"
ORIGIN      
        1 mgspgsqapa iaigisngrr ghtgslllrl llvafvlnac hvpptnakqi tkskvddqdf
       61 iladtqslqg svdldddeaf lippdseekl dkkftpegnw wsqglhrvrr slnsffgsdd
      121 ddqekererq rqrqnnrdaa nrqkelrrqq kesqnrekql rlerqerqrl akrnnhvvfn
      181 rvtdprkras dlydeneasg lneeetttyr tyfvvnepys ddykerdslq fqnlqkllde
      241 dlrnffnrnf ennddeeqei hstlervdqt kdhfkirvql rvdlpssind fgskleqqln
      301 vykridrlga stdgvftfte ssvykyehqy divtprvivs gqpitekpve apqefdedpi
      361 evalptdeve gsgqdsgscr gdatfqcrrs gkticdemrc dgsrdcpdae deegcevcne
      421 lqfkcdnkcl plnkrcdnry dcedqtdeag cqryeveesq pqpqpqpqpe pepepepepe
      481 pepepepepe epitdneqpe qnsecratef rcnngdcidi rkrcdhisdc segedeneec
      541 paacsgmeyq crdgtrcisl sqqcdghsdc sdaddeehcd gsgndgedcr fdefrcgtge
      601 cipmrqvcdn iydcndysde vscaeeeeds vgipigrppq rpapkhdwld eldaneyhvy
      661 hpsnvyelan sknpcasnqf rcattnvcip lhlrcdnfyh cndmsdekdc eqyqrrtttt
      721 trrpstsarp sftftfttqg pgllerrnst tsrttagstt rateapqwpw atrptetttt
      781 npittvgvas sspqssclen iefachnrdc ipiesvcdgt pdcgrseded dalckctadk
      841 ykcqhgggci pktqvcdgkp qcrdrsdesa chlngrlnkt rlgvqcqenq yqcgdgscis
      901 gykrcngind caddadeync iytynedyvd pddnplnecd ilefecdysl clplekkcdg
      961 yadcedlsde fecqsytatt rlkpsdcgpd qffcddlcyn rsircnghmd csdgsdeiac
     1021 sslsvlpcpq hqcpsgrcys esercdrhrh cedgsdeanc cyadqfrcnn gdciaesahc
     1081 dgnidcsdqs deldcggdsq clpnqfrckn gqcvsstarc nkrsdcldgs deqncanepn
     1141 nsgrgtnqlk lktypdnqii kesrevifrc rdegpnrakv kwsrpggrpl ppgftdrngr
     1201 leipnirved agayvceavg yanyipgqhv tvnlnverln ereirpdsac teyqatcmng
     1261 ecidksgicd ghpdcsdgsd ehscslglkc qpnqfmcsns kcvdrtwrcd gendcgdnsd
     1321 etscdpepsd apcrydefqc rsghcipksf qcdymndctd gtdeigcsvp spmtlpapsi
     1381 vvmeyevlel tcvgtgvptp tivwrlnwgh vpekcesksy ggtgtlrcpn mrpqdsgays
     1441 cefintrgtf ypktnsivtv tpvrsdvcka gffnmlarks eecvqcfcfg vstncdsanl
     1501 ftyaiqppil shrvvsvels pfrqivinea spgqdlltlh hgvqfrasnv hyngretpfl
     1561 alpaeymgnq lksyggnlry evryngngrp vsgpdviitg nsftlthrvr thpgqnnrvt
     1621 ipflpggwtk pdgrkgtred immilanvdn ilirlgylds tarevdlini aldsagsadq
     1681 glgsaslvek ctcppgyvgd scescasgyv rqargpwlgh cvpftpepcp agtygnprlg
     1741 vpcqecpcph agannfasgc qqspdgdvic rcnegyagkr cehcaqgyqg nplapggvcr
     1801 kipdsscnvd gtyniysngt cqckdsvige qcdtcapksf hlnsftytgc iecfcsgvgl
     1861 dcdssswyrn qvtstfgrtr vnhgfalisd ymrntpvtvp vsmstqanal sfvgsaeqag
     1921 ntlywslpaa flgnkltsyg gklsytlsys plpsgimsrn sapdvviksg edlrlihyrk
     1981 sqvspsvant yaveikesaw qrgdelvpnr ehvlmalsni taiyikatyt tstkeaslrs
     2041 vtldtatatn lgtaraveve qcrcpegylg lsceqcapgy trdpeagiyl glcrpcecng
     2101 hskycnsetg ecescsdnte gfncdrcaag yvgdatrgts ydcqyddggy ptsrppapgn
     2161 qtaeclvncq qegtagcrgy qceckrnvag drcdqcrpgt yglsaqnpdg ckecycsglt
     2221 nqcrsaslyr qlipvdfist pplitdefgd imdrdnlvpd vprnvytykh tsytpkywsl
     2281 rgsvlgnqll syggrleysl ivesvgrdhr gkdvvligng lkliwsrpdg hdneqeyhvr
     2341 lhedeqwtve drgsarqatr adfmtvlsdl qhililatpk vptvstsisn vilessittr
     2401 apgathasdi elcqcpsgyt gtscescapl hyrdasgrcs qcpcdasnte scglvsggnv
     2461 ecqcrprwrg drcreidtsp iieeppqicd lsrgfccsgf qfdiapneti sfndtlqiyk
     2521 gnriignmtk lrygcpsret neptpepdts tddpvrtqii vsiarpeiti lpvggsltls
     2581 ctgrmrwtns pvfvnwykqg shlpegvevq ggnlqlfnlq isdsgiyicq avsnetghsf
     2641 tdhvsitvsq edqrspahiv dlpndvtfee yvsneivcev egnppptvtw trvdghadaq
     2701 strtdnnrlv fdsprksdeg ryrcqaensl sreekyvvvy vrsnppqppp qqdrlyitpq
     2761 evngvagdsf qlscqftsaa slrydwshdg rslsassprn vvvrgnvlev rdanvrdsgt
     2821 ytcvafdlrt rrnftesarv yieqpnepgi lgdkphiltl eqniiivqge dlsitceasg
     2881 tpypsikwtk vqenlaenvr isgnvltiyg grsenrglys ciaenshgsd qsstsidiep
     2941 rerpsltidt atqkvsvgsq aslycaaqgi peptvewvrt dgqplsprhk vqapgyvvid
     3001 divlddsgty ecrasniagq vsglatinvq eptlvriepd rqhhivtqgd elslscvgsg
     3061 vptpsvfwsf egrdvdrmgv pegavfaqpf rtntadvkif rvskenegiy vchgsndage
     3121 dqqyirvevq prrgdvgagg ddngdvdtrq ppnrpqiqpn plsnerltte lgnnvtlicn
     3181 vdnvntewer vdgtplphna ytvrntlviv fvepqnlgqy rcngigrdgr veahvvrelv
     3241 llplpritfy pnipltvelg qnldvycqve nvrpedvhwt tdnnrplpss vriegnvlrf
     3301 asitqaaage yrcsatnqyg srsknarvvv kqpsgfqpvp hsqvqqrqvg dsiqlrcrlt
     3361 tqygdevrgn iqfnwyredg splprgvrpd sqvlqlvklq pedegryicn sydlgsgqql
     3421 ppvsidlqvl rtttqypfnr fkggvslkdt pcmvlyicaa vpaapqnpiy lppvapprsp
     3481 erilepqlsl svqssnlpag dgttvecfss ddsypdvvwe radgaplsen vqqvgnnlvi
     3541 snvastdagn yvckcktdeg dlyttsykle veeqphelks skivyakvgg nadlqcgade
     3601 drqpsyrwsr qygqlqagrs lqneklsldr vqandagtyv csaqysdget vdfpnilvvt
     3661 gaipqfrqep rsymsfptls nssfkfnfel tfrpenadgl llfngqtrgs gdyialslkd
     3721 ryaefrfdfg gkpllvraee plaldewhtv rvsrfkrdgy iqvddqhpva fptsqhqqip
     3781 qleliedlyi ggvpnweflp aeavgqqsgf vgcisrltlq grtvelirea kfkegitdcr
     3841 pcaqgpcqnk gvclesqteq aytcvcqpgw tgrdcaiegt qctagvcgsg rcentendme
     3901 clcplnragd rcqyneilne qslnfksnsf aaygtpkvtk vnitlsvrpa sledsvilyt
     3961 aestlpsgdy lalvlrggha ellintaarl dpvvvrsaep lplnrwtrie irrrlgegil
     4021 kvgdgperka kapgsdrils lkthlfvggv drstvkinrd vnitkgfdgc isklynsqks
     4081 vnllgdirda anvqncgean eidddeyemp valpspkvae nerqlmapca sdpcenggsc
     4141 seqedmaics cpfgfsgkhc qnhlqlsfna sfrgdgyvel nrshfqpale qtyshigivf
     4201 ttnkpngllf wwgqeageey tgqdfiaaav vdgyveysmr ldgeeavirn sdirvdnger
     4261 hiviakrden tamleldqil dtgdtrptin kamklpgnvf vggapdvaaf tgfrykdnfn
     4321 gcivvveget vgqinlssaa ingvnanvcp andeplggte ppvv