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PREDICTED: Drosophila takahashii Rho kinase (Rok), transcript


LOCUS       XM_070219213            6894 bp    mRNA    linear   INV 09-DEC-2024
            variant X1, mRNA.
ACCESSION   XM_070219213
VERSION     XM_070219213.1
DBLINK      BioProject: PRJNA1194641
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6894
                     /organism="Drosophila takahashii"
                     /mol_type="mRNA"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     gene            1..6894
                     /gene="Rok"
                     /note="Rho kinase; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 5 Proteins"
                     /db_xref="GeneID:108059116"
     CDS             737..4927
                     /gene="Rok"
                     /codon_start=1
                     /product="rho-associated protein kinase 1 isoform X1"
                     /protein_id="XP_070075314.1"
                     /db_xref="GeneID:108059116"
                     /translation="MPAGLEPVTSRRSMDVERRRRANTLEREMRDPTSICNVDCLLDT
                     VSALVSDCDHDSLRRLKNIEQYAAKYKPLALQINQLRMNVEDFDFIKLIGAGAFGEVQ
                     LVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYL
                     YMVMDFMPGGDIVSLMGDYDIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLD
                     SYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVG
                     IFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQR
                     LGRYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVF
                     PVPKGFDGNHLPFIGFTYTGDYQLLSSDTVDAESKEASAAVNSSGAASNNHGHGHGHN
                     HRHRPSNSNELKRLEALLERERGRSEALEQQDAGLRQQIELITKREAELQRIASEYEK
                     DLALRQHNYKVAMQKVEQEIELRKKTEALLVETQRNLENEQKTRARDLNINDKVVSLE
                     KQLLEMEQSYKTETEQTQRLKKHNTELDFTVKSQEEKVRDMVDMIDTLQKHKEELGQE
                     NAELQSLVVQEKNLRSQLKELHKEAENKMQTLINDIERTLGREQKAQEDNRALLEKIS
                     DLEKAHAGLDFELKAAQGRYQQEVKAHQETEKSRLVSREEANLQEVKALQSKLNEEKS
                     ARIKADQHSQEKERQLSMLSVDYRQIQLRLQKLEGECRQESEKVAALQSQLDQEHSKR
                     NALLSELSLHSSEVAHLRSRENQLQKELGVQREAKRRFEEDLGQLKGTHHEALANNRE
                     LQAQLEAEQCFSRLYKTQANENREESAERLAKIEDLEEERVSLKHQVQVAVARADSEA
                     LARSIAEETVADLEKEKTIKELELKDFVMKHRNEINAKEAALATLKEAEIELHKKLGQ
                     KGVECEDLLQQHKKQQEELALMRSSKDEEIAKLLDKCKQEVLLKQVAVNKLAEVMNRR
                     DSDLPKQKSKARSTAELRKKEKEMRRLQQELSQERDKFNQLLLKHQDLQQLCAEEQQV
                     KQKMVMEIDCKATEIEHLQSKLNETASLSSADNDPEDSQHSSLLSLTQDSVFEGWLSV
                     PNKQNRRRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAVLILDLSKVYHVRSVTQGD
                     VIRADAKEIPRIFQLLYAGEGASHRPDEQSQLDVSVLHGNSNEERPGTIVHKGHEFVH
                     ITYHMPTACEVCPKPLWHMFKPPAAYECKRCRNKIHKEHVDKHDPLAPCKLNHDPRSA
                     RDMLLLAATSEEQSLWVARLLKRIQKSGYKANSSNNNSSTTDGSKISPSQSTRSSYKP
                     YAVNVQRSATLPANSSLK"
     misc_feature    917..1969
                     /gene="Rok"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Rho-associated coiled-coil containing protein kinase;
                     Region: STKc_ROCK; cd05596"
                     /db_xref="CDD:270747"
     misc_feature    order(920..922,932..934,941..946,953..955,971..985,
                     992..994,1190..1192,1931..1939,1943..1948,1952..1954,
                     1967..1969)
                     /gene="Rok"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:270747"
     misc_feature    order(1013..1027,1037..1039,1076..1078,1082..1084,
                     1178..1180,1226..1231,1235..1237,1247..1249,1253..1255,
                     1361..1363,1367..1369,1373..1378,1382..1384,1412..1417,
                     1424..1426,1469..1486,1577..1579,1595..1597,1604..1606)
                     /gene="Rok"
                     /note="active site"
                     /db_xref="CDD:270747"
     misc_feature    order(1013..1027,1037..1039,1076..1078,1082..1084,
                     1178..1180,1229..1237,1247..1249,1361..1363,1367..1369,
                     1373..1378,1382..1384,1412..1417)
                     /gene="Rok"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270747"
     misc_feature    order(1025..1027,1247..1249,1253..1255,1361..1363,
                     1367..1369,1373..1375,1424..1426,1469..1486,1577..1579,
                     1595..1597,1604..1606)
                     /gene="Rok"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270747"
     misc_feature    1412..1486
                     /gene="Rok"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270747"
     misc_feature    1949..1966
                     /gene="Rok"
                     /note="hydrophobic motif (HM); other site"
                     /db_xref="CDD:270747"
     misc_feature    2327..>4027
                     /gene="Rok"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; Region:
                     Smc; COG1196"
                     /db_xref="CDD:440809"
     misc_feature    3293..3508
                     /gene="Rok"
                     /note="Shroom-binding domain found in Rho-associated
                     coiled-coil containing protein kinase; Region: ROCK_SBD;
                     cd22250"
                     /db_xref="CDD:409019"
     misc_feature    order(3296..3298,3305..3310,3314..3319,3326..3331,
                     3335..3340,3347..3352,3356..3361,3368..3373,3377..3382,
                     3389..3394,3401..3403,3410..3412)
                     /gene="Rok"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409019"
     misc_feature    order(3302..3304,3311..3316,3320..3328,3332..3337,
                     3341..3358,3365..3367)
                     /gene="Rok"
                     /note="Shroom binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:409019"
     misc_feature    4148..4498
                     /gene="Rok"
                     /note="Rho-associated coiled-coil containing protein
                     kinase pleckstrin homology (PH) domain; Region: PH_ROCK;
                     cd01242"
                     /db_xref="CDD:269948"
     misc_feature    4487..4678
                     /gene="Rok"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in the Rho-associated coiled-coil containing protein
                     kinase (ROCK) family; Region: C1_ROCK; cd20813"
                     /db_xref="CDD:410363"
     polyA_site      6894
                     /gene="Rok"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 accttcgata tgtaaacata attgccatct ctaccacagc accgaaccga aagaagaagt
       61 gcaacgcgca gcgtctaatt aaaaccaaat tgatcgattt ggccgcggcc gaaactggac
      121 attcgcaatt tgggcggtca gccgcccccg tcccgtcccg cccccccgcg cgtttcccgc
      181 tgccgcctgc gtacagcccg tcggtgtgac gcacgtctcg gtgtgtgtgt ggtgcgcctt
      241 gttattgttg ttgtagcatt tgctacgttc gccgttcgcg gtgcgctggt gtgcgagcga
      301 gcgaggcgac agtgtgtgcg tgtgtgtaag gtatcgttgg aattaacaaa aaagaaaaaa
      361 aaacagaaaa gaaaaacaag attggggaaa aaactgccaa aagccgagaa acaaagctaa
      421 tccctagcat cgccaagctc agtggcagac caagccaact gttgcatgcc gaggattggg
      481 ggggaaatcc tggccagcag cccctctacc cacagaggct tccaggcacc tgggaaggcc
      541 ccgggaaggc cccgggtgct ccactgcgtc cgcatgtggc gttggcggca ctccatctcc
      601 aaactgagcc aaactaacgc cgtgacctca tcgccggaac cagaacaaca gagctgcctt
      661 ctcacttacc actagcaatc cccgaaagca ggagcagcag cagagcagca gagcagcgga
      721 gcagcagagc atttgcatgc cagctggact agaacccgtg accagccggc gcagcatgga
      781 tgtggaacga aggcgccggg cgaatacgct cgagcgcgag atgcgcgatc cgaccagcat
      841 ctgcaatgtg gactgcctgc tggacacggt gtcggccttg gtcagcgatt gcgaccacga
      901 ctccctgagg cggcttaaga acatcgagca gtatgcggcc aaatataaac cactggccct
      961 gcagatcaac cagctgcgca tgaacgtcga ggatttcgac ttcatcaagc tcatcggcgc
     1021 cggcgccttc ggagaggtgc agctggtgcg gcacaagtcc tccagccagg tgtacgcgat
     1081 gaagcggctg tccaaattcg agatgatgaa gcgcccggac tccgccttct tctgggagga
     1141 gcgacacatc atggcgcacg ccaactccga gtggatcgtc cagcttcact ttgcctttca
     1201 ggatgccaaa tacttgtaca tggtgatgga cttcatgccc ggcggcgaca tagtgtcgct
     1261 gatgggcgac tacgacatac cggagaagtg ggccatcttc tacacgatgg aggtggtgct
     1321 ggccctggac accattcaca acatgggctt cgtgcaccgc gacgtcaagc cggacaacat
     1381 gctgctcgac agctatggcc acctgaagct ggccgacttc gggacgtgca tgcgaatggg
     1441 cgccaacggg caggtggtgt ccagcaatgc ggtgggcacg ccggactaca tcagccccga
     1501 ggtgctgcag tcgcagggcg tggacaacga gtacgggcgc gagtgcgact ggtggtcggt
     1561 gggcatcttc ctctacgaga tgctcttcgg cgagacgccc ttctatgcgg actccctggt
     1621 cggcacctac ggcaagatca tggaccacaa gaactcgctc agcttcccgc ccgaggtgga
     1681 gattagcgag caggccaagg ccctgatacg cgccttcctc acggaccgaa cgcagcgcct
     1741 gggacgctac ggcatcgagg acatcaaggc gcatccgttc ttccgcaacg acacctggtc
     1801 gttcgacaat atacgcgaga gcgtgccgcc cgtggtgccg gagctctcgt ccgacgacga
     1861 tacgcgcaac ttcgaggaca tcgagcggga cgagaagccg gaggaggtgt ttcccgtgcc
     1921 caagggcttc gatggcaacc acctgccctt catcggcttc acctacacgg gcgactacca
     1981 gctgctgtcc agcgacaccg tggacgccga gtccaaggag gccagtgcgg cggtgaacag
     2041 cagcggggcg gccagtaaca atcacggtca cggtcacggg cacaatcacc gccaccggcc
     2101 gtcgaactcc aacgagctga agcgcctgga ggccctgctg gagcgggagc gcggccgctc
     2161 ggaggccctg gagcagcagg acgccggtct gcggcagcag atcgagctga taacgaagcg
     2221 cgaggcggag ctgcagcgca tcgcctccga gtacgagaag gatctggcct tgcggcagca
     2281 caactacaag gtggccatgc agaaggtcga gcaggagatc gagctgcgca agaagaccga
     2341 ggcgctgctc gtcgagacgc agcgcaatct ggagaacgag cagaagacgc gggcacgcga
     2401 cctgaacatc aacgacaagg tcgtctcgct ggagaagcag ctactcgaga tggagcagag
     2461 ctacaagacg gagacggagc agacgcagag gctgaagaag cacaacaccg agctggactt
     2521 tacggtcaag tcgcaggagg agaaggtgcg cgacatggtc gacatgatcg acacgctgca
     2581 gaagcacaag gaggagctgg gccaggagaa cgccgagctg cagtcgctgg tggtgcagga
     2641 gaagaatctg cgctcgcagc tcaaggagct gcacaaggag gccgagaaca agatgcagac
     2701 gctgatcaac gacatcgagc ggacgctggg acgcgagcag aaggcccagg aggacaatcg
     2761 ggcgctgctc gagaagatca gcgatttgga gaaggcccat gccggcctcg acttcgagct
     2821 gaaggccgcg cagggccgct accagcagga ggtgaaggcc caccaggaga cggagaagtc
     2881 gcgactggtg tcgcgcgagg aggccaatct gcaggaggtc aaggcgctgc agtcgaagct
     2941 caacgaggag aagtccgccc gcatcaaggc cgatcagcat tcgcaggaga aggagcgcca
     3001 actgagcatg ctctcagtgg actatcgcca gatccagctg cgcctgcaga agctcgaggg
     3061 cgagtgccgc caggagtcgg agaaggtggc cgccctgcag tcgcagctcg accaggagca
     3121 cagcaagcgc aacgccctgc tctcggagct cagcctgcac agctcggagg tggcccacct
     3181 gcgatcccgc gagaaccagc tgcaaaagga gctgggcgtg cagcgcgagg cgaagcggcg
     3241 gttcgaggag gacctcggcc agctgaaggg cacccatcac gaggcgctgg ccaataaccg
     3301 ggagctgcag gcccaactcg aggccgagca gtgcttctcg cggctctaca agacgcaggc
     3361 gaacgagaac cgcgaggaga gcgccgagcg gctggccaag atcgaggacc tcgaggagga
     3421 gcgcgtctcg ctcaagcacc aggtccaggt ggccgtcgcc cgcgccgatt ccgaggctct
     3481 ggcccgctcc attgccgagg agacggtggc cgatctggag aaggagaaga ccatcaagga
     3541 gctcgagctg aaggactttg tgatgaagca ccgcaacgag atcaacgcca aggaggccgc
     3601 tttggccacg ctcaaggagg ccgagatcga gctgcacaag aagctgggcc agaagggcgt
     3661 cgagtgcgag gatctgctgc agcagcacaa gaagcagcag gaggagctgg cgctgatgag
     3721 gagcagcaag gacgaggaga tagccaagct gctggacaag tgcaagcagg aggttctgct
     3781 caagcaggtg gcggtgaata agctggccga ggtgatgaac cgtcgcgact ccgacctgcc
     3841 caagcaaaag agcaaggccc gctccaccgc cgagctgcgc aagaaggaga aggagatgcg
     3901 ccggctgcag caggagctat cgcaggagcg cgacaagttc aaccagctgc tgctcaagca
     3961 ccaggacctc cagcagctgt gcgccgagga gcagcaggtc aagcagaaga tggtcatgga
     4021 gatcgactgc aaggccaccg agatcgagca cctgcagagc aagctcaacg agacggcgtc
     4081 gctctcctcg gcggacaacg atcccgagga tagccagcac tcctctctgc tctccctcac
     4141 acaggactcg gtcttcgagg gctggctgag tgtgccgaac aagcagaacc ggcgacgtgg
     4201 tcacggctgg aagcggcagt atgtcatcgt ctcgtcgcgc aagatcatct tctacaactc
     4261 ggacattgac aagcacaaca ccaccgatgc tgtgctcatc ctggatctga gcaaggtgta
     4321 ccacgttcgc agcgtcactc agggcgatgt tatacgcgcc gatgccaaag agattccgcg
     4381 catcttccag ctgctgtacg ccggcgaggg tgcctcccat cgtcccgacg agcagagcca
     4441 gctggatgtg agcgttctgc atgggaatag caatgaggag cgcccgggca ctattgtcca
     4501 caaaggtcac gagttcgtcc acataaccta ccacatgccc acggcctgcg aggtgtgccc
     4561 gaagcctttg tggcacatgt tcaagccgcc ggcggcttac gaatgcaaga gatgccgcaa
     4621 caagattcac aaggagcatg tggacaagca cgacccgctg gcgccctgca agctgaacca
     4681 cgatccccgg agcgcaaggg acatgctgct gctggccgcc acgtccgagg agcagtcgct
     4741 gtgggtggcg cggctgctga agcgtatcca aaagagtgga tacaaggcca actcgtcgaa
     4801 caacaacagc agcaccaccg atggcagcaa gatatcgccc agccaatcga cgcgctcctc
     4861 ctacaagccg tatgcggtta atgtgcaacg ctccgcgacg ctgccagcca attcatcgct
     4921 gaaatgaacg cccaacgatc ccagatccca gatggcaaac tgcagctgga gccgggagcc
     4981 agcctccttc agccccaacg aaactaaatg ctatgcaaaa ctgatacacc gatatataga
     5041 gaggaaaata gcaagagaga aagagcagct gcaacttgaa gggcaactgc aactactatc
     5101 ttaaatatac gctctaaaca tacatgctac atgcgctagt aatctacaaa tattttttga
     5161 gtaatttaca agctaaaact aaactacaac taaactgaaa ctaaaactaa aacgaaaact
     5221 taaaacaaaa atactaaata ctaaaaaact gtatcttaaa gaacatgtaa agccaatgca
     5281 actcgtttaa cgcttaccta acatcaaact ggatggtgag aaggtctaca tagaacataa
     5341 aacatagaac acaaaagtgg caacgtcagg cggctcagaa gcgatgcact ttgttgtact
     5401 ttatattcta tatagtatat acatataaat ataaatacga tatggtattg tacgacttgc
     5461 tattgtattc tgtcatcgca ttcagcacaa cgatgagagc tgtatttagt taagtgaatc
     5521 catatccatg tcgctgcaaa aggtgatcct tcaccttttc ccatatatca aggccttgta
     5581 agaacgtttt ttttttcaca tatatatacc tatatacata ctgttgttgt tgtgtagcga
     5641 atcagattgg ccaaacgttg ttcttagttg taaagaaaca gagctataca atatatattt
     5701 gtagagatat atactagtat atatactcct ccaagagcat atcctgtaag ccaattgcca
     5761 gctaacaaca aacgaaaaga atcgagcaac caacaaaaac cagaactaag ttaaagccac
     5821 tttacaaagc tttaacttgt attccattta atgagcactc ttttttacat aaatagtata
     5881 gatttacgtg tacaagatgg aacgaattgc gcgatgatat cgatagaagc gaatatcaat
     5941 cagttactta aatagcaaac gcgaaagcaa ctaaaaatac tgtcctgttt cggtttgcag
     6001 ttccgattcc gattcctagt tgccttggag gcaaaacgaa agttaattct acagtttgta
     6061 ttttttattc ttaacgaacg gggaaccgga aacggaaacg taaacgaaac ggaatagagt
     6121 gtctctagcc atggacagag cgaaacatga atcgaaacta aaactaaaac taaaagtaaa
     6181 agtaaactaa actaaagtct aaagtaaagt aaagtacacc taactataca aaacgaaaga
     6241 tgcgacacca cagtgttgtg tgcaaaaggc tacatctaag tattaaatat ccaatatgtt
     6301 ctagttgtaa gctaagcaaa ttatttattt atatccctgt tcgatggcgc catctggcgt
     6361 tcgacaacag aaacggcagc agcagcttag cactctccaa tttgtttgta tttgatttgt
     6421 attccagtaa tgttgatttt accttaccta tctatctatg atttcgaaga acccgttttg
     6481 agtttttata attttataat ttgagtagtg gtagtttgtt ttacagagtg tacagagtga
     6541 gaggcgccag cgaattgcat ttaaaaagta acgataatag cgatatattt ccaagtttcg
     6601 ggccttcttc aaacatcggt agtcggttat tgttaatcgc caatcgccta tcgatagccg
     6661 caaacggccg caaagttcgg acttgggact ttgaaatcga agcgccgctt tcatttttta
     6721 ctttgtatct tatttgcact attattatga tcattcgtat tacgtttatg tttaattgta
     6781 ctctctagtt taaccacgtt tgtaattgca tttgtcctcg aatcttatcg gcaggcttcc
     6841 aaatggaatt gcaagcgtca agcaaataaa acgataatgt gtataaaatc agta