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LOCUS XM_070219216 14876 bp mRNA linear INV 09-DEC-2024 receptor-related protein megalin (mgl), transcript variant X3, mRNA. ACCESSION XM_070219216 VERSION XM_070219216.1 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..14876 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..14876 /gene="mgl" /note="low-density lipoprotein receptor-related protein megalin; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 20 Proteins" /db_xref="GeneID:108054711" CDS 451..14733 /gene="mgl" /codon_start=1 /product="low-density lipoprotein receptor-related protein 2" /protein_id="XP_070075317.1" /db_xref="GeneID:108054711" /translation="MNPTPMGIGFGFGRKPPNKARMRSRWRPPPPATTLLTPDPAEGD NPAADPLQVTEASASASAPSSPIGDHRHPQLDSSRAAEPRLQHQQQEAQHYRQHRGQL TTLALLLLALVALSNLETLLAVRTEGPRNRHGSPGGSLGSTGGINTECPTDSFRCNNG KCISHHWVCNYQKDCDDGEDEMQSCPPPECETPQLNCGQYVFNKTYCIPPHYRCDMIE DCEDKSDEAQCTYRKCQHTDVFCNAPNGAAPAEGARLAGPCVPKEKRCDGYLDCRTGK DEEGCSGVSCRLDQFRCANGHKCIDAALKCNHRDDCGDNSDEQGCNFPPCHHAQFRCS NALCIPYNFHCDGYHDCADKSDEANCTAIACPDNKHLCPRGGASGTPKCILKSQLCDG KRDCEDGSDEETNCSIASCPALSCEFKCGPSLTGGVCYCKPGQSLAPDNRTCVDLDEC AEWGHCDQLCTNTLGSYTCQCAQGYTLINDSKCIAPDANNLQLIFAHDRAIMQMKPHG SEPMVLANATAAAGVTFHYARNTLYWSDIKTRKVQSLPLDAQNKAVSPFDQTLPGTWA PVALAVDWVGDKIYVADLVGQKIDVFELSGQWHAVVLGSNLTSPADLALDPTAGLMFV ADGGQVLRAHMDGTHARSIVSEAAYKASGVTVDIIAKRVFWCDSLLDYIESVDYEGGH RVMVLRGQQVPSPSRLALFENRIYWTDATKQGIMSVDKFEGPTSIQVTHKSKDIREPK GIIAVHALSQPRVSNPCGNNNGGCNHMCIVTAVKGAPTGLGFRCACSTGYQLETDLKL CKPVSEFLMYSQQRFIKGKVLEPVIEGFSDAIMPVVSRRARFVGLDFDARDEFIYYSD VLQDVIYRVHRNGTGREIVLASQNEGVEGLAVDWASKNLYYIDSRKGTLNVLSTRNVT HRRTLLKNLKRPRAIVVHPNRGFIFFSEWDRPANITRANTDGSGLLVFKNVTLGWPNG LSIDFKEDRVYWCDALLDHVQHANLDGTDIKTVNSRLVRHPFSIVIHNDWMYITDWRL DAIIRLHKLTGEQEEMMVREPQTNRLYGVKVYSHEVQRIAETQPCHRNNGGCQKICFA VPIGGGNATTNGGTPSFGRLQSRCSCPYGERLAEDQMSCIPDPSAEPPVQPCPNSWDF TCNNQRCIPKSWVCDGDDDCLDNSDEEQNCTKPTCGSNEFQCRSGRCIPQNFRCDQEN DCGDNSDEQECGNVTCGTSQFACANGRCIPNMWKCDSENDCGDSSDEGDFCAEKTCAY FQFTCPRTGHCIPQSWVCDGDDDCFDKQDEKDCPPISCLANQFKCADLRQCVEESYKC DGIPDCNDGSDEVGCPPMGPNQCNLEKHFRCKSTGFCIPIAWHCDGSNDCSDHSDEQD CGQITCAQNFFKCNNTNCVFKAYICDGKDDCGDNSDEGAEHACVPPPFKCPHGQWQCP GVSERCVNITSVCDDTADCPNGSDEGEGCDLAECEHQAGQCSSFCQKTPNGALCICPP GSEIGEDGYTCIDTNECDPPGLCSQQCTNTKGSYFCSCQEGYILEPNKHTCKAVNHTA AFLIISNRHSILVADLKEQGLERVPIIVENVVATASNMHTGTIFWSDMKLKKISRLDR GMEPQEIINTGLDLVEGLAYDWIAQNLYWLDSKLNTIEVSAENGSNRLVLVRENITQP RGMCIDPSPGARWIFWTDWGENPRVERIGMDGTMRKTIINTKIYWPNGLTLDIATKRV YFADSKLDFIDFCYYNGTGRQQVLASSHYLLHPHSLSLFEDTLYWTDRQLNRVLSANK FRGKNQTVVSHLISQPLSIHVHHASLQPMTPNPCASARCQHLCLLSPSASEGYSCKCK PGFKLLSEGRCIEEENPFLMVVKGTQIVDLPLNGGDARAGALAPVIGIESSTGLDFDR KGETLYWVQGREDDDENCTIYTTPYGGGNKTLFLGTESGIVGAPYTIAFDWLGRNLYI GNRVASNIEAVRVDGKQKYRTIILANDGYANSVSRPKQIVLDPTDGKLFWIDEGVLEV PIKIGRVDMNGQNPIVVFQDFAHPESLAVDTEKKMLYYSASNPAVIGSMDYNGADHTL IVMKDSHPMAKPRSLGILDHRLYYLDPLYERIVRIDLPHGDNPKTIVDNESDLRSMMI YKKRALMQHPCQTNNGGCKHLCIPGSGATRTCSCGIGYRKENEINCVAYKTFAVVSQL DMIRGYSLSDSAEAMVPVSGPGHHILHVDVMYREQWIYWAEYNRGYWNGIFRSRPNGT DLQHVVKDGIGSNGIRGLTIDWVAGNMYFTNVYPHENYVEVCWLDGSNRKVLVKTTTD APRELAVNPVKRLLYWIDYGQHPRIGKALLDGSKWTPLVTSGISLPRDLTIDMQTHDI YWVDSKLDTIQKISFNGANRKVIRRDLPNPMGIAVYLNDVYWVDRNLMTVFKASKHSA NETATRVRTNLEKLRDIAIYNINNQPQDDTNPCAHLGNGGCDQLCFSFPPEGGATGPS GRNFRCECATGKLSADERKCEVVNEYLVFATRTEIRAVNLDPHSTEVPFTPLTNLTNV VGLDFDFADNRMLYTQIRPWAKIAYTKANKPGHDDITVVLNKGINPEGIAYDWTQSKI YWTDSSNNSIYAMNLDGSELVMIARVERPRAIVLDPCNGTLFFTDWGRFGTSGKIFRT TMAGSLKRAIVDKDLSQPSGLAIDYDERRLYWTDAVREKIERSDLDGQNRELLVAATI YPFAITVFRNYIYWTDLQLRGVYRAEKHTGANMVEMVKRLEDSPRDIRIYSADRQKCN VNPCRINNGGCAQSCHPAPNGKAECKCDDNTKVVNEGRMCAPRNNTCEASKFYCKNGR CISRMWSCDGDDDCGDNSDEDPNYCAYHSCSPNEFRCNNGRCIFKSWKCDHENDCKDG SDELGCTYPPCVDGEFTCGNGRCIPQAQVCNGVNDCKDNATSDETHERCPMNTTCPAN HLKCEKTNICVEPYWLCDGDNDCGDNSDEDPLHCGQRTCPTNSFRCPNHRCIPATWYC DGDDDCGDGADEPPDYCKSEGRTCFGDLFTCDNGNCIPRIYICDGDNDCLDNSDEDNR HQCNDRKCDEETEFTCVENKSWQRAQCIPKKWICDGDPDCVDGADENTTLHNCATQQP CGEDMFTCGNGRCINKGWICDHDNDCGDGTDEGKFCNSKYKTCSAQEFTCQNFKCIRN QSRCDGEDDCGDHSDEVGCAKENITCPQGQFACTNGQCIDYNLVCNKYPDCADESDEP AHCNVDECAKVEINQCGHKCVDTLTGYYCDCNEGYKLLADGKACADVDECLEQPGACS QHCSNTPGGFYCKCDETYYERQNDEHTCKRKDKIPPWLIFTNKYYVRNMSVDGHQYNL MHQDLMNVVALDFDIREEYMYFCDVTAKTIFRAKYGEADDEMPPEREAVIRHDSHGLE GIAIDWVGRKLYWLDRHSKNLDVSELDGTKRKTLRSGVVDPRAIVVHPGIGYLYFTSW HLQAYIAKMGMDGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYADLEG RHRHTVLSGSKVPHVFALSLFDDYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRPYD LHINHPLRQLPYTNPCGTNNGGCSHLCLIAPPPESTYLNIEGYIEEGAPIFKCACPNQ FYLARDMKTCVANCTAGQHLCGGRDEKCIPWFWKCDGEKDCKDGSDEPATCAARHCRA GTFQCKNTNCTPSATICDGVDDCGDRSDEQNCDLPCPLSDFKCKSSGRCILDSWRCDG DADCKDGSDEDPAVCFKRTCDPKTEFACKNGRCIPQLWMCDFDNDCGDDSDEPAYMCR QRNCTTGWQRCPGQSNYRCIPKWLFCDGKDDCRDNSDELPENCPKCNPETDFKCGNNR CIPKQWMCDFADDCGDASDENEAVCKGRYRECSESEFRCGNGKCISSRWQCDHEDDCG DNSDEMHCEGYQCKNGTFQCASGHCIASYFRCDGDRDCRDMSDEVGCPPRFPGGRYCP ESRFQCNNNLCVSLSDLCDGTDDCGDGSDEDPSVCSDFNCDTLRRFQCSNHRCVARYQ ICDGVDNCGDGSDENNMTLCASKQKPCDLYTQYQCANKHCIERSQVCDFSDDCGDASD ELGCHHTSSCSEQNRGGCQHHCHNLTDGGYICTCYPGYIIAGDNKKKCSDVDECLTRQ HTCSHQCHNLNGTYSCSCREGFHLTDGSSGVCRAEKEDVILVFANGQEIRGLDLQKRE EFDVIAEEKRIEALDYDAQQQIVFWADSYDKTIKRSYMVNAIDGRAKIGFAQDLNMKG GSKPTAVAVDWLASNLYWTEMDRTGSKPRGRVMVAKTDGRYRRSIVNAGLEVPTSIAV NPQLGRIYWSDAGSAPKIEVSWMDGSKRRPLITEQIRHPAGLTIDYSQDHIIYWVDTK LNAIESMRADGSRRKAIVKGDQLRHPVSLDLFESNMFWMTRDTGELVRQDKFGRGVQV VLHRNLVNPSGLKVYHDKRYNTSLPNPCDNSTCSHLCLLVPGGHRCACPDASGPPPSH RSTAEVICNAAAEHPRPAPRICPCQNGGLCKEDAQGELVCDCLAEFRGEHCETSTTGA FGHGGANVTAVVVPIMVILLVMMAAAGAWYVIRKRPFGKLARMPAMTSSQSVTFRHGS NVEFSESGFPGASAPGAGDVAPIEGYNLQTVNANKARDFANPMYDAVQSGTTADPGMG NGSGIYDVPGEPSAKGKAMGHHAGGSFTEPASAIIAPSSITHKASPQLQLRTRELDPS ADTGKDTQFLVEEDKSEC" misc_feature 898..996 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(913..915,937..939,970..975) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(949..951,958..960,970..972,988..993) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 979..993 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature <1069..1137 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1084..1086,1093..1095,1105..1107,1123..1128) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1114..1128 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1306..1413 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1321..1323,1348..1350,1381..1386) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1360..1362,1369..1371,1381..1383,1399..1404) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1390..1404 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1426..1530 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1441..1443,1465..1467,1498..1503) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1477..1479,1486..1488,1498..1500,1516..1521) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1507..1521 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1543..1668 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1558..1560,1600..1602,1633..1638) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1612..1614,1621..1623,1633..1635,1651..1656) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1642..1656 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature <1771..1896 /gene="mgl" /note="Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057" /db_xref="CDD:469594" misc_feature <1906..2334 /gene="mgl" /note="DNA-binding beta-propeller fold protein YncE [General function prediction only]; Region: YncE; COG3391" /db_xref="CDD:442618" misc_feature 2149..>2580 /gene="mgl" /note="NHL repeat unit of beta-propeller proteins; Region: NHL; cl18310" /db_xref="CDD:302697" misc_feature 2149..2262 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 2278..2394 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 2401..2511 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 2719..2847 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 2992..>3408 /gene="mgl" /note="Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Region: YvrE; COG3386" /db_xref="CDD:442613" misc_feature 3196..3324 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 3349..3453 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 3886..3966 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(3886..3888,3910..3912,3943..3948) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3922..3924,3931..3933,3943..3945,3961..3966) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3952..3966 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3988..4095 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: Ldl_recept_a; pfam00057" /db_xref="CDD:395011" misc_feature order(4006..4008,4030..4032,4063..4068) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4042..4044,4051..4053,4063..4065,4081..4086) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4072..4086 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4105..4203 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(4123..4125,4147..4149,4180..4185) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4159..4161,4168..4170,4180..4182,4198..4203) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4189..4203 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4228..4335 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4243..4245,4270..4272,4303..4308) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4282..4284,4291..4293,4303..4305,4321..4326) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4312..4326 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4348..4455 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4363..4365,4390..4392,4423..4428) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4402..4404,4411..4413,4423..4425,4441..4446) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4432..4446 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4492..4587 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4495..4497,4522..4524,4555..4560) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4534..4536,4543..4545,4555..4557,4573..4578) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4564..4578 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4597..4695 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(4615..4617,4639..4641,4672..4677) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4651..4653,4660..4662,4672..4674,4690..4695) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4681..4695 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4729..4833 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(4747..4749,4777..4779,4810..4815) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4789..4791,4798..4800,4810..4812,4828..4833) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4819..4833 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4990..5085 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 5299..5421 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 5425..5559 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 5494..5613 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 5560..5688 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 6460..6588 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 6877..>6963 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 7201..7341 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 7402..7524 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 7480..7602 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 8158..>8556 /gene="mgl" /note="NHL repeat unit of beta-propeller proteins; Region: NHL; cl18310" /db_xref="CDD:302697" misc_feature 8200..8289 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 8323..8457 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 8434..8562 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 9022..9126 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9037..9039,9061..9063,9094..9099) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9073..9075,9082..9084,9094..9096,9112..9117) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 9103..9117 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9139..9246 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9154..9156,9178..9180,9211..9216) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9190..9192,9199..9201,9211..9213,9235..9240) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature order(9220..9225,9232..9240) /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9271..9372 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9286..9288,9313..9315,9346..9351) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9325..9327,9334..9336,9346..9348,9364..9369) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 9355..9369 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9523..9621 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(9541..9543,9565..9567,9598..9603) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9577..9579,9586..9588,9598..9600,9616..9621) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 9607..9621 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9661..9768 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(9670..9672,9712..9714,9745..9750) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9724..9726,9733..9735,9745..9747,9763..9768) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 9754..9768 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9805..9900 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9820..9822,9844..9846,9877..9882) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9856..9858,9865..9867,9877..9879,9895..9900) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 9886..9900 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9931..10035 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9946..9948,9970..9972,10003..10008) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9982..9984,9991..9993,10003..10005,10021..10026) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 10012..10026 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 10051..10149 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(10069..10071,10093..10095,10126..10131) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(10105..10107,10114..10116,10126..10128,10144..10149) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 10135..10149 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 10198..10284 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 10300..10410 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 10507..10605 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 10639..10767 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 10825..10956 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 10915..11031 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 11029..11157 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 11242..11400 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 11410..11511 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(11425..11427,11455..11457,11488..11493) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(11467..11469,11476..11478,11488..11490,11506..11511) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 11497..11511 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 11536..11640 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(11551..11553,11575..11577,11608..11613) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(11587..11589,11596..11598,11608..11610,11626..11631) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 11617..11631 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 11650..11748 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(11665..11667,11692..11694,11725..11730) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(11704..11706,11713..11715,11725..11727,11743..11748) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 11734..11748 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 11773..11874 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(11794..11796,11818..11820,11851..11856) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(11830..11832,11839..11841,11851..11853,11869..11874) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 11860..11874 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 11902..12006 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(11917..11919,11950..11952,11983..11988) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(11962..11964,11971..11973,11983..11985,12001..12006) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 11992..12006 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12034..12126 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(12046..12048,12070..12072,12103..12108) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12082..12084,12091..12093,12103..12105,12121..12126) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12112..12126 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12160..12264 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(12175..12177,12199..12201,12232..12237) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12211..12213,12220..12222,12232..12234,12250..12255) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12241..12255 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12277..12381 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(12292..12294,12316..12318,12349..12354) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12328..12330,12337..12339,12349..12351,12367..12372) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12358..12372 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12409..12504 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(12424..12426,12448..12450,12481..12486) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12460..12462,12469..12471,12481..12483,12499..12504) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12490..12504 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12550..12636 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(12550..12552,12574..12576,12607..12612) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12586..12588,12595..12597,12607..12609,12625..12630) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12616..12630 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12679..12774 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(12685..12687,12709..12711,12742..12747) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12721..12723,12730..12732,12742..12744,12760..12765) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12751..12765 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12790..12900 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 12910..13005 /gene="mgl" /note="Calcium-binding EGF-like domain; Region: EGF_CA; smart00179" /db_xref="CDD:214542" misc_feature order(12910..12912,12919..12921,12961..12963) /gene="mgl" /note="Ca2+ binding site [ion binding]; other site" /db_xref="CDD:238011" misc_feature 13249..>13701 /gene="mgl" /note="NHL repeat unit of beta-propeller proteins; Region: NHL; cl18310" /db_xref="CDD:302697" misc_feature 13294..13431 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 13441..13542 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 13471..13596 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 13543..13674 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 13564..13689 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" ORIGIN 1 cagtcgctcg cggagcgtcg tcgtgaacgg tcagccagcg cggctaataa ctaactaact 61 ttggtgacag tgcgccatac tgactctgat ccgaacccga atcgaggccc acagcagcca 121 gaacatatta ccaacaatat atcagagcgg aaagtaaacg gagctactct gaacgaaaga 181 aagaccttct ctaagataaa tcctgttgag tgtttcgagt tttttttcga cagcagccca 241 ccaaacaaaa accaaacaaa aatatttcga aaaagaatag agaaatcaag ccagaagaga 301 gggaattctc aaaggcagaa gacagaagac cggtgggcag agaagaggtc accagaaggt 361 caccgaaacc ccaaaaaaga atccaaacct aaacccacgg ataagaagca aaggagcgaa 421 ggagccagcg aagcgaccaa cgaaccaaaa atgaatccga cgcccatggg cattggattc 481 ggatttggtc gcaagccgcc caacaaggcc agaatgcgtt cccgctggcg accaccgccg 541 ccggcgacaa ccctgctgac ccctgacccc gccgagggcg acaacccggc agccgatccg 601 ctgcaggtca cagaggcctc cgcctcagct tcggcgccat cctcgcccat cggcgaccac 661 cgccatccgc agctggacag cagcagagct gccgagccga ggctgcagca ccagcaacag 721 gaagcacagc actaccgcca gcaccgcggc cagttgacaa ccctggcgct gctgctactg 781 gccctcgtag ccctcagcaa cctggaaacc ctgctcgccg tgcgcaccga aggaccgcgc 841 aaccgccatg gatcaccagg tggcagcttg ggcagcacag gcggcatcaa taccgagtgt 901 ccgacggact ccttccgctg caacaacggc aagtgcatct cgcaccactg ggtctgcaat 961 taccaaaagg actgcgacga tggcgaggac gagatgcagt cgtgcccccc accggaatgc 1021 gaaactcccc agctgaactg cgggcagtat gtgttcaaca agacctattg catccctccg 1081 cactatcgtt gcgatatgat cgaggattgc gaggacaaat cggacgaggc ccagtgcact 1141 taccgcaagt gccagcacac ggacgtcttc tgcaacgccc ccaatggagc cgcccccgcg 1201 gagggcgccc gcctggccgg accctgtgtg ccgaaggaga aacgctgcga cggctacctg 1261 gactgccgca ccgggaagga cgaggagggc tgcagcggcg tctcctgtcg cctcgaccag 1321 ttccgctgcg ccaatggaca caagtgcatc gatgccgctc tgaagtgcaa ccaccgcgac 1381 gactgtggcg ataattccga cgaacaggga tgcaacttcc cgccctgcca ccacgcccag 1441 ttccggtgct cgaacgccct atgcattccg tacaacttcc actgcgatgg ctaccacgac 1501 tgcgccgaca agagcgacga ggccaactgc acggccatcg cctgtccgga caacaagcac 1561 ctctgtccac gaggaggcgc cagcggaaca cccaagtgca tcctgaagtc ccaactgtgc 1621 gacggcaagc gggactgcga ggatggtagc gacgaggaga ccaactgttc gattgcctct 1681 tgcccagctc tgagttgtga gttcaagtgc ggaccctcgc tgaccggagg cgtgtgctac 1741 tgcaaacctg gtcaatcgct ggccccggac aaccgaactt gtgtggacct cgacgagtgc 1801 gccgagtggg gtcactgcga ccagctgtgc acgaacaccc tgggctcgta cacctgccag 1861 tgtgcccagg gctacacgct gatcaacgac tccaagtgca ttgccccgga tgcgaataac 1921 ctgcagctga tcttcgccca cgatcgtgcc ataatgcaaa tgaagccgca tggcagtgaa 1981 cctatggtac tggccaatgc caccgctgcg gccggagtga ccttccatta tgcgaggaat 2041 acgctctact ggtcggacat caagacaagg aaggttcaat ctctgcctct ggatgcacag 2101 aacaaggctg tctcgccatt cgatcaaacg ctacccggaa cctgggctcc cgtagctctg 2161 gccgtcgatt gggtgggcga taagatatat gtggccgatt tggtgggtca gaagatcgat 2221 gtcttcgagc tgagtggtca atggcatgcc gtggtcctag gttcaaacct cacctcgccc 2281 gccgacctcg ctttggatcc cacggctggt ctgatgttcg tggcggatgg tggtcaagtg 2341 ctccgtgccc acatggatgg aacccatgcc cgttcgattg tctcggaggc tgcctacaag 2401 gcgagcggcg tgacggtgga catcattgcc aagcgcgtct tctggtgcga ctccctgctg 2461 gattatattg agtcggtaga ctatgagggt ggtcataggg ttatggtcct tcgaggacag 2521 caagtgccta gtccctcgcg actcgctctg ttcgaaaacc gcatctactg gacggatgcc 2581 accaagcagg gcatcatgtc ggtggacaag ttcgagggtc ccacctccat tcaggtgacc 2641 cacaagtcca aggacattcg ggagcccaaa ggcatcattg cggtgcatgc actgagtcaa 2701 ccgagggtct cgaatccatg tggcaataac aatggtggct gcaatcatat gtgcatcgtc 2761 accgcggtca agggagctcc cacgggattg ggtttccgtt gcgcctgctc gacgggctat 2821 caactggaga cggacttgaa gctttgcaaa ccggttagcg agttcctcat gtactcgcaa 2881 cagcgattta tcaagggcaa agtattagag cccgtgatcg agggcttcag cgatgccatt 2941 atgccagtgg tttcccgccg agctcgtttc gttggcctgg atttcgatgc ccgcgatgag 3001 ttcatctact actcggacgt tctgcaggat gtgatctata gggtgcatcg aaatggaaca 3061 ggtcgcgaga ttgttttggc ctcccaaaat gagggcgtcg agggactggc tgtcgattgg 3121 gcctctaaga atctctacta catcgattca cgcaagggca ccttgaatgt cttgtccacg 3181 aggaatgtca ctcatcgcag gactctgctg aagaatttga aacgtccaag ggccattgtg 3241 gtccacccta atcgcggctt catcttcttc tccgaatggg atcgaccggc gaatatcacg 3301 cgggcaaaca ccgatggcag tggtctgttg gtcttcaaga acgtcacttt gggatggccc 3361 aatggtctgt ctattgactt caaggaggat agggtttact ggtgcgatgc cttgctagac 3421 catgttcaac atgccaattt ggatggcacg gacatcaaga cagtgaactc gcgactggtg 3481 cgacatccct tctcgattgt catccacaac gattggatgt atattacgga ctggcgattg 3541 gatgccatta tcaggctgca caagctgacg ggcgagcagg aggagatgat ggtgagggag 3601 ccgcagacca acaggctgta tggggttaag gtgtacagtc acgaggttca gaggatcgcg 3661 gagacgcaac cctgtcaccg gaacaacggg ggatgccaga agatctgctt tgcggttccg 3721 attggaggag ggaatgctac aacgaatgga ggtacaccct cctttggtcg cctgcagtcg 3781 cggtgctcgt gtccctatgg cgagcggctg gccgaggatc agatgagctg catccccgat 3841 ccgagtgccg agccgccggt gcagccgtgc ccgaactcct gggacttcac gtgcaacaac 3901 cagcggtgca ttcccaagtc gtgggtctgc gatggcgacg acgactgcct ggacaacagc 3961 gatgaggagc agaactgcac gaaacccacc tgcggatcga acgagttcca gtgccgatcg 4021 ggccgctgca ttccgcagaa cttccgctgc gaccaggaga acgactgtgg cgacaactcg 4081 gacgagcagg aatgcggcaa cgtgacctgc ggcacctcgc agttcgcctg cgccaatggg 4141 cgatgcattc cgaatatgtg gaagtgcgac agcgagaacg attgtgggga tagcagcgat 4201 gagggtgact tttgtgccga gaagacctgc gcctacttcc agttcacgtg tccgcggacg 4261 ggtcactgca taccgcagag ttgggtgtgc gacggcgacg acgattgctt cgacaagcag 4321 gacgagaagg actgtccgcc gatctcctgt ctggccaatc agttcaagtg cgccgatctg 4381 cggcagtgcg tcgaggagtc gtacaaatgc gatggcatac cggactgcaa cgatggctcc 4441 gacgaggtgg gctgcccgcc catgggcccg aatcagtgta atctcgagaa gcacttccgc 4501 tgcaagtcta ctggcttctg tatacccatc gcctggcatt gtgatggctc gaatgattgc 4561 tcggatcatt cggatgagca ggactgcggt cagatcacct gtgcccagaa cttcttcaag 4621 tgcaacaaca cgaactgtgt gttcaaggcc tacatttgcg acggcaagga cgattgtggt 4681 gataactcgg atgagggtgc cgagcatgcc tgtgttccgc cgcccttcaa gtgtccccac 4741 ggtcagtggc aatgtcccgg ggtctcggag agatgcgtga acataacctc cgtttgcgat 4801 gacaccgccg attgtcccaa tggttccgat gagggtgaag gttgcgacct cgccgagtgc 4861 gaacatcagg cgggtcagtg ctccagtttc tgtcagaaga ccccgaatgg agctctgtgc 4921 atctgtccac ctggttcgga gatcggagaa gatggctata cctgtataga cactaatgaa 4981 tgcgatcccc cgggtctctg ttctcaacag tgtacgaaca ccaagggctc gtacttctgt 5041 tcctgccaag agggttacat tttggagccc aataagcaca cctgcaaggc agtcaatcac 5101 accgccgcct tcctgatcat ctccaatagg cattctatcc tagtggccga tctcaaggaa 5161 cagggactgg aaagggtgcc cattatagtg gagaatgtgg tggccaccgc ttcgaacatg 5221 cacacgggca ccattttctg gagcgacatg aagctgaaga agatctcgcg attggatagg 5281 ggaatggaac cgcaggagat tatcaacacg ggattggatc tggtggaggg actggcctac 5341 gattggatag cccagaatct ctactggctg gacagcaagc tgaacacgat cgaggtgtcg 5401 gcggagaatg gttcgaatcg attggttctt gttagagaga acatcactca gcccagaggc 5461 atgtgcatcg atccgagtcc cggggcaaga tggatcttct ggacggactg gggtgagaat 5521 ccgcgggtgg agcggatcgg catggatgga acgatgagga agacgatcat caatacgaag 5581 atctattggc ccaatggttt gaccctggac atagccacca agcgggttta ctttgcggat 5641 tccaagctgg actttataga cttttgctac tacaatggaa ccgggagaca gcaggttttg 5701 gccagcagtc actacctcct gcatccgcac tcgctgtccc tcttcgagga taccctgtac 5761 tggacggaca ggcaattgaa tcgggttctc tcggcgaata agtttagggg caagaatcag 5821 acggtggttt cgcacctgat tagccaaccg ctgtccatcc acgtgcatca tgcctccctg 5881 cagccgatga ccccgaatcc ctgtgcctca gcacgctgcc agcatctgtg tctgctgagt 5941 cccagcgcct cggagggcta ctcgtgcaag tgcaagccgg gcttcaagct gctcagcgag 6001 ggtcgctgca tcgaggagga gaatcccttc ctgatggtcg tcaagggcac gcagatagtg 6061 gatcttccgc tgaatggtgg cgatgcgagg gcaggagcct tggctccggt gattggaatc 6121 gagagcagca ctggcctgga ctttgatcgc aagggagaga ccctctattg ggtgcagggc 6181 agggaggatg atgacgagaa ttgcactatc tatacgacac catacggagg tggcaacaag 6241 accctcttcc tgggcaccga aagcggcatt gtcggagcac cctacaccat tgccttcgat 6301 tggttgggtc ggaatctcta cattggcaac cgggtggcca gtaatatcga ggcagtgcga 6361 gtggatggaa agcaaaagta ccggacaatc atcctagcca acgatggtta tgccaactcg 6421 gtgtcgcgac ccaagcaaat agtgctcgat cccaccgacg gcaagctctt ctggatcgac 6481 gagggcgtgc tggaggtgcc catcaagatc ggcagggtgg acatgaatgg gcagaacccc 6541 attgtggtct tccaggactt tgcccatccc gaatcgctgg ccgtggacac ggagaagaag 6601 atgctctact acagtgccag caatccggcg gtgattggtt cgatggatta taacggagct 6661 gatcacacgc tgattgtgat gaaggactcg catccgatgg ccaagccgag gagtctgggc 6721 atcctggatc accgactata ctatttggat cccttgtacg agcggattgt gcgaatcgat 6781 ctgccgcatg gcgataatcc caagacaatt gtggataatg aatcggattt gagatcgatg 6841 atgatctaca agaagcgcgc tttgatgcag catccctgcc agacgaacaa cggcggctgc 6901 aagcatctct gcattccggg atcgggagct acgaggacct gctcctgcgg cattggttat 6961 cgcaaggaga acgagatcaa ttgcgtggcc tacaagacct tcgcggtcgt ctcccagctg 7021 gacatgatca ggggatatag cttaagtgac agtgcagagg ccatggttcc ggtgagcgga 7081 cctggtcatc acatcctcca cgtggacgtc atgtatcggg agcaatggat ctactgggcg 7141 gaatacaatc ggggctactg gaatggcatc ttcaggtcgc gacccaatgg caccgatctg 7201 cagcatgtgg tcaaggatgg gatcggaagc aatggcatcc ggggactgac catcgattgg 7261 gtggccggta atatgtactt taccaatgtc tatccgcatg agaattacgt ggaggtctgc 7321 tggctggacg gtagcaatag gaaggtgttg gtcaagacca ccacggatgc accgcgtgaa 7381 ctcgcggtga atcccgtgaa gaggctgctc tactggatcg actatggtca gcatccgagg 7441 attgggaaag ctctgctgga cggaagcaag tggacgcctt tggtgacgtc ggggatctcg 7501 ttgccacgcg atctaaccat cgatatgcag acgcatgaca tctactgggt ggactcgaaa 7561 ctggacacca tccagaagat ctcctttaat ggggccaatc gcaaggtcat tcggagggat 7621 ctgcccaatc ccatgggcat cgctgtctat ctgaacgacg tgtactgggt ggacaggaac 7681 ctgatgaccg tgttcaaggc ctccaagcac agtgctaatg agacggccac cagggtgagg 7741 acgaatctgg agaagctgag ggacattgcg atctacaata tcaacaatca gccgcaggac 7801 gataccaatc cttgtgccca cttgggcaac ggcggctgcg atcagttgtg cttcagtttc 7861 ccacccgaag ggggagccac cggtccatcg ggcaggaatt tccgttgcga gtgtgcgacg 7921 ggtaagctga gtgccgacga gcgaaagtgc gaggtggtca acgagtatct ggtctttgcc 7981 acacgaaccg aaattcgagc cgttaacctc gatccccatt ccacggaggt gccttttacc 8041 ccgctgacta atctcacgaa tgtcgtgggt ctggactttg atttcgcgga caatcgaatg 8101 ttgtatacgc agattcgccc atgggccaag atcgcctata cgaaggcgaa taagccggga 8161 cacgatgaca tcacggtggt gctgaacaag ggcatcaatc ccgagggcat tgcgtacgat 8221 tggacgcagt cgaagatcta ttggacggac agctcgaaca actcgatcta tgcgatgaat 8281 ctggatggca gtgaactggt gatgattgcc cgggtggagc gtccccgagc gattgtcctg 8341 gatccctgca atggaacgct gttcttcacg gattggggaa gattcggaac ctctggcaag 8401 atattccgca cgacgatggc gggatctctg aagagagcga tcgtggataa ggacctgtcg 8461 cagcccagtg gcctggccat cgattacgat gagaggaggt tgtattggac ggatgcggtg 8521 agggagaaga tcgagcgatc cgatttggat ggtcagaaca gggagctcct ggtggccgcc 8581 accatatatc ccttcgcgat caccgtgttc cgtaactaca tctactggac ggatctccag 8641 ctgcgcggtg tctaccgggc ggagaagcac acgggtgcga atatggtgga gatggtgaag 8701 cgactggagg attcgccgcg agacattcgc atctacagtg cggatcggca gaagtgcaat 8761 gtgaatccgt gcaggatcaa caatggggga tgtgcccaga gttgtcaccc ggcgccgaat 8821 ggcaaggccg agtgcaaatg cgatgataat acgaaggtgg tgaacgaggg aaggatgtgt 8881 gcaccgagga ataatacgtg cgaggccagc aagttctact gcaagaatgg caggtgcatt 8941 tcgaggatgt ggtcctgcga tggcgacgac gactgtgggg ataattccga tgaggatccc 9001 aactactgtg cctatcactc ctgctcgccg aatgagttcc gttgcaacaa tggtcggtgt 9061 attttcaagt cttggaagtg cgatcacgag aacgattgca aggatggctc cgatgagctg 9121 ggctgcacct atccgccctg cgtcgatggt gagttcacct gcggcaatgg caggtgtatt 9181 ccccaggccc aggtgtgcaa tggggtgaac gattgcaagg acaatgccac ctcggacgag 9241 acgcacgaga ggtgtcccat gaacaccacc tgtccggcga atcatctcaa gtgcgagaag 9301 acgaatatct gtgtggagcc ctattggctg tgcgatggcg acaacgattg cggcgacaac 9361 tccgacgagg atcccctgca ttgtggtcag agaacttgtc ccacgaacag cttccgctgc 9421 cccaaccacc gatgcattcc ggccacctgg tactgcgatg gcgacgatga ttgcggcgat 9481 ggcgccgacg agccaccaga ttactgcaag tccgaaggac gcacttgctt cggggatctc 9541 ttcacctgcg acaatggcaa ctgcataccc agaatctaca tttgcgacgg tgacaacgat 9601 tgcctggaca acagtgacga ggacaaccgg catcagtgca atgaccgaaa gtgtgatgag 9661 gaaacggaat tcacctgcgt ggagaacaag tcctggcagc gagcccagtg catccccaaa 9721 aaatggatct gcgacggaga tccggattgt gtagatggag ccgacgagaa caccaccctg 9781 cacaactgtg ctacgcagca accctgtggc gaggacatgt tcacctgcgg caacggacgc 9841 tgcatcaata agggatggat ctgcgaccat gacaacgatt gcggcgacgg caccgacgag 9901 ggcaagttct gcaactccaa gtacaagacc tgctcggccc aggagttcac ctgccagaac 9961 ttcaagtgca tccgcaacca gtcgaggtgc gatggcgagg acgactgcgg cgatcactcg 10021 gacgaggtgg gctgcgccaa ggagaacatc acctgtccgc agggacagtt cgcctgtacg 10081 aatggccagt gcatcgacta caatctggtg tgcaacaagt atcccgactg tgccgacgag 10141 tccgatgagc cggcccactg caacgtggac gagtgcgcca aggtggagat caatcagtgc 10201 ggccacaagt gcgtggacac gctgacgggc tactactgtg actgcaatga gggctacaaa 10261 cttctggccg acggcaaggc atgtgcggat gtggacgagt gcctggagca gccgggcgcc 10321 tgttcccagc actgttcgaa caccccgggt ggattctact gcaagtgcga tgagacctac 10381 tacgagcggc agaacgatga gcacacgtgc aagcgaaagg acaagatacc accctggctg 10441 atcttcacca acaagtacta tgtgcgaaat atgtcggtgg atggacatca gtacaatttg 10501 atgcaccagg atctgatgaa tgtggtggcc ctggactttg acattcgcga ggagtacatg 10561 tacttctgcg acgtgacggc caagacgata ttccgggcca agtatgggga ggcagatgac 10621 gagatgccgc cggagcggga ggctgtgatc aggcacgatt cccatggact ggagggcatc 10681 gccatcgatt gggtgggtcg caagctctac tggttggaca ggcactccaa gaacctggat 10741 gtttccgaac tggatggaac caaacgcaag accctgagga gtggtgtcgt tgatccgcgt 10801 gccattgtcg tgcatcctgg catcggttat ctgtacttca cctcctggca tctgcaagcc 10861 tacattgcca aaatgggcat ggatggttcg aacttctcga ggatcctgaa ctggaacgac 10921 ggtatcgcct ggccgaatgc cctgtccatt gactacttca cggatcgtat ttactgggcg 10981 gacgcccact tggactacat agcctatgct gatttggagg gcaggcatcg gcatacggtg 11041 ctctctggca gcaaggtgcc tcatgtgttt gcactgagtc tcttcgacga ctacatctac 11101 tggagtgact ggaatctgaa ggccattgtg cgggccaaca agttccatgg tgccaactac 11161 acggtgctga ggaataccac ccatcgtccc tacgacctgc acatcaatca tccgctgagg 11221 caactgccct acaccaatcc ctgtggcacc aacaacggcg gttgctcgca tctctgcctg 11281 atagctccac cgccggagtc cacgtacctg aatatcgagg gctatatcga ggagggagct 11341 ccgatcttca agtgcgcctg tcccaatcag ttctacttgg cccgggacat gaagacttgc 11401 gtggccaatt gcacggccgg gcagcatttg tgcggcggtc gggatgagaa gtgcataccg 11461 tggttctgga agtgcgacgg ggagaaggac tgcaaggatg gcagcgatga gccagccacc 11521 tgtgccgcgc gacactgccg ggccggaacg ttccagtgca agaataccaa ctgcacaccc 11581 tcggcgacca tttgcgatgg cgtggacgac tgcggtgatc gtagcgacga acagaattgc 11641 gatctaccct gcccgctgtc cgatttcaag tgcaaatcca gtggtaggtg catcctggac 11701 agctggcgct gcgatggcga tgccgactgc aaggatggca gcgacgagga ccccgccgtg 11761 tgcttcaagc gcacctgcga tcccaagacg gagtttgcct gcaagaatgg ccgctgcatt 11821 ccgcaactgt ggatgtgcga tttcgacaac gattgcggcg atgattccga tgagccggcg 11881 tacatgtgcc gccagcgcaa ctgcaccacc ggctggcaga gatgccctgg tcagtcgaac 11941 taccgctgca ttcccaagtg gctgttctgc gacggcaagg acgattgtcg ggacaacagc 12001 gacgagctgc cagagaactg ccccaagtgt aatcccgaga cggacttcaa gtgcggcaac 12061 aaccgatgca tacccaagca atggatgtgt gactttgcgg acgattgtgg cgatgctagc 12121 gatgagaacg aggctgtctg caagggtcgc tatcgggagt gctccgaatc ggagttccgc 12181 tgcggcaacg gcaagtgcat ctcctcccgg tggcagtgcg atcatgagga cgactgcggc 12241 gacaactcgg acgagatgca ctgcgagggc tatcagtgca aaaacggcac cttccagtgc 12301 gcttccggtc attgcatagc ctcctacttc cgttgcgacg gcgatcgcga ttgccgcgac 12361 atgtccgacg aggtgggctg tccgccgcgc ttcccgggcg gtcgctactg tcccgagtcg 12421 cgtttccagt gcaacaacaa cctgtgcgtc tcgctgtcgg acctctgtga cggcacagat 12481 gattgcggtg atggcagcga cgaggatccc agcgtttgca gtgacttcaa ttgcgatacc 12541 ctgcggcgat tccagtgctc caatcatcga tgcgtggctc gctatcaaat ctgcgatggt 12601 gtggacaact gcggcgatgg cagtgatgag aacaacatga ccctgtgtgc cagcaaacag 12661 aagccctgcg atctgtacac ccagtaccag tgcgccaaca agcactgcat cgaacgctcg 12721 caggtgtgcg acttctccga cgattgtggc gatgccagcg atgagttggg ctgccaccac 12781 acgagcagct gctccgaaca gaatcgcggt gggtgtcagc atcactgcca caatctcacc 12841 gacggtgggt acatatgcac ctgctatccc ggctacatca tagccggcga caacaagaag 12901 aagtgctccg acgtggacga gtgcctcacg cgacagcaca cgtgttcgca tcagtgtcac 12961 aatctcaatg gcacctactc gtgcagttgc cgcgagggtt tccatctgac cgacggctcg 13021 agtggcgttt gtcgtgccga aaaggaggat gtcattttgg tatttgccaa cggtcaggag 13081 atccgaggtt tggacctcca gaaacgcgag gaattcgatg tgattgcgga ggagaagcgg 13141 atcgaggcac tggactacga tgcccagcag cagatcgtct tttgggcgga tagctatgac 13201 aagacgatca agcgttcgta catggtgaat gccatcgatg gcagggccaa gattggcttt 13261 gcccaggatc tgaacatgaa gggaggatcg aaacccaccg ccgtggccgt cgattggctg 13321 gcctcgaatc tctactggac ggaaatggac aggacgggct cgaagccgcg tggtcgagtg 13381 atggtggcca agacggatgg aaggtatcgc aggtcgattg tgaatgccgg tctggaggtg 13441 cccacttcga tagcggttaa tccacagctg ggcaggatct actggtcgga tgcgggctcc 13501 gcgcccaaga tagaggtctc ctggatggat gggtccaagc ggcgaccgct gatcaccgag 13561 cagattcgtc atcccgccgg cctgaccatc gattactcgc aggatcacat catctactgg 13621 gtggacacca agctgaatgc cattgaatcg atgcgggccg atggttcgcg tcgcaaggcc 13681 attgtgaagg gtgaccagct gaggcatccc gtttccctcg atctcttcga atccaacatg 13741 ttctggatga cacgcgacac cggggagctg gtgcgccagg ataagttcgg gcgcggagtg 13801 caggtggtgc tgcatcgcaa cctcgtcaat ccgtccggcc tgaaggtcta ccacgacaag 13861 cggtacaaca cctcgctgcc caatccgtgc gacaactcca cctgctcgca cctctgcctc 13921 ctggtgcccg gcggccatcg gtgcgcctgt cccgacgcct ccggtccgcc gccctcgcat 13981 cgcagcaccg ccgaggtgat ctgtaatgcc gccgccgagc atccgcgtcc ggcgccgagg 14041 atttgtccct gccagaacgg cgggctctgc aaggaggatg cccagggtga gctcgtctgc 14101 gactgtttgg ccgagttccg gggcgagcac tgcgagacga gcaccaccgg agcctttggt 14161 catgggggcg ccaatgtcac cgccgtcgtg gtgcccatca tggtcatcct gctggtgatg 14221 atggccgccg ccggcgcctg gtacgtcatc cggaagagac cttttggcaa attggctcgc 14281 atgccggcga tgacctcgtc gcagagcgtg accttccgcc acgggtcgaa tgtggagttc 14341 agcgagagcg gcttcccggg ggcatccgca ccgggggccg gcgatgtggc gcccatcgag 14401 ggctacaacc tgcagacggt gaacgcgaac aaggcgcgcg actttgccaa tccgatgtac 14461 gatgcagtgc agtcgggcac caccgccgat ccaggcatgg gcaacggctc gggcatctac 14521 gatgtgcccg gcgaaccgtc ggccaagggc aaggccatgg gccaccatgc gggcggatcc 14581 ttcacggagc ccgcctcggc gatcatcgcg cccagcagca tcacgcacaa ggcgtcgccg 14641 cagctgcagc tgcgcaccag ggagctggac ccctcggcgg acaccggcaa ggacacccag 14701 ttcctggtgg aggaggacaa gtccgagtgc tgatatcaag cccgtcaatc ggctgcagtt 14761 gcgatggcca gctgtcgccg gcagcagcag cagcagaagc agcagaagca tccggagaac 14821 agctatccgc tgcagacata acacagactg gtcaagcaaa ggaaggagca gcagca