rho GTPase-activating protein Graf isoform X3 [Drosophila

LOCUS       XP_016996147             992 aa            linear   INV 09-DEC-2024
            takahashii].
ACCESSION   XP_016996147
VERSION     XP_016996147.2
DBLINK      BioProject: PRJNA1194641
DBSOURCE    REFSEQ: accession XM_017140658.3
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 18, 2021 this sequence version replaced XP_016996147.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..992
                     /organism="Drosophila takahashii"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     Protein         1..992
                     /product="rho GTPase-activating protein Graf isoform X3"
                     /calculated_mol_wt=111886
     Region          27..233
                     /region_name="BAR_RhoGAP_OPHN1-like"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain of
                     Oligophrenin1-like Rho GTPase Activating Proteins;
                     cd07602"
                     /db_xref="CDD:153286"
     Site            order(36,39..40,44,46..47,50..51,53..54,57..58,60..61,
                     64..65,67..68,71,98,101..102,194,197..198,200,205,
                     208..209,211..212,216..217,220..221,223..224,226..227,
                     229..230)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153286"
     Region          273..390
                     /region_name="BAR-PH_GRAF_family"
                     /note="GTPase Regulator Associated with Focal adhesion and
                     related proteins Pleckstrin homology (PH) domain; cd01249"
                     /db_xref="CDD:269953"
     Region          383..584
                     /region_name="RhoGAP"
                     /note="GTPase-activator protein (GAP) for Rho-like
                     GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases.
                     Small GTPases (G proteins) cluster into distinct families,
                     and all act as molecular switches, active in their
                     GTP-bound form but inactive when bound to...; cl02570"
                     /db_xref="CDD:470621"
     Site            order(431,475,479,548,551..552,575)
                     /site_type="other"
                     /note="GTPase interaction site"
                     /db_xref="CDD:238090"
     Site            431
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238090"
     Region          934..987
                     /region_name="SH3_GRAF-like"
                     /note="Src Homology 3 domain of GTPase Regulator
                     Associated with Focal adhesion kinase and similar
                     proteins; cd11882"
                     /db_xref="CDD:212815"
     Site            order(939,941,944,948,967..968,981,983..984)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212815"
     CDS             1..992
                     /gene="Graf"
                     /coded_by="XM_017140658.3:446..3424"
                     /db_xref="GeneID:108056722"
ORIGIN      
        1 mgggknirrg leplefeeci vdspdfrenl nrhekeldht shqikriike vkdlmsaakm
       61 lstrmkqlai lltdfnfeci gtaqtddenv iceslkrfga iigniedere kmltladkhi
      121 iesledfrkk qiggvkenkk kfdkktekfc qsqerflnms tkkpentiqe adaslgmher
      181 eyiqeslsyv lriqevqeri kfefveilla fisgwlvfyh taheqaedhr dylqdlrhkv
      241 qktrenfeea rekvtelktk ymekrtkpee iftkrgylfl mekssilkis llepfkatwt
      301 kyyctfkkqk reftmlqfnq mnhnftrpea rddekltlfs cqrrasefek rfcfdltfke
      361 kpgvvytfqa lsekdhrywi samdgtepty lapgkikvse ayhldeagfm firrciqvle
      421 irgledegiy rksgvgtkis kllslglnqk etddvfvddk yrdlmesnti asalkmylrn
      481 lneplmtyqy hsdfieaakq etlnqrvnev hklvyklpqp nfqmldmvic hltdvsrkye
      541 knkmsvfnlg vvfgptllrp reesvaaild ikfnnivini lidnyerifk nkpsadvklp
      601 veaakapsim yparsspptr mprasqigka astgamgsts staaaaaaag npmflnqqki
      661 yrvvsksnct eptmssslqn ipngdnyasg gagcislspp mhmlngilsp tigsinnlht
      721 isknettvgt ttaagtrryv pndtaevatd ygiiganngg vtlqshhaip vssttnfrhp
      781 eylvtqsgst nhlytnssss vagaaatsgn rislnnvspp ntamrkerfl gstgsgpqqh
      841 ppvqrglhsy gqtkqqqqqh ysplmptsts ssndsnssls phlghgsacd evvtattvsc
      901 ggsanessey ppskmhrnrd inqikrdlst gtarvrtlya cmgesegels fepnqiitnv
      961 ryshepgwlq gtlngktgli penyvehlkp hh