1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase isoform

LOCUS       XP_070074253             948 aa            linear   INV 09-DEC-2024
            X3 [Drosophila takahashii].
ACCESSION   XP_070074253
VERSION     XP_070074253.1
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_070218152.1
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..948
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..948
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase isoform X3"
                     /calculated_mol_wt=107777
     Region          12..161
                     /region_name="EFh_NorpA_like"
                     /note="EF-hand motif found in Drosophila melanogaster No
                     receptor potential A protein (NorpA) and similar proteins;
                     cd16212"
                     /db_xref="CDD:320042"
     Region          12..38
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320042"
     Region          44..73
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320042"
     Region          82..111
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320042"
     Region          128..161
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320042"
     Region          173..506
                     /region_name="PI-PLCc_beta"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta; cd08591"
                     /db_xref="CDD:176533"
     Site            order(189..190,219,221,236,270,344,346,432,459,461)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176533"
     Site            order(189,236)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176533"
     Site            order(190,219,221,270)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176533"
     Region          542..659
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(557,583,614,616,618,620)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          718..762
                     /region_name="DUF1154"
                     /note="Protein of unknown function (DUF1154); pfam06631"
                     /db_xref="CDD:461969"
     CDS             1..948
                     /gene="norpA"
                     /coded_by="XM_070218152.1:176..3022"
                     /db_xref="GeneID:108060885"
ORIGIN      
        1 mlfvqmrqqp swmrlsycve ksgkipvktl aktfasgkte klvytcikda glpddknatm
       61 tkeqftfdkf yalyhkvcpr ndieelftsi tkgkqdfisl eqfiqfmndk qrdprmneil
      121 yplyeekrct eiindyelee ekkknnqmsl dgfkrylmsd enapvfldrl dfymemdqpl
      181 ahyyinsshn tylsgrqigg kssvemyrqt llagcrcvel dcwngkgede epivthghay
      241 cteilfkdci qaiadcafvs seypvilsfe nhcnraqqyk lakycddffg dlllkeplsd
      301 hpldpglplp ppcklkkkil iknkrmkpev ekvelelwlk gelktdddpe edasagkppe
      361 aaaapapape aaaaaegaae gggeaeaaaa nysgsttnvh pwlssmvnya qpikfqgfdk
      421 aiekniahnm ssfaesagmn ylkqssidfv nynkrqmsri ypkgtradss nympqvfwna
      481 gcqmvslnfq ssdlpmqlnq gkfeynggcg yllkpdfmrr adkdfdpfad apvdgviaaq
      541 csvkviagqf lsdkkvgtyv evdmfglpsd tvkkefrtrl vannglnpvy nedpfvfrkv
      601 vlpdlavlrf gvyeesgkil gqrilpldgl qagyrhvslr teanfpmslp mlfvnielki
      661 yvpdgfedfm amlsdprgfa gaakqqneqm kalgieeqsg gaardagkak eeekkepplv
      721 fepvtleslr qekgfqkvgk kqikeldtlr kkhakertsv qktqnaaidk likgkskddi
      781 rndatiknsi ndqtkqwtdm iarhrkeewd mlrqhvqdsq damkalmltv qaaqikqled
      841 rhardikdln akqakmsadt akevqndktl ktknekdrrl rekrqnnvkr fmeekkqigv
      901 kqgrameklk lahskqveef stdvqklmdm ykieeeaykt qgktefya