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LOCUS XP_070074521 4496 aa linear INV 09-DEC-2024 protein isoform X3 [Drosophila takahashii]. ACCESSION XP_070074521 VERSION XP_070074521.1 DBLINK BioProject: PRJNA1194641 DBSOURCE REFSEQ: accession XM_070218420.1 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..4496 /organism="Drosophila takahashii" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" Protein 1..4496 /product="basement membrane-specific heparan sulfate proteoglycan core protein isoform X3" /calculated_mol_wt=497585 Region 84..>169 /region_name="CCDC66" /note="Coiled-coil domain-containing protein 66; pfam15236" /db_xref="CDD:434558" Region 418..451 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(423,430,441..442) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(434,437,441,447..448) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 444..448 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 504..536 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(510,518,529..530) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(522,525,529,535..536) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 532..536 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 544..579 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(549,558,569..570) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(562,565,569,575..576) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 572..576 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 589..623 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(594,602,613..614) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(606,609,613,619..620) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 616..620 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 675..710 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(680,689,700..701) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(693,696,700,706..707) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 703..707 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 797..831 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(803,811,822..823) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(815,818,822,828..829) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 825..829 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 836..871 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(841,850,861..862) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(854,857,861,867..868) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 864..868 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 886..920 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(891,899,910..911) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(903,906,910,916..917) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 913..917 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 939..973 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(944,952,963..964) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(956,959,963,969..970) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 966..970 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 980..1013 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(985,992,1003..1004) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(996,999,1003,1009..1010) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1006..1010 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1016..1050 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1021,1029,1040..1041) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1033,1036,1040,1046..1047) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1043..1047 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1069..1101 /region_name="LDLa" /note="Low-density lipoprotein receptor domain class A; smart00192" /db_xref="CDD:197566" Site order(1075,1083,1094..1095) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1087,1090,1094,1100..1101) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1097..1101 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1119..1152 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1124,1131,1142..1143) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1135,1138,1142,1148..1149) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1145..1149 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1162..1192 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1163,1171,1182..1183) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1175,1178,1182,1188..1189) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1185..1189 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1193..1227 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1198,1206,1217..1218) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1210,1213,1217,1223..1224) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1220..1224 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1233..1267 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1238,1246,1257..1258) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1250,1253,1257,1263..1264) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1260..1264 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1282..1350 /region_name="Ig_3" /note="Immunoglobulin domain; pfam13927" /db_xref="CDD:464046" Region 1382..1416 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1387,1395,1406..1407) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1399,1402,1406,1412..1413) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1409..1413 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1422..1456 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1427,1435,1446..1447) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1439,1442,1446,1452..1453) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1449..1453 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1465..1499 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(1470,1478,1489..1490) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(1482,1485,1489,1495..1496) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 1492..1496 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 1517..1592 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 1520..1524 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 1533..1537 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 1556..1560 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 1570..1575 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 1584..1587 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region 1691..1821 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region 1878..1931 /region_name="Laminin_EGF" /note="Laminin EGF domain; pfam00053" /db_xref="CDD:395007" Site order(1878,1880,1892,1902,1904,1913) /site_type="active" /note="EGF-like motif [active]" /db_xref="CDD:238012" Region 2056..2192 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region <2193..2219 /region_name="EGF_Lam" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055" /db_xref="CDD:238012" Region 2227..2276 /region_name="EGF_Lam" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; cd00055" /db_xref="CDD:238012" Site order(2228,2230,2237,2244,2247,2256) /site_type="active" /note="EGF-like motif [active]" /db_xref="CDD:238012" Region <2313..2343 /region_name="Laminin_EGF" /note="Laminin EGF domain; pfam00053" /db_xref="CDD:395007" Region 2409..2543 /region_name="Laminin_B" /note="Laminin B (Domain IV); pfam00052" /db_xref="CDD:459652" Region 2698..2780 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 2709..2713 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 2725..2729 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 2744..2748 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 2758..2763 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 2773..2776 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region <2807..2860 /region_name="Ig_3" /note="Immunoglobulin domain; pfam13927" /db_xref="CDD:464046" Region 2891..2974 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 2902..2906 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 2915..2919 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 2938..2942 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 2952..2957 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 2987..3067 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 3004..3008 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409570" Region 3017..3021 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409570" Region 3036..3040 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409570" Region 3050..3055 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409570" Region 3063..3066 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409570" Region 3085..3161 /region_name="I-set" /note="Immunoglobulin I-set domain; pfam07679" /db_xref="CDD:400151" Region 3093..3097 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3106..3110 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3127..3131 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3141..3146 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3154..3157 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409353" Region 3174..3261 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3184..3188 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3197..3201 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3241..3246 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3386..3462 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3395..3399 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3408..3412 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3428..3432 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3442..3447 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3474..>3541 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3485..3489 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3501..3508 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3524..3528 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3624..3692 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 3648..3652 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3669..3672 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3682..3687 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3716..3782 /region_name="IG_like" /note="Immunoglobulin like; smart00410" /db_xref="CDD:214653" Region 3724..3728 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409353" Region 3737..3741 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409353" Region 3756..3760 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409353" Region 3770..3775 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409353" Region 3804..3951 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" Region 3974..4006 /region_name="EGF" /note="EGF-like domain; pfam00008" /db_xref="CDD:394967" Region 4054..4207 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" Region 4261..4293 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:238011" Region 4302..4455 /region_name="LamG" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; cd00110" /db_xref="CDD:238058" CDS 1..4496 /gene="trol" /coded_by="XM_070218420.1:209..13699" /db_xref="GeneID:108055788" ORIGIN 1 mgspgsqapa iaigisngrr ghtgslllrl llvafvlnac hvpptnakqi tkskvddqdf 61 iladtqslqg svdldddeaf lippdseekl dkkftpegnw wsqglhrvrr slnsffgsdd 121 ddqekererq rqrqnnrdaa nrqkelrrqq kesqnrekql rlerqerqrl akrnnhvvfn 181 rvtdprkras dlydeneasg lneeetttyr tyfvvnepys ddykerdslq fqnlqkllde 241 dlrnffnrnf ennddeeqei hstlervdqt kdhfkirvql rvdlpssind fgskleqqln 301 vykridrlga stdgvftfte ssvykyehqy divtprvivs gqpitekpve apqefdedpi 361 evalptdeve gsgqdsgscr gdatfqcrrs gkticdemrc dgsrdcpdae deegcevcne 421 lqfkcdnkcl plnkrcdnry dcedqtdeag cqryeveesq pqpqpqpqpe pepepepepe 481 pepepepepe epitdneqpe qnsecratef rcnngdcidi rkrcdhisdc segedeneec 541 paacsgmeyq crdgtrcisl sqqcdghsdc sdaddeehcd gsgndgedcr fdefrcgtge 601 cipmrqvcdn iydcndysde vscaeeeeds vgipigrppq rpapkhdwld eldaneyhvy 661 hpsnvyelan sknpcasnqf rcattnvcip lhlrcdnfyh cndmsdekdc eqyqrrtttt 721 trrpstsarp sftftfttqg pgllerrnst tsrttagstt rateapqwpw atrptetttt 781 npittvgvas sspqssclen iefachnrdc ipiesvcdgt pdcgrseded dalckctadk 841 ykcqhgggci pktqvcdgkp qcrdrsdesa chlngrlnkt rlgvqcqenq yqcgdgscis 901 gykrcngind caddadeync iytynedyvd pddnplnecd ilefecdysl clplekkcdg 961 yadcedlsde fecqsytenc llsefecdgy clprdqlcng iincqdgsde rnctfcreda 1021 ylcttgecva vnqrcngive cadgsderhc vnttetnyhy pthnpkpktc rthewqctnl 1081 eciemrlkcd dvpdcsdgsd edlsicfgta ttrlkpsdcg pdqffcddlc ynrsircngh 1141 mdcsdgsdei acsslsvlpc pqhqcpsgrc ysesercdrh rhcedgsdea nccyadqfrc 1201 nngdciaesa hcdgnidcsd qsdeldcggd sqclpnqfrc kngqcvssta rcnkrsdcld 1261 gsdeqncane pnnsgrgtnq lklktypdnq iikesrevif rcrdegpnra kvkwsrpggr 1321 plppgftdrn grleipnirv edagayvcea vgyanyipgq hvtvnlnver lnereirpds 1381 acteyqatcm ngecidksgi cdghpdcsdg sdehscslgl kcqpnqfmcs nskcvdrtwr 1441 cdgendcgdn sdetscdpep sdapcrydef qcrsghcipk sfqcdymndc tdgtdeigcs 1501 vpspmtlpap sivvmeyevl eltcvgtgvp tptivwrlnw ghvpekcesk syggtgtlrc 1561 pnmrpqdsga yscefintrg tfypktnsiv tvtpvrsdvc kagffnmlar kseecvqcfc 1621 fgvstncdsa nlftyaiqpp ilshrvvsve lspfrqivin easpgqdllt lhhgvqfras 1681 nvhyngretp flalpaeymg nqlksyggnl ryevryngng rpvsgpdvii tgnsftlthr 1741 vrthpgqnnr vtipflpggw tkpdgrkgtr edimmilanv dnilirlgyl dstarevdli 1801 nialdsagsa dqglgsaslv ekctcppgyv gdscescasg yvrqargpwl ghcvpftpep 1861 cpagtygnpr lgvpcqecpc phagannfas gcqqspdgdv icrcnegyag krcehcaqgy 1921 qgnplapggv crkipdsscn vdgtyniysn gtcqckdsvi geqcdtcapk sfhlnsftyt 1981 gciecfcsgv gldcdssswy rnqvtstfgr trvnhgfali sdymrntpvt vpvsmstqan 2041 alsfvgsaeq agntlywslp aaflgnklts yggklsytls ysplpsgims rnsapdvvik 2101 sgedlrlihy rksqvspsva ntyaveikes awqrgdelvp nrehvlmals nitaiyikat 2161 yttstkeasl rsvtldtata tnlgtarave veqcrcpegy lglsceqcap gytrdpeagi 2221 ylglcrpcec nghskycnse tgecescsdn tegfncdrca agyvgdatrg tsydcqyddg 2281 gyptsrppap gnqtaeclvn cqqegtagcr gyqceckrnv agdrcdqcrp gtyglsaqnp 2341 dgckecycsg ltnqcrsasl yrqlipvdfi stpplitdef gdimdrdnlv pdvprnvyty 2401 khtsytpkyw slrgsvlgnq llsyggrley slivesvgrd hrgkdvvlig nglkliwsrp 2461 dghdneqeyh vrlhedeqwt vedrgsarqa tradfmtvls dlqhililat pkvptvstsi 2521 snvilessit trapgathas dielcqcpsg ytgtscesca plhyrdasgr csqcpcdasn 2581 tescglvsgg nvecqcrprw rgdrcreidt spiieeppqi cdlsrgfccs gfqfdiapne 2641 tisfndtlqi ykgnriignm tklrygcpsr etneptpepd tstddpvrtq iivsiarpei 2701 tilpvggslt lsctgrmrwt nspvfvnwyk qgshlpegve vqggnlqlfn lqisdsgiyi 2761 cqavsnetgh sftdhvsitv sqedqrspah ivdlpndvtf eeyvsneivc evegnppptv 2821 twtrvdghad aqstrtdnnr lvfdsprksd egryrcqaen slsreekyvv vyvrsnppqp 2881 ppqqdrlyit pqevngvagd sfqlscqfts aaslrydwsh dgrslsassp rnvvvrgnvl 2941 evrdanvrds gtytcvafdl rtrrnftesa rvyieqpnep gilgdkphil tleqniiivq 3001 gedlsitcea sgtpypsikw tkvqenlaen vrisgnvlti yggrsenrgl ysciaenshg 3061 sdqsstsidi eprerpslti dtatqkvsvg sqaslycaaq gipeptvewv rtdgqplspr 3121 hkvqapgyvv iddivlddsg tyecrasnia gqvsglatin vqeptlvrie pdrqhhivtq 3181 gdelslscvg sgvptpsvfw sfegrdvdrm gvpegavfaq pfrtntadvk ifrvskeneg 3241 iyvchgsnda gedqqyirve vqprrgdvga ggddngdvdt rqppnrpqiq pnplsnerlt 3301 telgnnvtli cnvdnvntew ervdgtplph naytvrntlv ivfvepqnlg qyrcngigrd 3361 grveahvvre lvllplprit fypnipltve lgqnldvycq venvrpedvh wttdnnrplp 3421 ssvriegnvl rfasitqaaa geyrcsatnq ygsrsknarv vvkqpsgfqp vphsqvqqrq 3481 vgdsiqlrcr lttqygdevr gniqfnwyre dgsplprgvr pdsqvlqlvk lqpedegryi 3541 cnsydlgsgq qlppvsidlq vlrtttqypf nrfkggvslk dtpcmvlyic aavpaapqnp 3601 iylppvappr sperilepql slsvqssnlp agdgttvecf ssddsypdvv weradgapls 3661 envqqvgnnl visnvastda gnyvckcktd egdlyttsyk leveeqphel ksskivyakv 3721 ggnadlqcga dedrqpsyrw srqygqlqag rslqneklsl drvqandagt yvcsaqysdg 3781 etvdfpnilv vtgaipqfrq eprsymsfpt lsnssfkfnf eltfrpenad glllfngqtr 3841 gsgdyialsl kdryaefrfd fggkpllvra eeplaldewh tvrvsrfkrd gyiqvddqhp 3901 vafptsqhqq ipqleliedl yiggvpnwef lpaeavgqqs gfvgcisrlt lqgrtvelir 3961 eakfkegitd crpcaqgpcq nkgvclesqt eqaytcvcqp gwtgrdcaie gtqctagvcg 4021 sgrcentend meclcplnra gdrcqyneil neqslnfksn sfaaygtpkv tkvnitlsvr 4081 pasledsvil ytaestlpsg dylalvlrgg haellintaa rldpvvvrsa eplplnrwtr 4141 ieirrrlgeg ilkvgdgper kakapgsdri lslkthlfvg gvdrstvkin rdvnitkgfd 4201 gcisklynsq ksvnllgdir daanvqncge aneidddeye mpvalpspkv aenerqlmap 4261 casdpcengg scseqedmai cscpfgfsgk hcqnhlqlsf nasfrgdgyv elnrshfqpa 4321 leqtyshigi vfttnkpngl lfwwgqeage eytgqdfiaa avvdgyveys mrldgeeavi 4381 rnsdirvdng erhiviakrd entamleldq ildtgdtrpt inkamklpgn vfvggapdva 4441 aftgfrykdn fngcivvveg etvgqinlss aaingvnanv cpandeplgg teppvv