LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HUWE1 [Drosophila
LOCUS XP_041447860 5319 aa linear INV 14-MAY-2021
obscura].
ACCESSION XP_041447860
VERSION XP_041447860.1
DBLINK BioProject: PRJNA728747
DBSOURCE REFSEQ: accession XM_041591926.1
KEYWORDS RefSeq; corrected model.
SOURCE Drosophila obscura
ORGANISM Drosophila obscura
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT MODEL REFSEQ: This record is predicted by automated computational
analysis. This record is derived from a genomic sequence
(NW_024542752.1) annotated using gene prediction method: Gnomon.
Also see:
Documentation of NCBI's Annotation Process
##Genome-Annotation-Data-START##
Annotation Provider :: NCBI
Annotation Status :: Full annotation
Annotation Name :: Drosophila obscura Annotation
Release 101
Annotation Version :: 101
Annotation Pipeline :: NCBI eukaryotic genome annotation
pipeline
Annotation Software Version :: 8.6
Annotation Method :: Best-placed RefSeq; Gnomon
Features Annotated :: Gene; mRNA; CDS; ncRNA
##Genome-Annotation-Data-END##
##RefSeq-Attributes-START##
frameshifts :: corrected 1 indel
##RefSeq-Attributes-END##
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..5319
/organism="Drosophila obscura"
/isolate="BZ-5 IFL"
/db_xref="taxon:7282"
/chromosome="Unknown"
/sex="male"
/tissue_type="whole fly"
/dev_stage="Adult fly"
/geo_loc_name="Serbia: Babin Zub"
/collection_date="2017"
Protein 1..5319
/product="LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase
HUWE1"
/calculated_mol_wt=572158
Region 90..326
/region_name="DUF908"
/note="Domain of Unknown Function (DUF908); pfam06012"
/db_xref="CDD:428721"
Region 620..1005
/region_name="DUF913"
/note="Domain of Unknown Function (DUF913); pfam06025"
/db_xref="CDD:461803"
Region 1483..1522
/region_name="UBA_like_SF"
/note="UBA domain-like superfamily; cl21463"
/db_xref="CDD:473871"
Region 1796..1868
/region_name="WWE"
/note="Domain in Deltex and TRIP12 homologues. Possibly
involved in regulation of ubiquitin-mediated proteolysis;
smart00678"
/db_xref="CDD:128922"
Region 3836..3866
/region_name="UBM"
/note="Ubiquitin binding region; pfam14377"
/db_xref="CDD:464159"
Region 3885..3912
/region_name="UBM"
/note="Ubiquitin binding region; pfam14377"
/db_xref="CDD:464159"
Region 4964..5317
/region_name="HECTc"
/note="HECT domain; C-terminal catalytic domain of a
subclass of Ubiquitin-protein ligase (E3). It binds
specific ubiquitin-conjugating enzymes (E2), accepts
ubiquitin from E2, transfers ubiquitin to substrate lysine
side chains, and transfers additional...; cd00078"
/db_xref="CDD:238033"
Site order(4968,4998,5009,5070,5244,5280..5281,5284..5288,5308,
5316)
/site_type="active"
/note="catalytic cleft [active]"
/db_xref="CDD:238033"
Site order(5098,5101..5102,5104..5105,5108,5115,5117,
5121..5122,5124,5129,5134,5151,5155)
/site_type="active"
/note="E2 interaction site [active]"
/db_xref="CDD:238033"
CDS 1..5319
/gene="LOC111072461"
/coded_by="XM_041591926.1:370..16329"
/note="The sequence of the model RefSeq protein was
modified relative to its source genomic sequence to
represent the inferred CDS: deleted 1 base in 1 codon"
/db_xref="GeneID:111072461"
ORIGIN
1 mkvdtvklkk gsseltsecr elideltkrr traellefld kihvwiygkc elyhwieild
61 rfdkildeaa rhvnsnefvl qcdtqfhstd vtlllhvlnf ttlliehsfs rhlynsiehl
121 tqllssqnmd ivlavlnlly mfskrsnfip rlpfekkell ivklfniaer wgdpnyglsl
181 kdccigepkl eflyqlcidy vdehghaaql eipdmmdlch tasapevikt iagqiskpse
241 aikmriahrv rlisgfnnyk lrlqfvqarl qavsiliysn alqdntdkvl ypgfgeelce
301 lidkedvilv eiraavlrtl tsmlhfdrnp nvpsragsrl mkivhytgae rqggtlpllv
361 rdcinnltth glteryplil atslfsllyh lasyelggsa lvksgmmqsl lcviswpgvd
421 lehitfvtra vrvidlitni diarfhqnng lnvfidrlek eikscckala digitlkest
481 lrdegkldms ldlvdvdied gsgssphrdt sddhlgginl ddeeedppdd dedqdleaap
541 gpsgssnmiv avagsgddag tegsaqagss sdpadtglav vvypansyya rplaerkael
601 sqsqlppssv qpkkpscvtq raallksmln flkksiqdha hfsnmrnime tsltqslrhi
661 ianaeyygps lfllatdvvt vyvfnepsll sslqdlgits vmlkallqkd vpatrevlgs
721 lpnvfsalcl nerglfefls ydpfdkvlkv llspdylvam rrrrssdplg dtatnlgnam
781 ddlikhhpyl radateaivr llnelvrlgs dpsficwran kessgsgggs hgsgshgvlp
841 svtaspmvmv agaggtasvl qsaandnnds sgddddddde mssasqqqqq ppgtvvgggg
901 vvvvastsrg tasqaagssg tgtaggcltv attsasssss alvrasvtpp ereaiplidy
961 ilnvmkfiea ifsnspngdh crefvlhggl kpilqllslp nlpvdspvst tsqavanvck
1021 ailsqaqetk vldvalkqla divgklkpli khftfpggsv lltelvccqr ledgfanaey
1081 tpilhnmsfv hgyvvmlvhl crnastdmra illkrwgvnr etgvqllqql vqlyislvwe
1141 stillnlcsd eptqnpdliw deiaaqmsaa agtddpltea elsrkleraa efrtkytpee
1201 qfryikslla assrlgrala ellgtlvkls vgspqtrqrr indlisnink vptpeareia
1261 rilssilvng fshesilpkp vpklkltfli csvgftgpml fddkrsafhl misqfcaeng
1321 lkaffemfyw alsldaeskk fefkqwasme dlmqsheddk rdcpegtgef ldawlqllek
1381 mvnpramlds pytmsprlny mpdtvpfepv fylihihqla mqalrriwar rpianygasm
1441 fetmilivkh lvkshatlle ryhtrlkeik fenlyirstd dglnvehikt ltdmgfthyh
1501 vvdalrnngs leeatdylln npeasahssh aattsagats ggaptaptpp ptameigldg
1561 tgmeggessg ggsgstislg ptptptfsqy ksggnpssyd ykhlklmppm ifdrfcdeai
1621 grafefmeai pdvvnsasdl iavlyrrhnh lnkqvfvtnf vrnviqwvdf tlqlfenprq
1681 pgattrgtrl eecltgmtat rlfvrlktst llldenfsdm hrplveaina qdamvslvkl
1741 ldnmaqwmme qsekpqaeri tvprwvqnlv dlidaidsis hilqrksnmr avcsdvwrwy
1801 dastgkwnay sdannelirn aynsgerwlh inigrqrctv sfncmtqvse asgshrpvfp
1861 alklseaisn lnnpvaatkv ehllnrvmrt aadgqgttht delislrhlm tfgdgqqtpt
1921 mvqpaaaaaa patgtsddts ndgggntttt stsggarara rsppapmttr sksrqknaaa
1981 aaaakaktpt aassaaaaaa tpsipkrtqr imlseenvgl skfdcariig sivsllqppi
2041 llqhetklsl lrlcarltrn yenaqtfirc ggvkmllqlq qscsfmgfpt yaiiilrhvl
2101 eappvlqeam ervlgmraag ivpvgqrdli fvltqvstav srnpqifvaa akemlrgeyl
2161 mnsnssssna laddarvmvk skfgqqptaa aggpnpqtpp papvkeemwe dpmvqsavav
2221 lkelllalvq pcchysiaip tndhpkaaae lpqtdhpgtt qfgameedep apahskkgat
2281 ggggataaag agtaatgdgk yepccctwhv ptavhthskp tlsratllkl lsdatrayqs
2341 llpkvllghv ytptdspliq epqmtfmavl ldrflpitkr hhvpevstma rvlicsisdc
2401 yqmpgvqvqv aeelhaavar alaqpdssek htrlqvlmsl fpnliespml fdkvhmhrnn
2461 myrvllrqgv mtyltkiaqy kdlsnhntlc tlasilrpme illrfsvstt tlgskrilfg
2521 gastggaggt gagnnasgsg ggggnsgnnt ygaiinrrly prlaartaag aaversngmg
2581 gehvlrdiir nvlsdrrhaf efifnsdema vdpedaappa ggsgaagsga gagaglglgl
2641 glgmgssssn tsaaaasvid vvgernsgss ggggiggepn dgpsgsagaa ggsssggpvr
2701 pvlnfdqlwd dflqseglrl asraagtggs sgsssqqhpq ngaasgaasg gggagagsgs
2761 gssinvdprl rssqpdghla pdgtnasssg ggngssgndn glgggnsdga stssdtgare
2821 nrremnasll gdasssdsds dgssendern ddedddddda pdedadehse tdvdeerprq
2881 fievfdhiye pessetasnd advdaddddd dddedvdddd addddddedr aagiddpele
2941 nqidialals nsnnrprrsa aitasgepvp ddpipddddd dddvdddddd savneaasra
3001 eaflferlvv dnpllmptpp tsfrvrmnss iaqpldidvn gaggagnasg aggsgggtgg
3061 aagssaargg ssggaaggss sgerpaasal rpssrswiap dfsfisaagg ipqgasgsna
3121 aangneaggg sgggagggfh tpsggaaaav aaatasnnqn msnlldeqva sggaggsgga
3181 tvasgghqsg gggggsgsst mcnngvrrrl myldqqycvc mpthqnptee tqieiftqda
3241 lhwwleeaka ldmesqtdac lyaahfllpy lirqlkaahy qrkqeeaarq aamaaaaaat
3301 tattiatpta ttptpiptst ftsatatvts aagtgaptat ataaatatgs nssnnrrssi
3361 pvlipmlips plapaaaqal aargvnpdgt sttntpttta ttvattaaaa eaaaptvaat
3421 atavnpaegq alpqpyataa rsrplrapir natlrrnepr apfniyaeid ltndpdiddd
3481 dndvepagrg tgagtaaaaa aalaavqshq nvaieshpsm flppaeplav aprhppvphl
3541 paasgrpprl hvrvqdvnif nefgqsaprv lngrthrlmy gqqrlshagr gpappppppp
3601 ppplapapas vldfypaaaa avesggaemq pinldfdlep phrndasdqd nvqeeeeeev
3661 nllwpgtfde peqeaaqrqq qqqlqqeqeq qqqqeddeae svqsisgrpv pspqhsdrit
3721 ppiqvtitde plmggghthp sppsdhspsp taaaaaiayc cnlwrsqwes llgssptnag
3781 ggsssstssv tatapttaaa ssdeggsaas gsgtgtatrt vtdmspevra algdlevpeg
3841 vdpsflaalp semreeviqe hlrmqrirqr aqqnaiqiah dslvevnpef laalplsiqs
3901 evlmqqrieq qrqaaqtanp edpvdtaaff qnlpenlrqv ilsdmeesqi aslppelaae
3961 aqflrrdwet rngprlgdah ppsnalsrfq ntlqsleear whssiwydas gnaqpqhhqh
4021 ttivhhhahh hspnvgkpla llmmedenil ldpdslatll lflfvedqkv nsmrlhrvir
4081 nlchheptrd wiinaliniv qktneesanf ggtgqgqgqg skpdwlklrv daafgyksni
4141 flinhlhdet tsasgsgsas akgisinpqa aqmivrncld llfvlakhyp ssfvpyhret
4201 ktrrmlsavf gmpppvpgar ieeqqpqppp aggtldfrsr fyryqvanrm ramledhpri
4261 lapptppqpv qatatatats pldeapstsk aaaakaakaa tttdggsgyq tnsynfwdvv
4321 lnidrqteer mkhvakfpiv sqpswewvak tgdflsfsds pfgqllamlp ykvicrsphl
4381 tdmlvkllas lstelpkeee pgpviepqmp klipmnqavl nqqaqqnqem sqaaaaltga
4441 nasgdshtht srplpelkkm pppqltlpmp ikpkrkiyak nfsqlqlvie vlthqcgtte
4501 gldnvakliv nltqcsqasn aifiqyltaa ilglaeevrq aietllqeir aynsnaglps
4561 tsqqaaaaaa aavaaaaaas aaaaaaaaaa aagpstsagl lpnlavhegi mqdrftaehv
4621 iisapknakp tcelqlpsmk klmsnsssqp fflrtlkifm qvrdmyenqt vasddeedfi
4681 dilgdggats gsssdasrfr armetnqpsd gaidgdcdgd gddeddeeam plggssgacg
4741 gvaggvagas gtdsskpgkp tlsqilcldv lwhtlseclv aleeskdefa vlvlqptvea
4801 fflihashri pkkgargraa ssrasasnts sssvqdispl mdegsgsgst afssddaqda
4861 sntsignana npnagaatat gcgsglsahe aqlkqdrhkf lqfaekhrtv lnqilrqspt
4921 hlsdgpfavl vdhtrildfd vkrkyfqtel erldegirre ehtvsvrrvt vfedsfrvly
4981 rlgpeewknr fyivfedeeg qdaggllrew yviisreifn pmyalfcvsp gdrvtyminp
5041 sshanpnhls yfkfvgrvia kavhdnklle cyftrsfykh ilgkqvkhtd mesqdyefyk
5101 gldylmkndi snlgyeltfs tevqefgvtq irdlkpngrd tpvteenkfe yvqlvcqlkm
5161 sgsirqqlda flegfydiip khlisifneq elellisglp didiedlkan teyhkytsks
5221 aqiqwfwral rsfdqadrak flqfvtgtsk vplqgfgsle gmngiqkfqi hrddrstdrl
5281 pcahtcfnql dlpmyksydk lrscllkaih ecsegfgfa