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LOCUS XP_016995254 2019 aa linear INV 09-DEC-2024 [Drosophila takahashii]. ACCESSION XP_016995254 VERSION XP_016995254.2 DBLINK BioProject: PRJNA1194641 DBSOURCE REFSEQ: accession XM_017139765.3 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Oct 18, 2021 this sequence version replaced XP_016995254.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..2019 /organism="Drosophila takahashii" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" Protein 1..2019 /product="low-density lipoprotein receptor-related protein 4 isoform X1" /calculated_mol_wt=226669 Region 279..313 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(284,292,303..304) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(296,299,303,309..310) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 306..310 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 318..352 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(323,331,342..343) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(335,338,342,348..349) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 345..349 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 359..402 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(364,381,392..393) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(385,388,392,398..399) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 395..399 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 409..443 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(414,422,433..434) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(426,429,433,439..440) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 436..440 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 454..488 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(459,467,478..479) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(471,474,478,484..485) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 481..485 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 492..533 /region_name="LDLa" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; cd00112" /db_xref="CDD:238060" Site order(497,512,523..524) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238060" Site order(516,519,523,529..530) /site_type="other" /note="calcium-binding site [ion binding]" /db_xref="CDD:238060" Site 526..530 /site_type="other" /note="D-X-S-D-E motif" /db_xref="CDD:238060" Region 576..>607 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain; smart00179" /db_xref="CDD:214542" Site order(576,579,594) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:238011" Region 646..683 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 692..726 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 730..772 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 752..789 /region_name="Ldl_recept_b" /note="Low-density lipoprotein receptor repeat class B; pfam00058" /db_xref="CDD:459654" Region 773..815 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 818..850 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 894..924 /region_name="FXa_inhibition" /note="Coagulation Factor Xa inhibitory site; pfam14670" /db_xref="CDD:464251" Region 958..997 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region <979..1154 /region_name="NHL" /note="NHL repeat unit of beta-propeller proteins; cl18310" /db_xref="CDD:302697" Region 1000..1042 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 1010..1049 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 1050..1087 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 1063..1104 /region_name="Ldl_recept_b" /note="Low-density lipoprotein receptor repeat class B; pfam00058" /db_xref="CDD:459654" Region 1096..1131 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 1197..1232 /region_name="FXa_inhibition" /note="Coagulation Factor Xa inhibitory site; pfam14670" /db_xref="CDD:464251" Region 1272..>1457 /region_name="NHL" /note="NHL repeat unit of beta-propeller proteins; cl18310" /db_xref="CDD:302697" Region 1272..1308 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 1304..1346 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 1314..1349 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 1357..1395 /region_name="NHL repeat" /note="NHL repeat [structural motif]" /db_xref="CDD:271320" Region 1392..1433 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 1501..1535 /region_name="FXa_inhibition" /note="Coagulation Factor Xa inhibitory site; pfam14670" /db_xref="CDD:464251" Region 1541..1771 /region_name="Vgb" /note="Streptogramin lyase [Defense mechanisms]; COG4257" /db_xref="CDD:443399" Region 1610..1652 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 1653..1696 /region_name="LY" /note="Low-density lipoprotein-receptor YWTD domain; smart00135" /db_xref="CDD:214531" Region 1811..>1835 /region_name="FXa_inhibition" /note="Coagulation Factor Xa inhibitory site; pfam14670" /db_xref="CDD:464251" CDS 1..2019 /gene="Lrp4" /coded_by="XM_017139765.3:111..6170" /db_xref="GeneID:108056098" ORIGIN 1 myltafpfwp lvcfvwlcfg lgdltkfavk rnaphygihp tnalgrwdwn khkqlhsdar 61 qighletgne sredqlseel skfgekllpv snyppyqhnn nnnedrdsqe vhysgegrlh 121 tmespvpska rapgggggdt pkfrnigaqr grtevggglr eadrissrgr dgfigganhk 181 qkpfrvnlav lvqddpsqpg etsytncqns qesdencqtd gdgdgeaamp nlqrdcektg 241 lhvmcprtfr ciskywlcdg dddcgdysde thcgartnct edqfeclngf ciprtwlcdg 301 endckdfsde thcnrtscte ehftcndgyc islafrcdge hdcndnsdel kcaavinscp 361 egefkcrggl ggaggpsgqc ilnrfrcdgd ndcgdwsdee ncpqkpslct sneykcadgt 421 cipkrwkcdk eqdcdggede necgslgaeh pltcgsdeft cnngrcilkt wlcdgypdct 481 sgedevechl qcdlgqflcp tkqnitnlki cvhqkhicdg hnecpagede adcpkerkcl 541 epspceqlci etkagldeca crlgyvmdkn kvnctdidec qyltspvcsq kchntlgsfk 601 cscetgyilr pdlrsckalg gamtllvanr wdirrvtlsn nrytaivkgl hnaialdfhh 661 rkglmfwsdv stdvikmvym ngtrvrdvik wglespggia vdwihdllfw tdsgtrrvev 721 snfqgnlrtv iasydldkpr aivvhpgeal afwsdwgpnp kierafmdgt qrkviiskgv 781 twpnglaidf pnsklywada kqhaiecsnl dgsdrnkils thlphpfalt lfedtmywtd 841 wntktvsaad kitgkefrav henfhfpmdi hayhparqpe yadrcqkdrr glrggcshlc 901 lpnktsrrcg cpiglslked gktckstadk lvlvarrkdi rlrhlknnqa dpnevdmivp 961 ldnlkhaval dwcsdtdfiy wtdverstin kahlngsyqq rvvhsnlvsp vglaldwitd 1021 klywtdpstn rievattngk mrtlliwekl ykprdivvnp idglmfwsdw gdepmieran 1081 mdghdritis skrlkypngl aidyekskiy fvdggtktle nmnfdgsgrq vilnglghpf 1141 gldvnegrvf wtdwdtksvm sankltgket nviianstdl mdirvfhrtr rrifnacdkl 1201 nggcshlcll nptsytcact vgvqlkedgh tcsegptqyi lfahridirq isldfdhlid 1261 vvlplppisn avaldvdrkt gnifwsdtie nvimssspdg lhvhkvvgds lenpdglvvd 1321 sigrtiywad agrhtievas ldgsnrhvia ykdlesprgl aldydagllf wtdwghyrki 1381 ershldgner srivtanlgw pnglsldlks kriywvdarl ktidscdytg nqrklimssl 1441 hhpyalalse dniywtdwks kalhmterrn isakrdiitn idglmdikvi yqdqpltdnv 1501 cgsnngncsh lclrnpsgfs cqcpiglrlr qnsttqcqnl pedyllialr sgigmislns 1561 gdfmdvvlpi ngvhgavvld yhyrknllff advnldvirr vnllnftesk vivgtevltp 1621 ngiavdwiad nlywsdtdrk lievsrldgs srkrivednl gdprslivhp kkaylfwsdw 1681 sspakiersy ldgsnrtvli tsgigfptgl tidftnrrll wadalednig qvdfngkrrq 1741 tivpyaphpf gltmfdssif wtdwynksvy rsqrlprsgy gnafevrdal sgaldiravs 1801 lnrqpkswnh caqdnggcsh lclyryvdyv cacpdivdpk daacstkpkv lvhanlendq 1861 lleysdestd dstppdllge ssnhgddsht kksdqereff vlvalgvviv mvviiilvif 1921 mlafntskkk nkrnsrgssr svltfsnpny nvdgtpmepk tniwkrfkyd kshqeragvy 1981 eersltteta ssslfvptps pmaspstkti qlttlstit