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LOCUS XM_070218426 14129 bp mRNA linear INV 09-DEC-2024 (trol), transcript variant X9, mRNA. ACCESSION XM_070218426 VERSION XM_070218426.1 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..14129 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..14129 /gene="trol" /note="terribly reduced optic lobes; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 8 Proteins" /db_xref="GeneID:108055788" CDS 209..13456 /gene="trol" /codon_start=1 /product="basement membrane-specific heparan sulfate proteoglycan core protein isoform X9" /protein_id="XP_070074527.1" /db_xref="GeneID:108055788" /translation="MGSPGSQAPAIAIGISNGRRGHTGSLLLRLLLVAFVLNACHVPP TNAKQITKSKVDDQDFILADTQSLQGSVDLDDDEAFLIPPDSEEKLDKKFTPEGNWWS QGLHRVRRSLNSFFGSDDDDQEKERERQRQRQNNRDAANRQKELRRQQKESQNREKQL RLERQERQRLAKRNNHVVFNRVTDPRKRASDLYDENEASGLNEEETTTYRTYFVVNEP YSDDYKERDSLQFQNLQKLLDEDLRNFFNRNFENNDDEEQEIHSTLERVDQTKDHFKI RVQLRVDLPSSINDFGSKLEQQLNVYKRIDRLGASTDGVFTFTESSVYKYEHQYDIVT PRVIVSGQPITEKPVEAPQEFDEDPIEVALPTDEVEGSGQDSGSCRGDATFQCRRSGK TICDEMRCDGSRDCPDAEDEEGCEVCNELQFKCDNKCLPLNKRCDNRYDCEDQTDEAG CQRYEVEESQPQPQPQPQPEPEPEPEPEPEPEPEPEPEPEEPITDNEQPEQNSECRAT EFRCNNGDCIDIRKRCDHISDCSEGEDENEECPAACSGMEYQCRDGTRCISLSQQCDG HSDCSDADDEEHCDGSGNDGEDCRFDEFRCGTGECIPMRQVCDNIYDCNDYSDEVSCA EEEEDSVGIPIGRPPQRPAPKHDWLDELDANEYHVYHPSNVYELANSKNPCASNQFRC ATTNVCIPLHLRCDNFYHCNDMSDEKDCEQYQRRTTTTTRRPSTSARPSFTFTFTTQG PGLLERRNSTTSRTTAGSTTRATEAPQWPWATRPTETTTTNPITTVGVANLNGRLNKT RLGVQCQENQYQCGDGSCISGYKRCNGINDCADDADEYNCIYTYNEDYVDPDDNPLNE CDILEFECDYSLCLPLEKKCDGYADCEDLSDEFECQSYTENCLLSEFECDGYCLPRDQ LCNGIINCQDGSDERNCTFCREDAYLCTTGECVAVNQRCNGIVECADGSDERHCVVNT TETNYHYPTHNPKPKTCRTHEWQCTNLECIEMRLKCDDVPDCSDGSDEDLSICFGTAT TRLKPSDCGPDQFFCDDLCYNRSIRCNGHMDCSDGSDEIACSSLSVLPCPQHQCPSGR CYSESERCDRHRHCEDGSDEANCCYADQFRCNNGDCIAESAHCDGNIDCSDQSDELDC GGDSQCLPNQFRCKNGQCVSSTARCNKRSDCLDGSDEQNCANEPNNSGRGTNQLKLKT YPDNQIIKESREVIFRCRDEGPNRAKVKWSRPGGRPLPPGFTDRNGRLEIPNIRVEDA GAYVCEAVGYANYIPGQHVTVNLNVERLNEREIRPDSACTEYQATCMNGECIDKSGIC DGHPDCSDGSDEHSCSLGLKCQPNQFMCSNSKCVDRTWRCDGENDCGDNSDETSCDPE PSDAPCRYDEFQCRSGHCIPKSFQCDYMNDCTDGTDEIGCSVPSPMTLPAPSIVVMEY EVLELTCVGTGVPTPTIVWRLNWGHVPEKCESKSYGGTGTLRCPNMRPQDSGAYSCEF INTRGTFYPKTNSIVTVTPVRSDVCKAGFFNMLARKSEECVQCFCFGVSTNCDSANLF TYAIQPPILSHRVVSVELSPFRQIVINEASPGQDLLTLHHGVQFRASNVHYNGRETPF LALPAEYMGNQLKSYGGNLRYEVRYNGNGRPVSGPDVIITGNSFTLTHRVRTHPGQNN RVTIPFLPGGWTKPDGRKGTREDIMMILANVDNILIRLGYLDSTAREVDLINIALDSA GSADQGLGSASLVEKCTCPPGYVGDSCESCASGYVRQARGPWLGHCVPFTPEPCPAGT YGNPRLGVPCQECPCPHAGANNFASGCQQSPDGDVICRCNEGYAGKRCEHCAQGYQGN PLAPGGVCRKIPDSSCNVDGTYNIYSNGTCQCKDSVIGEQCDTCAPKSFHLNSFTYTG CIECFCSGVGLDCDSSSWYRNQVTSTFGRTRVNHGFALISDYMRNTPVTVPVSMSTQA NALSFVGSAEQAGNTLYWSLPAAFLGNKLTSYGGKLSYTLSYSPLPSGIMSRNSAPDV VIKSGEDLRLIHYRKSQVSPSVANTYAVEIKESAWQRGDELVPNREHVLMALSNITAI YIKATYTTSTKEASLRSVTLDTATATNLGTARAVEVEQCRCPEGYLGLSCEQCAPGYT RDPEAGIYLGLCRPCECNGHSKYCNSETGECESCSDNTEGFNCDRCAAGYVGDATRGT SYDCQYDDGGYPTSRPPAPGNQTAECLVNCQQEGTAGCRGYQCECKRNVAGDRCDQCR PGTYGLSAQNPDGCKECYCSGLTNQCRSASLYRQLIPVDFISTPPLITDEFGDIMDRD NLVPDVPRNVYTYKHTSYTPKYWSLRGSVLGNQLLSYGGRLEYSLIVESVGRDHRGKD VVLIGNGLKLIWSRPDGHDNEQEYHVRLHEDEQWTVEDRGSARQATRADFMTVLSDLQ HILILATPKVPTVSTSISNVILESSITTRAPGATHASDIELCQCPSGYTGTSCESCAP LHYRDASGRCSQCPCDASNTESCGLVSGGNVECQCRPRWRGDRCREIDTSPIIEEPPQ ICDLSRGFCCSGFQFDIAPNETISFNDTLQIYKGNRIIGNMTKLRYGCPSRETNEPTP EPDTSTDDPVRTQIIVSIARPEITILPVGGSLTLSCTGRMRWTNSPVFVNWYKQGSHL PEGVEVQGGNLQLFNLQISDSGIYICQAVSNETGHSFTDHVSITVSQEDQRSPAHIVD LPNDVTFEEYVSNEIVCEVEGNPPPTVTWTRVDGHADAQSTRTDNNRLVFDSPRKSDE GRYRCQAENSLSREEKYVVVYVRSNPPQPPPQQDRLYITPQEVNGVAGDSFQLSCQFT SAASLRYDWSHDGRSLSASSPRNVVVRGNVLEVRDANVRDSGTYTCVAFDLRTRRNFT ESARVYIEQPNEPGILGDKPHILTLEQNIIIVQGEDLSITCEASGTPYPSIKWTKVQE NLAENVRISGNVLTIYGGRSENRGLYSCIAENSHGSDQSSTSIDIEPRERPSLTIDTA TQKVSVGSQASLYCAAQGIPEPTVEWVRTDGQPLSPRHKVQAPGYVVIDDIVLDDSGT YECRASNIAGQVSGLATINVQEPTLVRIEPDRQHHIVTQGDELSLSCVGSGVPTPSVF WSFEGRDVDRMGVPEGAVFAQPFRTNTADVKIFRVSKENEGIYVCHGSNDAGEDQQYI RVEVQPRRGDVGAGGDDNGDVDTRQPPNRPQIQPNPLSNERLTTELGNNVTLICNVDN VNTEWERVDGTPLPHNAYTVRNTLVIVFVEPQNLGQYRCNGIGRDGRVEAHVVRELVL LPLPRITFYPNIPLTVELGQNLDVYCQVENVRPEDVHWTTDNNRPLPSSVRIEGNVLR FASITQAAAGEYRCSATNQYGSRSKNARVVVKQPSGFQPVPHSQVQQRQVGDSIQLRC RLTTQYGDEVRGNIQFNWYREDGSPLPRGVRPDSQVLQLVKLQPEDEGRYICNSYDLG SGQQLPPVSIDLQVLRTTTQYPFNRFKGGVSLKDTPCMVLYICAAVPAAPQNPIYLPP VAPPRSPERILEPQLSLSVQSSNLPAGDGTTVECFSSDDSYPDVVWERADGAPLSENV QQVGNNLVISNVASTDAGNYVCKCKTDEGDLYTTSYKLEVEEQPHELKSSKIVYAKVG GNADLQCGADEDRQPSYRWSRQYGQLQAGRSLQNEKLSLDRVQANDAGTYVCSAQYSD GETVDFPNILVVTGAIPQFRQEPRSYMSFPTLSNSSFKFNFELTFRPENADGLLLFNG QTRGSGDYIALSLKDRYAEFRFDFGGKPLLVRAEEPLALDEWHTVRVSRFKRDGYIQV DDQHPVAFPTSQHQQIPQLELIEDLYIGGVPNWEFLPAEAVGQQSGFVGCISRLTLQG RTVELIREAKFKEGITDCRPCAQGPCQNKGVCLESQTEQAYTCVCQPGWTGRDCAIEG TQCTAGVCGSGRCENTENDMECLCPLNRAGDRCQYNEILNEQSLNFKSNSFAAYGTPK VTKVNITLSVRPASLEDSVILYTAESTLPSGDYLALVLRGGHAELLINTAARLDPVVV RSAEPLPLNRWTRIEIRRRLGEGILKVGDGPERKAKAPGSDRILSLKTHLFVGGVDRS TVKINRDVNITKGFDGCISKLYNSQKSVNLLGDIRDAANVQNCGEANEIDDDEYEMPV ALPSPKVAENERQLMAPCASDPCENGGSCSEQEDMAICSCPFGFSGKHCQNHLQLSFN ASFRGDGYVELNRSHFQPALEQTYSHIGIVFTTNKPNGLLFWWGQEAGEEYTGQDFIA AAVVDGYVEYSMRLDGEEAVIRNSDIRVDNGERHIVIAKRDENTAMLELDQILDTGDT RPTINKAMKLPGNVFVGGAPDVAAFTGFRYKDNFNGCIVVVEGETVGQINLSSAAING VNANVCPANDEPLGGTEPPVV" misc_feature 458..>715 /gene="trol" /note="Coiled-coil domain-containing protein 66; Region: CCDC66; pfam15236" /db_xref="CDD:434558" misc_feature 1460..1561 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1475..1477,1496..1498,1529..1534) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1508..1510,1517..1519,1529..1531,1547..1552) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1538..1552 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1718..1816 /gene="trol" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(1736..1738,1760..1762,1793..1798) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1772..1774,1781..1783,1793..1795,1811..1816) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1802..1816 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1838..1945 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1853..1855,1880..1882,1913..1918) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1892..1894,1901..1903,1913..1915,1931..1936) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1922..1936 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1973..2077 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1988..1990,2012..2014,2045..2050) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2024..2026,2033..2035,2045..2047,2063..2068) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2054..2068 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2231..2338 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2246..2248,2273..2275,2306..2311) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2285..2287,2294..2296,2306..2308,2324..2329) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2315..2329 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2618..2722 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2633..2635,2657..2659,2690..2695) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2669..2671,2678..2680,2690..2692,2708..2713) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2699..2713 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2777..2881 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2792..2794,2816..2818,2849..2854) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2828..2830,2837..2839,2849..2851,2867..2872) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2858..2872 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2900..3001 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2915..2917,2936..2938,2969..2974) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2948..2950,2957..2959,2969..2971,2987..2992) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2978..2992 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3008..3112 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3023..3025,3047..3049,3080..3085) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3059..3061,3068..3070,3080..3082,3098..3103) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3089..3103 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3170..3268 /gene="trol" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(3188..3190,3212..3214,3245..3250) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3224..3226,3233..3235,3245..3247,3263..3268) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3254..3268 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3320..3421 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3335..3337,3356..3358,3389..3394) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3368..3370,3377..3379,3389..3391,3407..3412) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3398..3412 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3449..3541 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3452..3454,3476..3478,3509..3514) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3488..3490,3497..3499,3509..3511,3527..3532) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3518..3532 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3542..3646 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3557..3559,3581..3583,3614..3619) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3593..3595,3602..3604,3614..3616,3632..3637) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3623..3637 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3662..3766 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3677..3679,3701..3703,3734..3739) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3713..3715,3722..3724,3734..3736,3752..3757) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3743..3757 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3809..4015 /gene="trol" /note="Immunoglobulin domain; Region: Ig_3; pfam13927" /db_xref="CDD:464046" misc_feature 4109..4213 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4124..4126,4148..4150,4181..4186) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4160..4162,4169..4171,4181..4183,4199..4204) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4190..4204 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4229..4333 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4244..4246,4268..4270,4301..4306) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4280..4282,4289..4291,4301..4303,4319..4324) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4310..4324 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4358..4462 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4373..4375,4397..4399,4430..4435) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4409..4411,4418..4420,4430..4432,4448..4453) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4439..4453 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4514..4741 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 4523..4537 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 4562..4576 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 4631..4645 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 4673..4690 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 4715..4726 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature 5036..5428 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature 5597..5758 /gene="trol" /note="Laminin EGF domain; Region: Laminin_EGF; pfam00053" /db_xref="CDD:395007" misc_feature order(5597..5599,5603..5605,5639..5641,5669..5671, 5675..5677,5702..5704) /gene="trol" /note="EGF-like motif [active]" /db_xref="CDD:238012" misc_feature 6131..6541 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature <6542..6622 /gene="trol" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; Region: EGF_Lam; cd00055" /db_xref="CDD:238012" misc_feature 6644..6793 /gene="trol" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; Region: EGF_Lam; cd00055" /db_xref="CDD:238012" misc_feature order(6647..6649,6653..6655,6674..6676,6695..6697, 6704..6706,6731..6733) /gene="trol" /note="EGF-like motif [active]" /db_xref="CDD:238012" misc_feature <6902..6994 /gene="trol" /note="Laminin EGF domain; Region: Laminin_EGF; pfam00053" /db_xref="CDD:395007" misc_feature 7190..7594 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature 8057..8305 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 8090..8104 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 8138..8152 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 8195..8209 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 8237..8254 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 8282..8293 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature <8384..8545 /gene="trol" /note="Immunoglobulin domain; Region: Ig_3; pfam13927" /db_xref="CDD:464046" misc_feature 8636..8887 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 8669..8683 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 8708..8722 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 8777..8791 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 8819..8836 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 8924..9166 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 8975..8989 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409570" misc_feature 9014..9028 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409570" misc_feature 9071..9085 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409570" misc_feature 9113..9130 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409570" misc_feature 9152..9163 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409570" misc_feature 9218..9448 /gene="trol" /note="Immunoglobulin I-set domain; Region: I-set; pfam07679" /db_xref="CDD:400151" misc_feature 9242..9256 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 9281..9295 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 9344..9358 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 9386..9403 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 9425..9436 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature 9485..9748 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 9515..9529 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 9554..9568 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 9686..9703 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 10121..10351 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 10148..10162 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 10187..10201 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 10247..10261 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 10289..10306 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 10385..>10588 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 10418..10432 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 10466..10489 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 10535..10549 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 10835..11041 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 10907..10921 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 10970..10981 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 11009..11026 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 11111..11311 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 11135..11149 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 11174..11188 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 11231..11245 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 11273..11290 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 11375..11818 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" misc_feature 11885..11983 /gene="trol" /note="EGF-like domain; Region: EGF; pfam00008" /db_xref="CDD:394967" misc_feature 12125..12586 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" misc_feature 12746..12844 /gene="trol" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054" /db_xref="CDD:238011" misc_feature 12869..13330 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" polyA_site 14129 /gene="trol" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN 1 attaggttgc gcgccatcgt tccaggcggt cgcacattcc acgtgccata gccgtaacaa 61 caacctgcca accgcttaaa accaaactca aatacgaacc gaaactgcct tcacacacac 121 aagtacctaa accaaatcta aatagctgcc aaaagaaacc aaaaattcca gagacgtcgt 181 agcatccgtt ccccggaaga agaagaagat gggatcgccg ggatcccaag cgcccgcgat 241 cgcgatcggg atcagtaacg ggcggagagg tcacacgggg tcgctgctcc tgcgcctcct 301 tctcgtggcc ttcgtcctca acgcctgcca cgtacccccg accaatgcca agcaaattac 361 gaaaagtaaa gttgatgacc aggactttat actggccgac acacaatcgc tgcagggcag 421 cgttgacctt gacgatgacg aagcgttcct gattcctccg gattccgaag agaagttgga 481 taagaagttc acgccggagg gcaactggtg gagccagggg ctccatcgtg ttcgccgctc 541 cctaaatagc ttcttcggct ccgacgacga tgatcaggaa aaggaacgtg agcgtcagag 601 gcaaaggcaa aataatcgcg atgccgccaa ccggcaaaag gaacttcggc gccagcaaaa 661 ggagagccag aaccgcgaga agcagctgcg attggagcgc caggagaggc agcgccttgc 721 caagcggaac aatcacgtgg tcttcaatcg cgtcaccgat ccccgcaagc gggcatccga 781 cctttacgac gagaacgagg catctggcct aaacgaggag gaaaccacca cctatcgcac 841 ctactttgtt gttaatgagc catattcaga cgactacaag gagcgggaca gcctccagtt 901 ccagaatctg caaaaacttc ttgacgagga cctgcgcaac ttcttcaatc gcaatttcga 961 aaataacgat gatgaagagc aggaaatcca tagcacccta gagcgagtcg atcaaaccaa 1021 ggaccatttt aaaattcgcg tgcaacttag ggtagatctg cccagttcaa tcaacgactt 1081 tggaagtaag ttggagcaac aactgaatgt ctacaagcga atcgatcgtt tgggtgccag 1141 taccgatggc gtcttcacct ttaccgaatc gagcgtctac aaatacgaac accaatacga 1201 tattgtgaca ccgagagtaa ttgtatctgg acaaccgata actgaaaaac cagtcgaagc 1261 accccaagaa ttcgatgagg atcctatcga agttgcattg cccacggatg aggtggaggg 1321 ctccggccaa gattccggta gctgtcgcgg cgatgccacc ttccagtgtc gaaggagtgg 1381 aaagactatt tgcgatgaaa tgcgatgcga tggatctcgc gattgtcccg atgccgagga 1441 cgaggaaggc tgcgaggttt gcaacgaact tcagttcaag tgcgataaca agtgtctgcc 1501 gctcaataag cgctgcgata atcgatacga ttgtgaggat cagacggacg aggctggttg 1561 tcaacggtac gaagtagaag agtctcagcc tcagccgcag ccgcaacctc agcctgaacc 1621 ggaacctgaa cctgaacctg agcctgagcc tgaacctgaa ccagaaccag aacctgaaga 1681 gcctataaca gacaatgaac agcctgagca aaactcagaa tgccgggcca ccgagttcag 1741 atgcaacaat ggggactgca tcgatattag aaagcgttgc gatcacattt cggactgtag 1801 cgaaggcgag gacgagaacg aggagtgccc cgccgcctgc agcggaatgg agtatcaatg 1861 tcgcgacggc acgcgctgca taagtttgag tcagcagtgc gacggtcatt ccgattgcag 1921 cgacgccgac gacgaggagc attgcgacgg aagtggtaac gatggtgagg attgtcggtt 1981 cgatgagttc cgttgcggaa ctggtgagtg cataccgatg cgtcaggtgt gcgataacat 2041 ctacgattgc aacgattatt ccgatgaggt cagctgcgcc gaggaggagg aagatagtgt 2101 gggcataccc attggccgtc caccgcagag gccagcgccc aaacacgact ggctggacga 2161 attggacgcc aatgagtacc acgtctatca tccaagtaat gtctatgagt tggccaattc 2221 caagaatccc tgtgccagca atcaatttcg ctgcgccacc acgaatgtgt gcatccccct 2281 gcatttgcgt tgcgataatt tctatcactg caacgatatg agcgatgaga aggactgcga 2341 gcagtatcaa cgacgcacca ccaccaccac ccgacgacct tcgacctcgg cccggccctc 2401 cttcaccttc accttcacga cccaggggcc aggcttgctg gagcgtcgca atagcaccac 2461 cagtagaacc accgcaggca gcaccaccag agccaccgaa gcaccacaat ggccatgggc 2521 aaccagaccc accgagacca cgaccactaa cccaataaca acagttggcg tagcgaatct 2581 caatggaaga ttaaataaga ctcgtttggg ggtccagtgc caggaaaacc agtatcaatg 2641 tggcgatgga agctgcatct ccggctacaa acgctgcaat ggcatcaacg attgcgccga 2701 tgacgccgac gaatataact gcatctacac ctacaacgaa gactacgtag acccggacga 2761 caatccattg aatgaatgtg atatccttga gtttgaatgt gactacagtc tgtgtttacc 2821 gctagagaag aaatgcgatg gctatgcaga ctgtgaagac ttgagcgacg agttcgagtg 2881 tcagtcgtac acagagaatt gtctattgtc tgagttcgaa tgcgatggct actgcctgcc 2941 ccgcgatcag ttatgcaacg gaataatcaa ttgccaagat ggcagcgacg agcgcaactg 3001 taccttttgc cgggaagatg cctacctctg caccaccggc gagtgtgtgg ccgtaaatca 3061 gagatgcaac ggcatcgtcg aatgcgccga tggcagcgac gagcgtcact gcgtagtcaa 3121 caccacagag accaactacc attatcccac acacaatcct aaaccaaaaa cctgccgaac 3181 ccacgagtgg cagtgtacga atctcgagtg catcgagatg agattgaagt gcgatgatgt 3241 tccggattgc tcggatggat ccgatgagga cctcagcatt tgcttcggca cggccaccac 3301 acgactaaag cccagcgact gcggtccgga tcagttcttc tgcgatgatt tatgctataa 3361 tcgctctatt cgatgcaatg gccatatgga ttgctcagat ggcagtgatg agatcgcttg 3421 tagctcgctg tcagtgcttc catgtccaca gcaccagtgt cccagtggca ggtgttattc 3481 ggaaagtgag cgatgcgatc gccacaggca ctgcgaggat ggctccgatg aggccaactg 3541 ctgttacgcg gatcaattcc gctgcaataa tggtgactgc attgcggaat cggctcattg 3601 cgatggaaat atcgattgta gcgaccagtc cgatgaactc gactgcggag gagactcgca 3661 gtgtctgccc aaccaattcc gctgcaagaa tggccaatgt gtgagctcta cagcgcgttg 3721 caacaagcgt tccgattgtt tggatggctc cgatgagcag aattgtgcca atgaacctaa 3781 caactccgga cgtggaacga accaattgaa actcaagacc tatcccgaca accaaatcat 3841 taaggagagt cgtgaggtca tcttccgttg ccgtgacgaa ggtcccaacc gcgccaaggt 3901 caagtggtcg cgacccggcg gacgtcccct gccccccggt ttcaccgatc gcaatggccg 3961 cctggagatc cccaacatca gggtggagga tgctggcgcc tatgtctgcg aggccgtggg 4021 ctatgccaac tatattcccg gtcagcacgt caccgtaaac ctcaacgtcg agcgcttaaa 4081 cgaacgcgaa atccgtccgg actcagcctg tacggagtac caggccacct gcatgaacgg 4141 cgagtgtatc gataagtcgg gcatctgcga tggacatccg gactgttcgg atggctccga 4201 tgagcacagc tgcagtttgg gtttgaagtg tcagcccaac cagttcatgt gctccaattc 4261 caagtgtgtg gatcgcacct ggcgctgtga tggcgagaac gactgcggcg ataactccga 4321 tgagacctct tgcgatccgg aaccaagtga tgctccgtgc cgatacgacg aattccagtg 4381 ccgcagcggt cattgcattc ccaagagctt ccagtgcgac tatatgaacg attgtaccga 4441 tggtaccgat gaaattggat gctcggtgcc ctctccaatg accctacccg caccctcgat 4501 tgtcgtgatg gagtacgagg tcctcgagct gacctgcgtg ggcaccggcg tcccgacgcc 4561 gacgatcgtg tggcgtctca actggggcca tgtgcccgag aagtgtgaat cgaagagcta 4621 cggcggaacc ggaaccctgc gctgtccgaa catgaggccc caggacagtg gtgcctactc 4681 gtgcgagttc atcaacacac gcggcacctt ctatccgaaa acgaactcga ttgtcaccgt 4741 tacgccggtg cgctcggatg tctgcaaggc cggattcttc aatatgctgg cccgcaagtc 4801 ggaggaatgc gtccagtgct tctgctttgg cgtttcgacc aactgtgaca gtgccaattt 4861 gttcacctac gccattcagc caccgatcct ttcgcaccgc gtggtcagcg ttgaactcag 4921 tccgttccgt caaattgtca tcaatgaggc tagtccgggt caggatctgc tcaccttgca 4981 ccatggtgtt cagttcaggg catcgaacgt acactacaac ggccgggaga caccattctt 5041 ggccctgccc gctgagtata tgggcaacca gctgaagtcc tatggcggca atctgcgcta 5101 cgaggtcagg tacaatggca acggtagacc ggtcagcgga cccgatgtca tcatcaccgg 5161 caacagtttc acgctaaccc atcgcgttcg cactcatccg ggtcagaaca acagggtgac 5221 tattcccttc ctgccgggag gctggacgaa gccggatggt cgcaagggaa cgcgagagga 5281 catcatgatg atactggcca atgtggacaa tattctgatt cgactgggct acctggatag 5341 cacagctcgc gaagtggatc tgataaatat cgccttggat tcggccggaa gtgccgatca 5401 gggattgggc agtgcctcgc tcgtggagaa gtgcacctgt ccgcccggct atgttggtga 5461 ttcgtgcgag tcctgtgcct cgggctatgt tcgccaggcc cgcggacctt ggctgggtca 5521 ttgtgtgccc ttcaccccgg aaccgtgccc agcgggaacc tacggcaatc cccgacttgg 5581 tgttccctgc caggagtgtc cgtgccccca cgcgggcgcc aataactttg ccagcggctg 5641 ccaacagagt cccgatggcg atgtgatttg ccgctgcaac gaaggctatg ccggcaagag 5701 gtgcgagcac tgcgcccagg gttaccaggg taatccgttg gcaccgggag gagtctgtcg 5761 caagataccc gatagttcgt gcaatgtcga cggcacctac aacatctaca gcaatggaac 5821 gtgccagtgc aaggatagcg tgattggcga acagtgcgac acctgcgcgc cgaagagttt 5881 ccacctcaat tcgttcacct acaccggttg catcgagtgc ttctgcagtg gagtgggctt 5941 ggattgtgac agtagttcgt ggtatcgcaa ccaggtcacc agcacctttg gacgaacgcg 6001 cgtcaatcat ggattcgccc tgattagcga ctatatgcgc aataccccgg taacggtgcc 6061 cgtttccatg tccacccagg ccaatgcctt gagcttcgtg ggatccgccg agcaggccgg 6121 taatacgctc tactggagtc ttcccgccgc cttcctgggc aacaagctga cctcgtacgg 6181 aggcaagttg agctacacgc tcagctacag tcccctgccc agcggcatta tgtcgcgcaa 6241 cagtgccccc gatgtggtga tcaagagcgg cgaggatctg aggctcatcc attacaggaa 6301 gtcgcaggtc agtcccagtg tggccaacac ctatgccgtg gagatcaagg agagcgcatg 6361 gcagcgcggc gatgaactgg tgcctaaccg tgaacacgtc ctgatggccc tcagcaatat 6421 tacggccatc tatatcaagg ccacgtacac gactagcacc aaggaggcct cgctgcgatc 6481 ggtcacattg gatacggcca cggccaccaa tctgggcacc gcacgtgccg tcgaagtgga 6541 gcagtgccgc tgtcccgagg gctatttggg tctctcctgc gagcagtgtg ctcctggcta 6601 tacgcgcgat ccggaggcag gaatctatct gggtctctgc aggccctgcg agtgcaatgg 6661 acattccaag tattgcaaca gtgagacagg cgaatgcgaa agctgttccg acaacaccga 6721 aggattcaat tgtgaccgat gcgccgccgg ctatgtgggt gatgccaccc gaggaacttc 6781 gtacgactgt caatacgatg acggcggcta tccgacgtcg cgtccaccgg caccgggcaa 6841 tcagacggcc gaatgcctgg tgaattgcca acaggaggga accgccggtt gccgcggcta 6901 ccagtgcgag tgcaagagga atgtggctgg cgatcgatgc gatcagtgcc gccccggaac 6961 ctatggactg tcggcccaaa atccggacgg ttgcaaggag tgctactgct ccggactgac 7021 caaccagtgc cgctcggcgt ctctctaccg ccagctgata cccgtggact tcatttcgac 7081 gccaccattg ataacagacg aattcggcga catcatggat agggataacc ttgtgcccga 7141 cgtgcccagg aatgtgtata cctacaagca cacctcctac acgcccaagt actggagcct 7201 gaggggtagt gtgctgggca accagctgtt gtcgtacggc ggccgcttgg agtacagcct 7261 gattgtggag tccgttggcc gggaccatcg tggcaaggat gtggtcctaa ttggcaacgg 7321 actcaagctg atctggtcgc gacccgatgg ccatgacaac gagcaggaat accatgtgcg 7381 tttgcatgag gacgagcagt ggacggttga ggatcgtgga tcggcacgac aggccacgcg 7441 ggccgacttc atgactgtgc tgtcggatct gcagcacatc ctgatcctgg ccacacccaa 7501 ggtgcccacg gtcagcacct cgattagcaa tgtcatcctg gagagttcga taaccacgag 7561 agcgcctgga gctacgcatg cctccgatat cgagttgtgc cagtgtccat ccggttatac 7621 gggcacttcc tgtgagtcct gcgcaccact gcactaccgc gacgcctctg gacgctgcag 7681 tcagtgtcct tgcgacgctt ccaacacgga atcctgcggc ttggtcagcg gcggtaacgt 7741 cgaatgccag tgcaggccac gctggagggg tgatcgctgc cgggaaattg acacatcgcc 7801 cattatcgaa gaaccgcccc agatatgtga tttaagcagg ggattctgtt gcagcggctt 7861 tcagttcgat atcgcaccga acgagacaat ctcgtttaat gacaccctgc agatatataa 7921 gggcaacaga atcataggaa atatgaccaa gctgcgctac ggctgtccat cgcgagaaac 7981 taacgaaccg actccggaac cggataccag taccgatgat cccgtgcgca cccagatcat 8041 agtgtcgatt gccaggccag agattaccat tctgcccgtg ggtggatcgc tgaccctcag 8101 ctgtaccggt cgaatgcgct ggaccaatag cccagtgttt gtgaactggt acaagcaggg 8161 cagtcacctg cccgagggag tcgaggtgca aggcggtaat ctgcagctgt tcaacctgca 8221 gatcagcgat tctggaatct acatctgcca ggccgtaagc aacgagaccg gccacagctt 8281 tacggaccac gtctccatca ccgtttccca ggaggaccaa cgctcgccgg ctcacattgt 8341 ggatttgccc aacgacgtga ccttcgagga gtacgtaagc aatgagatcg tctgcgaggt 8401 ggagggcaac ccaccaccca ctgtcacctg gactcgcgtg gatggccatg cggacgccca 8461 aagtacgcga acggacaaca atcggctggt cttcgattcg ccgaggaaat cggacgaggg 8521 tcgctatcgc tgccaggcag agaatagcct gagtcgggag gagaagtacg tagtcgtgta 8581 tgtccggagc aatcctcccc agccgccgcc gcagcaggat cgtttgtaca tcacaccgca 8641 ggaggtgaac ggtgtggccg gtgactcctt ccagttgtcc tgccaattca ccagcgctgc 8701 ctctctgcgc tacgattggt cccacgatgg tcgctccctg tccgcgtcgt caccccgaaa 8761 tgttgtggtc cgcggaaatg tcctggaagt ccgcgatgcc aacgttcgcg actccggcac 8821 ctacacctgt gtggccttcg acctgcgcac ccgacgcaac ttcaccgaga gcgcacgggt 8881 ctacatcgag cagcccaacg agccgggaat ccttggcgac aagccgcata tcttgacctt 8941 ggagcagaac atcataattg tgcaaggcga ggacttgagc atcacatgtg aggcaagtgg 9001 aacgccctat ccctcgatta agtggaccaa ggtgcaggag aatctggccg aaaatgtccg 9061 catcagtggc aatgtgctca ccatctacgg aggccgcagt gagaatcgtg gtctttactc 9121 ctgcatcgcc gagaactctc acggcagcga tcagtccagc acaagcatcg atattgaacc 9181 ccgggagcgg ccgagtctta cgattgatac ggccacccaa aaggtttcgg ttggctccca 9241 ggcgtccctt tactgtgccg cccagggcat tcccgaaccg accgtcgagt gggttcgaac 9301 ggatggtcag ccactgtcgc cgcgtcacaa ggtccaggca cccggctatg ttgtgatcga 9361 tgacattgtg ctcgatgata gcggtaccta cgagtgccgg gcgagcaaca tagctggcca 9421 ggtgagcggc ttggccacca ttaacgtcca ggagccaact cttgtgcgga tcgaaccaga 9481 taggcaacac catatcgtca cccagggcga cgaactctcg ctcagctgcg tgggcagtgg 9541 cgtccctact ccttcggtct tttggagttt cgagggaaga gacgttgaca ggatgggagt 9601 accggaaggt gctgtttttg cgcaaccttt ccgaaccaac actgccgacg tgaaaatctt 9661 ccgggtgagc aaggagaacg aaggcatcta cgtctgtcac ggatccaatg acgcgggtga 9721 agatcaacaa tacattcgcg tggaggtaca acccagacgg ggtgacgtcg gtgcaggagg 9781 agatgacaat ggtgatgtcg atacccgaca gccccccaat cggccccaaa tccaaccgaa 9841 tccattgagc aacgaacgcc tgaccaccga attgggcaac aatgtgaccc tcatctgcaa 9901 cgtggacaac gtgaacacgg aatgggaacg cgtcgatggc acacccctgc cgcacaatgc 9961 ctacacggtg agaaatacgc tggtgattgt cttcgtggag ccgcagaatc tgggtcagta 10021 ccgctgcaat ggaatcggtc gcgatggacg tgtggaggcc catgtggtga gggagctggt 10081 tctcctgccc ctgcccagga tcaccttcta tcccaacatc ccgctgaccg tggagctggg 10141 ccagaacttg gatgtctact gccaggtgga gaacgtgcgt ccggaggacg tgcattggac 10201 caccgacaac aatcgaccac tgcccagttc cgtacgcatc gagggcaatg tcctcaggtt 10261 cgcgtccatc actcaggctg ctgccggtga ataccgctgc tcggccacca atcaatatgg 10321 aagccgatcg aagaacgcca gggtggtggt gaaacagccc agtggcttcc agcccgttcc 10381 ccactcgcag gtgcaacagc gtcaggtggg cgactccatc cagttgcgat gccgcctgac 10441 cacccagtac ggcgacgagg ttcgcggcaa tatccagttc aactggtacc gtgaggacgg 10501 cagccccttg ccccgcggtg tccgtccgga tagccaggtg ctgcagctgg ttaaattgca 10561 gcccgaggac gagggccgct acatctgcaa ctcgtacgat ttgggcagcg ggcagcaact 10621 gccccccgtc tccatcgact tgcaagtact aagaactact acccagtatc ctttcaatcg 10681 gtttaagggc ggtgtctccc tgaaagacac gccctgcatg gttctgtata tttgtgcagc 10741 ggtaccagcg gctccccaga accccatcta cctgccgcca gtggcgccac cacgttcgcc 10801 cgaaaggatc ctcgagcccc aactgagcct gagtgtacaa tcctcgaacc tgccagccgg 10861 cgacggcacc accgtcgagt gcttctcctc cgatgactcc tacccagatg tcgtgtggga 10921 acgcgccgat ggagctccac tcagcgaaaa tgtccagcaa gtgggcaata acctggtgat 10981 tagtaacgtg gcctccaccg atgccggtaa ctatgtgtgc aagtgcaaga cggacgaggg 11041 agatctgtat accaccagct acaaactgga ggtcgaggag cagccccatg aactgaagag 11101 ctccaagata gtctacgcca aggttggcgg aaatgccgac ttgcagtgcg gagccgatga 11161 agatcgacag cccagctacc gttggtctcg ccaatacgga caacttcagg cgggacgcag 11221 tctgcagaat gagaaacttt cgttggatcg cgttcaggcc aacgatgccg gaacttatgt 11281 ttgttcggcc caatacagcg atggcgagac ggttgacttc cccaacattc tggttgtgac 11341 cggggcgatt ccccagttcc gccaggagcc ccgcagctac atgagcttcc ccacgctctc 11401 gaactcctcg ttcaagttca acttcgagct gaccttccgg ccggaaaacg ccgacggact 11461 gctgctcttc aatggacaga cccgcggaag cggtgactat atcgcactct cgctgaagga 11521 tcgctatgcg gagttccggt tcgattttgg cggtaaaccg ttgctggtgc gagcggagga 11581 gccactggct ttggatgaat ggcacacggt gcgcgtgagt cgcttcaagc gggatggcta 11641 catccaggtg gacgaccagc atccggtggc cttccccacc tcccagcatc agcagatacc 11701 ccagttggaa ctgattgagg atctgtacat tggcggcgtg cccaactggg agttcctgcc 11761 cgccgaggcg gtgggtcagc aatcaggctt cgtgggctgc attagccggc tgaccctgca 11821 gggacgcacc gtggagctga tccgggaggc caagttcaag gagggcatca ccgattgccg 11881 gccctgcgcc cagggaccct gccagaacaa gggcgtctgc ctggagagcc agacggagca 11941 ggcctacacc tgcgtctgcc agccgggctg gactggccgg gattgtgcca tcgagggcac 12001 ccagtgcacc gcaggagttt gcggctcggg acgctgcgag aatacggaga acgacatgga 12061 gtgcctgtgc ccgctgaaca gggcaggcga tcgatgccag tacaatgaga ttctaaatga 12121 acagagcttg aatttcaaga gcaacagctt tgcggcctac ggaactccca aggtcaccaa 12181 agtaaacatc acactctccg ttcgtcccgc gagcctggag gactctgtga tcctgtacac 12241 ggcggaatcc actctgccca gcggcgatta cctggctttg gtccttcgcg gtggccacgc 12301 ggagctgctg atcaacacgg ccgcccgctt ggatcccgtg gtggtgcgtt cggcggaacc 12361 gctgcccctc aatcgctgga ccagaatcga gatcaggcgt cgcctgggcg agggaatcct 12421 caaggtgggc gatggacccg agcgaaaggc caaggcaccg ggatccgatc gcattctgtc 12481 gctcaagacc cacctctttg tgggcggcgt cgatcggtcg accgtaaaga tcaaccgtga 12541 tgtgaacatc accaagggct tcgatggctg catctcgaag ctgtacaact cgcagaaatc 12601 cgtcaatctg ctgggtgaca tcagggatgc ggcgaatgtc cagaactgtg gggaggcgaa 12661 tgagatagat gacgatgagt atgagatgcc agtagcgctg ccatcgccta aggtcgccga 12721 gaatgaacgt cagctgatgg cgccgtgtgc cagtgatccc tgcgagaacg ggggaagctg 12781 cagcgagcag gaggacatgg ccatctgctc ctgtcccttc ggcttcagcg gcaaacactg 12841 ccagaatcac ctccagctga gcttcaatgc ctcgttccgc ggcgatggct acgtggagct 12901 gaaccgcagc cacttccaac ccgccctgga gcagacgtac tcccacattg gcattgtgtt 12961 caccaccaac aagccgaatg gcctgctttt ctggtggggc caggaggccg gggaggagta 13021 caccggacag gacttcattg ccgccgccgt ggtcgatggc tatgtggagt actcgatgag 13081 gctcgatggc gaggaggcgg tcattcggaa cagcgatatc cgcgtggaca atggcgagcg 13141 gcacattgtg atcgccaagc gggatgagaa caccgccatg ctggaactcg atcagatcct 13201 ggacacgggc gatacgcgac ccaccatcaa caaggcaatg aagctgccgg gcaatgtgtt 13261 tgtcggtggc gctcctgatg tcgcggcatt cacgggcttc cgctacaagg acaatttcaa 13321 cggctgcatt gtggtcgtcg agggcgaaac cgtgggccaa attaacctta gttcagctgc 13381 catcaatgga gtgaatgcca acgtgtgtcc cgctaacgac gaacctctgg gaggaaccga 13441 accgccagtc gtctgaggac acaaccagca accgaaatta gctttttaat taaacattaa 13501 caaatgaaac aaaaagaaaa acaattttta tatatacaac atatgaataa gccccaagca 13561 aacctacaaa aaattgaata ttatacgacg aacagataat ataaaaacaa aaaaagagag 13621 aaacgatcac ttctactaca attgcttctt cgatccttaa gtctaggtta aagattgtag 13681 caagaaaaca agcgaatatc acaaacattt atttaacaag aacgccatgc gagaagtgaa 13741 acgaaacaga aacaataatg caattaatgc agataataca gataaagcct agaaccctaa 13801 gaactaacta actaactcga acaagaacaa caacgcatac tagccaactg caaccacaac 13861 aaccacaata gtgaaggcat tttaattata attttagtct ctagcttata actatgacta 13921 cgactcgttt tttttgtgag cccagtgtaa aatgttggaa atcggaaatt ggccctacac 13981 acaaacacac acaagttatt aattaaatac caattgatac catataatga taaatgaaat 14041 actatgaatg caactattgt gaacgaacga aaaccgttga gtggataaaa agcataagca 14101 gaagatatat taaaatgaaa tcaacaaca