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LOCUS XM_070218998 16600 bp mRNA linear INV 09-DEC-2024 containing E3 ubiquitin protein ligase 1 (HUWE1), transcript variant X1, mRNA. ACCESSION XM_070218998 VERSION XM_070218998.1 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..16600 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..16600 /gene="HUWE1" /note="HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 2 Proteins" /db_xref="GeneID:108068620" CDS 468..15836 /gene="HUWE1" /codon_start=1 /product="E3 ubiquitin-protein ligase HUWE1 isoform X1" /protein_id="XP_070075099.1" /db_xref="GeneID:108068620" /translation="MKVDTVKLKKGSSELTAECRELIDELTKRRTRAELLEFLDTIHV WIYGKCELYHWIEILDRFDKILEEASRHVNANEFVLQCDTNFQETDVTLLLHVLNFTT LLIEHSFSRHLYNSIEHLTVLLSSQNMDIVLAVLNLLYMFSKRSNFIPRLPFEKKELL IVKLFNIAERWGDPNYGLSLKDCCIGEPKLEFLYQLCIDYVDEHGHAAQLEIPDMMDL CHTASAPEVIKTIAGQISKPSEAIKMRIAHRVRLISGFNNYKLRLQFVQARLQAVSIL IYSNALQDNTDKVLYAGFGEELCELIDKEDVHLVEIRAAVLRTLTSMLHFDRNPNVPS RAGSRLMKIVHYTGAERQGGTLPLLVRDCIDNLTTHGLTERYPLILATSLFSLLYHLA SYEMGGSALVKSGMMQSLLCVISWPGVDLEHITFVTRAVRVIDLITNIDIARFHQNNG LNVFIDRLEKEIKSCCKALADIGITLKESTLRDDHKLDNSLEQVDDDVEETGENTSVA SGGGSPRRENSSDGLTGAGSSAYRAYHEHSGGGAGSGAGLLDIGGARSAGGGSSGGAS AAPIIGLINRDGSAARPPAIMYPTNSYYARPLAERKAELSSQLPSSLAPKKPSCVTQR AALLKSMLNFLKKSIQDHAHFSNMRNIMETSLTQSLRHIIANAEYYGPSLFLLATDVV TVYVFNEPSLLSSLQDLGITSVMLKALLQKDVPATREVLGSLPNVFSALCLNERGLFE FLSYDPFDKVLKVLLSPDYLVAMRRRRSSDPLGDTATNLGNAMDDLIKHHPYLRADAT EAIVRLLNELVRLGSDPSFICWRANKESSGSGSGSGSHGGGGSHHVASTPSPMAVMVA GSGGSTSVLQGAADTNDSSGDDDDDDDEMSSASQQQQQSGGATTPRTQQPGGGVATPQ AVKVVTPPEREAIPLIDYILNVMKFIEAIFSNSPNGDHCREFVLHGGLKPILQLLSLP NLPVDSPVSTTSQAVANVCKAILSQAQETKVLDVALKQLADIVAQLKPLIKHFTFPGG SVLLAELVCCQRLEDGFANAEYTPILHNMSFVHGYVVMLVHLCRNASNDMRAILLKRW GVNRETGVQLLQQLVQLYISLVWESTILLNLCSDEPTQHPDLIWDEIAAQMSAAAGTA DPLTEAELSRKLERAAEFRTKYSPEEQFRYIKSLLAASSRLGRALAELLGTLVKLSVG SPQTRQRRINDLISNINKVPTPEAREIARILSSILVNGFSHESILPKPVPKLKLTFLI CSVGFTGPMLFDDKRSAFHLMISQFCAENGLKAFFEMFYWALSLDNVSQKFDFDQWAS MEDLMQSHEDDKRDCPEGTGEFLDAWLQLLEKMVNPRAMLDSPYTMSPRLNYLPDSVP FEPVFYLIHIHQLAMQALRRIWARRPIPNYGPSMFETMILILKHLIKSHQTLLDRYHT RMKEIKFENLYIRSTDDGLNADHIKTLTDMGFMHYHVIEALRTNASLEEATDYLLNNP EASALSTTTGGSAAPPPPPPPPPSTMDIDMDLPADGGEKSSSSSANSSYDYKHLKLMP SIIFDRFCDEAISRAFEFMEAIPDTVNSAADLIAVLYRRHNHLNKQVFVTNFVRNIIQ WVDFTLQLFEPSKTAASKASRLEECLTGLTATRLFVRLKTSTRLLEENYSDLHRPLVE AITAQDAMVSLVKLLDCMSQWMLEQSVDSRATVPRWVQNLVDLIDSIDSISHILQRKA NMRAVSSEVWRWYDASTGKWNAYSEANNELIRNAYAAGERWLHINIGRQRCTVSLNCM TQVSEASGTHRPVCPALKLSEAITALNSPVSLHKVEHLLNRVVRTSPDGSGTVHSDEL ISLRQLINFSDGQQPQENPANEEGTNEDSGSPLAAMTTRSKSRQKSAAAAAAAQKKSS SHGSPPIPKRTQKIILNEEQVGLSKFDCGRIIGSIVDLLQPSHLMLNETKLSLLRLCA RLTRNYDNAQVFIRRGGVKMLLHLQQACSFMGFPTYANIILRHVLEAPPVLQEAMERV LGMRAAGIVPVGHRDLIYVLTQVSSAVSRNPQIFVAAAKEMLKGEYLLNTNSTTLADD ARVMVKSKFGQQPTAAAGGATPNSQTSTPPDEQLKDDPQVQSSVAVLKDLLHGLVQPC WHYGGTGSLDRGPGAAELLQPDQPPGTAAQGGHDEELYFRFQETPAPASSKKQSSGGG ASAGQPQTTEKFEPCCCTWHIPTSGHTHAKPTISRATLLKLLADSTRAYQSLVPRVLL SHIYTPADSPLISAPQQTFLGVLLDRFLPITQRHHVPEVSTMTRVLICSLSDCYQQPG VQVHVAEELHAAVARALAQPDSAEKHTRLQVLMSLFPNLIESPMLYDKVHMHRNNMYR VLLRQGVMTYLTKVAQYKDLSNHNTLSTLAAILRPMEILLRFSVSTTTLGSKRILFGG GGGGAGGANGAGSGNSAVGGGSGTGPGSGNTYGTIINRRLYPRLAARTAVSAAVERSN AMGGEHVLRDIIRNVLSDRRHAFEFIFNSDEMAVDSEDSAAPAVGGNGSGAGGIGAGG SGAAVIDVVEERSNGGDTSDPPGNVNSGSGTGAVQSSTSGGPVRPVLNFDQLWDDFLQ SEGLRLASRSGGGAGSGAGSTGAGSTGQQNGGNATGGSANSGSNSVSGDPRLRTNPDV DVGGGGNGGGQSSNSGVVNDNGIGGGGGSDGASTSSDTGAPGGERRDLNASLLGDVST SESDSDASTENDERNEEDEDEDDDAPDEDVDEHSETDVDEERPRQFIEVFDHIYEPES SETASNDADVDNDDDDDEDEDDVDDDDDDDEDNDDEDREEGQSVMDAELENQIDIALA LVSSNNRPRRSAAVNASGDASANRDPNPDEEVDDEDDDVDADPDGDPDVDPIGGPSAA QAEAYLYERLGSGLMPTPPVGFRVRMNSSIAQPLDIDVNGGNGGGGSGGSGAGVTGTA GGSGRGSSSGGTTASIGAIASAALRPSSGSWMAPDFNFIGVSGGGGASGSGGASGSNA NGGEVNAFLTPAMSQLERSGGASGSGQNMSNLLDEQPSVSGNGGGGGGSGGGSASGNG GVSGGGGANGGGTAGQHPNATLCANGVRRRLLYLDQQYCVCMPTHQNPTEETQMETFT QDALHWWLEEATVLDMESQTDACLYAAHFLLPHLIKELKTAHQQRKQEEAARQTATNT TTPASSASSSAGAPATSILSNTAAPTATASIASSLLANAVAAGSGGSSSSGSGLVVPP VAASATGGTRRSSIPVLIPSSFGGPGSATTGDATATTGGTTSSSSYTTTSISGSGSLE SQTTTRAPRQRGGLRQHSQLPFNIYAEIDLTNEQDSQGATSTGSAPNDGAESQAQQPQ QQQQQQNSSAPSLAQGAVLQHQRHPPVPLLPSSGRPSRPHSRLDEAELLLLQLADRQA VRSRLQVSSGHTNSSRTSGSALINARPNRDLPARLQRLVQAHGSLSSRINASAASTPA PTLVSMPTPMSSAALEQLNVTPAGPDVVGPDRNFALPPSLEVDVDVLPGILDRILPQQ QQEQQEAQQQEEEEEQLLLPPPPPPPPSETAPLLLTEEDMWQGTREEEEDSTSTVAVA GSSEAANESNQSDQTPESSESVSPNPQAPPPAAESGEGGAGGAGGAASASTQTPATAE ESAVGGTTATATTTAATVTDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEVIQEH LRMQRIRQRAQQNAIQIAHDSLVEVNPEFLAALPLNIQSEVLMQQRIEQQRQAAQTAN PEDPVDTAAFFQNLPENLRQAILTDMEESQIASLPPELAAEAQFLRRDWESRNGARMD AHPPSNALSRFQTTLQSLDEARWHSSIWYDASGNAQPQHHQHTTIVHHHAHAHHAPTM GKPLALLMMEDENILLDPDSLATLLLFLFVEDQKVNSMRLHRVIRNLCHHEPTRDWII SALISIVQKTNEDNANFGAGQAGGKPEWLKLRVDAAFGYKSNIFLINRLYEGSARSIS INPQAAQMIVRNCLDLLFVLAKHYPSSFVPFNREVKARRILSAVFGMPSPTGGASTAG AGAPARNIDDFPPPGGTLDFRSRFCRYQVANRLRGILDDHPAAAPKPQSATPLDEAPS TSKAAAAKAAATAKVSSQSSQSVPYQTNAKNFWDVVLNIDRQTQVRLANVAQFPLTSQ PAWEWQANSADFLSFSDSPFGQLLEMLPYKVICRSPHLTDMLVKLLASLSTELPKEEE QLPLSDQMPTLIPINQAAAAAADSPANPSEIGDGLAANVEQEATPASGNPASGDSNAA AKRTQLPTLSVALPVAPSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVN LTQCSQASNAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNSHHGVTASTSGAAAAG ATVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQP YFLRTLKIFMQVRDMYEAQNGLSTGGGLAGAAGDNDDDIIDIEGDGGASGGSSSDMAP GSASTISPPPPPPMETNQNINDEEEDEDGEEEEDDDDAARASPAAASAGKSSKPTLSQ ILCLDVLWHTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRAGAKKSGRGGVVG SGLRAAGGLGAAASAAQEHSPSMDDTSSANTLSSASFEDEPRMQDASTNTPLSSNSSA ATTVLSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAVLVDHTRILDF DVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFED EEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFV GRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTL GYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAF LEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRA LRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCF NQLDLPMYKSYDKLRSCLLKAIHECSEGFGFA" misc_feature 735..1445 /gene="HUWE1" /note="Domain of Unknown Function (DUF908); Region: DUF908; pfam06012" /db_xref="CDD:428721" misc_feature 2334..3398 /gene="HUWE1" /note="Domain of Unknown Function (DUF913); Region: DUF913; pfam06025" /db_xref="CDD:461803" misc_feature 4830..4949 /gene="HUWE1" /note="UBA domain-like superfamily; Region: UBA_like_SF; cl21463" /db_xref="CDD:473871" misc_feature 5670..5888 /gene="HUWE1" /note="Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis; Region: WWE; smart00678" /db_xref="CDD:128922" misc_feature 11484..11576 /gene="HUWE1" /note="Ubiquitin binding region; Region: UBM; pfam14377" /db_xref="CDD:464159" misc_feature 11631..11714 /gene="HUWE1" /note="Ubiquitin binding region; Region: UBM; pfam14377" /db_xref="CDD:464159" misc_feature 14766..15827 /gene="HUWE1" /note="HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; Region: HECTc; cd00078" /db_xref="CDD:238033" misc_feature order(14778..14780,14868..14870,14901..14903,15084..15086, 15606..15608,15714..15719,15726..15740,15798..15800, 15822..15824) /gene="HUWE1" /note="catalytic cleft [active]" /db_xref="CDD:238033" misc_feature order(15168..15170,15177..15182,15186..15191,15198..15200, 15219..15221,15225..15227,15237..15242,15246..15248, 15261..15263,15276..15278,15327..15329,15339..15341) /gene="HUWE1" /note="E2 interaction site [active]" /db_xref="CDD:238033" polyA_site 16600 /gene="HUWE1" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN 1 catttgcctt caatttgcca aaaagaataa acgccagcgc ctatcgatag ccatcgatag 61 gcagagtcga ttgcaattct tcgttgccgt ggattggagc ggtgcgtggt cacactaatg 121 cttgcatttt ttttgtctgt ggaaatttca tttcacaaaa accgagatag ttaaattaac 181 caaattatag cgtttcagat cgaaataaca atagcagcaa tatgctgcag ttaaatataa 241 tttttattga acacgctgac gtatacgttt aaaccgcaac tcgatgccca acctataaac 301 aatcgacgcc cgacgccttt tcaccacgaa ccacccaatc tacacaagcc gcccactcga 361 caaacagccg gaggaagagg aggaggagga ggaggaagga ggaggagcac caccacccca 421 agtggtggcc acctgctgct ccattagctc cactagctcc acgaacaatg aaggtggaca 481 cggtgaagct gaagaagggc tcctcggagc tcaccgccga gtgccgcgag ctcatcgacg 541 agctcaccaa gcggcggacg cgggccgagc tgctcgagtt cctcgacacc atccacgtct 601 ggatctacgg caagtgcgag ctctaccact ggatcgagat cctcgaccgg ttcgacaaga 661 tcctcgagga ggcgtcgcgc catgtcaacg ccaacgagtt cgtgctgcag tgcgacacca 721 atttccagga aacggatgtc acactgctgt tgcacgttct taacttcacc acactgctga 781 tcgagcactc gttctcgcgg cacctctaca actccatcga acacctgacg gtgctgctct 841 cctcccagaa catggacatc gtcctggccg tcctcaatct gctgtacatg ttctccaagc 901 gcagcaactt cataccccgc ctgccgttcg agaagaagga actgctgatt gtcaagctgt 961 ttaacatagc cgagcgctgg ggcgatccca actacggact gtcgctcaag gactgctgca 1021 ttggcgagcc gaagctggaa ttcctttacc agctgtgcat cgactatgtg gacgagcacg 1081 gtcatgccgc ccagctggaa atcccggaca tgatggacct ctgccacacg gcgtccgcgc 1141 ccgaggtgat caagacgatt gccggacaga tctcaaagcc cagcgaggca atcaagatgc 1201 gcattgctca tcgggtgcgc ttgatctcag gcttcaacaa ctacaagctg cgcctccagt 1261 tcgtccaggc tcgcctgcag gccgtctcca ttctgatcta ctcgaatgcc ctgcaggaca 1321 acacggacaa ggtgctgtat gccggcttcg gcgaggagct gtgcgagctg atcgacaagg 1381 aggacgtgca tctcgtggag atacgggcgg cagtgctgcg cacactcacc tcgatgctgc 1441 actttgaccg caatccgaat gtgcccagca gggccggttc gcgactgatg aagatcgttc 1501 actacacagg agccgagcgg cagggcggca ctttgccact gctggtgcgc gactgcattg 1561 ataatttaac cacccatgga ctcaccgaac gctacccgct catcctggcc acgtcactct 1621 tctcgctgct ctaccatttg gccagctacg aaatgggcgg ctctgctctg gtcaaaagcg 1681 gcatgatgca gtccctcctg tgcgtcatca gctggccggg agtcgacctc gagcacatta 1741 cgttcgtgac gcgggcggtg cgggtgatcg acctgataac caacatagat atcgcacggt 1801 tccatcagaa caacggactc aacgtgttca ttgaccgtct ggagaaggag atcaagagct 1861 gctgcaaggc actggccgac attggcatca cgctgaagga gtcgacgctg cgcgatgacc 1921 acaagttgga taactcgctg gagcaagtgg acgatgatgt ggaagagacc ggagagaaca 1981 cgtccgtggc cagtggaggt ggatcgccgc gtcgcgagaa ctcgagtgac gggctcaccg 2041 gtgccgggag cagcgcctac agagcctatc acgagcacag tggaggagga gcgggctcag 2101 gagcgggact cctggacatt ggtggagcac gcagcgcagg aggaggatca tcgggtggtg 2161 cttcagccgc accgatcatt ggattaatca accgggacgg aagtgccgct cgtccgccgg 2221 ccatcatgta ccccacaaac agttactacg cccgtccgct ggccgagcgc aaggcggagc 2281 tctcctcgca gctgccgagc agcctggcgc cgaagaagcc ctcctgcgtc acccagcggg 2341 cggcgctgct caagtcgatg ctgaatttcc tgaagaagag catccaggat catgcgcact 2401 ttagcaacat gcgcaacatc atggagacca gcttaacgca gtcgcttcgc cacatcatag 2461 ccaatgcgga gtactacggg ccgtcgctct tcctgctggc caccgatgtg gtcaccgtgt 2521 acgtgttcaa cgagccctcg ctgctctcct cgctgcagga tctgggcatc acgagtgtca 2581 tgctgaaggc gctgctccag aaggatgtgc cggccacgcg ggaagtgctg ggctccctgc 2641 cgaatgtctt ttccgccctg tgcctgaatg agcgtggcct ttttgagttc ctctcctatg 2701 atccttttga caaggtgctg aaggtgctgc tctcgccgga ctatctggtg gccatgcgca 2761 ggcgccgctc ctcggatccg ctgggcgata cggccaccaa tttgggcaat gccatggacg 2821 atctgatcaa gcatcatccg tatttgcgag ccgatgccac ggaggcgatt gtgaggcttt 2881 tgaatgagct ggttcgcctt ggttccgatc ccagtttcat ttgctggcgg gccaacaagg 2941 agagcagtgg ctctggctcg ggttcaggca gccatggcgg cggcggttcg catcacgtgg 3001 cctccacacc ctcgcccatg gccgtcatgg tggctggctc gggaggatcg acgtcggtgc 3061 tccagggagc cgcggatacg aacgacagca gcggcgacga tgacgacgat gatgatgaaa 3121 tgagctcggc ttcgcagcaa cagcagcaaa gtggaggagc caccacaccc aggacgcaac 3181 aaccaggagg aggagtagcc accccgcagg ccgtcaaggt ggtgacgccc ccggaacgag 3241 aggcaatacc cctaatcgac tatatcttga atgtgatgaa gttcatcgag gcgattttca 3301 gcaacagtcc gaatggcgat cactgccggg agtttgtcct ccacggcgga ctaaagccca 3361 ttctgcaact gctgtcgctg cccaatctgc cggtggattc acccgtttcc accacctcac 3421 aggcggtggc caatgtctgc aaggccatac tcagccaggc gcaggaaacg aaggttctcg 3481 atgtggcgct caagcagctg gctgatattg tggcccagct gaagccgctg atcaagcact 3541 ttacctttcc cggcggcagt gtcctcctcg cagagctcgt ctgctgtcag cggctggagg 3601 atggcttcgc caatgccgaa tacacaccga tactgcacaa catgagcttt gtgcacggct 3661 atgtggtgat gctggtgcat ctctgtcgca acgcctccaa cgacatgcga gcgattctgc 3721 tcaagcgttg gggcgtcaat cgcgagactg gagtgcaatt gctgcagcag ctggtccagc 3781 tgtacatttc gctggtgtgg gagagcacca tactgctgaa tctctgctcg gatgagccca 3841 cccagcatcc ggatctcatt tgggacgaga ttgcggccca gatgtcggcg gcagcgggca 3901 ccgcggatcc cctgaccgaa gcggagctct cgcggaagct ggagcgtgcg gcggaattcc 3961 ggacgaagta ctcgcccgag gagcagttcc ggtacatcaa atccctgctg gcggcgagct 4021 ctcggctcgg cagggcgctc gccgagctgc tgggcacgct ggtgaagcta tcggtgggtt 4081 cgccgcagac gcgacagcga cgcatcaacg atctgatcag caatatcaac aaagttccta 4141 cgcccgaggc tcgcgaaata gcccgcatcc tcagctcgat tctggtgaat ggcttcagtc 4201 acgagagcat tctaccgaag cctgtgccca agttgaagct caccttcctc atctgctcgg 4261 tgggattcac cggtccaatg ctgttcgacg acaagcgcag cgcctttcac ctgatgatat 4321 cgcaattctg cgcagagaat ggattgaaag ccttctttga gatgttctac tgggcgctgt 4381 cgctggataa tgtctcgcag aagttcgatt tcgatcagtg ggcctcgatg gaggatctga 4441 tgcagtcgca cgaggacgac aagcgcgatt gccccgaggg cacgggcgag tttctcgacg 4501 cctggctgca gctgctcgag aagatggtga atccgcgtgc catgctcgat tcgccgtata 4561 cgatgagtcc gcggctgaat tacctgcccg attcggtgcc cttcgagccg gtcttttacc 4621 tcattcacat ccaccagctg gccatgcagg cactgcgcag gatctgggca cgtcgcccga 4681 ttcccaacta tggacccagt atgttcgaga ccatgatact gatcctgaag catctgatca 4741 agtcgcatca aacgctgctc gatcgctatc acacgcggat gaaggagatc aagttcgaga 4801 acctctacat ccgcagcacg gacgatggcc taaatgcgga tcacatcaag acgctgacgg 4861 acatgggctt catgcattac cacgttattg aggctctccg cacgaatgcc tcgctggagg 4921 aggccaccga ttatctgctg aataacccag aagccagtgc tttgtccaca acgactggtg 4981 gttctgctgc tcctccgccg ccgccaccgc caccgccttc caccatggac attgacatgg 5041 atttgccagc ggatggggga gagaaatcta gctctagttc ggcgaactcc agctatgact 5101 acaagcacct caaactgatg ccgtcgatca tcttcgatcg cttctgcgac gaggccattt 5161 cgcgggcctt tgagttcatg gaggccattc cggatacggt gaacagtgcc gcagatctga 5221 tagccgtgct gtatagacgc cacaatcacc tgaacaagca ggtctttgtg accaactttg 5281 tgcgcaacat tatccagtgg gtggacttta ccctgcagct ctttgaacca tcgaaaacgg 5341 cagcgtcgaa ggcttcgcgg ttggaggaat gcttgacggg attgacggcc acccggttgt 5401 ttgtgcggct caagacatcg acgcggctgc tcgaggagaa ctacagtgat ttgcatcgtc 5461 cgctggtgga ggcaataacc gcccaggatg ccatggtgtc gctggtcaag ctgctcgact 5521 gcatgagcca gtggatgctg gagcaatcag tggattctag ggctacggtc ccccgatggg 5581 tgcagaacct ggtggatcta atcgattcga tcgacagcat cagccacatt ctgcagcgca 5641 aggccaacat gcgggcggtg agcagcgagg tgtggcgctg gtacgacgcc tccacgggca 5701 agtggaatgc ctattcggag gccaacaatg agctcattcg gaatgcctat gccgccggcg 5761 agcggtggct gcacattaac atcggcaggc aaaggtgtac ggtgagcctg aactgcatga 5821 cgcaggtgag cgaggcatcc ggcacacatc gtcctgtttg tccggctctc aagctcagtg 5881 aagccatcac tgcgctcaac agtcccgtgt cgctgcacaa agtggagcat ctgctgaacc 5941 gcgtggtgcg aacctcaccc gatggctcgg gaaccgtgca ttccgacgaa ttgatttccc 6001 tgcgccagct gatcaacttt tcggatggtc agcagccgca ggagaacccg gcgaatgaag 6061 agggaacaaa tgaagatagt ggatctcctc tggccgccat gaccacgcgc agcaagtcgc 6121 ggcaaaagag cgccgccgct gcagccgctg cccagaagaa atcctcgtcg catggctcac 6181 cgcccatacc caaacgcacc cagaagatca tactcaacga ggagcaggtg ggactgagta 6241 aattcgactg cggtcggata attggcagca ttgtggatct cctgcagcct tcgcatctca 6301 tgctcaacga aacgaagctt tcgctgctgc ggctgtgtgc aagattaacc cgaaactacg 6361 acaatgccca ggtgttcatc cggcggggcg gcgttaagat gctgctgcat ctgcagcagg 6421 cctgcagctt catgggcttc cccacctatg cgaatatcat actgcgtcac gtgctcgagg 6481 cgccgccggt gctgcaggag gccatggaac gagtgctggg catgcgggca gccggcattg 6541 tgcccgtggg gcatcgggat ctaatctatg tactcaccca ggtatcctca gcggtttcgc 6601 gcaatccgca gatctttgtg gccgccgcca aggagatgct caagggagag tacctcctga 6661 acacgaacag cacgacgctg gcggacgatg cgcgggtgat ggtcaagtcc aagtttggtc 6721 aacaaccgac ggcagcggct ggcggagcca cgccaaattc gcagacgtcc acgccgccgg 6781 atgagcagct caaggacgat ccccaggttc agtcatcggt ggctgtgctt aaggatctac 6841 tgcatggatt ggtgcagccc tgctggcact acggcggcac gggatccttg gatcgcggcc 6901 ctggcgccgc cgagctgctg caaccggacc agccaccggg aacggccgcc cagggaggcc 6961 acgacgagga gttgtatttc cgcttccagg aaacccccgc acctgcgagc agcaagaagc 7021 aatcctcagg aggaggagca tctgctgggc agccacagac gacggagaag ttcgagccct 7081 gctgctgcac gtggcacatc ccgaccagcg gccacacgca cgccaagccg accatttcgc 7141 gggcgacgct gctcaagctg ctggcggatt caacgagggc ctatcagtct ttagtgcccc 7201 gcgtgctgct atcccacatt tacacgcccg ccgacagtcc gctgatctcg gcgccgcagc 7261 agacgttcct gggcgtcctc ctcgatcgct ttctgcccat cacgcagcgg catcatgtgc 7321 ccgaggtgag cacgatgacg agggtgctca tttgctccct ttctgactgc taccagcagc 7381 cgggagtcca ggtccatgtg gccgaggagc tgcacgcggc ggtggccagg gctttggccc 7441 aaccggactc ggcggagaag cacacgcgac tccaggtgct gatgagcctg tttcccaatc 7501 tcatcgagtc gccgatgctg tacgataagg tgcacatgca tcgcaacaac atgtaccgag 7561 tgctgctgcg ccagggagtg atgacctacc tgaccaaggt ggcccagtac aaggatctgt 7621 ccaatcacaa cacgctgagc actctggcgg ccatcctgcg acccatggag atcttgctga 7681 ggtttagtgt gtccaccaca acgctcggat cgaagaggat tctctttggc ggcggcggcg 7741 gaggagctgg cggagcaaat ggagcaggga gcgggaacag tgctgtcgga ggaggcagtg 7801 gaactggccc gggatcgggc aatacatatg gaaccatcat caatcgtcgg ctatatcctc 7861 gtttggccgc ccgcaccgca gtcagtgcgg ccgtggagcg atccaatgcg atgggtggcg 7921 agcatgtgct gcgcgacatt atacgcaatg tgctctccga tcggcggcac gcctttgagt 7981 ttatcttcaa ctcggacgag atggccgtgg actcggagga ctcggctgcc ccggcggtgg 8041 gtggtaatgg atcgggagca ggcggaatag gagcaggagg atcaggagca gccgtcatcg 8101 atgtggtgga ggagcgcagc aatggcgggg ataccagcga tcccccaggt aatgtaaact 8161 ccggatctgg aacgggcgca gttcaatctt caaccagtgg aggtcccgtg cggccagttc 8221 tgaactttga ccagctgtgg gacgacttcc tgcagagcga gggactgcga ttggcctcgc 8281 ggagcggcgg aggcgcggga tctggagcag gatccacagg agcaggctca acgggtcagc 8341 aaaacggtgg caatgccact ggtggctctg caaactccgg cagcaattca gtcagcggag 8401 atcctcgcct gcgcaccaat cccgatgtgg atgtgggcgg cggtggaaat ggcggtggtc 8461 agtcatccaa ttcgggtgtg gtaaacgata atggaattgg cggcggcggc ggcagcgatg 8521 gcgcctccac atcctcggac actggagctc cgggcggcga acgtcgcgat ttgaatgcct 8581 cgctgctggg cgatgtcagc acctcggaat ccgattcgga tgcctccacg gagaacgacg 8641 agcggaatga ggaggacgag gacgaggatg acgatgcccc cgatgaagat gtggacgagc 8701 atagcgaaac ggatgtggat gaggaaaggc cacgtcaatt tatcgaggtc tttgatcaca 8761 tctacgaacc ggaatcctcg gaaaccgctt ccaatgatgc ggatgtggat aacgacgacg 8821 atgatgacga ggatgaggac gatgtggacg acgacgatga tgatgacgag gataacgacg 8881 atgaggatcg cgaggagggc cagagtgtca tggatgccga gttggagaac caaatagaca 8941 ttgccctcgc cttggtttcg tccaacaatc gtccgcgacg cagtgcagcg gttaatgctt 9001 cgggcgatgc gtccgccaat cgagatccca atcccgacga ggaggtggac gacgaggacg 9061 acgatgtgga cgccgatccc gatggagatc ccgatgtgga ccccattggc ggcccctcgg 9121 ctgcccaggc ggaggcctat ctgtacgagc gactgggcag cggcctgatg cccacgccac 9181 cggtgggttt ccgcgtccgc atgaacagct cgattgccca gcccctggac attgatgtga 9241 atggcggaaa tggcggtggt ggatctggtg gatccggagc aggcgtcact ggaacggccg 9301 gtggatccgg aagaggctcc tcgtcgggcg gaacaacggc cagtattgga gccattgcct 9361 ccgctgcctt gcgtccctcg tccggttctt ggatggcgcc ggactttaat ttcattggag 9421 tctcgggcgg tggaggagcc agtggctctg gaggcgcctc agggagcaat gccaacgggg 9481 gcgaggtgaa cgccttcctc acgcccgcca tgtcgcagct ggaacgcagt ggtggcgcct 9541 cgggcagtgg ccaaaacatg agcaatctgc tggacgaaca accgtcggtc agtggcaacg 9601 gcggcggagg aggaggaagt ggcggaggtt ccgcctctgg taacggcggc gtcagcggtg 9661 gaggaggagc caatggcggc ggtaccgcag gacagcatcc gaatgccacg ctctgcgcca 9721 acggagtgcg ccggcggttg ctctatttgg accagcagta ctgcgtctgc atgcccacgc 9781 atcagaatcc cacggaagag acccagatgg agacgttcac ccaggatgct ctgcattggt 9841 ggctggagga ggccacggtc ttggatatgg agagccagac tgacgcctgc ctgtacgccg 9901 ctcacttcct gctgccgcat ctcatcaagg agctgaagac ggcccaccag cagcgcaagc 9961 aggaggaggc cgcccgccag acggccacga acaccacaac acctgcatca tcggcttcgt 10021 cttcggccgg agctccggcg acctccatcc tatcgaacac agcggcccca acagcgacgg 10081 cctccattgc gtccagtcta ctggcgaatg ccgtggccgc gggctcaggc ggcagcagca 10141 gcagcggcag cggattggtg gtgccaccgg tggcagcctc cgccacggga ggcacccggc 10201 gcagctcgat tcccgtgctg attccctcga gcttcggcgg tcctggtagt gcaaccactg 10261 gcgatgccac ggccacaacg ggaggaacca ccagcagcag ttcctacaca accacatcca 10321 ttagcggcag tggctccttg gagtcgcaga cgacgactcg agcgcctcgg caacgcggtg 10381 gattgcgcca gcacagccag ctgcccttca acatctacgc ggagatcgat ctgaccaacg 10441 aacaggatag ccagggcgcc acgtcaacgg gctctgctcc aaacgatgga gcggaatcac 10501 aggcacagca gccgcagcag cagcagcagc agcaaaactc ctccgctcct tcgttggcgc 10561 agggggcggt ccttcagcat cagcgtcatc caccggtgcc gctcctgccg tccagtggaa 10621 ggccttcgcg acctcactcg cgtctcgacg aggcggagct gcttctgttg cagttggccg 10681 atcgccaggc tgttcgcagt cgcctgcaag tgtccagcgg tcacacgaat tcctcgcgca 10741 cctcgggatc ggcgctgatc aacgctcggc ccaatcgcga tctacccgcc cgcctgcagc 10801 gcctcgtcca ggcacatggc tccctttcca gtcgcatcaa tgcatccgcc gccagcacgc 10861 cggctccgac gctcgtctcc atgcccacgc ccatgtccag tgcggcgctg gagcagctga 10921 atgtcacgcc cgccggcccg gatgttgtgg gcccagacag gaactttgca ttgccacctt 10981 ccctggaggt tgatgtggat gtgctgcctg gaatactgga tcgcatactg ccgcagcagc 11041 agcaggagca gcaggaagcg cagcagcagg aggaggagga ggaacagctg ttgctaccac 11101 cgccacctcc gccgccgccc agtgaaacgg cgcccttgct cctcaccgag gaggatatgt 11161 ggcaagggac aagagaggag gaggaggatt ccacttccac agtggcagtt gccggcagca 11221 gcgaggctgc aaacgagtca aaccaatcgg atcagacgcc ggagagcagc gaatctgttt 11281 ccccgaaccc gcaggctcct cccccagcag cagaatccgg cgaaggagga gcagggggag 11341 caggaggagc tgcctcggct agcacacaaa ccccggcaac cgcagaagaa tccgctgtag 11401 gtggaacaac agcaacagca acaacgacag cagccaccgt aacggacatg agtcccgagg 11461 tgcgggccgc tctcggggat ctggaggtgc ccgagggcgt ggatccctcc ttcctggccg 11521 ccctgcccag cgagatgcgc gaggaggtga tccaggagca tctgcggatg cagcgcattc 11581 gccagcgggc gcagcagaat gccattcaga ttgcgcacga ttcgctcgtc gaggtgaatc 11641 ccgagttcct cgccgccctg ccgctgaaca ttcagtccga ggtgctgatg cagcagcgga 11701 tcgagcagca gcgccaggcg gcgcagaccg cgaatcccga ggatcccgtc gacacggccg 11761 ccttctttca gaacctgccc gagaatctgc ggcaagcgat actcaccgac atggaggagt 11821 cgcagatagc cagtttgccg cccgagttgg cggcggaggc gcagttcctg cgtcgcgact 11881 gggagtcccg caatggcgcc cgcatggacg cccatccgcc cagcaatgcg ttgtcccgct 11941 tccagacgac gctgcagagc ctggacgagg cccgctggca cagctccatt tggtacgacg 12001 ccagcggcaa tgcccagccg cagcaccacc agcacaccac gattgtgcac caccatgccc 12061 acgcacatca cgcccccacg atgggcaaac ccctagccct gctgatgatg gaggacgaga 12121 acatcctgct cgatccggac tcgctggcca ccctgctgct cttcctgttc gtcgaggatc 12181 agaaggtgaa cagcatgcgg ctgcatcgtg tgattcgcaa cctttgccac cacgaaccca 12241 cgcgcgattg gatcatcagc gctctgatta gcatcgtcca aaagaccaac gaggataacg 12301 ccaactttgg agctggacag gcgggcggca aaccggagtg gctgaagctg cgcgtggacg 12361 ccgcctttgg ctacaagagc aacatcttcc tcatcaatcg gctgtacgag ggcagtgcgc 12421 ggagcatcag catcaatccg caggccgcac agatgatagt gcgcaactgt ctggatctgc 12481 tcttcgtgct ggccaagcac tatccgtcca gctttgtgcc cttcaaccgc gaggtgaagg 12541 ccaggcgcat actgagtgcg gtatttggca tgccatcgcc cacgggtggt gcttctactg 12601 ctggagctgg agctcctgca cgcaatatag atgactttcc accgcccggc ggaactctgg 12661 actttcgctc gcgtttctgc cgctaccagg tggccaatcg actgcgcggc atactcgacg 12721 atcatccggc ggcggccccg aaaccccaaa gtgcaactcc cctggatgag gcaccctcca 12781 catcgaaggc ggctgctgcc aaggcagctg ccacggctaa ggtttcgagt cagagcagtc 12841 agtcggtgcc gtatcaaacg aatgcgaaga atttctggga tgtggtgctc aacatcgatc 12901 gacagaccca agtgcgtttg gccaatgtgg cccagtttcc actcacctcg cagccagctt 12961 gggaatggca agcgaacagc gccgacttcc tgtcgttcag cgattcgcct ttcggacagc 13021 tgctggaaat gctgccctac aaggtcatct gccggtcgcc acatctcacc gatatgctgg 13081 tcaagttgct cgcctcgctg agcaccgagt tgcccaagga ggaggaacag ttgccgctga 13141 gcgatcaaat gcccaccctg atacccatta atcaggcggc ggcagcggca gcagattccc 13201 cagcgaatcc atcagagatt ggtgacggac tggccgcaaa tgtggagcag gaagccacgc 13261 cggccagcgg taatccagcc tccggtgaca gcaatgcggc tgccaagcga acacagctgc 13321 ccacattgag tgtagccctg ccagttgctc cgtcgaagcc gcggcgcaag atctactcga 13381 agaacttctc gcaactgcag ctggtcatcg aggtgctgac ccaccagtgc ggcaccaccg 13441 agggcctgga caacgtggcc aagctgattg tgaatctaac gcagtgctcg caggcatcca 13501 atgcgatttt cattcagtac ctgaccgctg ccatcctggg attggccgag gaggtgcgcc 13561 aggcgataca gatgctgctg aatgagatac gcatgtacaa cagtcatcat ggagtgacgg 13621 cctccacatc cggagcagcg gcagcgggag ccaccgtttc aggagccagt ctgctgccta 13681 acctcgccgt tcacgagggc atcatgcagg atcgcttcac cgccgagcat gtcatcattt 13741 cggcgccgaa gaacgccaag cccacctgcg aactccagct gccgtcgatg aagaagctta 13801 tgtccaactc atccgcccag ccgtacttcc tgcgcaccct gaagatcttc atgcaggtgc 13861 gcgacatgta cgaggcgcag aatggtttat ccacgggcgg tggtttggct ggagcagctg 13921 gcgacaacga tgacgacatc atcgacattg agggcgatgg cggagcttcg ggcggcagca 13981 gttcggatat ggcgcccggt tcggcgagca caatatctcc gccgccgccg ccaccgatgg 14041 aaaccaatca gaacattaac gatgaggagg aggatgagga tggggaggag gaggaggacg 14101 atgatgatgc ggccagggca tcgccagcgg cggcaagtgc tggcaagtca agcaagccca 14161 cgctcagcca gatcctctgc ctcgacgtcc tttggcacac gctcagcgaa tgcctggtgg 14221 cgctggagga gtccaaggac gagttcgccg tcctggtgct gcagcccacc gtggaggcct 14281 tcttcctcat ccacgcctcg catcgcgcgg gggctaagaa gtcgggtcgc ggcggagttg 14341 tgggctccgg actgcgggca gctggaggat tgggagcagc tgcgtcggcg gcccaggagc 14401 acagtccatc gatggacgac accagcagcg ccaataccct tagttcggcc agtttcgaag 14461 atgagccgcg aatgcaggac gcctccacaa acacgccgct ttcgagcaac agctccgccg 14521 ccaccactgt gctgagcgca cacgaggcgc agctgcgaca ggatcgccag aagttcctgc 14581 agttcgccga gaaacaccgc accgtgctca accaaatact gcgccagtcg cccactcatc 14641 tctccgacgg acccttcgcc gttctcgtcg accacacgcg catcctggac tttgacgtca 14701 agcggaagta cttccagacg gagctggagc gcctggacga gggcattcgg cgcgaggagc 14761 acacggtcag tgtgcggcgc gtgaccgtct tcgaggattc gttccgcgtg ttgtaccgcc 14821 tgggaccgga ggagtggaag aaccgcttct acattgtctt cgaggacgag gaaggccagg 14881 atgctggcgg cctgctgcgc gaatggtatg tgatcatatc gcgcgagatc ttcaatccga 14941 tgtatgcctt gttctgcgta tcgccgggcg atcgcgtcac ctacatgatc aatccctcca 15001 gccatgccaa tccgaatcat ctgagctact tcaagttcgt cggccgcgta attgccaagg 15061 ccgtgcacga taacaagctg ctggagtgct acttcacccg atccttctac aagcacatcc 15121 tgggcaagca ggtgaagcac acggacatgg agtcgcagga ctacgagttc tacaagggcc 15181 tcgactatct gatgaagaac gacatctcca ccctgggcta cgagctgacc ttctccacgg 15241 aggtgcagga gttcggtgtc acccagatcc gtgatctcaa gccaaacgga cgcgacaccg 15301 cggtgaccga ggaaaacaag ttcgagtatg tgcagctggt gtgccagctg aagatgagcg 15361 gctccattcg acagcaattg gacgcattcc tcgagggctt ctacgacatt attccaaagc 15421 atttaatttc gatattcaac gaacaggaac tggaacttct catatccggc ctgccggata 15481 ttgacattga agatctaaag gcgaacaccg agtaccacaa gtacacctcc aaatcggccc 15541 agattcaatg gttctggcgt gcattgcgca gcttcgacca agcggaccgg gccaagttcc 15601 tgcagttcgt cactggcaca tcgaaggtgc cgctgcaggg cttcggctcc ctggagggca 15661 tgaacgggat tcagaagttc caaatccatc gggacgatcg gtccactgat cgattgccct 15721 gtgcacacac ctgcttcaac caactggatc ttccgatgta caagtcatac gacaaactgc 15781 ggagctgctt gctgaaggcc atacacgagt gctccgaggg ctttggcttc gcctaagcgg 15841 gaacatcagt ggctttcggt cctccagcct ccagcgaggc cagccaacca agcagccagg 15901 aacccatgga cgcaactcta ttcctagttc gcccaattca cgggcgacac gacgagaaat 15961 gcataattga tttgaacaga acagaacagc cactgctaat ttgcgatagc ggcaacagaa 16021 actgcataca tacacagtac atatagttat atagtatata taaaaatgtt gaattaatta 16081 ttaattttcg cgcctatata tatacaatat atattttctt aaattttcaa aagaaaacgg 16141 aaaaaagtct aaggaaacct acaaaaaaaa aataagatac aaacgcgaaa cagcatattc 16201 gatttaaatt tgtctgcgta actcatccct attatatatt ttctcggaat ctatccctgt 16261 cgttttgcac attttcatta aaacaaaagg atttatataa aaaaacatac acaatttgac 16321 atatttttat ttacctaaac acgaaaccga atagcaaagg attaaacgta gtctatagaa 16381 cgcaaatgca aatgcacata aacagatttc ttgtttactt aagtgaattt accgaagatg 16441 agacggggag gcagcggaaa taattaaatg gattaaagta tttcgatgta agagataagt 16501 ccttatgtta tgcattttat gtttaccttt ggaataatga gccgcagatg taacttaaag 16561 aatgtggaat aaagtaagag taagctcatt tatcaaaata