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LOCUS XM_070219001 16487 bp mRNA linear INV 09-DEC-2024 containing E3 ubiquitin protein ligase 1 (HUWE1), transcript variant X3, mRNA. ACCESSION XM_070219001 VERSION XM_070219001.1 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..16487 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..16487 /gene="HUWE1" /note="HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 2 Proteins" /db_xref="GeneID:108068620" CDS 355..15723 /gene="HUWE1" /codon_start=1 /product="E3 ubiquitin-protein ligase HUWE1 isoform X1" /protein_id="XP_070075102.1" /db_xref="GeneID:108068620" /translation="MKVDTVKLKKGSSELTAECRELIDELTKRRTRAELLEFLDTIHV WIYGKCELYHWIEILDRFDKILEEASRHVNANEFVLQCDTNFQETDVTLLLHVLNFTT LLIEHSFSRHLYNSIEHLTVLLSSQNMDIVLAVLNLLYMFSKRSNFIPRLPFEKKELL IVKLFNIAERWGDPNYGLSLKDCCIGEPKLEFLYQLCIDYVDEHGHAAQLEIPDMMDL CHTASAPEVIKTIAGQISKPSEAIKMRIAHRVRLISGFNNYKLRLQFVQARLQAVSIL IYSNALQDNTDKVLYAGFGEELCELIDKEDVHLVEIRAAVLRTLTSMLHFDRNPNVPS RAGSRLMKIVHYTGAERQGGTLPLLVRDCIDNLTTHGLTERYPLILATSLFSLLYHLA SYEMGGSALVKSGMMQSLLCVISWPGVDLEHITFVTRAVRVIDLITNIDIARFHQNNG LNVFIDRLEKEIKSCCKALADIGITLKESTLRDDHKLDNSLEQVDDDVEETGENTSVA SGGGSPRRENSSDGLTGAGSSAYRAYHEHSGGGAGSGAGLLDIGGARSAGGGSSGGAS AAPIIGLINRDGSAARPPAIMYPTNSYYARPLAERKAELSSQLPSSLAPKKPSCVTQR AALLKSMLNFLKKSIQDHAHFSNMRNIMETSLTQSLRHIIANAEYYGPSLFLLATDVV TVYVFNEPSLLSSLQDLGITSVMLKALLQKDVPATREVLGSLPNVFSALCLNERGLFE FLSYDPFDKVLKVLLSPDYLVAMRRRRSSDPLGDTATNLGNAMDDLIKHHPYLRADAT EAIVRLLNELVRLGSDPSFICWRANKESSGSGSGSGSHGGGGSHHVASTPSPMAVMVA GSGGSTSVLQGAADTNDSSGDDDDDDDEMSSASQQQQQSGGATTPRTQQPGGGVATPQ AVKVVTPPEREAIPLIDYILNVMKFIEAIFSNSPNGDHCREFVLHGGLKPILQLLSLP NLPVDSPVSTTSQAVANVCKAILSQAQETKVLDVALKQLADIVAQLKPLIKHFTFPGG SVLLAELVCCQRLEDGFANAEYTPILHNMSFVHGYVVMLVHLCRNASNDMRAILLKRW GVNRETGVQLLQQLVQLYISLVWESTILLNLCSDEPTQHPDLIWDEIAAQMSAAAGTA DPLTEAELSRKLERAAEFRTKYSPEEQFRYIKSLLAASSRLGRALAELLGTLVKLSVG SPQTRQRRINDLISNINKVPTPEAREIARILSSILVNGFSHESILPKPVPKLKLTFLI CSVGFTGPMLFDDKRSAFHLMISQFCAENGLKAFFEMFYWALSLDNVSQKFDFDQWAS MEDLMQSHEDDKRDCPEGTGEFLDAWLQLLEKMVNPRAMLDSPYTMSPRLNYLPDSVP FEPVFYLIHIHQLAMQALRRIWARRPIPNYGPSMFETMILILKHLIKSHQTLLDRYHT RMKEIKFENLYIRSTDDGLNADHIKTLTDMGFMHYHVIEALRTNASLEEATDYLLNNP EASALSTTTGGSAAPPPPPPPPPSTMDIDMDLPADGGEKSSSSSANSSYDYKHLKLMP SIIFDRFCDEAISRAFEFMEAIPDTVNSAADLIAVLYRRHNHLNKQVFVTNFVRNIIQ WVDFTLQLFEPSKTAASKASRLEECLTGLTATRLFVRLKTSTRLLEENYSDLHRPLVE AITAQDAMVSLVKLLDCMSQWMLEQSVDSRATVPRWVQNLVDLIDSIDSISHILQRKA NMRAVSSEVWRWYDASTGKWNAYSEANNELIRNAYAAGERWLHINIGRQRCTVSLNCM TQVSEASGTHRPVCPALKLSEAITALNSPVSLHKVEHLLNRVVRTSPDGSGTVHSDEL ISLRQLINFSDGQQPQENPANEEGTNEDSGSPLAAMTTRSKSRQKSAAAAAAAQKKSS SHGSPPIPKRTQKIILNEEQVGLSKFDCGRIIGSIVDLLQPSHLMLNETKLSLLRLCA RLTRNYDNAQVFIRRGGVKMLLHLQQACSFMGFPTYANIILRHVLEAPPVLQEAMERV LGMRAAGIVPVGHRDLIYVLTQVSSAVSRNPQIFVAAAKEMLKGEYLLNTNSTTLADD ARVMVKSKFGQQPTAAAGGATPNSQTSTPPDEQLKDDPQVQSSVAVLKDLLHGLVQPC WHYGGTGSLDRGPGAAELLQPDQPPGTAAQGGHDEELYFRFQETPAPASSKKQSSGGG ASAGQPQTTEKFEPCCCTWHIPTSGHTHAKPTISRATLLKLLADSTRAYQSLVPRVLL SHIYTPADSPLISAPQQTFLGVLLDRFLPITQRHHVPEVSTMTRVLICSLSDCYQQPG VQVHVAEELHAAVARALAQPDSAEKHTRLQVLMSLFPNLIESPMLYDKVHMHRNNMYR VLLRQGVMTYLTKVAQYKDLSNHNTLSTLAAILRPMEILLRFSVSTTTLGSKRILFGG GGGGAGGANGAGSGNSAVGGGSGTGPGSGNTYGTIINRRLYPRLAARTAVSAAVERSN AMGGEHVLRDIIRNVLSDRRHAFEFIFNSDEMAVDSEDSAAPAVGGNGSGAGGIGAGG SGAAVIDVVEERSNGGDTSDPPGNVNSGSGTGAVQSSTSGGPVRPVLNFDQLWDDFLQ SEGLRLASRSGGGAGSGAGSTGAGSTGQQNGGNATGGSANSGSNSVSGDPRLRTNPDV DVGGGGNGGGQSSNSGVVNDNGIGGGGGSDGASTSSDTGAPGGERRDLNASLLGDVST SESDSDASTENDERNEEDEDEDDDAPDEDVDEHSETDVDEERPRQFIEVFDHIYEPES SETASNDADVDNDDDDDEDEDDVDDDDDDDEDNDDEDREEGQSVMDAELENQIDIALA LVSSNNRPRRSAAVNASGDASANRDPNPDEEVDDEDDDVDADPDGDPDVDPIGGPSAA QAEAYLYERLGSGLMPTPPVGFRVRMNSSIAQPLDIDVNGGNGGGGSGGSGAGVTGTA GGSGRGSSSGGTTASIGAIASAALRPSSGSWMAPDFNFIGVSGGGGASGSGGASGSNA NGGEVNAFLTPAMSQLERSGGASGSGQNMSNLLDEQPSVSGNGGGGGGSGGGSASGNG GVSGGGGANGGGTAGQHPNATLCANGVRRRLLYLDQQYCVCMPTHQNPTEETQMETFT QDALHWWLEEATVLDMESQTDACLYAAHFLLPHLIKELKTAHQQRKQEEAARQTATNT TTPASSASSSAGAPATSILSNTAAPTATASIASSLLANAVAAGSGGSSSSGSGLVVPP VAASATGGTRRSSIPVLIPSSFGGPGSATTGDATATTGGTTSSSSYTTTSISGSGSLE SQTTTRAPRQRGGLRQHSQLPFNIYAEIDLTNEQDSQGATSTGSAPNDGAESQAQQPQ QQQQQQNSSAPSLAQGAVLQHQRHPPVPLLPSSGRPSRPHSRLDEAELLLLQLADRQA VRSRLQVSSGHTNSSRTSGSALINARPNRDLPARLQRLVQAHGSLSSRINASAASTPA PTLVSMPTPMSSAALEQLNVTPAGPDVVGPDRNFALPPSLEVDVDVLPGILDRILPQQ QQEQQEAQQQEEEEEQLLLPPPPPPPPSETAPLLLTEEDMWQGTREEEEDSTSTVAVA GSSEAANESNQSDQTPESSESVSPNPQAPPPAAESGEGGAGGAGGAASASTQTPATAE ESAVGGTTATATTTAATVTDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEVIQEH LRMQRIRQRAQQNAIQIAHDSLVEVNPEFLAALPLNIQSEVLMQQRIEQQRQAAQTAN PEDPVDTAAFFQNLPENLRQAILTDMEESQIASLPPELAAEAQFLRRDWESRNGARMD AHPPSNALSRFQTTLQSLDEARWHSSIWYDASGNAQPQHHQHTTIVHHHAHAHHAPTM GKPLALLMMEDENILLDPDSLATLLLFLFVEDQKVNSMRLHRVIRNLCHHEPTRDWII SALISIVQKTNEDNANFGAGQAGGKPEWLKLRVDAAFGYKSNIFLINRLYEGSARSIS INPQAAQMIVRNCLDLLFVLAKHYPSSFVPFNREVKARRILSAVFGMPSPTGGASTAG AGAPARNIDDFPPPGGTLDFRSRFCRYQVANRLRGILDDHPAAAPKPQSATPLDEAPS TSKAAAAKAAATAKVSSQSSQSVPYQTNAKNFWDVVLNIDRQTQVRLANVAQFPLTSQ PAWEWQANSADFLSFSDSPFGQLLEMLPYKVICRSPHLTDMLVKLLASLSTELPKEEE QLPLSDQMPTLIPINQAAAAAADSPANPSEIGDGLAANVEQEATPASGNPASGDSNAA AKRTQLPTLSVALPVAPSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVN LTQCSQASNAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNSHHGVTASTSGAAAAG ATVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQP YFLRTLKIFMQVRDMYEAQNGLSTGGGLAGAAGDNDDDIIDIEGDGGASGGSSSDMAP GSASTISPPPPPPMETNQNINDEEEDEDGEEEEDDDDAARASPAAASAGKSSKPTLSQ ILCLDVLWHTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRAGAKKSGRGGVVG SGLRAAGGLGAAASAAQEHSPSMDDTSSANTLSSASFEDEPRMQDASTNTPLSSNSSA ATTVLSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAVLVDHTRILDF DVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFED EEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFV GRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTL GYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAF LEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRA LRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCF NQLDLPMYKSYDKLRSCLLKAIHECSEGFGFA" misc_feature 622..1332 /gene="HUWE1" /note="Domain of Unknown Function (DUF908); Region: DUF908; pfam06012" /db_xref="CDD:428721" misc_feature 2221..3285 /gene="HUWE1" /note="Domain of Unknown Function (DUF913); Region: DUF913; pfam06025" /db_xref="CDD:461803" misc_feature 4717..4836 /gene="HUWE1" /note="UBA domain-like superfamily; Region: UBA_like_SF; cl21463" /db_xref="CDD:473871" misc_feature 5557..5775 /gene="HUWE1" /note="Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; Region: WWE; smart00678" /db_xref="CDD:128922" misc_feature 11371..11463 /gene="HUWE1" /note="Ubiquitin binding region; Region: UBM; pfam14377" /db_xref="CDD:464159" misc_feature 11518..11601 /gene="HUWE1" /note="Ubiquitin binding region; Region: UBM; pfam14377" /db_xref="CDD:464159" misc_feature 14653..15714 /gene="HUWE1" /note="HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; Region: HECTc; cd00078" /db_xref="CDD:238033" misc_feature order(14665..14667,14755..14757,14788..14790,14971..14973, 15493..15495,15601..15606,15613..15627,15685..15687, 15709..15711) /gene="HUWE1" /note="catalytic cleft [active]" /db_xref="CDD:238033" misc_feature order(15055..15057,15064..15069,15073..15078,15085..15087, 15106..15108,15112..15114,15124..15129,15133..15135, 15148..15150,15163..15165,15214..15216,15226..15228) /gene="HUWE1" /note="E2 interaction site [active]" /db_xref="CDD:238033" polyA_site 16487 /gene="HUWE1" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN 1 caagaaacaa caacaacagc aacaaaagtc tgtttctgtt aatgcgcgcg cgctctgttt 61 ggctttttcc cgctgttgcc agtgggaaat tcgctgtcca attggcttgg ctctcagctg 121 acaagtgcat ttattgaaca cgctgacgta tacgtttaaa ccgcaactcg atgcccaacc 181 tataaacaat cgacgcccga cgccttttca ccacgaacca cccaatctac acaagccgcc 241 cactcgacaa acagccggag gaagaggagg aggaggagga ggaaggagga ggagcaccac 301 caccccaagt ggtggccacc tgctgctcca ttagctccac tagctccacg aacaatgaag 361 gtggacacgg tgaagctgaa gaagggctcc tcggagctca ccgccgagtg ccgcgagctc 421 atcgacgagc tcaccaagcg gcggacgcgg gccgagctgc tcgagttcct cgacaccatc 481 cacgtctgga tctacggcaa gtgcgagctc taccactgga tcgagatcct cgaccggttc 541 gacaagatcc tcgaggaggc gtcgcgccat gtcaacgcca acgagttcgt gctgcagtgc 601 gacaccaatt tccaggaaac ggatgtcaca ctgctgttgc acgttcttaa cttcaccaca 661 ctgctgatcg agcactcgtt ctcgcggcac ctctacaact ccatcgaaca cctgacggtg 721 ctgctctcct cccagaacat ggacatcgtc ctggccgtcc tcaatctgct gtacatgttc 781 tccaagcgca gcaacttcat accccgcctg ccgttcgaga agaaggaact gctgattgtc 841 aagctgttta acatagccga gcgctggggc gatcccaact acggactgtc gctcaaggac 901 tgctgcattg gcgagccgaa gctggaattc ctttaccagc tgtgcatcga ctatgtggac 961 gagcacggtc atgccgccca gctggaaatc ccggacatga tggacctctg ccacacggcg 1021 tccgcgcccg aggtgatcaa gacgattgcc ggacagatct caaagcccag cgaggcaatc 1081 aagatgcgca ttgctcatcg ggtgcgcttg atctcaggct tcaacaacta caagctgcgc 1141 ctccagttcg tccaggctcg cctgcaggcc gtctccattc tgatctactc gaatgccctg 1201 caggacaaca cggacaaggt gctgtatgcc ggcttcggcg aggagctgtg cgagctgatc 1261 gacaaggagg acgtgcatct cgtggagata cgggcggcag tgctgcgcac actcacctcg 1321 atgctgcact ttgaccgcaa tccgaatgtg cccagcaggg ccggttcgcg actgatgaag 1381 atcgttcact acacaggagc cgagcggcag ggcggcactt tgccactgct ggtgcgcgac 1441 tgcattgata atttaaccac ccatggactc accgaacgct acccgctcat cctggccacg 1501 tcactcttct cgctgctcta ccatttggcc agctacgaaa tgggcggctc tgctctggtc 1561 aaaagcggca tgatgcagtc cctcctgtgc gtcatcagct ggccgggagt cgacctcgag 1621 cacattacgt tcgtgacgcg ggcggtgcgg gtgatcgacc tgataaccaa catagatatc 1681 gcacggttcc atcagaacaa cggactcaac gtgttcattg accgtctgga gaaggagatc 1741 aagagctgct gcaaggcact ggccgacatt ggcatcacgc tgaaggagtc gacgctgcgc 1801 gatgaccaca agttggataa ctcgctggag caagtggacg atgatgtgga agagaccgga 1861 gagaacacgt ccgtggccag tggaggtgga tcgccgcgtc gcgagaactc gagtgacggg 1921 ctcaccggtg ccgggagcag cgcctacaga gcctatcacg agcacagtgg aggaggagcg 1981 ggctcaggag cgggactcct ggacattggt ggagcacgca gcgcaggagg aggatcatcg 2041 ggtggtgctt cagccgcacc gatcattgga ttaatcaacc gggacggaag tgccgctcgt 2101 ccgccggcca tcatgtaccc cacaaacagt tactacgccc gtccgctggc cgagcgcaag 2161 gcggagctct cctcgcagct gccgagcagc ctggcgccga agaagccctc ctgcgtcacc 2221 cagcgggcgg cgctgctcaa gtcgatgctg aatttcctga agaagagcat ccaggatcat 2281 gcgcacttta gcaacatgcg caacatcatg gagaccagct taacgcagtc gcttcgccac 2341 atcatagcca atgcggagta ctacgggccg tcgctcttcc tgctggccac cgatgtggtc 2401 accgtgtacg tgttcaacga gccctcgctg ctctcctcgc tgcaggatct gggcatcacg 2461 agtgtcatgc tgaaggcgct gctccagaag gatgtgccgg ccacgcggga agtgctgggc 2521 tccctgccga atgtcttttc cgccctgtgc ctgaatgagc gtggcctttt tgagttcctc 2581 tcctatgatc cttttgacaa ggtgctgaag gtgctgctct cgccggacta tctggtggcc 2641 atgcgcaggc gccgctcctc ggatccgctg ggcgatacgg ccaccaattt gggcaatgcc 2701 atggacgatc tgatcaagca tcatccgtat ttgcgagccg atgccacgga ggcgattgtg 2761 aggcttttga atgagctggt tcgccttggt tccgatccca gtttcatttg ctggcgggcc 2821 aacaaggaga gcagtggctc tggctcgggt tcaggcagcc atggcggcgg cggttcgcat 2881 cacgtggcct ccacaccctc gcccatggcc gtcatggtgg ctggctcggg aggatcgacg 2941 tcggtgctcc agggagccgc ggatacgaac gacagcagcg gcgacgatga cgacgatgat 3001 gatgaaatga gctcggcttc gcagcaacag cagcaaagtg gaggagccac cacacccagg 3061 acgcaacaac caggaggagg agtagccacc ccgcaggccg tcaaggtggt gacgcccccg 3121 gaacgagagg caatacccct aatcgactat atcttgaatg tgatgaagtt catcgaggcg 3181 attttcagca acagtccgaa tggcgatcac tgccgggagt ttgtcctcca cggcggacta 3241 aagcccattc tgcaactgct gtcgctgccc aatctgccgg tggattcacc cgtttccacc 3301 acctcacagg cggtggccaa tgtctgcaag gccatactca gccaggcgca ggaaacgaag 3361 gttctcgatg tggcgctcaa gcagctggct gatattgtgg cccagctgaa gccgctgatc 3421 aagcacttta cctttcccgg cggcagtgtc ctcctcgcag agctcgtctg ctgtcagcgg 3481 ctggaggatg gcttcgccaa tgccgaatac acaccgatac tgcacaacat gagctttgtg 3541 cacggctatg tggtgatgct ggtgcatctc tgtcgcaacg cctccaacga catgcgagcg 3601 attctgctca agcgttgggg cgtcaatcgc gagactggag tgcaattgct gcagcagctg 3661 gtccagctgt acatttcgct ggtgtgggag agcaccatac tgctgaatct ctgctcggat 3721 gagcccaccc agcatccgga tctcatttgg gacgagattg cggcccagat gtcggcggca 3781 gcgggcaccg cggatcccct gaccgaagcg gagctctcgc ggaagctgga gcgtgcggcg 3841 gaattccgga cgaagtactc gcccgaggag cagttccggt acatcaaatc cctgctggcg 3901 gcgagctctc ggctcggcag ggcgctcgcc gagctgctgg gcacgctggt gaagctatcg 3961 gtgggttcgc cgcagacgcg acagcgacgc atcaacgatc tgatcagcaa tatcaacaaa 4021 gttcctacgc ccgaggctcg cgaaatagcc cgcatcctca gctcgattct ggtgaatggc 4081 ttcagtcacg agagcattct accgaagcct gtgcccaagt tgaagctcac cttcctcatc 4141 tgctcggtgg gattcaccgg tccaatgctg ttcgacgaca agcgcagcgc ctttcacctg 4201 atgatatcgc aattctgcgc agagaatgga ttgaaagcct tctttgagat gttctactgg 4261 gcgctgtcgc tggataatgt ctcgcagaag ttcgatttcg atcagtgggc ctcgatggag 4321 gatctgatgc agtcgcacga ggacgacaag cgcgattgcc ccgagggcac gggcgagttt 4381 ctcgacgcct ggctgcagct gctcgagaag atggtgaatc cgcgtgccat gctcgattcg 4441 ccgtatacga tgagtccgcg gctgaattac ctgcccgatt cggtgccctt cgagccggtc 4501 ttttacctca ttcacatcca ccagctggcc atgcaggcac tgcgcaggat ctgggcacgt 4561 cgcccgattc ccaactatgg acccagtatg ttcgagacca tgatactgat cctgaagcat 4621 ctgatcaagt cgcatcaaac gctgctcgat cgctatcaca cgcggatgaa ggagatcaag 4681 ttcgagaacc tctacatccg cagcacggac gatggcctaa atgcggatca catcaagacg 4741 ctgacggaca tgggcttcat gcattaccac gttattgagg ctctccgcac gaatgcctcg 4801 ctggaggagg ccaccgatta tctgctgaat aacccagaag ccagtgcttt gtccacaacg 4861 actggtggtt ctgctgctcc tccgccgccg ccaccgccac cgccttccac catggacatt 4921 gacatggatt tgccagcgga tgggggagag aaatctagct ctagttcggc gaactccagc 4981 tatgactaca agcacctcaa actgatgccg tcgatcatct tcgatcgctt ctgcgacgag 5041 gccatttcgc gggcctttga gttcatggag gccattccgg atacggtgaa cagtgccgca 5101 gatctgatag ccgtgctgta tagacgccac aatcacctga acaagcaggt ctttgtgacc 5161 aactttgtgc gcaacattat ccagtgggtg gactttaccc tgcagctctt tgaaccatcg 5221 aaaacggcag cgtcgaaggc ttcgcggttg gaggaatgct tgacgggatt gacggccacc 5281 cggttgtttg tgcggctcaa gacatcgacg cggctgctcg aggagaacta cagtgatttg 5341 catcgtccgc tggtggaggc aataaccgcc caggatgcca tggtgtcgct ggtcaagctg 5401 ctcgactgca tgagccagtg gatgctggag caatcagtgg attctagggc tacggtcccc 5461 cgatgggtgc agaacctggt ggatctaatc gattcgatcg acagcatcag ccacattctg 5521 cagcgcaagg ccaacatgcg ggcggtgagc agcgaggtgt ggcgctggta cgacgcctcc 5581 acgggcaagt ggaatgccta ttcggaggcc aacaatgagc tcattcggaa tgcctatgcc 5641 gccggcgagc ggtggctgca cattaacatc ggcaggcaaa ggtgtacggt gagcctgaac 5701 tgcatgacgc aggtgagcga ggcatccggc acacatcgtc ctgtttgtcc ggctctcaag 5761 ctcagtgaag ccatcactgc gctcaacagt cccgtgtcgc tgcacaaagt ggagcatctg 5821 ctgaaccgcg tggtgcgaac ctcacccgat ggctcgggaa ccgtgcattc cgacgaattg 5881 atttccctgc gccagctgat caacttttcg gatggtcagc agccgcagga gaacccggcg 5941 aatgaagagg gaacaaatga agatagtgga tctcctctgg ccgccatgac cacgcgcagc 6001 aagtcgcggc aaaagagcgc cgccgctgca gccgctgccc agaagaaatc ctcgtcgcat 6061 ggctcaccgc ccatacccaa acgcacccag aagatcatac tcaacgagga gcaggtggga 6121 ctgagtaaat tcgactgcgg tcggataatt ggcagcattg tggatctcct gcagccttcg 6181 catctcatgc tcaacgaaac gaagctttcg ctgctgcggc tgtgtgcaag attaacccga 6241 aactacgaca atgcccaggt gttcatccgg cggggcggcg ttaagatgct gctgcatctg 6301 cagcaggcct gcagcttcat gggcttcccc acctatgcga atatcatact gcgtcacgtg 6361 ctcgaggcgc cgccggtgct gcaggaggcc atggaacgag tgctgggcat gcgggcagcc 6421 ggcattgtgc ccgtggggca tcgggatcta atctatgtac tcacccaggt atcctcagcg 6481 gtttcgcgca atccgcagat ctttgtggcc gccgccaagg agatgctcaa gggagagtac 6541 ctcctgaaca cgaacagcac gacgctggcg gacgatgcgc gggtgatggt caagtccaag 6601 tttggtcaac aaccgacggc agcggctggc ggagccacgc caaattcgca gacgtccacg 6661 ccgccggatg agcagctcaa ggacgatccc caggttcagt catcggtggc tgtgcttaag 6721 gatctactgc atggattggt gcagccctgc tggcactacg gcggcacggg atccttggat 6781 cgcggccctg gcgccgccga gctgctgcaa ccggaccagc caccgggaac ggccgcccag 6841 ggaggccacg acgaggagtt gtatttccgc ttccaggaaa cccccgcacc tgcgagcagc 6901 aagaagcaat cctcaggagg aggagcatct gctgggcagc cacagacgac ggagaagttc 6961 gagccctgct gctgcacgtg gcacatcccg accagcggcc acacgcacgc caagccgacc 7021 atttcgcggg cgacgctgct caagctgctg gcggattcaa cgagggccta tcagtcttta 7081 gtgccccgcg tgctgctatc ccacatttac acgcccgccg acagtccgct gatctcggcg 7141 ccgcagcaga cgttcctggg cgtcctcctc gatcgctttc tgcccatcac gcagcggcat 7201 catgtgcccg aggtgagcac gatgacgagg gtgctcattt gctccctttc tgactgctac 7261 cagcagccgg gagtccaggt ccatgtggcc gaggagctgc acgcggcggt ggccagggct 7321 ttggcccaac cggactcggc ggagaagcac acgcgactcc aggtgctgat gagcctgttt 7381 cccaatctca tcgagtcgcc gatgctgtac gataaggtgc acatgcatcg caacaacatg 7441 taccgagtgc tgctgcgcca gggagtgatg acctacctga ccaaggtggc ccagtacaag 7501 gatctgtcca atcacaacac gctgagcact ctggcggcca tcctgcgacc catggagatc 7561 ttgctgaggt ttagtgtgtc caccacaacg ctcggatcga agaggattct ctttggcggc 7621 ggcggcggag gagctggcgg agcaaatgga gcagggagcg ggaacagtgc tgtcggagga 7681 ggcagtggaa ctggcccggg atcgggcaat acatatggaa ccatcatcaa tcgtcggcta 7741 tatcctcgtt tggccgcccg caccgcagtc agtgcggccg tggagcgatc caatgcgatg 7801 ggtggcgagc atgtgctgcg cgacattata cgcaatgtgc tctccgatcg gcggcacgcc 7861 tttgagttta tcttcaactc ggacgagatg gccgtggact cggaggactc ggctgccccg 7921 gcggtgggtg gtaatggatc gggagcaggc ggaataggag caggaggatc aggagcagcc 7981 gtcatcgatg tggtggagga gcgcagcaat ggcggggata ccagcgatcc cccaggtaat 8041 gtaaactccg gatctggaac gggcgcagtt caatcttcaa ccagtggagg tcccgtgcgg 8101 ccagttctga actttgacca gctgtgggac gacttcctgc agagcgaggg actgcgattg 8161 gcctcgcgga gcggcggagg cgcgggatct ggagcaggat ccacaggagc aggctcaacg 8221 ggtcagcaaa acggtggcaa tgccactggt ggctctgcaa actccggcag caattcagtc 8281 agcggagatc ctcgcctgcg caccaatccc gatgtggatg tgggcggcgg tggaaatggc 8341 ggtggtcagt catccaattc gggtgtggta aacgataatg gaattggcgg cggcggcggc 8401 agcgatggcg cctccacatc ctcggacact ggagctccgg gcggcgaacg tcgcgatttg 8461 aatgcctcgc tgctgggcga tgtcagcacc tcggaatccg attcggatgc ctccacggag 8521 aacgacgagc ggaatgagga ggacgaggac gaggatgacg atgcccccga tgaagatgtg 8581 gacgagcata gcgaaacgga tgtggatgag gaaaggccac gtcaatttat cgaggtcttt 8641 gatcacatct acgaaccgga atcctcggaa accgcttcca atgatgcgga tgtggataac 8701 gacgacgatg atgacgagga tgaggacgat gtggacgacg acgatgatga tgacgaggat 8761 aacgacgatg aggatcgcga ggagggccag agtgtcatgg atgccgagtt ggagaaccaa 8821 atagacattg ccctcgcctt ggtttcgtcc aacaatcgtc cgcgacgcag tgcagcggtt 8881 aatgcttcgg gcgatgcgtc cgccaatcga gatcccaatc ccgacgagga ggtggacgac 8941 gaggacgacg atgtggacgc cgatcccgat ggagatcccg atgtggaccc cattggcggc 9001 ccctcggctg cccaggcgga ggcctatctg tacgagcgac tgggcagcgg cctgatgccc 9061 acgccaccgg tgggtttccg cgtccgcatg aacagctcga ttgcccagcc cctggacatt 9121 gatgtgaatg gcggaaatgg cggtggtgga tctggtggat ccggagcagg cgtcactgga 9181 acggccggtg gatccggaag aggctcctcg tcgggcggaa caacggccag tattggagcc 9241 attgcctccg ctgccttgcg tccctcgtcc ggttcttgga tggcgccgga ctttaatttc 9301 attggagtct cgggcggtgg aggagccagt ggctctggag gcgcctcagg gagcaatgcc 9361 aacgggggcg aggtgaacgc cttcctcacg cccgccatgt cgcagctgga acgcagtggt 9421 ggcgcctcgg gcagtggcca aaacatgagc aatctgctgg acgaacaacc gtcggtcagt 9481 ggcaacggcg gcggaggagg aggaagtggc ggaggttccg cctctggtaa cggcggcgtc 9541 agcggtggag gaggagccaa tggcggcggt accgcaggac agcatccgaa tgccacgctc 9601 tgcgccaacg gagtgcgccg gcggttgctc tatttggacc agcagtactg cgtctgcatg 9661 cccacgcatc agaatcccac ggaagagacc cagatggaga cgttcaccca ggatgctctg 9721 cattggtggc tggaggaggc cacggtcttg gatatggaga gccagactga cgcctgcctg 9781 tacgccgctc acttcctgct gccgcatctc atcaaggagc tgaagacggc ccaccagcag 9841 cgcaagcagg aggaggccgc ccgccagacg gccacgaaca ccacaacacc tgcatcatcg 9901 gcttcgtctt cggccggagc tccggcgacc tccatcctat cgaacacagc ggccccaaca 9961 gcgacggcct ccattgcgtc cagtctactg gcgaatgccg tggccgcggg ctcaggcggc 10021 agcagcagca gcggcagcgg attggtggtg ccaccggtgg cagcctccgc cacgggaggc 10081 acccggcgca gctcgattcc cgtgctgatt ccctcgagct tcggcggtcc tggtagtgca 10141 accactggcg atgccacggc cacaacggga ggaaccacca gcagcagttc ctacacaacc 10201 acatccatta gcggcagtgg ctccttggag tcgcagacga cgactcgagc gcctcggcaa 10261 cgcggtggat tgcgccagca cagccagctg cccttcaaca tctacgcgga gatcgatctg 10321 accaacgaac aggatagcca gggcgccacg tcaacgggct ctgctccaaa cgatggagcg 10381 gaatcacagg cacagcagcc gcagcagcag cagcagcagc aaaactcctc cgctccttcg 10441 ttggcgcagg gggcggtcct tcagcatcag cgtcatccac cggtgccgct cctgccgtcc 10501 agtggaaggc cttcgcgacc tcactcgcgt ctcgacgagg cggagctgct tctgttgcag 10561 ttggccgatc gccaggctgt tcgcagtcgc ctgcaagtgt ccagcggtca cacgaattcc 10621 tcgcgcacct cgggatcggc gctgatcaac gctcggccca atcgcgatct acccgcccgc 10681 ctgcagcgcc tcgtccaggc acatggctcc ctttccagtc gcatcaatgc atccgccgcc 10741 agcacgccgg ctccgacgct cgtctccatg cccacgccca tgtccagtgc ggcgctggag 10801 cagctgaatg tcacgcccgc cggcccggat gttgtgggcc cagacaggaa ctttgcattg 10861 ccaccttccc tggaggttga tgtggatgtg ctgcctggaa tactggatcg catactgccg 10921 cagcagcagc aggagcagca ggaagcgcag cagcaggagg aggaggagga acagctgttg 10981 ctaccaccgc cacctccgcc gccgcccagt gaaacggcgc ccttgctcct caccgaggag 11041 gatatgtggc aagggacaag agaggaggag gaggattcca cttccacagt ggcagttgcc 11101 ggcagcagcg aggctgcaaa cgagtcaaac caatcggatc agacgccgga gagcagcgaa 11161 tctgtttccc cgaacccgca ggctcctccc ccagcagcag aatccggcga aggaggagca 11221 gggggagcag gaggagctgc ctcggctagc acacaaaccc cggcaaccgc agaagaatcc 11281 gctgtaggtg gaacaacagc aacagcaaca acgacagcag ccaccgtaac ggacatgagt 11341 cccgaggtgc gggccgctct cggggatctg gaggtgcccg agggcgtgga tccctccttc 11401 ctggccgccc tgcccagcga gatgcgcgag gaggtgatcc aggagcatct gcggatgcag 11461 cgcattcgcc agcgggcgca gcagaatgcc attcagattg cgcacgattc gctcgtcgag 11521 gtgaatcccg agttcctcgc cgccctgccg ctgaacattc agtccgaggt gctgatgcag 11581 cagcggatcg agcagcagcg ccaggcggcg cagaccgcga atcccgagga tcccgtcgac 11641 acggccgcct tctttcagaa cctgcccgag aatctgcggc aagcgatact caccgacatg 11701 gaggagtcgc agatagccag tttgccgccc gagttggcgg cggaggcgca gttcctgcgt 11761 cgcgactggg agtcccgcaa tggcgcccgc atggacgccc atccgcccag caatgcgttg 11821 tcccgcttcc agacgacgct gcagagcctg gacgaggccc gctggcacag ctccatttgg 11881 tacgacgcca gcggcaatgc ccagccgcag caccaccagc acaccacgat tgtgcaccac 11941 catgcccacg cacatcacgc ccccacgatg ggcaaacccc tagccctgct gatgatggag 12001 gacgagaaca tcctgctcga tccggactcg ctggccaccc tgctgctctt cctgttcgtc 12061 gaggatcaga aggtgaacag catgcggctg catcgtgtga ttcgcaacct ttgccaccac 12121 gaacccacgc gcgattggat catcagcgct ctgattagca tcgtccaaaa gaccaacgag 12181 gataacgcca actttggagc tggacaggcg ggcggcaaac cggagtggct gaagctgcgc 12241 gtggacgccg cctttggcta caagagcaac atcttcctca tcaatcggct gtacgagggc 12301 agtgcgcgga gcatcagcat caatccgcag gccgcacaga tgatagtgcg caactgtctg 12361 gatctgctct tcgtgctggc caagcactat ccgtccagct ttgtgccctt caaccgcgag 12421 gtgaaggcca ggcgcatact gagtgcggta tttggcatgc catcgcccac gggtggtgct 12481 tctactgctg gagctggagc tcctgcacgc aatatagatg actttccacc gcccggcgga 12541 actctggact ttcgctcgcg tttctgccgc taccaggtgg ccaatcgact gcgcggcata 12601 ctcgacgatc atccggcggc ggccccgaaa ccccaaagtg caactcccct ggatgaggca 12661 ccctccacat cgaaggcggc tgctgccaag gcagctgcca cggctaaggt ttcgagtcag 12721 agcagtcagt cggtgccgta tcaaacgaat gcgaagaatt tctgggatgt ggtgctcaac 12781 atcgatcgac agacccaagt gcgtttggcc aatgtggccc agtttccact cacctcgcag 12841 ccagcttggg aatggcaagc gaacagcgcc gacttcctgt cgttcagcga ttcgcctttc 12901 ggacagctgc tggaaatgct gccctacaag gtcatctgcc ggtcgccaca tctcaccgat 12961 atgctggtca agttgctcgc ctcgctgagc accgagttgc ccaaggagga ggaacagttg 13021 ccgctgagcg atcaaatgcc caccctgata cccattaatc aggcggcggc agcggcagca 13081 gattccccag cgaatccatc agagattggt gacggactgg ccgcaaatgt ggagcaggaa 13141 gccacgccgg ccagcggtaa tccagcctcc ggtgacagca atgcggctgc caagcgaaca 13201 cagctgccca cattgagtgt agccctgcca gttgctccgt cgaagccgcg gcgcaagatc 13261 tactcgaaga acttctcgca actgcagctg gtcatcgagg tgctgaccca ccagtgcggc 13321 accaccgagg gcctggacaa cgtggccaag ctgattgtga atctaacgca gtgctcgcag 13381 gcatccaatg cgattttcat tcagtacctg accgctgcca tcctgggatt ggccgaggag 13441 gtgcgccagg cgatacagat gctgctgaat gagatacgca tgtacaacag tcatcatgga 13501 gtgacggcct ccacatccgg agcagcggca gcgggagcca ccgtttcagg agccagtctg 13561 ctgcctaacc tcgccgttca cgagggcatc atgcaggatc gcttcaccgc cgagcatgtc 13621 atcatttcgg cgccgaagaa cgccaagccc acctgcgaac tccagctgcc gtcgatgaag 13681 aagcttatgt ccaactcatc cgcccagccg tacttcctgc gcaccctgaa gatcttcatg 13741 caggtgcgcg acatgtacga ggcgcagaat ggtttatcca cgggcggtgg tttggctgga 13801 gcagctggcg acaacgatga cgacatcatc gacattgagg gcgatggcgg agcttcgggc 13861 ggcagcagtt cggatatggc gcccggttcg gcgagcacaa tatctccgcc gccgccgcca 13921 ccgatggaaa ccaatcagaa cattaacgat gaggaggagg atgaggatgg ggaggaggag 13981 gaggacgatg atgatgcggc cagggcatcg ccagcggcgg caagtgctgg caagtcaagc 14041 aagcccacgc tcagccagat cctctgcctc gacgtccttt ggcacacgct cagcgaatgc 14101 ctggtggcgc tggaggagtc caaggacgag ttcgccgtcc tggtgctgca gcccaccgtg 14161 gaggccttct tcctcatcca cgcctcgcat cgcgcggggg ctaagaagtc gggtcgcggc 14221 ggagttgtgg gctccggact gcgggcagct ggaggattgg gagcagctgc gtcggcggcc 14281 caggagcaca gtccatcgat ggacgacacc agcagcgcca atacccttag ttcggccagt 14341 ttcgaagatg agccgcgaat gcaggacgcc tccacaaaca cgccgctttc gagcaacagc 14401 tccgccgcca ccactgtgct gagcgcacac gaggcgcagc tgcgacagga tcgccagaag 14461 ttcctgcagt tcgccgagaa acaccgcacc gtgctcaacc aaatactgcg ccagtcgccc 14521 actcatctct ccgacggacc cttcgccgtt ctcgtcgacc acacgcgcat cctggacttt 14581 gacgtcaagc ggaagtactt ccagacggag ctggagcgcc tggacgaggg cattcggcgc 14641 gaggagcaca cggtcagtgt gcggcgcgtg accgtcttcg aggattcgtt ccgcgtgttg 14701 taccgcctgg gaccggagga gtggaagaac cgcttctaca ttgtcttcga ggacgaggaa 14761 ggccaggatg ctggcggcct gctgcgcgaa tggtatgtga tcatatcgcg cgagatcttc 14821 aatccgatgt atgccttgtt ctgcgtatcg ccgggcgatc gcgtcaccta catgatcaat 14881 ccctccagcc atgccaatcc gaatcatctg agctacttca agttcgtcgg ccgcgtaatt 14941 gccaaggccg tgcacgataa caagctgctg gagtgctact tcacccgatc cttctacaag 15001 cacatcctgg gcaagcaggt gaagcacacg gacatggagt cgcaggacta cgagttctac 15061 aagggcctcg actatctgat gaagaacgac atctccaccc tgggctacga gctgaccttc 15121 tccacggagg tgcaggagtt cggtgtcacc cagatccgtg atctcaagcc aaacggacgc 15181 gacaccgcgg tgaccgagga aaacaagttc gagtatgtgc agctggtgtg ccagctgaag 15241 atgagcggct ccattcgaca gcaattggac gcattcctcg agggcttcta cgacattatt 15301 ccaaagcatt taatttcgat attcaacgaa caggaactgg aacttctcat atccggcctg 15361 ccggatattg acattgaaga tctaaaggcg aacaccgagt accacaagta cacctccaaa 15421 tcggcccaga ttcaatggtt ctggcgtgca ttgcgcagct tcgaccaagc ggaccgggcc 15481 aagttcctgc agttcgtcac tggcacatcg aaggtgccgc tgcagggctt cggctccctg 15541 gagggcatga acgggattca gaagttccaa atccatcggg acgatcggtc cactgatcga 15601 ttgccctgtg cacacacctg cttcaaccaa ctggatcttc cgatgtacaa gtcatacgac 15661 aaactgcgga gctgcttgct gaaggccata cacgagtgct ccgagggctt tggcttcgcc 15721 taagcgggaa catcagtggc tttcggtcct ccagcctcca gcgaggccag ccaaccaagc 15781 agccaggaac ccatggacgc aactctattc ctagttcgcc caattcacgg gcgacacgac 15841 gagaaatgca taattgattt gaacagaaca gaacagccac tgctaatttg cgatagcggc 15901 aacagaaact gcatacatac acagtacata tagttatata gtatatataa aaatgttgaa 15961 ttaattatta attttcgcgc ctatatatat acaatatata ttttcttaaa ttttcaaaag 16021 aaaacggaaa aaagtctaag gaaacctaca aaaaaaaaat aagatacaaa cgcgaaacag 16081 catattcgat ttaaatttgt ctgcgtaact catccctatt atatattttc tcggaatcta 16141 tccctgtcgt tttgcacatt ttcattaaaa caaaaggatt tatataaaaa aacatacaca 16201 atttgacata tttttattta cctaaacacg aaaccgaata gcaaaggatt aaacgtagtc 16261 tatagaacgc aaatgcaaat gcacataaac agatttcttg tttacttaag tgaatttacc 16321 gaagatgaga cggggaggca gcggaaataa ttaaatggat taaagtattt cgatgtaaga 16381 gataagtcct tatgttatgc attttatgtt tacctttgga ataatgagcc gcagatgtaa 16441 cttaaagaat gtggaataaa gtaagagtaa gctcatttat caaaata