1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase isoform

LOCUS       XP_044252131            1093 aa            linear   INV 09-DEC-2024
            X2 [Drosophila takahashii].
ACCESSION   XP_044252131
VERSION     XP_044252131.1
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_044396196.2
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1093
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..1093
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase isoform X2"
                     /calculated_mol_wt=124597
     Region          17..149
                     /region_name="PH_PLC_beta"
                     /note="Phospholipase C-beta (PLC-beta) pleckstrin homology
                     (PH) domain; cd13361"
                     /db_xref="CDD:270167"
     Site            order(22,24,41,58,123)
                     /site_type="other"
                     /note="Rac1 binding site [polypeptide binding]"
                     /db_xref="CDD:270167"
     Site            order(25,27,38,40,42,57..58)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270167"
     Region          154..306
                     /region_name="EFh_NorpA_like"
                     /note="EF-hand motif found in Drosophila melanogaster No
                     receptor potential A protein (NorpA) and similar proteins;
                     cd16212"
                     /db_xref="CDD:320042"
     Region          154..183
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320042"
     Region          189..218
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320042"
     Region          227..256
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320042"
     Region          273..306
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320042"
     Region          318..651
                     /region_name="PI-PLCc_beta"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta; cd08591"
                     /db_xref="CDD:176533"
     Site            order(334..335,364,366,381,415,489,491,577,604,606)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176533"
     Site            order(334,381)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176533"
     Site            order(335,364,366,415)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176533"
     Region          687..804
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(702,728,759,761,763,765)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          863..907
                     /region_name="DUF1154"
                     /note="Protein of unknown function (DUF1154); pfam06631"
                     /db_xref="CDD:461969"
     CDS             1..1093
                     /gene="norpA"
                     /coded_by="XM_044396196.2:875..4156"
                     /db_xref="GeneID:108060885"
ORIGIN      
        1 mtkkyefdwi ipvppelttg cvfdrwfene ketkendfer dalfkvdeyg fflywksegr
       61 dgdvielcqv sdiraggtpr dpkildkvtk kngtnipeld krslticsnt dyinityhhv
      121 icpdaataks wqknlrlith nnratnvcpr vnlmkhwmrl sycveksgki pvktlaktfa
      181 sgkteklvyt cikdaglpdd knatmtkeqf tfdkfyalyh kvcprndiee lftsitkgkq
      241 dfisleqfiq fmndkqrdpr mneilyplye ekrcteiind yeleeekkkn nqmsldgfkr
      301 ylmsdenapv fldrldfyme mdqplahyyi nsshntylsg rqiggkssve myrqtllagc
      361 rcveldcwng kgedeepivt hghaycteil fkdciqaiad cafvsseypv ilsfenhcnr
      421 aqqyklakyc ddffgdlllk eplsdhpldp glplpppckl kkkiliknkr mkpevekvel
      481 elwlkgelkt dddpeedasa gkppeaaaap apapeaaaaa egaaegggea eaaaanysgs
      541 ttnvhpwlss mvnyaqpikf qgfdkaiekn iahnmssfae sagmnylkqs sidfvnynkr
      601 qmsriypkgt radssnympq vfwnagcqmv slnfqssdlp mqlnqgkfey nggcgyllkp
      661 dfmrradkdf dpfadapvdg viaaqcsvkv iagqflsdkk vgtyvevdmf glpsdtvkke
      721 frtrlvanng lnpvynedpf vfrkvvlpdl avlrfgvyee sgkilgqril pldglqagyr
      781 hvslrteanf pmslpmlfvn ielkiyvpdg fedfmamlsd prgfagaakq qneqmkalgi
      841 eeqsggaard agkakeeekk epplvfepvt leslrqekgf qkvgkkqike ldtlrkkhak
      901 ertsvqktqn aaidklikgk skddirndat iknsindqtk qwtdmiarhr keewdmlrqh
      961 vqdsqdamka lmltvqaaqi kqledrhard ikdlnakqak msadtakevq ndktlktkne
     1021 kdrrlrekrq nnvkrfmeek kqigvkqgra meklklahsk qveefstdvq klmdmykiee
     1081 eayktqgkte fya