1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase isoform

LOCUS       XP_013114312            1094 aa            linear   INV 02-SEP-2023
            X2 [Stomoxys calcitrans].
ACCESSION   XP_013114312
VERSION     XP_013114312.1
DBLINK      BioProject: PRJNA1009844
DBSOURCE    REFSEQ: accession XM_013258858.2
KEYWORDS    RefSeq.
SOURCE      Stomoxys calcitrans (stable fly)
  ORGANISM  Stomoxys calcitrans
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Muscoidea; Muscidae; Stomoxys.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_081555) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_963082655.1-RS_2023_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/29/2023
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1094
                     /organism="Stomoxys calcitrans"
                     /db_xref="taxon:35570"
                     /chromosome="4"
     Protein         1..1094
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase isoform X2"
                     /calculated_mol_wt=124611
     Region          17..149
                     /region_name="PH_PLC_beta"
                     /note="Phospholipase C-beta (PLC-beta) pleckstrin homology
                     (PH) domain; cd13361"
                     /db_xref="CDD:270167"
     Site            order(22,24,41,58,123)
                     /site_type="other"
                     /note="Rac1 binding site [polypeptide binding]"
                     /db_xref="CDD:270167"
     Site            order(25,27,38,40,42,57..58)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270167"
     Region          154..306
                     /region_name="EFh_PI-PLC"
                     /note="EF-hand motif found in eukaryotic
                     phosphoinositide-specific phospholipase C (PI-PLC, EC
                     3.1.4.11) isozymes; cl28895"
                     /db_xref="CDD:333715"
     Region          154..183
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320042"
     Region          189..217
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320042"
     Region          227..256
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320042"
     Region          273..306
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320042"
     Region          318..652
                     /region_name="PI-PLCc_beta"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta; cd08591"
                     /db_xref="CDD:176533"
     Site            order(334..335,364,366,381,415,467,469,578,605,607)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176533"
     Site            order(334,381)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176533"
     Site            order(335,364,366,415)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176533"
     Region          688..805
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(703,729,760,762,764,766)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          <826..>1081
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          864..908
                     /region_name="DUF1154"
                     /note="Protein of unknown function (DUF1154); pfam06631"
                     /db_xref="CDD:461969"
     CDS             1..1094
                     /gene="LOC106092100"
                     /coded_by="XM_013258858.2:630..3914"
                     /db_xref="GeneID:106092100"
ORIGIN      
        1 mtkkyefdwi ipvppelttg cvfdrwfene ketkendfek dalfkvdeyg fflywksdgr
       61 egdvielcqv sdiraggvpk dpkildkvtk kcgadlaald kkslticsnt dyinityhhv
      121 vcpdpetaki wlqglrkith nvkannicpm mclrkhwmrl sfsvekggki pikvvaktfa
      181 sgkteklvyq cikdvglpdd ksatmtpdqf tfdkfyalyh kvcprndiee lfttitkgks
      241 evitmdqfiq fmnekqrdpr mneilyplye ekrcteiind yelneerkka geismdgfkr
      301 ylmsdencpv fldrlemymd meqplshyyi nsshntylsg rqiggkssve myrqtllagc
      361 rcveldcwng kgedeepivt hghaycteil ykdciqaiad cafvassypv ilsfenhcnr
      421 aqqyklakyc ddffgelllk ealpdhplep glplpppckl qrkiliknkr mkpevekvel
      481 emwlkgelkt dddpeedata akppeaappp pdapppegae gapadgaape ggeqaaaysg
      541 sttnvhpwls smvnyaqpik fqgfdkaiek niahnmssfa esagmnylkq naidfvnynk
      601 rqmsriypkg tradssnymp qvfwnagcqm vslnfqtsdl pmqlnqgkfe ynggcgyllk
      661 pdfmrrgdkd fdpfadapvd gviaaqcsvk iiagqflsdk kvgtyvevdm fglpsdtvkk
      721 efrtrlvpnn glnpvynedp fvfrkvvlpd lavlrfgvye esgkmigqri lpldglqagy
      781 rhvslrtean fpmslpmlfv qvelkiyvpd gfedfmamls dprgfagaaq kqneqlkglg
      841 ieeqssgaak dagkskeeek keaplvfepv tleslrnekg fqkqakkqnk eldtlkkkht
      901 kermavqktq naaidklikg kskdeirnds aiknaiaeqt kqwtemiakh kkeewdllrq
      961 hvqdsqeamk almlvvqanq ikqleerhar dvkdlnakqa ktsadtakev qndktlktkn
     1021 ekdrrlrekr qnnikrfmee kkqigvkqgr ameklkmahn kqveefstdv qklldmykve
     1081 eeayklhgks efya