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PREDICTED: Drosophila takahashii MYC binding protein highwire


LOCUS       XM_070219172           16929 bp    mRNA    linear   INV 09-DEC-2024
            (hiw), mRNA.
ACCESSION   XM_070219172
VERSION     XM_070219172.1
DBLINK      BioProject: PRJNA1194641
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16929
                     /organism="Drosophila takahashii"
                     /mol_type="mRNA"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     gene            1..16929
                     /gene="hiw"
                     /note="MYC binding protein highwire; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 2
                     Proteins"
                     /db_xref="GeneID:108069519"
     CDS             342..16178
                     /gene="hiw"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase highwire"
                     /protein_id="XP_070075273.1"
                     /db_xref="GeneID:108069519"
                     /translation="MVGLLNPLKYGDHFYELYTNSTRRKMQHDRKVLTKRKSRKDKSA
                     AAMAAAAAAAVLEGNAGAGGLVNPLDPPLVKEQLMILPSFPVAHIELDPNASKFAVFS
                     AIRSTVLEAETRYSLFQEGGGAAGGAAGGSASGSSVKKWSNSPNPSCCMMCAHSCMVS
                     NILDCPCHAHLGMHGAAGPLGNPVHGAPVGVIVEGRAQAAVPVVVGGGGGGGPGLPAE
                     KRPRRDSANSDADSDTEEPAEREPVYATVPLIVGAGLRSLFELIADARHVHPLLCTKA
                     LKALLDVIQGQQPESFKLEPEELINPLYDLLLDLATMPAALNSATGAEANWSAMACAA
                     LLGLCIARGDTGKMLKAIAAMLMTPRQLSAQIVQLPVVLATLQHTVVSAALNKPTRPD
                     FHSHGVPHNSLIDEFPLKLPPLSTGAPITSPAMACDGVFVYLLYGGTLLKIGTGFGGS
                     YKGHVYAQNEDFSHERSAWLGYSGGQLYFRRTCRRSAGDQLQMVGLDTLAIKAMSPLS
                     MLHMREGLNYVLFTDDDSLHAICSNRDDTLVVKKLNLYHNSYNIDPPPFELPLQLARK
                     KFRTLGYAAFEDELLNQYQIQRIQSAHNSFEPKLPAPCRDADVDVMGMACGKEFGLVR
                     ASNGRVYYYGKSAALGLKCVGRTPTLKLTELVISKAANIVHVAVGHDGIHALLVNDDG
                     TVFFAGTARRGEDGDSSKNRRQPKAVKPKKMTKIDGHVVVHAACNNGTSAFVTKTGKL
                     IMYGKDTAHCDAMGFVSELLDQHVTKVALGKAHCVALNAKGQLFSFGLNNKGQCGRIF
                     NKLQPVKDVPPFASSSTAAACFASLLPLDKRLKLDFSTLCDYDDHNLVQGQCRVCVIC
                     RECTGYNVSCVSALNVPLDQRLAGSICPCGHGDAGCAKCGLCAACIALQDSDEAKTEL
                     KPPPSDVQQRQQRSKTLIMRRKERKGELETGAAGGGAATPTDLDKDPPRVAPLAPQLL
                     QLTSSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQVAGAI
                     SQVAAGSNHTVLLTSKGMVYTFGNYQKGQLGRLPSDYGIKPPPQEDDSPVGAGSDGAA
                     GGGGGGGSPTVAPVGMPGPERPQSPMAAVQPSGSKEIPPPLMPVLTQRQKFLWNCSPG
                     AVFGLGPCYGKKVTWIGANGDQTFIKIDESLITAQMLPKMHVVANKKTILLIPSIPLS
                     FHTLSINRRDGSCTAHYRGQTNFVKLMQAQPEQLQPEINSNLDVAVTPVADSPAHASS
                     SSSSLLTALTGTATAGVPINEQMSRSMHEARNQIFEEQPTAAPPEVGSSAAAAAGGGG
                     GAGVGGSGGAAPGTPGSGSAVAGGSVPRARRSGGKQGASSPEAIPSPPQLAFTMDPTY
                     NVLWVFDGAARKLRCHNVVASDINESDANSATYRSLLSPELSLPDRVDSRVARSQASL
                     NLLACLDILTSAQDNIPGCFEQPLLKQTQQTAETQAGEFQVVSRFDNFGGGWGYSGHS
                     VEAIRFSADTDIVICGFGMFGGRGEYSCKLKLFDLGGDGGGYEKEGILISETKEVPYE
                     CGARSKHHILLPKPVSAVAGRWYLVWARIAGPSSDCGSCGQASVTTEDQVVFSFKSSK
                     KANNGTDVNSGQIPAILYRLVTQDCKQTPTQMDADPVQRISRAFANSVSRECFESLVV
                     LLSWSWDCFKLQLREERDRSRPLQLQQSLQYLGYVIKSCLRLLRKYTNEIYPQRSSSS
                     SSGGSSNAAHGSGLGTSAKMIQSKANKDKNAPRVVGNGAVMAKYFGDPSPSVAPAMIS
                     SGGSGGAPSTSASAAVAAGSSGTPVTRKTNMENIQLAECIGNVRALLIGIFCDDIFKD
                     IATDEGYELSLEILDECHLSFVACFDAFYPTSSLKWNCLCDLLAQMDRGALHSRLLSA
                     ILAGLCSPSVKLRATFSLLSAAGNERQSIISPSDNSGLPMLSSTDAHPYPVLVEQMIY
                     RTQQEKSDFLSNSWTFKDVLVRLLDIIASPIRSRIEAIYSRSLGSCLAAAKESVNQGL
                     IDNCCHLLARVLAEIVYQTAMGEYDKLFMPPRTLHSTGARFARCDVSRTWNTGNFGPD
                     AIAFAVDRPGVAIAGAMVYSGSGSYDYQLELLYDNTADLQPQHKWETLESVSGSYDQE
                     AVHNDLAEIKFDHPVHIKENARYALRLCSQGARTCSGDAGMPAVRGPCGAQFHFYACD
                     LSFNGTTPARGQLPCILYYSTPAKQDGKGVEGLPGMEERMMLLGPHEVSTRDTALQIA
                     ADITKKCTELLILARNAMAASCSPSDNSSNHTQTIDSEHNITPIEEHMDINWANNSRT
                     AAQLPPSATVDPQLSTARDLGKRIESFSKGLMETLKFDKRSTNPFEMEIEIGATEVEE
                     SADLRNGQSQSQSQSQSQSQSVPINGNERTSTDFEIAEQPAQLTMPLQVHSDSEEAPL
                     EAAAGGGGASGAGEVPLGSQVAGVQLLEVFNLAASNMFHTLLPLVYAHIANLACSDPK
                     SSVQILGLIKEILPHIAALNQLHVSKDQRQPEQPASSSGSTSSSSSTTSNHYCLVESE
                     HPYRSASISSYRVEFPPCVQWLTIEFDPQCGTAQLEDYLLLSIPMRPASQAPPVPHVD
                     DYLEQADNNVAGARRTEGLASSGAAPISHQRSASVQLTMASCCRSPGGGNAPGSAAAP
                     SATPLRSQDPNDREWIVVKKFNTASTWLHNVLILPGNCVEFSLETASLYAQDPHNNRY
                     GFKCLVVGYDNPTSINASNSCLIRLEQELAYLGGMCSANLMKKELNLPDDKVVEDMSG
                     IEETINAHHTLLSKGFALSEPQLTVHQALESYLPIGSQSNERQFLKDFISGAPGSSGA
                     RLAAWLQPESRLDPNKCELNTITEPLRYGWPSQVTVTIRDQYGDAVLVPELKVEIKAI
                     PTGSGPNAAGGGGTAGGGTGVTGPNLWMRRASGDTWGWGGMAPPPRLNYEPTSKEKMV
                     FKAITFMKPFTNYSFEELRYASPVQTRITELLNAKDMEDGTFSVQWTPSSVGAYCLAV
                     TIDGIPLEEVYRVDVKEGILPPPTQRSSAQRRPQAPSKLRRFQARHSSGLRIRSHPTL
                     QSEQVGVVRVGGVISFIDEIENDDGVWLRLSTESIRQHCTMGWYPTEAWCLQFNQHLA
                     RMLLQPVADKELNPNSNTNPRRKAAEEAEEEEEEEEEEGQPPVSPSASGEASPEPDRD
                     PSPVLSPAKSKPPRFLAGHQSTNPFHYPAKHHVDLAEREKEKQEEEERERVEAEEEPE
                     QEALPAVELLPAHIGSAIAGVVGGGAIKLQALQKWFKGDGAVEAGQPLTPSHSPPLAG
                     VSVRELVRAMGGQDTSIPPRGNGNRSQQADSQEPEFSLASMRRPNYSASQTAALLSTP
                     KHTPKRSAIAPTSSSETGGLEDELSLLQITTTTTTQGEQQSELQLATTSSASAKRMGP
                     IKRAMPPSFAESIRAVFAALLWHEGVVHDAMACASFLKFHPGLPKEGATVVTRRGDSG
                     DSRVQLSREQKAQQRHSVEVANAGNYLNIRPSTLETLTKSGNCSLHNRSKYRKNLLAG
                     GVTNPGEDPAQKLQALPEMVSVLPPALRCLVYLWEQICSGCVQIVQSNALEQRETRLL
                     SPGSRDLNGDAEAEGKDGGGGKGADQGSGGEKELGRKCKRKKKDDGSWCEICELFLPM
                     PVTYHMRIAHPGCGKSAKGKGYNSVGIFCEGWAGNCGEGGKGASSWFLMCDPCRDRYL
                     ASCRSANNINSAARQLESSAAEGNELNLFGVKSTTLIANAEVYTTMRENATFLLELCS
                     SSSSASGAVASLAASSSNAKRSPQQMAVVAMPVVIEHQLGNSDLKPSTSRCSRMARLS
                     GSKFCPGVGATGAFRKSFVGGPPTAPENVWLAPESFACLECLGTAGHEDLPYEMFGLG
                     PNSNDNGYDRPLSEISFESCEQNNYELIPGSLAPGSTAPGSVSKFHRSYSMGQGWASL
                     AQHPQPQPQLHLQQQQQPYHHPHHPQSQHHQQQPLHLHLQQHQQPTTAAEGQPKVVYR
                     RRNNSTSEGDGSLLICYPSEHLRRLVPHKLLASVCVMQAAGEAKDHSTGTLGLDQSAG
                     QNGGGNLLLSRPAMAFITQKHQLDRLRAAMRRSLRIAACRIYALQALNWLLRSVTQGV
                     CLHDLMWWFVSSLTASGGGGHSAEGRGEDAAEPALEHPVAYTQISGRFAHLITQSLHV
                     LLQSVADLTLHLPLGSPLQRVAIQCFGIRFRQADHQFLHSSHVFGNISKILSKSDEQN
                     DAMAVSMILKPDCDAEQNQVHPVATGSGSGGAGARLLCYTDLAGMFEVTVSSRPAMAE
                     SLTDNSTETFWESDEEDRNKCKIIELSLTKLNYACRYLLVHIDNSRDIQNKVLNVVFY
                     AGQSLGDTNVIKSADVDPKACSWISAKICDDSCTHFRLELHGPENTLRVRQIKLLGLP
                     TGGGGGGSMGLEEPAEHKHQPHLRLSHASRIQQQICEAETLRVFRLITGQVFGKLISN
                     VGSDLVPPDSAGIGPPSSGAASTSLLADSLDLREHMVGILFSRSKLSHLQKQVIVHIV
                     HAIRKEAQRAKEDWELANLAHALKQPPQLQAASASAALPASSESSPERSRAPDTYCFE
                     MLSMVLALSGSVVGRSYLSQQHGLLRDLLGLLHTGSDRVQRQVTALLRRILPEISPES
                     FAELLGVQRLPPADYSIAHQSASDFDMSRLGLLDIFLAVIAKSLQLQVKVKTTAAAAG
                     GATGSGGAGGSGAAALKPGQQEKTPAFVRLCSSLDLSVQQLRSRPPTGEPAGADPFQF
                     EALPPRKESKRNLNQRWFLNGVISTKQAESIIGLIRDLASGKLSEKWSQITKAAIAES
                     VLNLTRLEEIYRSPEHCTKTSTLWLALASLCVLERDHVEKLSSGQWSKLCDTRPLCSN
                     HDDGETAAIIQCETCGSLCGDCDRFLHLNRKTRSHKRTVCKEEEEAIRVELHESCGRT
                     KLFWLLALADSKTLKAMVEFRDGSHTIISGPQEAVGRCRFCGLTGNSGLLEIGNVCAD
                     AQCQEYAANSCLKTKPCGHACGGVTGERKCLPCLQHVCHARENELAEELRDPKLTQDA
                     DDMCMICFVEAVSCAPSIHLECGHVFHYHCCKAVLEKRWSGPRITFGFSLCPICKADI
                     QHPLLADILEPINGLKQDVKRKALMRIKYEGVVKDTDSKDVNMTQLAMDRYAYYVCFK
                     CQKAYYGGEARCDAEIGEKFDPEELVCGGCSDVARAQMCPKHGTDFLEYKCRYCCSVA
                     VFFCFGTTHFCDTCHDDFQRLTNIPKVKLPQCPAGPKAKQLLGDECPLHVMHPPTGEE
                     FALGCGVCRNAQTF"
     misc_feature    2184..3527
                     /gene="hiw"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; Region:
                     ATS1; COG5184"
                     /db_xref="CDD:444065"
     misc_feature    4776..5228
                     /gene="hiw"
                     /note="PHR domain; Region: PHR; pfam08005"
                     /db_xref="CDD:462339"
     misc_feature    6507..6968
                     /gene="hiw"
                     /note="PHR domain; Region: PHR; pfam08005"
                     /db_xref="CDD:462339"
     misc_feature    14901..15047
                     /gene="hiw"
                     /note="B-box-type 2 zinc finger found in Myc-binding
                     protein 2 (MYCBP2) and similar proteins; Region:
                     Bbox2_MYCBP2; cd19799"
                     /db_xref="CDD:380857"
     misc_feature    15438..15602
                     /gene="hiw"
                     /note="RING finger, H2 subclass, found in the PHR
                     (Pam/Highwire/RPM-1) protein family; Region: RING-H2_PHR;
                     cd16463"
                     /db_xref="CDD:438126"
ORIGIN      
        1 cagttctctc gttcccattg taccgttgcg ttgtcgttcg gtgtgtgttt ttttttgcgt
       61 gaaagtgaca aaagcaaatg acaaatggca aaaacaaagc gcactaaaaa cgccagacga
      121 tgctcgtcga aatagttaat tcctagttgt tagttcatat ttcgtttaat aaccgctgtg
      181 caatataaat cattagccaa aaaggagaga gaacgaagaa gagagagaga gagagagcaa
      241 tacgttgtaa cggtagacgg taacggtaac ggtagcggag cactagaaat atatagaaaa
      301 tatcgattgg agccctggat ctaacggcaa atcgggccaa aatggtgggc ctgctcaatc
      361 cgctcaagta cggcgaccac ttctacgagc tgtacacgaa cagcacgcgc agaaaaatgc
      421 agcacgatcg caaggtgtta acgaagcgca aaagtcggaa ggacaaatcg gcggcggcga
      481 tggccgcggc agcagcggcg gcggttctgg aggggaatgc gggcgccggc ggcctggtga
      541 atcccctgga tccgcccctg gtcaaggagc agctgatgat cctgccctcg tttccggtgg
      601 cgcacatcga gctcgatccg aatgcctcca agtttgcggt cttctcggcg attcgctcca
      661 cggtgctgga ggcggagacc cggtactcgc tgttccagga gggcggcgga gcggcaggag
      721 gagctgccgg cggatcggcc tccggatctt cggtgaagaa gtggagcaac agcccaaatc
      781 catcctgctg catgatgtgc gcccacagct gcatggttag caacatactg gactgcccct
      841 gccacgccca tttggggatg cacggggcag ctggaccgct gggaaatccc gttcatggtg
      901 cgcccgtcgg cgtgattgtc gagggacgag ctcaggcagc ggtgcccgtg gtggtgggcg
      961 gcggcggcgg cggaggacct gggctgccgg cggagaagcg accacgacgg gatagcgcca
     1021 atagcgatgc cgattcggat acggaggagc ccgccgaacg ggagcccgtc tatgccaccg
     1081 tgcccctgat tgtgggcgcc ggactgcgca gcctgttcga gctgatcgcc gatgcccggc
     1141 acgtccatcc gctgctgtgc accaaggcac tgaaggccct gctggacgtc atccaaggtc
     1201 agcagccgga gagcttcaag ctggagcccg aggagctgat caatccactg tacgatctcc
     1261 tactggatct ggccaccatg ccggcggccc tcaattcggc caccggtgcg gaggccaact
     1321 ggtcggccat ggcctgcgcc gccctcctgg gactctgcat cgcccgcggc gacaccggca
     1381 agatgctcaa ggccatcgcc gccatgctga tgacgccgcg ccagctctcc gcccagattg
     1441 tccagctgcc ggtcgtcctg gccacgctcc agcacacggt ggtcagtgcc gccctgaaca
     1501 aacccaccag gccggacttc cacagccacg gggtgccgca caattcactg atcgatgagt
     1561 tccccctgaa gctgcccccc ctgagcacgg gtgcgcccat cacctcgccg gcgatggcct
     1621 gcgatggagt gtttgtgtac ctgctctacg gtggaaccct gctgaagatc ggcaccggat
     1681 tcgggggctc ctacaaggga catgtctatg cccagaacga ggacttcagc cacgagcgga
     1741 gcgcctggct gggctacagt ggcgggcagc tctacttccg gcgcacctgt cgccgcagcg
     1801 ccggcgacca gctgcaaatg gtgggcctgg acacgctggc catcaaggcg atgagcccgc
     1861 tgagcatgct gcacatgcgc gaaggactca actacgtgct ctttaccgat gacgactcac
     1921 tgcacgccat ctgcagcaac cgcgatgaca cgctggtggt gaagaaactg aatctgtacc
     1981 acaatagcta caacattgac ccgccgccct tcgagctgcc gctgcagttg gcccgcaaga
     2041 agttccgcac gctgggctac gcggccttcg aggacgagct gctcaaccag taccagatcc
     2101 agcgcatcca gtcggcccac aacagcttcg agccgaagct gccggctccc tgccgcgatg
     2161 cggacgtgga tgtgatgggc atggcctgcg gcaaggagtt cggcctggtg agggccagca
     2221 atggaagggt ctattactac ggcaagtcgg cggcactggg actcaagtgc gtgggtcgca
     2281 cgcccacgct gaagctcacc gagctggtca tctccaaggc ggccaatata gtccatgtgg
     2341 ccgtgggaca cgacggcatc catgccctct tggtcaacga cgacggcacc gttttctttg
     2401 cgggcacagc ccgtcggggc gaggatggcg atagcagcaa gaaccggcga caaccgaagg
     2461 ctgtgaagcc caagaaaatg accaagatcg atggccatgt ggtggtgcat gccgcctgca
     2521 acaatggaac ctccgccttt gtcaccaaaa ccgggaagct gatcatgtac ggcaaggata
     2581 cggcgcactg cgatgccatg ggcttcgtca gcgagctgct ggaccagcat gtgaccaagg
     2641 tggccctggg caaggcccat tgcgtggccc tcaatgcgaa ggggcagctc ttctcgttcg
     2701 ggctgaacaa caagggccag tgcggcagga tattcaacaa gctgcagccg gtgaaggatg
     2761 tgcccccatt tgcctcatcc tcgacggccg ccgcctgttt tgcatccctg ctgccgctgg
     2821 acaagcgcct caagctggac ttctcgacgc tctgcgacta cgacgaccac aatctggtgc
     2881 agggccagtg ccgggtgtgc gtcatctgtc gcgagtgcac cggctacaac gtgagctgcg
     2941 tctcggccct gaatgtcccg ctggaccagc gactggcggg cagcatctgt ccctgcggcc
     3001 acggcgatgc gggctgcgcc aagtgcggcc tgtgcgccgc ctgcattgcc ctccaggata
     3061 gcgatgaagc caagacggaa ctgaagccgc ctcccagtga cgtccagcag cgccagcagc
     3121 gctccaagac gctgatcatg cggcgcaagg agcgcaaggg tgaactggag acaggagccg
     3181 ccggcggagg agctgccacg cccacggacc tggacaagga tccgccgcgg gtggctccac
     3241 tggcgccgca gctgctgcag ctcacgagct cctcgccggt ggtccaggtg gcctgtggcc
     3301 tgcaccacac ggtggtgctc accctggccg gcgaggtcta cacctttggg agcaaccagt
     3361 acggccagct gggcagcgga gatctgcagc cggtgagcgg accggtgcgc gtccaggtgg
     3421 ccggcgccat cagccaagtg gccgccggga gcaatcacac cgtgctgctg acttctaagg
     3481 gaatggtgta cactttcggc aactaccaga agggacaact gggacgactg cccagtgatt
     3541 atggcataaa gccaccgcct caggaggacg actcgccggt gggagcagga tcggatgggg
     3601 cagcaggagg aggaggaggc ggcggatcgc caactgttgc gcccgtggga atgcccggac
     3661 cggagcgacc ccaatccccg atggccgccg ttcagccaag cggctccaag gagatcccac
     3721 cgccgctgat gccggtgctc acccagcgcc agaagttcct gtggaactgc tcgcccggag
     3781 ccgtctttgg cctgggtccc tgctatggca aaaaggtgac ctggatagga gccaatggcg
     3841 atcagacctt tatcaagatt gacgaatccc tgattacggc acaaatgctg cccaagatgc
     3901 atgtggtggc caacaagaag acgatattgc tcattcccag cattccgctg tccttccaca
     3961 cgctctccat aaatcgacgg gatggcagtt gcactgccca ctatcgcgga caaacgaact
     4021 tcgtgaagct gatgcaggcc cagccggagc aactgcagcc ggagattaac tccaatctgg
     4081 atgtggctgt cactccggtg gcggattcac ccgcacatgc ctcctcgtcc tcgtcctcgc
     4141 tgctgaccgc cttgacgggc acagccaccg cgggagttcc aatcaacgag cagatgtcga
     4201 ggagcatgca cgaagctcgc aatcagatct tcgaggagca gccgactgcg gcgccgccgg
     4261 aggtgggatc atccgctgca gcggcagcag gtggaggagg aggagctgga gtgggaggat
     4321 caggaggagc agctcctgga actccgggct ccggatcagc ggtggctggg ggctctgtgc
     4381 cacgagcacg acgcagtggt gggaagcagg gagccagctc cccggaagcc attccatcgc
     4441 caccccaact ggccttcacc atggacccca cctacaatgt cctgtgggtc ttcgatggag
     4501 ctgcccggaa gctgcggtgc cacaatgtcg tggccagtga catcaacgaa agcgatgcga
     4561 actcggccac ctaccgatcg ctgctctcgc cggaactctc gctgccggat cgcgtggact
     4621 cgcgggtggc gcggtcgcag gcctccctca atctgctcgc ctgcctggac atcctgacct
     4681 ccgcccagga caacataccc ggctgcttcg agcagccgct gctcaagcag acgcagcaga
     4741 cggcggagac gcaggcgggc gagttccagg tggtcagccg gttcgacaac ttcggcggcg
     4801 gctggggcta ctccggccac agtgtggagg ccatacgctt ctccgccgac acggacatcg
     4861 tgatctgtgg cttcgggatg ttcggcggac gtggcgagta cagctgcaag ctgaagctct
     4921 tcgacctggg cggcgatggc ggtggctacg agaaggaggg catcctgatc agcgaaacca
     4981 aggaggtgcc gtacgagtgt ggcgcccgga gcaagcacca catcctcctg cccaagccgg
     5041 tgagtgcggt ggccgggcga tggtatctgg tgtgggcccg catcgccgga ccctcctccg
     5101 actgcggctc ctgcggccag gcctccgtga ccaccgagga ccaggtggtc ttctccttca
     5161 agtccagcaa gaaggccaac aacggcaccg acgtcaactc cggccagata cccgccatcc
     5221 tgtaccgcct ggtcacccag gactgcaaac agacgcccac ccagatggac gccgatcccg
     5281 tccagcggat ctcgcgggcc ttcgccaaca gcgtgagccg cgagtgcttc gagagcctgg
     5341 tggtgctgct cagctggtcc tgggactgct tcaagctgca gctgcgcgag gagcgggatc
     5401 gctcgcggcc tctccagctg cagcagtcgc tgcagtacct cggctatgtg atcaagtcct
     5461 gtctgcgcct gctgcgcaag tacacgaatg agatctaccc gcagaggagc tcctcctcct
     5521 cctccggcgg ctcctccaat gccgcccatg gcagtggcct tggcacctcg gccaagatga
     5581 tccagtcgaa ggcgaacaag gacaagaatg caccgcgtgt ggtgggcaat ggagccgtga
     5641 tggccaagta ctttggcgac ccctcgccgt cggtggctcc ggcgatgatc agcagcggcg
     5701 gcagcggcgg agctccgtcc acatccgcct cggctgcggt ggccgccggg agcagcggaa
     5761 ctcccgtcac ccggaagacc aacatggaga acatccagtt ggccgagtgc atcggcaatg
     5821 taagggccct gctcatcggc atcttttgtg atgacatatt caaggacatc gccacggatg
     5881 agggctacga actctctttg gagatcctgg acgagtgcca cctgagcttt gtggcctgct
     5941 tcgatgcctt ctatccgacc tcctcgctga agtggaactg cctgtgcgac ctgctggccc
     6001 agatggaccg tggtgccctc cactcgcggc tgctcagcgc cattctggcg ggcctctgtt
     6061 cgccctcggt gaagctgcgg gccaccttct cgctgctgag tgccgccggc aacgagcgcc
     6121 agtcgatcat cagtcccagc gacaattccg gcctgcccat gctctcctcc acggacgccc
     6181 atccgtatcc ggtgctggtg gagcagatga tctaccggac gcagcaggag aagagcgact
     6241 ttctgagcaa ctcgtggacc ttcaaggatg tgctcgtgcg tctcctagac atcatcgcca
     6301 gtccaataag atctcgcatc gaggcgatct acagccggag tctgggcagc tgcctggctg
     6361 ctgccaagga aagcgtcaat cagggcctca tcgacaactg ctgccacctg ctggcccgag
     6421 ttctggccga gatcgtttac cagacggcga tgggcgagta cgacaagctg tttatgccac
     6481 cgaggacgct ccactcgacg ggcgcccgct tcgcccgctg cgatgtgagc aggacctgga
     6541 atacgggtaa ctttggaccc gatgccattg cctttgccgt cgatcgaccc ggagtggcca
     6601 tagccggtgc gatggtctac tcgggatcgg gtagctatga ctatcagctg gagttgctgt
     6661 acgataatac ggcggatctg cagccgcagc acaagtggga gactctggag tcggtgtcgg
     6721 gtagctacga ccaggaggcg gtgcacaacg atctggcgga gatcaagttc gatcatccgg
     6781 tgcatatcaa ggagaatgct cgctatgcct tgaggctctg ctcccaggga gctcgcacct
     6841 gttccggtga tgcaggaatg ccggcggttc gaggaccctg tggcgcccag tttcacttct
     6901 atgcctgcga tctgagcttc aatggaacta ccccagcaag gggtcaattg ccctgcatcc
     6961 tgtactacag cacgccggcg aagcaggatg gcaagggggt ggagggtctg ccgggcatgg
     7021 aggagcgcat gatgctcctg ggaccacatg aggtgtccac cagagacact gccctccaga
     7081 tagccgctga tatcaccaag aaatgcactg agctgctgat cctggccaga aatgccatgg
     7141 ctgcctcgtg ttcgccatcg gacaacagct cgaatcacac acagaccatc gattcggagc
     7201 acaacatcac gcccatcgag gagcacatgg acatcaactg ggcgaacaac tcgcggacag
     7261 ccgcccagct gccaccgagt gccaccgtcg atccgcagct gtcgacggcc agggatctgg
     7321 gcaagcgcat cgagtccttc tccaagggcc tcatggagac gctcaagttc gacaagcgat
     7381 ccactaatcc cttcgaaatg gagatcgaga tcggggccac cgaagtggag gagtcggcgg
     7441 atctcaggaa tggccaaagt caaagccaga gtcaaagtca aagtcagagt cagagtgttc
     7501 ccatcaatgg caacgagcga acctccacgg actttgagat cgccgagcaa ccggcccaac
     7561 tgacgatgcc cctgcaggtg cactccgatt cggaggaggc tccgctggag gcggcggctg
     7621 gaggaggagg agcatccgga gcaggagaag taccccttgg cagccaggtg gcgggagtgc
     7681 agctgctgga ggtcttcaat ctggccgcct cgaacatgtt ccacaccctc ctgccgctgg
     7741 tctatgccca catcgccaat ctggcctgca gcgatcccaa gagctccgtt cagattctcg
     7801 gtctgatcaa ggagattctg ccccacatcg ctgctttaaa tcaactgcac gtttctaagg
     7861 atcagcggca accggagcag ccggcctcca gttcgggctc cacttcctcc agcagcagca
     7921 ccaccagcaa tcattattgt ctggtggaga gcgagcatcc ctatcgcagc gccagcatca
     7981 gtagctaccg cgtcgagttc ccgccctgcg tccagtggct gaccattgag ttcgatccgc
     8041 agtgcggcac cgcccagctg gaggattacc tgctgctctc gatacccatg cgtccagctt
     8101 cgcaggcgcc tccagtgccc catgtggatg actacctgga gcaggcggac aacaatgtgg
     8161 cgggtgcgcg acgcaccgag ggattggcca gcagcggagc agctcccatt tcgcaccagc
     8221 gctccgccag cgtccaactg accatggcca gttgctgccg cagtccgggc ggcggaaatg
     8281 cccccggatc cgctgcggcg cccagtgcca cgcccctgcg cagccaggat cccaacgaca
     8341 gggagtggat tgtggtcaag aagtttaaca ccgcctccac ctggctgcac aacgtcctca
     8401 tcctgcccgg caactgtgtg gagttctcgc tggaaacggc ctcactttat gcccaggatc
     8461 cgcacaacaa tcgctatggc ttcaagtgcc tggtggtggg ctatgacaat cccacttcga
     8521 tcaatgccag caactcgtgt ctgatacgct tggaacagga gttggcctac ctgggcggca
     8581 tgtgcagtgc caatctgatg aagaaggagc tcaatctgcc agatgacaag gtcgtggagg
     8641 acatgagcgg cattgaggag accatcaacg cccaccacac cctgctctcc aagggattcg
     8701 ccctatccga accccagttg accgtgcatc aggccctgga atcgtatcta cccattggat
     8761 cccagtcgaa tgagcggcag ttcctcaagg actttatcag cggggcgcca ggatcgtcgg
     8821 gcgcccgttt ggctgcctgg ttgcagccag agtcgcgact cgatcccaat aaatgtgagc
     8881 tgaacacgat cacggagccg ctgcgctacg gctggccctc ccaggtgacg gtcaccattc
     8941 gggatcagta cggcgatgcg gttttggtgc cggagctcaa ggtggagatc aaggcgatac
     9001 ccacgggctc gggtccgaat gcagccggcg gaggcggaac agccggaggc ggaaccggcg
     9061 tgaccggtcc gaatctgtgg atgcgacggg cctccggcga cacgtggggt tggggcggaa
     9121 tggcgccacc gccgcgcctc aactacgagc ccacctccaa ggagaagatg gtcttcaagg
     9181 ccatcacgtt catgaagccc ttcaccaact actcgttcga ggagctgcgc tacgcgagtc
     9241 cggtgcaaac gagaattacc gagctgctga acgccaagga catggaggac ggcaccttca
     9301 gtgtccagtg gacgcccagc tcggtgggtg cctactgcct ggccgtgacc atcgatggga
     9361 ttccgctgga ggaggtctac cgcgtggacg tcaaggaggg catcctgccg ccgcccactc
     9421 agcggagcag cgcccagcga aggccgcagg cgcccagcaa gctgcgtcga tttcaggctc
     9481 gccacagttc gggactgcgg atccgttccc atcccacgct gcagtcggag caggtgggcg
     9541 tggtgcgcgt gggcggcgtg atctcgttca tcgacgagat cgagaacgac gacggcgtct
     9601 ggctgcgcct gtccacggag tccatccggc agcactgcac catgggctgg tatccgacgg
     9661 aggcgtggtg cctgcagttc aaccagcacc tggcccgcat gctcctccag ccggtggccg
     9721 acaaggagct caatccgaat tcgaatacga atccgcggcg caaggcggcg gaggaagcgg
     9781 aggaagagga ggaggaggag gaggaggagg ggcagccgcc agtcagtccg tctgccagcg
     9841 gagaggccag tccggaaccc gatcgggatc ccagtccggt gctcagtccg gccaagtcga
     9901 agccaccgcg cttcctggcc ggccatcagt ccacgaatcc cttccactat cccgccaagc
     9961 accatgtgga tctcgcggag agggagaagg agaagcagga ggaggaggag cgggagcgag
    10021 tggaagcgga ggaggagccg gaacaggagg ctctgcctgc ggtggagctg ctccccgccc
    10081 acataggatc cgccatagcg ggcgtggtgg gcggcggggc catcaagctg caggcgctgc
    10141 aaaaatggtt caagggggat ggcgccgtgg aggcgggaca gcccctgacc ccctcccact
    10201 cacctcccct ggccggagtt tcggtgaggg aactggtgag ggccatgggc ggtcaggaca
    10261 cctcgattcc gccacgcggc aatggcaatc gcagtcagca agcggattcc caggaacccg
    10321 aattcagttt ggccagcatg aggagaccca actactcggc cagtcagacg gcagcgctgc
    10381 tctccacgcc gaagcacacg cccaagcgga gtgccattgc tccgaccagc agcagtgaaa
    10441 ctggtggcct ggaggatgag ctcagtctgc tgcagatcac caccaccacc acgacgcagg
    10501 gggagcagca gagcgaactc cagctggcca ccacatcatc ggcgtcggcc aagagaatgg
    10561 gtcccatcaa gcgggcaatg ccgccatcct tcgccgagag cattcgggcg gtctttgcag
    10621 cgctcctctg gcacgagggc gtcgttcacg atgccatggc ctgcgccagc ttcctcaagt
    10681 tccatcccgg gctgcccaag gagggggcca ccgtggtgac gcgacgcggc gattccggcg
    10741 attcgagggt tcagctctcg cgggagcaga aggcccagca gcggcactcg gtggaggtgg
    10801 ccaatgcggg caactacctg aacatccggc cgagcactct ggagacgctg accaagagcg
    10861 gcaactgttc gctgcacaat cgcagcaagt accgcaagaa tctgctcgcc ggcggagtaa
    10921 ccaatcccgg cgaggatccc gcccagaagc tgcaggccct gcccgagatg gtcagcgttc
    10981 tgccgcccgc cctgcgatgc ctcgtctatc tgtgggagca gatctgctcc ggctgcgtcc
    11041 aaattgtcca gtcgaatgct ttggagcagc gggagacgcg cctgctgtcg ccgggaagca
    11101 gggatttgaa tggagatgcg gaggcggagg gcaaggatgg cggcggcggg aagggagcgg
    11161 accagggatc cggcggcgag aaggagctgg gcaggaagtg caagcgcaag aagaaggacg
    11221 acggcagctg gtgcgaaatc tgcgagctct tcctccccat gccggtcacc taccacatga
    11281 ggatcgccca tccgggctgc gggaagtcgg ccaagggcaa gggctacaac tcggtgggca
    11341 tcttctgcga gggatgggcg ggcaactgcg gcgagggagg aaagggagcc tcgtcctggt
    11401 tcttgatgtg cgatccctgc cgcgatcggt acctcgcctc ctgtcgcagc gccaacaaca
    11461 tcaacagcgc cgcccgacaa ctggagtcca gtgccgccga aggcaacgaa ctgaatctgt
    11521 tcggcgtcaa gtccaccaca ctgatagcca atgccgaggt ctacaccaca atgcgtgaga
    11581 atgccacctt cctgctggag ctctgctcga gttccagttc cgcctctgga gcagtcgcca
    11641 gtttggcggc cagcagctcc aatgcgaagc gatcgccgca gcagatggcc gtggtggcca
    11701 tgccggtggt gatcgagcac cagctgggca actcggacct caagccgagc accagtcgct
    11761 gcagccggat ggcccgactg agtggctcca agttctgtcc gggtgtcgga gcaacgggag
    11821 cgttccgcaa gagcttcgtg ggcggaccgc cgacggcgcc ggagaacgtc tggctggcgc
    11881 cggagagctt tgcgtgcctc gagtgcctgg gcaccgccgg ccacgaggat ctgccctacg
    11941 aaatgttcgg actgggaccc aattcgaatg acaatggcta cgataggccc ctttcggaga
    12001 tctccttcga gtcctgcgag cagaacaact acgagctgat ccccggatcc ctggcgccgg
    12061 gctccacggc tcctggttcg gtgtccaagt tccatcgcag ctactcgatg ggtcagggct
    12121 gggcgtcgct ggcccagcat ccgcagccgc agccgcagct ccacctgcag cagcagcagc
    12181 agccgtacca ccatccgcac cacccgcagt cgcagcacca ccagcagcag ccgttgcacc
    12241 tgcatctcca gcagcaccag cagccgacga cggcggcgga gggccagccg aaggtggtct
    12301 accggcggcg gaacaactcg accagcgagg gcgacggctc cctgctcatc tgctatccct
    12361 cggagcacct gcgtcgcctg gtgccgcaca agctgctggc cagtgtgtgc gtcatgcagg
    12421 ccgctggcga ggccaaggat cattccacgg ggacgctggg actggatcag tcggcgggcc
    12481 agaatggcgg gggcaacctg ctgctcagcc ggccggccat ggcgttcatc acgcagaagc
    12541 accagctgga caggctgagg gcggccatgc ggaggagcct gaggatcgcc gcctgccgga
    12601 tttatgccct gcaggcgctc aactggctgc tgaggagcgt cacccagggc gtgtgtctgc
    12661 acgatctgat gtggtggttc gtcagctcgc tgaccgcttc agggggtggt ggtcattcgg
    12721 cggagggccg gggtgaggat gccgcggagc cggcactcga gcacccggtg gcctacacgc
    12781 agatcagcgg aaggttcgcc catctgatca cccaatccct gcacgtgctc ctccaatcgg
    12841 tggccgatct cacgctccac ctgccgctcg gttcgccatt gcagcgggtg gccatccagt
    12901 gcttcggcat ccgcttccgc caggcggacc accagttcct ccacagttct catgtctttg
    12961 ggaacatttc gaagatactg tccaagtcgg atgagcagaa cgatgccatg gccgtgtcga
    13021 tgatcctcaa gcccgactgc gatgccgagc agaatcaggt gcatccagtg gccacgggat
    13081 cgggatcggg aggagctgga gcccggctcc tctgctacac agatctggcg gggatgttcg
    13141 aggtcaccgt gtcctcgcgt cccgccatgg cggaatcctt gacggacaac tccacggaga
    13201 ctttctggga gagcgacgag gaggatcgca acaagtgcaa gatcatcgag ttgtcgctga
    13261 ccaagctcaa ctacgcctgt cgctatcttc tcgtccacat cgacaatagt cgggacattc
    13321 agaacaaggt gcttaatgtg gtcttttatg ccggacagtc gctgggcgac acgaatgtaa
    13381 taaagtcggc ggacgtggat ccgaaggcct gttcctggat ctcggcgaag atctgcgacg
    13441 acagctgcac ccacttccgc ctggagctcc atggaccgga gaacaccctt cgcgtgcggc
    13501 agatcaagtt gctcggtctg ccgacaggag gaggaggagg aggatccatg ggcctggagg
    13561 agcccgcgga gcacaagcac cagccccacc tgcgtctcag tcatgcgtcg cgcatccagc
    13621 agcagatttg cgaggcggaa actttgaggg ttttccgcct gatcaccggt caggtgttcg
    13681 gcaagctgat cagcaatgtg ggttccgatc tggtgcctcc agattccgcg ggcattgggc
    13741 caccgagcag cggagccgcc agcacttccc tgctggccga ctccctggat ctccgcgaac
    13801 acatggtggg cattctgttc tcgcgcagca aactgtcgca tctgcagaaa caggtgattg
    13861 tgcatattgt gcatgccatc cgcaaggagg ctcagcgggc caaggaggat tgggagctgg
    13921 ccaatctggc ccatgccctg aagcagccac cccagttgca ggctgcctcc gcctctgcag
    13981 ctctgcccgc ctccagcgaa agttcgccgg agaggagtcg agccccggac acctactgct
    14041 tcgagatgct cagcatggtg ttggccctgt cgggcagcgt ggtgggtcgc tcctatcttt
    14101 cccagcagca cggactcctc cgcgatctcc tcgggctgct gcacaccggc agcgatcgag
    14161 tgcagcgcca ggtgaccgct ctgctgcgcc gcatcctgcc ggaaatatcg ccggagagct
    14221 ttgccgagct gcttggcgtg cagcgactgc cgccggcgga ctacagcatc gcccatcagt
    14281 cggccagcga ctttgatatg agtcggctgg gcctgctcga cattttcctg gccgtcatcg
    14341 ccaagtccct gcagctgcag gtcaaggtga agaccacggc tgccgctgca ggaggagcaa
    14401 ctggatcggg aggagctgga ggatctggag cagctgcttt gaagcctggt cagcaggaga
    14461 agacgcccgc ctttgtgcgg ctctgcagtt cgctggatct ctccgtgcag cagctgagat
    14521 cgcgaccgcc caccggtgag ccggctgggg ccgatccctt ccagttcgag gccctaccgc
    14581 cgcgcaagga gtcgaagcgg aatcttaacc agcggtggtt cctcaacggc gtcatctcca
    14641 ccaagcaggc ggagagcatt atcggactca tcagggattt ggccagcggc aaactcagcg
    14701 agaagtggtc gcagatcacc aaggcggcca ttgccgagtc cgtgttgaat ctcacccggc
    14761 tagaggagat ctaccgctcg ccggagcact gcaccaagac ctcgaccttg tggctggctt
    14821 tggccagtct gtgcgtcctg gagcgcgacc acgtggagaa gctatcctcg ggccagtggt
    14881 cgaagctgtg cgacacccgg ccgctgtgca gcaaccatga cgacggcgag acggcggcca
    14941 tcattcagtg cgagacctgc ggctccctct gcggcgactg cgatcggttt ctgcatctga
    15001 atcgcaagac tcgctcgcac aagcgaacgg tttgcaagga ggaggaggag gccatccgcg
    15061 tggagctgca cgagtcctgc ggccgcacca agctcttctg gctgctggcc ctggccgatt
    15121 ccaagaccct gaaggccatg gtcgagttcc gcgacggcag ccacacgatc atctcggggc
    15181 cccaggaggc ggtgggccgc tgccgcttct gcggcctcac cggcaactcg gggctgctgg
    15241 agatcgggaa cgtgtgtgcc gacgcccagt gccaggagta tgcggccaac tcgtgcctga
    15301 agaccaagcc gtgtggtcat gcctgcggcg gagtcaccgg cgaacggaag tgcctgccct
    15361 gcctgcagca cgtgtgccat gcacgggaga acgaactggc cgaggagctg agggatccga
    15421 agctcaccca ggatgcggac gacatgtgca tgatttgctt cgtggaggcc gtgtcctgtg
    15481 ctccctctat acatctggag tgcggccatg tgttccacta ccactgctgc aaggcggtgc
    15541 tggagaagcg ctggagcgga ccgcgcatca ccttcggctt ctccctgtgt cccatctgca
    15601 aggcggacat ccagcatccg ctgctggccg acatcctgga gccgatcaat ggactcaagc
    15661 aggacgtcaa gcgcaaggcg ctcatgcgca tcaagtacga gggcgtcgtc aaggacacgg
    15721 acagcaagga cgtgaatatg acccagctgg cgatggatcg gtatgcctac tacgtgtgct
    15781 tcaagtgcca aaaggcctac tacggcggcg aggcgcgctg cgatgcggaa atcggcgaga
    15841 agttcgatcc cgaggagctg gtctgcggcg gctgctcgga tgtggccagg gcgcagatgt
    15901 gccccaagca cgggaccgat ttcctggagt acaagtgccg ctactgctgc tcggtggcgg
    15961 tgttcttctg cttcgggacg acgcactttt gcgacacctg ccacgacgac ttccagcggc
    16021 tgaccaacat acccaaggtc aagctgccgc agtgcccggc gggtccgaag gccaagcagc
    16081 tgctgggcga cgagtgcccg ctgcatgtga tgcatccgcc caccggcgag gagttcgccc
    16141 tgggatgcgg cgtctgtcgc aatgcgcaaa cattttagcc agacacttgg attggacccg
    16201 atggcgagtg gagaacagcc cggcgaactc gggtcccgca tgatgatgat gatgatgatg
    16261 atgacgaaga tgatgatgat gatgatgatg atgacgatga tgatgatgat gaggagttgg
    16321 cgccggatat gtgggcgaac gtttggtccc agtcggacga ctcgcggaca tatttgtaga
    16381 gattaaaaac cccaaaatgc agacccagaa caccccatgc gaaggatcga tctttcatcc
    16441 ctctagatat taactcacac atcggattgg aaataacgaa acggatagat attttctagg
    16501 atagctgata tttgaacgat ggatattgga ttacagatta gcaaatagca aatagcatat
    16561 agcatacttt atcccaggca atattatttt gtaaaactcg aaatcgaatt gaaacggaac
    16621 gaatcgaatc tcgaatctcc cattttaaga tcaaaaactc actatttatt taatgtacaa
    16681 ttcggagttg agcgagcgag tgcgagcgaa agcgagctgg tgcggcagag agcgcgagaa
    16741 gtgtgtacat aatcctccag catcccgacc tctgacctcc atgaccttct cccgccacca
    16801 cctcaccctc ctcctcctcc gactcctttt cctcctcacc ctcatcccaa caaaggcaca
    16861 ttatgctaca tttatatata ttgcaaataa ctaaattata tatatttatt ataaatgcga
    16921 cgagcggat