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LOCUS XM_070219217 14882 bp mRNA linear INV 09-DEC-2024 receptor-related protein megalin (mgl), transcript variant X4, mRNA. ACCESSION XM_070219217 VERSION XM_070219217.1 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..14882 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..14882 /gene="mgl" /note="low-density lipoprotein receptor-related protein megalin; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 20 Proteins" /db_xref="GeneID:108054711" CDS 457..14739 /gene="mgl" /codon_start=1 /product="low-density lipoprotein receptor-related protein 2" /protein_id="XP_070075318.1" /db_xref="GeneID:108054711" /translation="MNPTPMGIGFGFGRKPPNKARMRSRWRPPPPATTLLTPDPAEGD NPAADPLQVTEASASASAPSSPIGDHRHPQLDSSRAAEPRLQHQQQEAQHYRQHRGQL TTLALLLLALVALSNLETLLAVRTEGPRNRHGSPGGSLGSTGGINTECPTDSFRCNNG KCISHHWVCNYQKDCDDGEDEMQSCPPPECETPQLNCGQYVFNKTYCIPPHYRCDMIE DCEDKSDEAQCTYRKCQHTDVFCNAPNGAAPAEGARLAGPCVPKEKRCDGYLDCRTGK DEEGCSGVSCRLDQFRCANGHKCIDAALKCNHRDDCGDNSDEQGCNFPPCHHAQFRCS NALCIPYNFHCDGYHDCADKSDEANCTAIACPDNKHLCPRGGASGTPKCILKSQLCDG KRDCEDGSDEETNCSIASCPALSCEFKCGPSLTGGVCYCKPGQSLAPDNRTCVDLDEC AEWGHCDQLCTNTLGSYTCQCAQGYTLINDSKCIAPDANNLQLIFAHDRAIMQMKPHG SEPMVLANATAAAGVTFHYARNTLYWSDIKTRKVQSLPLDAQNKAVSPFDQTLPGTWA PVALAVDWVGDKIYVADLVGQKIDVFELSGQWHAVVLGSNLTSPADLALDPTAGLMFV ADGGQVLRAHMDGTHARSIVSEAAYKASGVTVDIIAKRVFWCDSLLDYIESVDYEGGH RVMVLRGQQVPSPSRLALFENRIYWTDATKQGIMSVDKFEGPTSIQVTHKSKDIREPK GIIAVHALSQPRVSNPCGNNNGGCNHMCIVTAVKGAPTGLGFRCACSTGYQLETDLKL CKPVSEFLMYSQQRFIKGKVLEPVIEGFSDAIMPVVSRRARFVGLDFDARDEFIYYSD VLQDVIYRVHRNGTGREIVLASQNEGVEGLAVDWASKNLYYIDSRKGTLNVLSTRNVT HRRTLLKNLKRPRAIVVHPNRGFIFFSEWDRPANITRANTDGSGLLVFKNVTLGWPNG LSIDFKEDRVYWCDALLDHVQHANLDGTDIKTVNSRLVRHPFSIVIHNDWMYITDWRL DAIIRLHKLTGEQEEMMVREPQTNRLYGVKVYSHEVQRIAETQPCHRNNGGCQKICFA VPIGGGNATTNGGTPSFGRLQSRCSCPYGERLAEDQMSCIPDPSAEPPVQPCPNSWDF TCNNQRCIPKSWVCDGDDDCLDNSDEEQNCTKPTCGSNEFQCRSGRCIPQNFRCDQEN DCGDNSDEQECGNVTCGTSQFACANGRCIPNMWKCDSENDCGDSSDEGDFCAEKTCAY FQFTCPRTGHCIPQSWVCDGDDDCFDKQDEKDCPPISCLANQFKCADLRQCVEESYKC DGIPDCNDGSDEVGCPPMGPNQCNLEKHFRCKSTGFCIPIAWHCDGSNDCSDHSDEQD CGQITCAQNFFKCNNTNCVFKAYICDGKDDCGDNSDEGAEHACVPPPFKCPHGQWQCP GVSERCVNITSVCDDTADCPNGSDEGEGCDLAECEHQAGQCSSFCQKTPNGALCICPP GSEIGEDGYTCIDTNECDPPGLCSQQCTNTKGSYFCSCQEGYILEPNKHTCKAVNHTA AFLIISNRHSILVADLKEQGLERVPIIVENVVATASNMHTGTIFWSDMKLKKISRLDR GMEPQEIINTGLDLVEGLAYDWIAQNLYWLDSKLNTIEVSAENGSNRLVLVRENITQP RGMCIDPSPGARWIFWTDWGENPRVERIGMDGTMRKTIINTKIYWPNGLTLDIATKRV YFADSKLDFIDFCYYNGTGRQQVLASSHYLLHPHSLSLFEDTLYWTDRQLNRVLSANK FRGKNQTVVSHLISQPLSIHVHHASLQPMTPNPCASARCQHLCLLSPSASEGYSCKCK PGFKLLSEGRCIEEENPFLMVVKGTQIVDLPLNGGDARAGALAPVIGIESSTGLDFDR KGETLYWVQGREDDDENCTIYTTPYGGGNKTLFLGTESGIVGAPYTIAFDWLGRNLYI GNRVASNIEAVRVDGKQKYRTIILANDGYANSVSRPKQIVLDPTDGKLFWIDEGVLEV PIKIGRVDMNGQNPIVVFQDFAHPESLAVDTEKKMLYYSASNPAVIGSMDYNGADHTL IVMKDSHPMAKPRSLGILDHRLYYLDPLYERIVRIDLPHGDNPKTIVDNESDLRSMMI YKKRALMQHPCQTNNGGCKHLCIPGSGATRTCSCGIGYRKENEINCVAYKTFAVVSQL DMIRGYSLSDSAEAMVPVSGPGHHILHVDVMYREQWIYWAEYNRGYWNGIFRSRPNGT DLQHVVKDGIGSNGIRGLTIDWVAGNMYFTNVYPHENYVEVCWLDGSNRKVLVKTTTD APRELAVNPVKRLLYWIDYGQHPRIGKALLDGSKWTPLVTSGISLPRDLTIDMQTHDI YWVDSKLDTIQKISFNGANRKVIRRDLPNPMGIAVYLNDVYWVDRNLMTVFKASKHSA NETATRVRTNLEKLRDIAIYNINNQPQDDTNPCAHLGNGGCDQLCFSFPPEGGATGPS GRNFRCECATGKLSADERKCEVVNEYLVFATRTEIRAVNLDPHSTEVPFTPLTNLTNV VGLDFDFADNRMLYTQIRPWAKIAYTKANKPGHDDITVVLNKGINPEGIAYDWTQSKI YWTDSSNNSIYAMNLDGSELVMIARVERPRAIVLDPCNGTLFFTDWGRFGTSGKIFRT TMAGSLKRAIVDKDLSQPSGLAIDYDERRLYWTDAVREKIERSDLDGQNRELLVAATI YPFAITVFRNYIYWTDLQLRGVYRAEKHTGANMVEMVKRLEDSPRDIRIYSADRQKCN VNPCRINNGGCAQSCHPAPNGKAECKCDDNTKVVNEGRMCAPRNNTCEASKFYCKNGR CISRMWSCDGDDDCGDNSDEDPNYCAYHSCSPNEFRCNNGRCIFKSWKCDHENDCKDG SDELGCTYPPCVDGEFTCGNGRCIPQAQVCNGVNDCKDNATSDETHERCPMNTTCPAN HLKCEKTNICVEPYWLCDGDNDCGDNSDEDPLHCGQRTCPTNSFRCPNHRCIPATWYC DGDDDCGDGADEPPDYCKSEGRTCFGDLFTCDNGNCIPRIYICDGDNDCLDNSDEDNR HQCNDRKCDEETEFTCVENKSWQRAQCIPKKWICDGDPDCVDGADENTTLHNCATQQP CGEDMFTCGNGRCINKGWICDHDNDCGDGTDEGKFCNSKYKTCSAQEFTCQNFKCIRN QSRCDGEDDCGDHSDEVGCAKENITCPQGQFACTNGQCIDYNLVCNKYPDCADESDEP AHCNVDECAKVEINQCGHKCVDTLTGYYCDCNEGYKLLADGKACADVDECLEQPGACS QHCSNTPGGFYCKCDETYYERQNDEHTCKRKDKIPPWLIFTNKYYVRNMSVDGHQYNL MHQDLMNVVALDFDIREEYMYFCDVTAKTIFRAKYGEADDEMPPEREAVIRHDSHGLE GIAIDWVGRKLYWLDRHSKNLDVSELDGTKRKTLRSGVVDPRAIVVHPGIGYLYFTSW HLQAYIAKMGMDGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYADLEG RHRHTVLSGSKVPHVFALSLFDDYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRPYD LHINHPLRQLPYTNPCGTNNGGCSHLCLIAPPPESTYLNIEGYIEEGAPIFKCACPNQ FYLARDMKTCVANCTAGQHLCGGRDEKCIPWFWKCDGEKDCKDGSDEPATCAARHCRA GTFQCKNTNCTPSATICDGVDDCGDRSDEQNCDLPCPLSDFKCKSSGRCILDSWRCDG DADCKDGSDEDPAVCFKRTCDPKTEFACKNGRCIPQLWMCDFDNDCGDDSDEPAYMCR QRNCTTGWQRCPGQSNYRCIPKWLFCDGKDDCRDNSDELPENCPKCNPETDFKCGNNR CIPKQWMCDFADDCGDASDENEAVCKGRYRECSESEFRCGNGKCISSRWQCDHEDDCG DNSDEMHCEGYQCKNGTFQCASGHCIASYFRCDGDRDCRDMSDEVGCPPRFPGGRYCP ESRFQCNNNLCVSLSDLCDGTDDCGDGSDEDPSVCSDFNCDTLRRFQCSNHRCVARYQ ICDGVDNCGDGSDENNMTLCASKQKPCDLYTQYQCANKHCIERSQVCDFSDDCGDASD ELGCHHTSSCSEQNRGGCQHHCHNLTDGGYICTCYPGYIIAGDNKKKCSDVDECLTRQ HTCSHQCHNLNGTYSCSCREGFHLTDGSSGVCRAEKEDVILVFANGQEIRGLDLQKRE EFDVIAEEKRIEALDYDAQQQIVFWADSYDKTIKRSYMVNAIDGRAKIGFAQDLNMKG GSKPTAVAVDWLASNLYWTEMDRTGSKPRGRVMVAKTDGRYRRSIVNAGLEVPTSIAV NPQLGRIYWSDAGSAPKIEVSWMDGSKRRPLITEQIRHPAGLTIDYSQDHIIYWVDTK LNAIESMRADGSRRKAIVKGDQLRHPVSLDLFESNMFWMTRDTGELVRQDKFGRGVQV VLHRNLVNPSGLKVYHDKRYNTSLPNPCDNSTCSHLCLLVPGGHRCACPDASGPPPSH RSTAEVICNAAAEHPRPAPRICPCQNGGLCKEDAQGELVCDCLAEFRGEHCETSTTGA FGHGGANVTAVVVPIMVILLVMMAAAGAWYVIRKRPFGKLARMPAMTSSQSVTFRHGS NVEFSESGFPGASAPGAGDVAPIEGYNLQTVNANKARDFANPMYDAVQSGTTADPGMG NGSGIYDVPGEPSAKGKAMGHHAGGSFTEPASAIIAPSSITHKASPQLQLRTRELDPS ADTGKDTQFLVEEDKSEC" misc_feature 904..1002 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(919..921,943..945,976..981) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(955..957,964..966,976..978,994..999) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 985..999 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature <1075..1143 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1090..1092,1099..1101,1111..1113,1129..1134) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1120..1134 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1312..1419 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1327..1329,1354..1356,1387..1392) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1366..1368,1375..1377,1387..1389,1405..1410) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1396..1410 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1432..1536 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1447..1449,1471..1473,1504..1509) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1483..1485,1492..1494,1504..1506,1522..1527) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1513..1527 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1549..1674 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1564..1566,1606..1608,1639..1644) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1618..1620,1627..1629,1639..1641,1657..1662) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1648..1662 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature <1777..1902 /gene="mgl" /note="Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057" /db_xref="CDD:469594" misc_feature <1912..2340 /gene="mgl" /note="DNA-binding beta-propeller fold protein YncE [General function prediction only]; Region: YncE; COG3391" /db_xref="CDD:442618" misc_feature 2155..>2586 /gene="mgl" /note="NHL repeat unit of beta-propeller proteins; Region: NHL; cl18310" /db_xref="CDD:302697" misc_feature 2155..2268 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 2284..2400 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 2407..2517 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 2725..2853 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 2998..>3414 /gene="mgl" /note="Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Region: YvrE; COG3386" /db_xref="CDD:442613" misc_feature 3202..3330 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 3355..3459 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 3892..3972 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(3892..3894,3916..3918,3949..3954) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3928..3930,3937..3939,3949..3951,3967..3972) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3958..3972 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3994..4101 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: Ldl_recept_a; pfam00057" /db_xref="CDD:395011" misc_feature order(4012..4014,4036..4038,4069..4074) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4048..4050,4057..4059,4069..4071,4087..4092) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4078..4092 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4111..4209 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(4129..4131,4153..4155,4186..4191) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4165..4167,4174..4176,4186..4188,4204..4209) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4195..4209 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4234..4341 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4249..4251,4276..4278,4309..4314) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4288..4290,4297..4299,4309..4311,4327..4332) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4318..4332 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4354..4461 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4369..4371,4396..4398,4429..4434) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4408..4410,4417..4419,4429..4431,4447..4452) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4438..4452 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4498..4593 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4501..4503,4528..4530,4561..4566) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4540..4542,4549..4551,4561..4563,4579..4584) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4570..4584 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4603..4701 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(4621..4623,4645..4647,4678..4683) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4657..4659,4666..4668,4678..4680,4696..4701) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4687..4701 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4735..4839 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(4753..4755,4783..4785,4816..4821) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4795..4797,4804..4806,4816..4818,4834..4839) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4825..4839 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4996..5091 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 5305..5427 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 5431..5565 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 5500..5619 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 5566..5694 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 6466..6594 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 6883..>6969 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 7207..7347 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 7408..7530 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 7486..7608 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 8164..>8562 /gene="mgl" /note="NHL repeat unit of beta-propeller proteins; Region: NHL; cl18310" /db_xref="CDD:302697" misc_feature 8206..8295 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 8329..8463 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 8440..8568 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 9028..9132 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9043..9045,9067..9069,9100..9105) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9079..9081,9088..9090,9100..9102,9118..9123) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 9109..9123 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9145..9252 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9160..9162,9184..9186,9217..9222) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9196..9198,9205..9207,9217..9219,9241..9246) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature order(9226..9231,9238..9246) /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9277..9378 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9292..9294,9319..9321,9352..9357) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9331..9333,9340..9342,9352..9354,9370..9375) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 9361..9375 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9529..9627 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(9547..9549,9571..9573,9604..9609) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9583..9585,9592..9594,9604..9606,9622..9627) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 9613..9627 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9667..9774 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(9676..9678,9718..9720,9751..9756) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9730..9732,9739..9741,9751..9753,9769..9774) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 9760..9774 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9811..9906 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9826..9828,9850..9852,9883..9888) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9862..9864,9871..9873,9883..9885,9901..9906) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 9892..9906 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9937..10041 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9952..9954,9976..9978,10009..10014) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9988..9990,9997..9999,10009..10011,10027..10032) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 10018..10032 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 10057..10155 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(10075..10077,10099..10101,10132..10137) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(10111..10113,10120..10122,10132..10134,10150..10155) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 10141..10155 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 10204..10290 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 10306..10416 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 10513..10611 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 10645..10773 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 10831..10962 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 10921..11037 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 11035..11163 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 11248..11406 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 11416..11517 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(11431..11433,11461..11463,11494..11499) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(11473..11475,11482..11484,11494..11496,11512..11517) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 11503..11517 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 11542..11646 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(11557..11559,11581..11583,11614..11619) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(11593..11595,11602..11604,11614..11616,11632..11637) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 11623..11637 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 11656..11754 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(11671..11673,11698..11700,11731..11736) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(11710..11712,11719..11721,11731..11733,11749..11754) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 11740..11754 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 11779..11880 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(11800..11802,11824..11826,11857..11862) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(11836..11838,11845..11847,11857..11859,11875..11880) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 11866..11880 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 11908..12012 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(11923..11925,11956..11958,11989..11994) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(11968..11970,11977..11979,11989..11991,12007..12012) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 11998..12012 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12040..12132 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(12052..12054,12076..12078,12109..12114) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12088..12090,12097..12099,12109..12111,12127..12132) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12118..12132 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12166..12270 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(12181..12183,12205..12207,12238..12243) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12217..12219,12226..12228,12238..12240,12256..12261) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12247..12261 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12283..12387 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(12298..12300,12322..12324,12355..12360) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12334..12336,12343..12345,12355..12357,12373..12378) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12364..12378 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12415..12510 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(12430..12432,12454..12456,12487..12492) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12466..12468,12475..12477,12487..12489,12505..12510) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12496..12510 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12556..12642 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(12556..12558,12580..12582,12613..12618) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12592..12594,12601..12603,12613..12615,12631..12636) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12622..12636 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12685..12780 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(12691..12693,12715..12717,12748..12753) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12727..12729,12736..12738,12748..12750,12766..12771) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12757..12771 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12796..12906 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 12916..13011 /gene="mgl" /note="Calcium-binding EGF-like domain; Region: EGF_CA; smart00179" /db_xref="CDD:214542" misc_feature order(12916..12918,12925..12927,12967..12969) /gene="mgl" /note="Ca2+ binding site [ion binding]; other site" /db_xref="CDD:238011" misc_feature 13255..>13707 /gene="mgl" /note="NHL repeat unit of beta-propeller proteins; Region: NHL; cl18310" /db_xref="CDD:302697" misc_feature 13300..13437 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 13447..13548 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 13477..13602 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 13549..13680 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 13570..13695 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" ORIGIN 1 cagtcgctcg cggagcgtcg tcgtgaacgg tcagccagcg cggctaataa ctaactaact 61 ttggtgacag tgcgccatac tgactctgat ccgaacccga atcgaggccc acagcagcca 121 gaacatatta ccaacaatat atcagagcgg aaagtaaacg gagctactct gaacgaaaga 181 aagaccttct ctaagataaa tcctgttgag tgtttcgagt tttttttcga gtgagtgcgc 241 agcccaccaa acaaaaacca aacaaaaata tttcgaaaaa gaatagagaa atcaagccag 301 aagagaggga attctcaaag gcagaagaca gaagaccggt gggcagagaa gaggtcacca 361 gaaggtcacc gaaaccccaa aaaagaatcc aaacctaaac ccacggataa gaagcaaagg 421 agcgaaggag ccagcgaagc gaccaacgaa ccaaaaatga atccgacgcc catgggcatt 481 ggattcggat ttggtcgcaa gccgcccaac aaggccagaa tgcgttcccg ctggcgacca 541 ccgccgccgg cgacaaccct gctgacccct gaccccgccg agggcgacaa cccggcagcc 601 gatccgctgc aggtcacaga ggcctccgcc tcagcttcgg cgccatcctc gcccatcggc 661 gaccaccgcc atccgcagct ggacagcagc agagctgccg agccgaggct gcagcaccag 721 caacaggaag cacagcacta ccgccagcac cgcggccagt tgacaaccct ggcgctgctg 781 ctactggccc tcgtagccct cagcaacctg gaaaccctgc tcgccgtgcg caccgaagga 841 ccgcgcaacc gccatggatc accaggtggc agcttgggca gcacaggcgg catcaatacc 901 gagtgtccga cggactcctt ccgctgcaac aacggcaagt gcatctcgca ccactgggtc 961 tgcaattacc aaaaggactg cgacgatggc gaggacgaga tgcagtcgtg ccccccaccg 1021 gaatgcgaaa ctccccagct gaactgcggg cagtatgtgt tcaacaagac ctattgcatc 1081 cctccgcact atcgttgcga tatgatcgag gattgcgagg acaaatcgga cgaggcccag 1141 tgcacttacc gcaagtgcca gcacacggac gtcttctgca acgcccccaa tggagccgcc 1201 cccgcggagg gcgcccgcct ggccggaccc tgtgtgccga aggagaaacg ctgcgacggc 1261 tacctggact gccgcaccgg gaaggacgag gagggctgca gcggcgtctc ctgtcgcctc 1321 gaccagttcc gctgcgccaa tggacacaag tgcatcgatg ccgctctgaa gtgcaaccac 1381 cgcgacgact gtggcgataa ttccgacgaa cagggatgca acttcccgcc ctgccaccac 1441 gcccagttcc ggtgctcgaa cgccctatgc attccgtaca acttccactg cgatggctac 1501 cacgactgcg ccgacaagag cgacgaggcc aactgcacgg ccatcgcctg tccggacaac 1561 aagcacctct gtccacgagg aggcgccagc ggaacaccca agtgcatcct gaagtcccaa 1621 ctgtgcgacg gcaagcggga ctgcgaggat ggtagcgacg aggagaccaa ctgttcgatt 1681 gcctcttgcc cagctctgag ttgtgagttc aagtgcggac cctcgctgac cggaggcgtg 1741 tgctactgca aacctggtca atcgctggcc ccggacaacc gaacttgtgt ggacctcgac 1801 gagtgcgccg agtggggtca ctgcgaccag ctgtgcacga acaccctggg ctcgtacacc 1861 tgccagtgtg cccagggcta cacgctgatc aacgactcca agtgcattgc cccggatgcg 1921 aataacctgc agctgatctt cgcccacgat cgtgccataa tgcaaatgaa gccgcatggc 1981 agtgaaccta tggtactggc caatgccacc gctgcggccg gagtgacctt ccattatgcg 2041 aggaatacgc tctactggtc ggacatcaag acaaggaagg ttcaatctct gcctctggat 2101 gcacagaaca aggctgtctc gccattcgat caaacgctac ccggaacctg ggctcccgta 2161 gctctggccg tcgattgggt gggcgataag atatatgtgg ccgatttggt gggtcagaag 2221 atcgatgtct tcgagctgag tggtcaatgg catgccgtgg tcctaggttc aaacctcacc 2281 tcgcccgccg acctcgcttt ggatcccacg gctggtctga tgttcgtggc ggatggtggt 2341 caagtgctcc gtgcccacat ggatggaacc catgcccgtt cgattgtctc ggaggctgcc 2401 tacaaggcga gcggcgtgac ggtggacatc attgccaagc gcgtcttctg gtgcgactcc 2461 ctgctggatt atattgagtc ggtagactat gagggtggtc atagggttat ggtccttcga 2521 ggacagcaag tgcctagtcc ctcgcgactc gctctgttcg aaaaccgcat ctactggacg 2581 gatgccacca agcagggcat catgtcggtg gacaagttcg agggtcccac ctccattcag 2641 gtgacccaca agtccaagga cattcgggag cccaaaggca tcattgcggt gcatgcactg 2701 agtcaaccga gggtctcgaa tccatgtggc aataacaatg gtggctgcaa tcatatgtgc 2761 atcgtcaccg cggtcaaggg agctcccacg ggattgggtt tccgttgcgc ctgctcgacg 2821 ggctatcaac tggagacgga cttgaagctt tgcaaaccgg ttagcgagtt cctcatgtac 2881 tcgcaacagc gatttatcaa gggcaaagta ttagagcccg tgatcgaggg cttcagcgat 2941 gccattatgc cagtggtttc ccgccgagct cgtttcgttg gcctggattt cgatgcccgc 3001 gatgagttca tctactactc ggacgttctg caggatgtga tctatagggt gcatcgaaat 3061 ggaacaggtc gcgagattgt tttggcctcc caaaatgagg gcgtcgaggg actggctgtc 3121 gattgggcct ctaagaatct ctactacatc gattcacgca agggcacctt gaatgtcttg 3181 tccacgagga atgtcactca tcgcaggact ctgctgaaga atttgaaacg tccaagggcc 3241 attgtggtcc accctaatcg cggcttcatc ttcttctccg aatgggatcg accggcgaat 3301 atcacgcggg caaacaccga tggcagtggt ctgttggtct tcaagaacgt cactttggga 3361 tggcccaatg gtctgtctat tgacttcaag gaggataggg tttactggtg cgatgccttg 3421 ctagaccatg ttcaacatgc caatttggat ggcacggaca tcaagacagt gaactcgcga 3481 ctggtgcgac atcccttctc gattgtcatc cacaacgatt ggatgtatat tacggactgg 3541 cgattggatg ccattatcag gctgcacaag ctgacgggcg agcaggagga gatgatggtg 3601 agggagccgc agaccaacag gctgtatggg gttaaggtgt acagtcacga ggttcagagg 3661 atcgcggaga cgcaaccctg tcaccggaac aacgggggat gccagaagat ctgctttgcg 3721 gttccgattg gaggagggaa tgctacaacg aatggaggta caccctcctt tggtcgcctg 3781 cagtcgcggt gctcgtgtcc ctatggcgag cggctggccg aggatcagat gagctgcatc 3841 cccgatccga gtgccgagcc gccggtgcag ccgtgcccga actcctggga cttcacgtgc 3901 aacaaccagc ggtgcattcc caagtcgtgg gtctgcgatg gcgacgacga ctgcctggac 3961 aacagcgatg aggagcagaa ctgcacgaaa cccacctgcg gatcgaacga gttccagtgc 4021 cgatcgggcc gctgcattcc gcagaacttc cgctgcgacc aggagaacga ctgtggcgac 4081 aactcggacg agcaggaatg cggcaacgtg acctgcggca cctcgcagtt cgcctgcgcc 4141 aatgggcgat gcattccgaa tatgtggaag tgcgacagcg agaacgattg tggggatagc 4201 agcgatgagg gtgacttttg tgccgagaag acctgcgcct acttccagtt cacgtgtccg 4261 cggacgggtc actgcatacc gcagagttgg gtgtgcgacg gcgacgacga ttgcttcgac 4321 aagcaggacg agaaggactg tccgccgatc tcctgtctgg ccaatcagtt caagtgcgcc 4381 gatctgcggc agtgcgtcga ggagtcgtac aaatgcgatg gcataccgga ctgcaacgat 4441 ggctccgacg aggtgggctg cccgcccatg ggcccgaatc agtgtaatct cgagaagcac 4501 ttccgctgca agtctactgg cttctgtata cccatcgcct ggcattgtga tggctcgaat 4561 gattgctcgg atcattcgga tgagcaggac tgcggtcaga tcacctgtgc ccagaacttc 4621 ttcaagtgca acaacacgaa ctgtgtgttc aaggcctaca tttgcgacgg caaggacgat 4681 tgtggtgata actcggatga gggtgccgag catgcctgtg ttccgccgcc cttcaagtgt 4741 ccccacggtc agtggcaatg tcccggggtc tcggagagat gcgtgaacat aacctccgtt 4801 tgcgatgaca ccgccgattg tcccaatggt tccgatgagg gtgaaggttg cgacctcgcc 4861 gagtgcgaac atcaggcggg tcagtgctcc agtttctgtc agaagacccc gaatggagct 4921 ctgtgcatct gtccacctgg ttcggagatc ggagaagatg gctatacctg tatagacact 4981 aatgaatgcg atcccccggg tctctgttct caacagtgta cgaacaccaa gggctcgtac 5041 ttctgttcct gccaagaggg ttacattttg gagcccaata agcacacctg caaggcagtc 5101 aatcacaccg ccgccttcct gatcatctcc aataggcatt ctatcctagt ggccgatctc 5161 aaggaacagg gactggaaag ggtgcccatt atagtggaga atgtggtggc caccgcttcg 5221 aacatgcaca cgggcaccat tttctggagc gacatgaagc tgaagaagat ctcgcgattg 5281 gataggggaa tggaaccgca ggagattatc aacacgggat tggatctggt ggagggactg 5341 gcctacgatt ggatagccca gaatctctac tggctggaca gcaagctgaa cacgatcgag 5401 gtgtcggcgg agaatggttc gaatcgattg gttcttgtta gagagaacat cactcagccc 5461 agaggcatgt gcatcgatcc gagtcccggg gcaagatgga tcttctggac ggactggggt 5521 gagaatccgc gggtggagcg gatcggcatg gatggaacga tgaggaagac gatcatcaat 5581 acgaagatct attggcccaa tggtttgacc ctggacatag ccaccaagcg ggtttacttt 5641 gcggattcca agctggactt tatagacttt tgctactaca atggaaccgg gagacagcag 5701 gttttggcca gcagtcacta cctcctgcat ccgcactcgc tgtccctctt cgaggatacc 5761 ctgtactgga cggacaggca attgaatcgg gttctctcgg cgaataagtt taggggcaag 5821 aatcagacgg tggtttcgca cctgattagc caaccgctgt ccatccacgt gcatcatgcc 5881 tccctgcagc cgatgacccc gaatccctgt gcctcagcac gctgccagca tctgtgtctg 5941 ctgagtccca gcgcctcgga gggctactcg tgcaagtgca agccgggctt caagctgctc 6001 agcgagggtc gctgcatcga ggaggagaat cccttcctga tggtcgtcaa gggcacgcag 6061 atagtggatc ttccgctgaa tggtggcgat gcgagggcag gagccttggc tccggtgatt 6121 ggaatcgaga gcagcactgg cctggacttt gatcgcaagg gagagaccct ctattgggtg 6181 cagggcaggg aggatgatga cgagaattgc actatctata cgacaccata cggaggtggc 6241 aacaagaccc tcttcctggg caccgaaagc ggcattgtcg gagcacccta caccattgcc 6301 ttcgattggt tgggtcggaa tctctacatt ggcaaccggg tggccagtaa tatcgaggca 6361 gtgcgagtgg atggaaagca aaagtaccgg acaatcatcc tagccaacga tggttatgcc 6421 aactcggtgt cgcgacccaa gcaaatagtg ctcgatccca ccgacggcaa gctcttctgg 6481 atcgacgagg gcgtgctgga ggtgcccatc aagatcggca gggtggacat gaatgggcag 6541 aaccccattg tggtcttcca ggactttgcc catcccgaat cgctggccgt ggacacggag 6601 aagaagatgc tctactacag tgccagcaat ccggcggtga ttggttcgat ggattataac 6661 ggagctgatc acacgctgat tgtgatgaag gactcgcatc cgatggccaa gccgaggagt 6721 ctgggcatcc tggatcaccg actatactat ttggatccct tgtacgagcg gattgtgcga 6781 atcgatctgc cgcatggcga taatcccaag acaattgtgg ataatgaatc ggatttgaga 6841 tcgatgatga tctacaagaa gcgcgctttg atgcagcatc cctgccagac gaacaacggc 6901 ggctgcaagc atctctgcat tccgggatcg ggagctacga ggacctgctc ctgcggcatt 6961 ggttatcgca aggagaacga gatcaattgc gtggcctaca agaccttcgc ggtcgtctcc 7021 cagctggaca tgatcagggg atatagctta agtgacagtg cagaggccat ggttccggtg 7081 agcggacctg gtcatcacat cctccacgtg gacgtcatgt atcgggagca atggatctac 7141 tgggcggaat acaatcgggg ctactggaat ggcatcttca ggtcgcgacc caatggcacc 7201 gatctgcagc atgtggtcaa ggatgggatc ggaagcaatg gcatccgggg actgaccatc 7261 gattgggtgg ccggtaatat gtactttacc aatgtctatc cgcatgagaa ttacgtggag 7321 gtctgctggc tggacggtag caataggaag gtgttggtca agaccaccac ggatgcaccg 7381 cgtgaactcg cggtgaatcc cgtgaagagg ctgctctact ggatcgacta tggtcagcat 7441 ccgaggattg ggaaagctct gctggacgga agcaagtgga cgcctttggt gacgtcgggg 7501 atctcgttgc cacgcgatct aaccatcgat atgcagacgc atgacatcta ctgggtggac 7561 tcgaaactgg acaccatcca gaagatctcc tttaatgggg ccaatcgcaa ggtcattcgg 7621 agggatctgc ccaatcccat gggcatcgct gtctatctga acgacgtgta ctgggtggac 7681 aggaacctga tgaccgtgtt caaggcctcc aagcacagtg ctaatgagac ggccaccagg 7741 gtgaggacga atctggagaa gctgagggac attgcgatct acaatatcaa caatcagccg 7801 caggacgata ccaatccttg tgcccacttg ggcaacggcg gctgcgatca gttgtgcttc 7861 agtttcccac ccgaaggggg agccaccggt ccatcgggca ggaatttccg ttgcgagtgt 7921 gcgacgggta agctgagtgc cgacgagcga aagtgcgagg tggtcaacga gtatctggtc 7981 tttgccacac gaaccgaaat tcgagccgtt aacctcgatc cccattccac ggaggtgcct 8041 tttaccccgc tgactaatct cacgaatgtc gtgggtctgg actttgattt cgcggacaat 8101 cgaatgttgt atacgcagat tcgcccatgg gccaagatcg cctatacgaa ggcgaataag 8161 ccgggacacg atgacatcac ggtggtgctg aacaagggca tcaatcccga gggcattgcg 8221 tacgattgga cgcagtcgaa gatctattgg acggacagct cgaacaactc gatctatgcg 8281 atgaatctgg atggcagtga actggtgatg attgcccggg tggagcgtcc ccgagcgatt 8341 gtcctggatc cctgcaatgg aacgctgttc ttcacggatt ggggaagatt cggaacctct 8401 ggcaagatat tccgcacgac gatggcggga tctctgaaga gagcgatcgt ggataaggac 8461 ctgtcgcagc ccagtggcct ggccatcgat tacgatgaga ggaggttgta ttggacggat 8521 gcggtgaggg agaagatcga gcgatccgat ttggatggtc agaacaggga gctcctggtg 8581 gccgccacca tatatccctt cgcgatcacc gtgttccgta actacatcta ctggacggat 8641 ctccagctgc gcggtgtcta ccgggcggag aagcacacgg gtgcgaatat ggtggagatg 8701 gtgaagcgac tggaggattc gccgcgagac attcgcatct acagtgcgga tcggcagaag 8761 tgcaatgtga atccgtgcag gatcaacaat gggggatgtg cccagagttg tcacccggcg 8821 ccgaatggca aggccgagtg caaatgcgat gataatacga aggtggtgaa cgagggaagg 8881 atgtgtgcac cgaggaataa tacgtgcgag gccagcaagt tctactgcaa gaatggcagg 8941 tgcatttcga ggatgtggtc ctgcgatggc gacgacgact gtggggataa ttccgatgag 9001 gatcccaact actgtgccta tcactcctgc tcgccgaatg agttccgttg caacaatggt 9061 cggtgtattt tcaagtcttg gaagtgcgat cacgagaacg attgcaagga tggctccgat 9121 gagctgggct gcacctatcc gccctgcgtc gatggtgagt tcacctgcgg caatggcagg 9181 tgtattcccc aggcccaggt gtgcaatggg gtgaacgatt gcaaggacaa tgccacctcg 9241 gacgagacgc acgagaggtg tcccatgaac accacctgtc cggcgaatca tctcaagtgc 9301 gagaagacga atatctgtgt ggagccctat tggctgtgcg atggcgacaa cgattgcggc 9361 gacaactccg acgaggatcc cctgcattgt ggtcagagaa cttgtcccac gaacagcttc 9421 cgctgcccca accaccgatg cattccggcc acctggtact gcgatggcga cgatgattgc 9481 ggcgatggcg ccgacgagcc accagattac tgcaagtccg aaggacgcac ttgcttcggg 9541 gatctcttca cctgcgacaa tggcaactgc atacccagaa tctacatttg cgacggtgac 9601 aacgattgcc tggacaacag tgacgaggac aaccggcatc agtgcaatga ccgaaagtgt 9661 gatgaggaaa cggaattcac ctgcgtggag aacaagtcct ggcagcgagc ccagtgcatc 9721 cccaaaaaat ggatctgcga cggagatccg gattgtgtag atggagccga cgagaacacc 9781 accctgcaca actgtgctac gcagcaaccc tgtggcgagg acatgttcac ctgcggcaac 9841 ggacgctgca tcaataaggg atggatctgc gaccatgaca acgattgcgg cgacggcacc 9901 gacgagggca agttctgcaa ctccaagtac aagacctgct cggcccagga gttcacctgc 9961 cagaacttca agtgcatccg caaccagtcg aggtgcgatg gcgaggacga ctgcggcgat 10021 cactcggacg aggtgggctg cgccaaggag aacatcacct gtccgcaggg acagttcgcc 10081 tgtacgaatg gccagtgcat cgactacaat ctggtgtgca acaagtatcc cgactgtgcc 10141 gacgagtccg atgagccggc ccactgcaac gtggacgagt gcgccaaggt ggagatcaat 10201 cagtgcggcc acaagtgcgt ggacacgctg acgggctact actgtgactg caatgagggc 10261 tacaaacttc tggccgacgg caaggcatgt gcggatgtgg acgagtgcct ggagcagccg 10321 ggcgcctgtt cccagcactg ttcgaacacc ccgggtggat tctactgcaa gtgcgatgag 10381 acctactacg agcggcagaa cgatgagcac acgtgcaagc gaaaggacaa gataccaccc 10441 tggctgatct tcaccaacaa gtactatgtg cgaaatatgt cggtggatgg acatcagtac 10501 aatttgatgc accaggatct gatgaatgtg gtggccctgg actttgacat tcgcgaggag 10561 tacatgtact tctgcgacgt gacggccaag acgatattcc gggccaagta tggggaggca 10621 gatgacgaga tgccgccgga gcgggaggct gtgatcaggc acgattccca tggactggag 10681 ggcatcgcca tcgattgggt gggtcgcaag ctctactggt tggacaggca ctccaagaac 10741 ctggatgttt ccgaactgga tggaaccaaa cgcaagaccc tgaggagtgg tgtcgttgat 10801 ccgcgtgcca ttgtcgtgca tcctggcatc ggttatctgt acttcacctc ctggcatctg 10861 caagcctaca ttgccaaaat gggcatggat ggttcgaact tctcgaggat cctgaactgg 10921 aacgacggta tcgcctggcc gaatgccctg tccattgact acttcacgga tcgtatttac 10981 tgggcggacg cccacttgga ctacatagcc tatgctgatt tggagggcag gcatcggcat 11041 acggtgctct ctggcagcaa ggtgcctcat gtgtttgcac tgagtctctt cgacgactac 11101 atctactgga gtgactggaa tctgaaggcc attgtgcggg ccaacaagtt ccatggtgcc 11161 aactacacgg tgctgaggaa taccacccat cgtccctacg acctgcacat caatcatccg 11221 ctgaggcaac tgccctacac caatccctgt ggcaccaaca acggcggttg ctcgcatctc 11281 tgcctgatag ctccaccgcc ggagtccacg tacctgaata tcgagggcta tatcgaggag 11341 ggagctccga tcttcaagtg cgcctgtccc aatcagttct acttggcccg ggacatgaag 11401 acttgcgtgg ccaattgcac ggccgggcag catttgtgcg gcggtcggga tgagaagtgc 11461 ataccgtggt tctggaagtg cgacggggag aaggactgca aggatggcag cgatgagcca 11521 gccacctgtg ccgcgcgaca ctgccgggcc ggaacgttcc agtgcaagaa taccaactgc 11581 acaccctcgg cgaccatttg cgatggcgtg gacgactgcg gtgatcgtag cgacgaacag 11641 aattgcgatc taccctgccc gctgtccgat ttcaagtgca aatccagtgg taggtgcatc 11701 ctggacagct ggcgctgcga tggcgatgcc gactgcaagg atggcagcga cgaggacccc 11761 gccgtgtgct tcaagcgcac ctgcgatccc aagacggagt ttgcctgcaa gaatggccgc 11821 tgcattccgc aactgtggat gtgcgatttc gacaacgatt gcggcgatga ttccgatgag 11881 ccggcgtaca tgtgccgcca gcgcaactgc accaccggct ggcagagatg ccctggtcag 11941 tcgaactacc gctgcattcc caagtggctg ttctgcgacg gcaaggacga ttgtcgggac 12001 aacagcgacg agctgccaga gaactgcccc aagtgtaatc ccgagacgga cttcaagtgc 12061 ggcaacaacc gatgcatacc caagcaatgg atgtgtgact ttgcggacga ttgtggcgat 12121 gctagcgatg agaacgaggc tgtctgcaag ggtcgctatc gggagtgctc cgaatcggag 12181 ttccgctgcg gcaacggcaa gtgcatctcc tcccggtggc agtgcgatca tgaggacgac 12241 tgcggcgaca actcggacga gatgcactgc gagggctatc agtgcaaaaa cggcaccttc 12301 cagtgcgctt ccggtcattg catagcctcc tacttccgtt gcgacggcga tcgcgattgc 12361 cgcgacatgt ccgacgaggt gggctgtccg ccgcgcttcc cgggcggtcg ctactgtccc 12421 gagtcgcgtt tccagtgcaa caacaacctg tgcgtctcgc tgtcggacct ctgtgacggc 12481 acagatgatt gcggtgatgg cagcgacgag gatcccagcg tttgcagtga cttcaattgc 12541 gataccctgc ggcgattcca gtgctccaat catcgatgcg tggctcgcta tcaaatctgc 12601 gatggtgtgg acaactgcgg cgatggcagt gatgagaaca acatgaccct gtgtgccagc 12661 aaacagaagc cctgcgatct gtacacccag taccagtgcg ccaacaagca ctgcatcgaa 12721 cgctcgcagg tgtgcgactt ctccgacgat tgtggcgatg ccagcgatga gttgggctgc 12781 caccacacga gcagctgctc cgaacagaat cgcggtgggt gtcagcatca ctgccacaat 12841 ctcaccgacg gtgggtacat atgcacctgc tatcccggct acatcatagc cggcgacaac 12901 aagaagaagt gctccgacgt ggacgagtgc ctcacgcgac agcacacgtg ttcgcatcag 12961 tgtcacaatc tcaatggcac ctactcgtgc agttgccgcg agggtttcca tctgaccgac 13021 ggctcgagtg gcgtttgtcg tgccgaaaag gaggatgtca ttttggtatt tgccaacggt 13081 caggagatcc gaggtttgga cctccagaaa cgcgaggaat tcgatgtgat tgcggaggag 13141 aagcggatcg aggcactgga ctacgatgcc cagcagcaga tcgtcttttg ggcggatagc 13201 tatgacaaga cgatcaagcg ttcgtacatg gtgaatgcca tcgatggcag ggccaagatt 13261 ggctttgccc aggatctgaa catgaaggga ggatcgaaac ccaccgccgt ggccgtcgat 13321 tggctggcct cgaatctcta ctggacggaa atggacagga cgggctcgaa gccgcgtggt 13381 cgagtgatgg tggccaagac ggatggaagg tatcgcaggt cgattgtgaa tgccggtctg 13441 gaggtgccca cttcgatagc ggttaatcca cagctgggca ggatctactg gtcggatgcg 13501 ggctccgcgc ccaagataga ggtctcctgg atggatgggt ccaagcggcg accgctgatc 13561 accgagcaga ttcgtcatcc cgccggcctg accatcgatt actcgcagga tcacatcatc 13621 tactgggtgg acaccaagct gaatgccatt gaatcgatgc gggccgatgg ttcgcgtcgc 13681 aaggccattg tgaagggtga ccagctgagg catcccgttt ccctcgatct cttcgaatcc 13741 aacatgttct ggatgacacg cgacaccggg gagctggtgc gccaggataa gttcgggcgc 13801 ggagtgcagg tggtgctgca tcgcaacctc gtcaatccgt ccggcctgaa ggtctaccac 13861 gacaagcggt acaacacctc gctgcccaat ccgtgcgaca actccacctg ctcgcacctc 13921 tgcctcctgg tgcccggcgg ccatcggtgc gcctgtcccg acgcctccgg tccgccgccc 13981 tcgcatcgca gcaccgccga ggtgatctgt aatgccgccg ccgagcatcc gcgtccggcg 14041 ccgaggattt gtccctgcca gaacggcggg ctctgcaagg aggatgccca gggtgagctc 14101 gtctgcgact gtttggccga gttccggggc gagcactgcg agacgagcac caccggagcc 14161 tttggtcatg ggggcgccaa tgtcaccgcc gtcgtggtgc ccatcatggt catcctgctg 14221 gtgatgatgg ccgccgccgg cgcctggtac gtcatccgga agagaccttt tggcaaattg 14281 gctcgcatgc cggcgatgac ctcgtcgcag agcgtgacct tccgccacgg gtcgaatgtg 14341 gagttcagcg agagcggctt cccgggggca tccgcaccgg gggccggcga tgtggcgccc 14401 atcgagggct acaacctgca gacggtgaac gcgaacaagg cgcgcgactt tgccaatccg 14461 atgtacgatg cagtgcagtc gggcaccacc gccgatccag gcatgggcaa cggctcgggc 14521 atctacgatg tgcccggcga accgtcggcc aagggcaagg ccatgggcca ccatgcgggc 14581 ggatccttca cggagcccgc ctcggcgatc atcgcgccca gcagcatcac gcacaaggcg 14641 tcgccgcagc tgcagctgcg caccagggag ctggacccct cggcggacac cggcaaggac 14701 acccagttcc tggtggagga ggacaagtcc gagtgctgat atcaagcccg tcaatcggct 14761 gcagttgcga tggccagctg tcgccggcag cagcagcagc agaagcagca gaagcatccg 14821 gagaacagct atccgctgca gacataacac agactggtca agcaaaggaa ggagcagcag 14881 ca