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PREDICTED: Drosophila takahashii RAS p21 protein activator vap


LOCUS       XM_070219328            3639 bp    mRNA    linear   INV 09-DEC-2024
            (vap), transcript variant X1, mRNA.
ACCESSION   XM_070219328
VERSION     XM_070219328.1
DBLINK      BioProject: PRJNA1194641
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3639
                     /organism="Drosophila takahashii"
                     /mol_type="mRNA"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     gene            1..3639
                     /gene="vap"
                     /note="RAS p21 protein activator vap; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 8
                     Proteins"
                     /db_xref="GeneID:108056092"
     CDS             314..3178
                     /gene="vap"
                     /codon_start=1
                     /product="ras GTPase-activating protein 1"
                     /protein_id="XP_070075429.1"
                     /db_xref="GeneID:108056092"
                     /translation="MADLIHLGNIDVVIQKDKPGSPTGCSDDGNLAGLGGMSGLGGMM
                     AAGGIDLGDLAQELDHDEFDGPHMLNGERPAIIAPPESEWYHGRLDRYSAESRLRGSS
                     KLGSYLVRESDRKPGSYVLSYYGRTGINHFRITAVCGDFYIGGRQFISLSDLVGYYTS
                     CSDLLKRERLAIPVAPPEPVNDKKRVVAILPYTKMPETDELSFQKGDIFFVHNDMGDG
                     WLWVTAHRTGEQGMIFRELVDDLDVSIDPNTVFPWFHPNCTKNEAVDMLVKAGPGSFL
                     VRPSDNSPGDYSLFFHINNQIQRFRIEKKGVRYLMGGRTFECLDAVINRYRKEQIVEG
                     HSLNHPVVNGIQPEFNQQYVVEKAAEKIYATLRECRDQIGLKKIKGIKHHGHLNKKSD
                     KTTKWKQLYFALINDGSETQLCFYDNPKKTKPKGLIDLSCAYLYQCHDSLWERPYCFQ
                     IVERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLSRAQKKVSRLRELRCLNLHV
                     LEAHRLPFKLVPHPYCSISLNQVKVGKTRVKIAPEPVWEEEFVLDDVPPDVVSLTITL
                     ISRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTPMGEWGSLRLRMRYLDDLIM
                     PCEEYSPLQQLLLESELYAVKALAELCHNDRVPLATALLRVFRQEKRETELIRMLCQA
                     EVTRENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELNPTK
                     MDVNDDACTNAEFLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERLVR
                     TRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGGKE
                     QYMEVVNPFILKNKERMIVFLDQLSSVNDPNQPLGMFVEQSTNLNSQDTGRELATLHH
                     ICVSHSQELHELSNILSIKKLVTVTDMLTKHKLKYREMIS"
     misc_feature    503..811
                     /gene="vap"
                     /note="N-terminal Src homology 2 (SH2) domain found in Ras
                     GTPase-activating protein 1 (GAP); Region:
                     SH2_Nterm_RasGAP; cd10353"
                     /db_xref="CDD:198216"
     misc_feature    order(584..586,641..643,704..706,710..712)
                     /gene="vap"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198216"
     misc_feature    order(707..709,785..787)
                     /gene="vap"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198216"
     misc_feature    860..1036
                     /gene="vap"
                     /note="Src Homology 3 domain of Ras GTPase-Activating
                     Protein 1; Region: SH3_RasGAP; cd11788"
                     /db_xref="CDD:212722"
     misc_feature    1067..1291
                     /gene="vap"
                     /note="C-terminal Src homology 2 (SH2) domain found in Ras
                     GTPase-activating protein 1 (GAP); Region:
                     SH2_Cterm_RasGAP; cd10354"
                     /db_xref="CDD:198217"
     misc_feature    order(1091..1093,1145..1147,1208..1210,1214..1216)
                     /gene="vap"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198217"
     misc_feature    order(1211..1213,1289..1291)
                     /gene="vap"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198217"
     misc_feature    1448..1765
                     /gene="vap"
                     /note="RAS p21 protein activator (GTPase activating
                     protein) 1 Pleckstrin homology (PH) domain; Region:
                     PH_RASA1; cd13260"
                     /db_xref="CDD:270080"
     misc_feature    1808..2179
                     /gene="vap"
                     /note="C2 domain present in RAS p21 protein activator 1
                     (RasA1); Region: C2_Ras_p21A1; cd08400"
                     /db_xref="CDD:176045"
     misc_feature    2171..3175
                     /gene="vap"
                     /note="Ras GTPase Activating Domain; Region: RasGAP;
                     cl02569"
                     /db_xref="CDD:470620"
     misc_feature    order(2276..2278,2384..2386,2390..2392,2396..2401,
                     2405..2407,2414..2416,2426..2428,2711..2713,2735..2740,
                     2747..2752,2759..2761,2822..2824,2831..2836,2843..2845,
                     2855..2857,2861..2863,2876..2881)
                     /gene="vap"
                     /note="RAS interface [polypeptide binding]; other site"
                     /db_xref="CDD:213340"
     polyA_site      3639
                     /gene="vap"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 ctctgttata tcttagatag tgaatacgtc ataagcttaa ttgttactcg aaaaattcta
       61 aaacctcttt aaaattataa taaagaacac acgttttcag tacaaaacta aaattgtgta
      121 aaaattgtgg gatacaaaag tcttagcaca taatcatcac ggaaaactga gtacaatcac
      181 caaagcttcc gtttttccta agtaaacgca aagacatcgt tgctatatgt ggcttttatc
      241 aaagggaatt tcgctgaaag ttaaatatag attaagattc ccattcactg agcagagatc
      301 ataaaggaag atcatggcgg acctaattca cttgggaaac atagatgttg tcatccagaa
      361 agataagccc ggctcgccga cgggctgctc ggatgatgga aacctggcag gtctgggcgg
      421 catgagtgga ttgggcggga tgatggccgc cggtggcatt gatctgggtg acttggcgca
      481 ggaattggat cacgatgaat tcgatggacc acacatgcta aatggtgaac gtccagcgat
      541 tattgctcct cccgaaagtg aatggtacca cggacgactt gatcgttact cagctgaatc
      601 acgtctgcgg ggcagcagta aactgggaag ctacttagtt cgtgaaagtg accgcaagcc
      661 tggctcctat gttctaagtt attatgggcg taccggcata aaccattttc ggatcacggc
      721 tgtgtgcgga gacttctata tcggtggacg acaattcata tcgttgagcg atctggttgg
      781 ctactatacc tcatgcagtg acctactgaa gcgcgaacga ttggccatac cagtggctcc
      841 gccggagcca gttaatgata agaagcgagt cgttgccatc ctgccttata caaaaatgcc
      901 agagaccgat gagctgagct tccagaaagg tgatattttc ttcgtgcaca atgacatggg
      961 cgacggttgg ctgtgggtca ctgcccatcg tactggcgag cagggaatga ttttccgaga
     1021 gcttgtggat gatctggatg tatccatcga tccgaatacc gtctttccgt ggtttcatcc
     1081 gaattgcacc aaaaacgaag ctgtcgatat gttggttaaa gctggacccg gcagcttctt
     1141 ggttcgcccc agcgacaact caccgggcga ttactccctc tttttccata ttaacaacca
     1201 gatccaacga tttcgcatcg agaagaaggg cgtgcgatat ttgatgggtg ggcggacatt
     1261 tgaatgcctc gatgcggtga ttaatcgtta ccgcaaggag caaattgtcg agggccattc
     1321 gctcaatcat ccggttgtca atggcataca gccagagttc aatcagcaat atgttgtgga
     1381 aaaggctgcg gaaaagatat atgccacact gcgcgagtgc cgtgaccaaa tcggtctgaa
     1441 gaagatcaag ggaatcaaac atcatgggca tttgaacaag aaatcggaca aaacgacgaa
     1501 atggaagcaa ctatatttcg ctctaatcaa cgatggctcc gagacgcaac tttgcttcta
     1561 cgacaatccg aagaagacca agccgaaggg tctgatcgat ttgtcatgtg cttacctcta
     1621 tcaatgtcac gattccctct gggagcgtcc ctattgcttt caaattgtgg aaagggctct
     1681 gccctgtttg gccactgtga catatctgtg tgctcctagt caggaaagct acgtggagtg
     1741 gatcaattcg ctgaaggccc aatgcgactc ccagctaagt cgggcccaga agaaggtctc
     1801 acggctacgc gagcttcggt gtctcaatct gcatgtgcta gaagctcatc gcttaccatt
     1861 taaattagtg ccacatccat actgcagtat ttcactcaat caagtcaaag tgggtaaaac
     1921 acgtgtcaaa attgcacccg aaccggtttg ggaggaggaa tttgtactgg atgacgttcc
     1981 cccagatgtt gtctccctaa ccattacgtt aatatcgcgc ggtaaacgcg gcaaagattc
     2041 ggaagtggcc gagctaacga tcgatttgtc tagtctgaag aatggccaag agactgaggg
     2101 ctggtaccag ctcaccggaa tgacgccgat gggcgaatgg ggctcgctgc gtctgcgtat
     2161 gcgttacctc gacgatctga taatgccctg cgaggagtac agtccactgc agcaattgct
     2221 actcgaatcg gagctgtatg cggtgaaggc gctggcggag ctctgtcaca acgatcgagt
     2281 gccattggcg acggctctgt tgcgagtctt tcggcaggag aagcgcgaga cggagctaat
     2341 tcgaatgctg tgccaggcgg aggtgacacg cgaaaacgag acgacgacac ttttccgggg
     2401 cgcctccttg gccaccacac taatggattt gtatatgcga accgaatgca gtggattctt
     2461 gcagtcggcg gtcagcgaaa ccgttcagcg cattttggag agcaagcagt cggcggaatt
     2521 aaatccaacg aaaatggacg tcaacgatga tgcctgcacg aatgccgagt ttctgctgca
     2581 aatcctcgat ctggtcaccc agtcgatatt tacttcaccg gacgcctgtc cccggaatgt
     2641 gcgcttcatt tgcagctgcc tgcagaaggc tgtgatggcc aagtggccga cagagcggct
     2701 ggttcgcacc cgagtcgtct ccgggttcat attcttgcgc ctcctatgcc cagccctgct
     2761 gaatcctcga caatttggcc tggtcagcga gacgcctccg atggcggcca ctcgttcttt
     2821 ggtcatggtc gccaagtgtc ttcaaaattt ggccaacttg attgagtttg gcggcaagga
     2881 acaatacatg gaggttgtca atccgtttat tttgaaaaac aaggaacgca tgattgtctt
     2941 cttggatcaa ctgtcctccg tcaacgatcc gaatcaaccg cttggaatgt ttgtcgaaca
     3001 aagtacaaat ctgaattcac aagacactgg gcgcgagctg gctaccttac atcacatctg
     3061 tgtatcgcat tcgcaagagc ttcacgagct atccaacata ctttcaatta agaagctggt
     3121 cacagtaacg gacatgttga ccaagcataa actgaagtac cgcgagatga tcagctaaaa
     3181 taaagataat aaacgcgatg tcttcttatc tacacaagtc ccttcatacc tttttataac
     3241 aaatatttat atgtgtatac tattagaata catgataaca ataagaactc ataataactg
     3301 gttgaattgt attggaatag taaacagaag aatatcattt ataaaaatta tttatacgaa
     3361 atgaaatatt atatttaact gacaggtata tgcatttatt tattattaaa aattacttat
     3421 ataatacact agcttacacg gagtactctc cgtatagccg caaaaaactc agaaattata
     3481 catggttttg cttttgatat tgtgttttaa atttacagaa acagaaacca cttttatcca
     3541 aaatccatac atttttttcg agacaaataa cgcataaaat cgaaataaat taatgaattt
     3601 ataaaaaaaa gagtgcaaaa gacttcctct gaaaaaata