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LOCUS XM_070218424 14189 bp mRNA linear INV 09-DEC-2024 (trol), transcript variant X7, mRNA. ACCESSION XM_070218424 VERSION XM_070218424.1 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..14189 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..14189 /gene="trol" /note="terribly reduced optic lobes; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 11 Proteins" /db_xref="GeneID:108055788" CDS 209..13516 /gene="trol" /codon_start=1 /product="basement membrane-specific heparan sulfate proteoglycan core protein isoform X7" /protein_id="XP_070074525.1" /db_xref="GeneID:108055788" /translation="MGSPGSQAPAIAIGISNGRRGHTGSLLLRLLLVAFVLNACHVPP TNAKQITKSKVDDQDFILADTQSLQGSVDLDDDEAFLIPPDSEEKLDKKFTPEGNWWS QGLHRVRRSLNSFFGSDDDDQEKERERQRQRQNNRDAANRQKELRRQQKESQNREKQL RLERQERQRLAKRNNHVVFNRVTDPRKRASDLYDENEASGLNEEETTTYRTYFVVNEP YSDDYKERDSLQFQNLQKLLDEDLRNFFNRNFENNDDEEQEIHSTLERVDQTKDHFKI RVQLRVDLPSSINDFGSKLEQQLNVYKRIDRLGASTDGVFTFTESSVYKYEHQYDIVT PRVIVSGQPITEKPVEAPQEFDEDPIEVALPTDEVEGSGQDSGSCRGDATFQCRRSGK TICDEMRCDGSRDCPDAEDEEGCEVCNELQFKCDNKCLPLNKRCDNRYDCEDQTDEAG CQRYEVEESQPQPQPQPQPEPEPEPEPEPEPEPEPEPEPEEPITDNEQPEQNSECRAT EFRCNNGDCIDIRKRCDHISDCSEGEDENEECPAACSGMEYQCRDGTRCISLSQQCDG HSDCSDADDEEHCDGSGNDGEDCRFDEFRCGTGECIPMRQVCDNIYDCNDYSDEVSCA EEEEDSVGIPIGRPPQRPAPKHDWLDELDANEYHVYHPSNVYELANSKNPCASNQFRC ATTNVCIPLHLRCDNFYHCNDMSDEKDCEQYQRRTTTTTRRPSTSARPSFTFTFTTQG PGLLERRNSTTSRTTAGSTTRATEAPQWPWATRPTETTTTNPITTVGVASSSPQSSCL ENIEFACHNRDCIPIESVCDGTPDCGRSEDEDDALCKCTADKYKCQHGGGCIPKTQVC DGKPQCRDRSDESACHLNGRLNKTRLGVQCQENQYQCGDGSCISGYKRCNGINDCADD ADEYNCIYTYNEDYVDPDDNPLNECDILEFECDYSLCLPLEKKCDGYADCEDLSDEFE CQSYTENCLLSEFECDGYCLPRDQLCNGIINCQDGSDERNCTFCREDAYLCTTGECVA VNQRCNGIVECADGSDERHCVVNTTETNYHYPTHNPKPKTCRTHEWQCTNLECIEMRL KCDDVPDCSDGSDEDLSICFGTATTRLKPSDCGPDQFFCDDLCYNRSIRCNGHMDCSD GSDEIACSSLSVLPCPQHQCPSGRCYSESERCDRHRHCEDGSDEANCCYADQFRCNNG DCIAESAHCDGNIDCSDQSDELDCGGDSQCLPNQFRCKNGQCVSSTARCNKRSDCLDG SDEQNCANEPNNSGRGTNQLKLKTYPDNQIIKESREVIFRCRDEGPNRAKVKWSRPGG RPLPPGFTDRNGRLEIPNIRVEDAGAYVCEAVGYANYIPGQHVTVNLNVERLNEREIR PDSACTEYQATCMNGECIDKSGICDGHPDCSDGSDEHSCSLGLKCQPNQFMCSNSKCV DRTWRCDGENDCGDNSDETSCDPEPSDAPCRYDEFQCRSGHCIPKSFQCDYMNDCTDG TDEIGCSVPSPMTLPAPSIVVMEYEVLELTCVGTGVPTPTIVWRLNWGHVPEKCESKS YGGTGTLRCPNMRPQDSGAYSCEFINTRGTFYPKTNSIVTVTPVRSDVCKAGFFNMLA RKSEECVQCFCFGVSTNCDSANLFTYAIQPPILSHRVVSVELSPFRQIVINEASPGQD LLTLHHGVQFRASNVHYNGRETPFLALPAEYMGNQLKSYGGNLRYEVRYNGNGRPVSG PDVIITGNSFTLTHRVRTHPGQNNRVTIPFLPGGWTKPDGRKGTREDIMMILANVDNI LIRLGYLDSTAREVDLINIALDSAGSADQGLGSASLVEKCTCPPGYVGDSCESCASGY VRQARGPWLGHCVPFTPEPCPAGTYGNPRLGVPCQECPCPHAGANNFASGCQQSPDGD VICRCNEGYAGKRCEHCAQGYQGNPLAPGGVCRKIPDSSCNVDGTYNIYSNGTCQCKD SVIGEQCDTCAPKSFHLNSFTYTGCIECFCSGVGLDCDSSSWYRNQVTSTFGRTRVNH GFALISDYMRNTPVTVPVSMSTQANALSFVGSAEQAGNTLYWSLPAAFLGNKLTSYGG KLSYTLSYSPLPSGIMSRNSAPDVVIKSGEDLRLIHYRKSQVSPSVANTYAVEIKESA WQRGDELVPNREHVLMALSNITAIYIKATYTTSTKEASLRSVTLDTATATNLGTARAV EVEQCRCPEGYLGLSCEQCAPGYTRDPEAGIYLGLCRPCECNGHSKYCNSETGECESC SDNTEGFNCDRCAAGYVGDATRGTSYDCQYDDGGYPTSRPPAPGNQTAECLVNCQQEG TAGCRGYQCECKRNVAGDRCDQCRPGTYGLSAQNPDGCKECYCSGLTNQCRSASLYRQ LIPVDFISTPPLITDEFGDIMDRDNLVPDVPRNVYTYKHTSYTPKYWSLRGSVLGNQL LSYGGRLEYSLIVESVGRDHRGKDVVLIGNGLKLIWSRPDGHDNEQEYHVRLHEDEQW TVEDRGSARQATRADFMTVLSDLQHILILATPKVPTVSTSISNVILESSITTRAPGAT HASDIELCQCPSGYTGTSCESCAPLHYRDASGRCSQCPCDASNTESCGLVSGGNVECQ CRPRWRGDRCREIETNEPTPEPDTSTDDPVRTQIIVSIARPEITILPVGGSLTLSCTG RMRWTNSPVFVNWYKQGSHLPEGVEVQGGNLQLFNLQISDSGIYICQAVSNETGHSFT DHVSITVSQEDQRSPAHIVDLPNDVTFEEYVSNEIVCEVEGNPPPTVTWTRVDGHADA QSTRTDNNRLVFDSPRKSDEGRYRCQAENSLSREEKYVVVYVRSNPPQPPPQQDRLYI TPQEVNGVAGDSFQLSCQFTSAASLRYDWSHDGRSLSASSPRNVVVRGNVLEVRDANV RDSGTYTCVAFDLRTRRNFTESARVYIEQPNEPGILGDKPHILTLEQNIIIVQGEDLS ITCEASGTPYPSIKWTKVQENLAENVRISGNVLTIYGGRSENRGLYSCIAENSHGSDQ SSTSIDIEPRERPSLTIDTATQKVSVGSQASLYCAAQGIPEPTVEWVRTDGQPLSPRH KVQAPGYVVIDDIVLDDSGTYECRASNIAGQVSGLATINVQEPTLVRIEPDRQHHIVT QGDELSLSCVGSGVPTPSVFWSFEGRDVDRMGVPEGAVFAQPFRTNTADVKIFRVSKE NEGIYVCHGSNDAGEDQQYIRVEVQPRRGDVGAGGDDNGDVDTRQPPNRPQIQPNPLS NERLTTELGNNVTLICNVDNVNTEWERVDGTPLPHNAYTVRNTLVIVFVEPQNLGQYR CNGIGRDGRVEAHVVRELVLLPLPRITFYPNIPLTVELGQNLDVYCQVENVRPEDVHW TTDNNRPLPSSVRIEGNVLRFASITQAAAGEYRCSATNQYGSRSKNARVVVKQPSGFQ PVPHSQVQQRQVGDSIQLRCRLTTQYGDEVRGNIQFNWYREDGSPLPRGVRPDSQVLQ LVKLQPEDEGRYICNSYDLGSGQQLPPVSIDLQVLRTTTQYPFNRFKGGVSLKDTPCM VLYICAAVPAAPQNPIYLPPVAPPRSPERILEPQLSLSVQSSNLPAGDGTTVECFSSD DSYPDVVWERADGAPLSENVQQVGNNLVISNVASTDAGNYVCKCKTDEGDLYTTSYKL EVEEQPHELKSSKIVYAKVGGNADLQCGADEDRQPSYRWSRQYGQLQAGRSLQNEKLS LDRVQANDAGTYVCSAQYSDGETVDFPNILVVTGAIPQFRQEPRSYMSFPTLSNSSFK FNFELTFRPENADGLLLFNGQTRGSGDYIALSLKDRYAEFRFDFGGKPLLVRAEEPLA LDEWHTVRVSRFKRDGYIQVDDQHPVAFPTSQHQQIPQLELIEDLYIGGVPNWEFLPA EAVGQQSGFVGCISRLTLQGRTVELIREAKFKEGITDCRPCAQGPCQNKGVCLESQTE QAYTCVCQPGWTGRDCAIEGTQCTAGVCGSGRCENTENDMECLCPLNRAGDRCQYNEI LNEQSLNFKSNSFAAYGTPKVTKVNITLSVRPASLEDSVILYTAESTLPSGDYLALVL RGGHAELLINTAARLDPVVVRSAEPLPLNRWTRIEIRRRLGEGILKVGDGPERKAKAP GSDRILSLKTHLFVGGVDRSTVKINRDVNITKGFDGCISKLYNSQKSVNLLGDIRDAA NVQNCGEANEIDDDEYEMPVALPSPKVAENERQLMAPCASDPCENGGSCSEQEDMAIC SCPFGFSGKHCQNHLQLSFNASFRGDGYVELNRSHFQPALEQTYSHIGIVFTTNKPNG LLFWWGQEAGEEYTGQDFIAAAVVDGYVEYSMRLDGEEAVIRNSDIRVDNGERHIVIA KRDENTAMLELDQILDTGDTRPTINKAMKLPGNVFVGGAPDVAAFTGFRYKDNFNGCI VVVEGETVGQINLSSAAINGVNANVCPANDEPLGGTEPPVV" misc_feature 458..>715 /gene="trol" /note="Coiled-coil domain-containing protein 66; Region: CCDC66; pfam15236" /db_xref="CDD:434558" misc_feature 1460..1561 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1475..1477,1496..1498,1529..1534) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1508..1510,1517..1519,1529..1531,1547..1552) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1538..1552 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1718..1816 /gene="trol" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(1736..1738,1760..1762,1793..1798) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1772..1774,1781..1783,1793..1795,1811..1816) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1802..1816 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1838..1945 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1853..1855,1880..1882,1913..1918) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1892..1894,1901..1903,1913..1915,1931..1936) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1922..1936 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1973..2077 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1988..1990,2012..2014,2045..2050) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2024..2026,2033..2035,2045..2047,2063..2068) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2054..2068 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2231..2338 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2246..2248,2273..2275,2306..2311) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2285..2287,2294..2296,2306..2308,2324..2329) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2315..2329 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2597..2701 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2615..2617,2639..2641,2672..2677) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2651..2653,2660..2662,2672..2674,2690..2695) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2681..2695 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2714..2821 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2729..2731,2756..2758,2789..2794) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2768..2770,2777..2779,2789..2791,2807..2812) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2798..2812 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2864..2968 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2879..2881,2903..2905,2936..2941) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2915..2917,2924..2926,2936..2938,2954..2959) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2945..2959 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3023..3127 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3038..3040,3062..3064,3095..3100) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3074..3076,3083..3085,3095..3097,3113..3118) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3104..3118 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3146..3247 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3161..3163,3182..3184,3215..3220) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3194..3196,3203..3205,3215..3217,3233..3238) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3224..3238 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3254..3358 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3269..3271,3293..3295,3326..3331) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3305..3307,3314..3316,3326..3328,3344..3349) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3335..3349 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3416..3514 /gene="trol" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(3434..3436,3458..3460,3491..3496) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3470..3472,3479..3481,3491..3493,3509..3514) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3500..3514 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3566..3667 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3581..3583,3602..3604,3635..3640) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3614..3616,3623..3625,3635..3637,3653..3658) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3644..3658 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3695..3787 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3698..3700,3722..3724,3755..3760) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3734..3736,3743..3745,3755..3757,3773..3778) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3764..3778 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3788..3892 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3803..3805,3827..3829,3860..3865) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3839..3841,3848..3850,3860..3862,3878..3883) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3869..3883 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3908..4012 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3923..3925,3947..3949,3980..3985) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3959..3961,3968..3970,3980..3982,3998..4003) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3989..4003 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4055..4261 /gene="trol" /note="Immunoglobulin domain; Region: Ig_3; pfam13927" /db_xref="CDD:464046" misc_feature 4355..4459 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4370..4372,4394..4396,4427..4432) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4406..4408,4415..4417,4427..4429,4445..4450) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4436..4450 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4475..4579 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4490..4492,4514..4516,4547..4552) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4526..4528,4535..4537,4547..4549,4565..4570) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4556..4570 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4604..4708 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4619..4621,4643..4645,4676..4681) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4655..4657,4664..4666,4676..4678,4694..4699) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4685..4699 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4760..4987 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 4769..4783 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 4808..4822 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 4877..4891 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 4919..4936 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 4961..4972 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature 5282..5674 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature 5843..6004 /gene="trol" /note="Laminin EGF domain; Region: Laminin_EGF; pfam00053" /db_xref="CDD:395007" misc_feature order(5843..5845,5849..5851,5885..5887,5915..5917, 5921..5923,5948..5950) /gene="trol" /note="EGF-like motif [active]" /db_xref="CDD:238012" misc_feature 6377..6787 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature <6788..6868 /gene="trol" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; Region: EGF_Lam; cd00055" /db_xref="CDD:238012" misc_feature 6890..7039 /gene="trol" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; Region: EGF_Lam; cd00055" /db_xref="CDD:238012" misc_feature order(6893..6895,6899..6901,6920..6922,6941..6943, 6950..6952,6977..6979) /gene="trol" /note="EGF-like motif [active]" /db_xref="CDD:238012" misc_feature <7148..7240 /gene="trol" /note="Laminin EGF domain; Region: Laminin_EGF; pfam00053" /db_xref="CDD:395007" misc_feature 7436..7840 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature 8117..8365 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 8150..8164 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 8198..8212 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 8255..8269 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 8297..8314 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 8342..8353 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature <8444..8605 /gene="trol" /note="Immunoglobulin domain; Region: Ig_3; pfam13927" /db_xref="CDD:464046" misc_feature 8696..8947 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 8729..8743 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 8768..8782 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 8837..8851 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 8879..8896 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 8984..9226 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 9035..9049 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409570" misc_feature 9074..9088 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409570" misc_feature 9131..9145 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409570" misc_feature 9173..9190 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409570" misc_feature 9212..9223 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409570" misc_feature 9278..9508 /gene="trol" /note="Immunoglobulin I-set domain; Region: I-set; pfam07679" /db_xref="CDD:400151" misc_feature 9302..9316 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 9341..9355 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 9404..9418 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 9446..9463 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 9485..9496 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature 9545..9808 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 9575..9589 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 9614..9628 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 9746..9763 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 10181..10411 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 10208..10222 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 10247..10261 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 10307..10321 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 10349..10366 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 10445..>10648 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 10478..10492 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 10526..10549 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 10595..10609 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 10895..11101 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 10967..10981 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 11030..11041 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 11069..11086 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 11171..11371 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 11195..11209 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 11234..11248 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 11291..11305 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 11333..11350 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 11435..11878 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" misc_feature 11945..12043 /gene="trol" /note="EGF-like domain; Region: EGF; pfam00008" /db_xref="CDD:394967" misc_feature 12185..12646 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" misc_feature 12806..12904 /gene="trol" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054" /db_xref="CDD:238011" misc_feature 12929..13390 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" polyA_site 14189 /gene="trol" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN 1 attaggttgc gcgccatcgt tccaggcggt cgcacattcc acgtgccata gccgtaacaa 61 caacctgcca accgcttaaa accaaactca aatacgaacc gaaactgcct tcacacacac 121 aagtacctaa accaaatcta aatagctgcc aaaagaaacc aaaaattcca gagacgtcgt 181 agcatccgtt ccccggaaga agaagaagat gggatcgccg ggatcccaag cgcccgcgat 241 cgcgatcggg atcagtaacg ggcggagagg tcacacgggg tcgctgctcc tgcgcctcct 301 tctcgtggcc ttcgtcctca acgcctgcca cgtacccccg accaatgcca agcaaattac 361 gaaaagtaaa gttgatgacc aggactttat actggccgac acacaatcgc tgcagggcag 421 cgttgacctt gacgatgacg aagcgttcct gattcctccg gattccgaag agaagttgga 481 taagaagttc acgccggagg gcaactggtg gagccagggg ctccatcgtg ttcgccgctc 541 cctaaatagc ttcttcggct ccgacgacga tgatcaggaa aaggaacgtg agcgtcagag 601 gcaaaggcaa aataatcgcg atgccgccaa ccggcaaaag gaacttcggc gccagcaaaa 661 ggagagccag aaccgcgaga agcagctgcg attggagcgc caggagaggc agcgccttgc 721 caagcggaac aatcacgtgg tcttcaatcg cgtcaccgat ccccgcaagc gggcatccga 781 cctttacgac gagaacgagg catctggcct aaacgaggag gaaaccacca cctatcgcac 841 ctactttgtt gttaatgagc catattcaga cgactacaag gagcgggaca gcctccagtt 901 ccagaatctg caaaaacttc ttgacgagga cctgcgcaac ttcttcaatc gcaatttcga 961 aaataacgat gatgaagagc aggaaatcca tagcacccta gagcgagtcg atcaaaccaa 1021 ggaccatttt aaaattcgcg tgcaacttag ggtagatctg cccagttcaa tcaacgactt 1081 tggaagtaag ttggagcaac aactgaatgt ctacaagcga atcgatcgtt tgggtgccag 1141 taccgatggc gtcttcacct ttaccgaatc gagcgtctac aaatacgaac accaatacga 1201 tattgtgaca ccgagagtaa ttgtatctgg acaaccgata actgaaaaac cagtcgaagc 1261 accccaagaa ttcgatgagg atcctatcga agttgcattg cccacggatg aggtggaggg 1321 ctccggccaa gattccggta gctgtcgcgg cgatgccacc ttccagtgtc gaaggagtgg 1381 aaagactatt tgcgatgaaa tgcgatgcga tggatctcgc gattgtcccg atgccgagga 1441 cgaggaaggc tgcgaggttt gcaacgaact tcagttcaag tgcgataaca agtgtctgcc 1501 gctcaataag cgctgcgata atcgatacga ttgtgaggat cagacggacg aggctggttg 1561 tcaacggtac gaagtagaag agtctcagcc tcagccgcag ccgcaacctc agcctgaacc 1621 ggaacctgaa cctgaacctg agcctgagcc tgaacctgaa ccagaaccag aacctgaaga 1681 gcctataaca gacaatgaac agcctgagca aaactcagaa tgccgggcca ccgagttcag 1741 atgcaacaat ggggactgca tcgatattag aaagcgttgc gatcacattt cggactgtag 1801 cgaaggcgag gacgagaacg aggagtgccc cgccgcctgc agcggaatgg agtatcaatg 1861 tcgcgacggc acgcgctgca taagtttgag tcagcagtgc gacggtcatt ccgattgcag 1921 cgacgccgac gacgaggagc attgcgacgg aagtggtaac gatggtgagg attgtcggtt 1981 cgatgagttc cgttgcggaa ctggtgagtg cataccgatg cgtcaggtgt gcgataacat 2041 ctacgattgc aacgattatt ccgatgaggt cagctgcgcc gaggaggagg aagatagtgt 2101 gggcataccc attggccgtc caccgcagag gccagcgccc aaacacgact ggctggacga 2161 attggacgcc aatgagtacc acgtctatca tccaagtaat gtctatgagt tggccaattc 2221 caagaatccc tgtgccagca atcaatttcg ctgcgccacc acgaatgtgt gcatccccct 2281 gcatttgcgt tgcgataatt tctatcactg caacgatatg agcgatgaga aggactgcga 2341 gcagtatcaa cgacgcacca ccaccaccac ccgacgacct tcgacctcgg cccggccctc 2401 cttcaccttc accttcacga cccaggggcc aggcttgctg gagcgtcgca atagcaccac 2461 cagtagaacc accgcaggca gcaccaccag agccaccgaa gcaccacaat ggccatgggc 2521 aaccagaccc accgagacca cgaccactaa cccaataaca acagttggcg tagcgagcag 2581 ctcacctcag tcctcctgtc tcgaaaacat cgaattcgcg tgtcacaatc gcgattgcat 2641 tccgattgag agcgtctgcg atggcacccc cgactgcgga cgcagtgaag acgaggacga 2701 cgctctttgc aagtgcaccg ccgacaagta caaatgccaa cacggcggag gctgcattcc 2761 gaaaacccag gtgtgcgatg gcaaacctca gtgccgcgac cgcagcgacg agagcgcctg 2821 ccatctcaat ggaagattaa ataagactcg tttgggggtc cagtgccagg aaaaccagta 2881 tcaatgtggc gatggaagct gcatctccgg ctacaaacgc tgcaatggca tcaacgattg 2941 cgccgatgac gccgacgaat ataactgcat ctacacctac aacgaagact acgtagaccc 3001 ggacgacaat ccattgaatg aatgtgatat ccttgagttt gaatgtgact acagtctgtg 3061 tttaccgcta gagaagaaat gcgatggcta tgcagactgt gaagacttga gcgacgagtt 3121 cgagtgtcag tcgtacacag agaattgtct attgtctgag ttcgaatgcg atggctactg 3181 cctgccccgc gatcagttat gcaacggaat aatcaattgc caagatggca gcgacgagcg 3241 caactgtacc ttttgccggg aagatgccta cctctgcacc accggcgagt gtgtggccgt 3301 aaatcagaga tgcaacggca tcgtcgaatg cgccgatggc agcgacgagc gtcactgcgt 3361 agtcaacacc acagagacca actaccatta tcccacacac aatcctaaac caaaaacctg 3421 ccgaacccac gagtggcagt gtacgaatct cgagtgcatc gagatgagat tgaagtgcga 3481 tgatgttccg gattgctcgg atggatccga tgaggacctc agcatttgct tcggcacggc 3541 caccacacga ctaaagccca gcgactgcgg tccggatcag ttcttctgcg atgatttatg 3601 ctataatcgc tctattcgat gcaatggcca tatggattgc tcagatggca gtgatgagat 3661 cgcttgtagc tcgctgtcag tgcttccatg tccacagcac cagtgtccca gtggcaggtg 3721 ttattcggaa agtgagcgat gcgatcgcca caggcactgc gaggatggct ccgatgaggc 3781 caactgctgt tacgcggatc aattccgctg caataatggt gactgcattg cggaatcggc 3841 tcattgcgat ggaaatatcg attgtagcga ccagtccgat gaactcgact gcggaggaga 3901 ctcgcagtgt ctgcccaacc aattccgctg caagaatggc caatgtgtga gctctacagc 3961 gcgttgcaac aagcgttccg attgtttgga tggctccgat gagcagaatt gtgccaatga 4021 acctaacaac tccggacgtg gaacgaacca attgaaactc aagacctatc ccgacaacca 4081 aatcattaag gagagtcgtg aggtcatctt ccgttgccgt gacgaaggtc ccaaccgcgc 4141 caaggtcaag tggtcgcgac ccggcggacg tcccctgccc cccggtttca ccgatcgcaa 4201 tggccgcctg gagatcccca acatcagggt ggaggatgct ggcgcctatg tctgcgaggc 4261 cgtgggctat gccaactata ttcccggtca gcacgtcacc gtaaacctca acgtcgagcg 4321 cttaaacgaa cgcgaaatcc gtccggactc agcctgtacg gagtaccagg ccacctgcat 4381 gaacggcgag tgtatcgata agtcgggcat ctgcgatgga catccggact gttcggatgg 4441 ctccgatgag cacagctgca gtttgggttt gaagtgtcag cccaaccagt tcatgtgctc 4501 caattccaag tgtgtggatc gcacctggcg ctgtgatggc gagaacgact gcggcgataa 4561 ctccgatgag acctcttgcg atccggaacc aagtgatgct ccgtgccgat acgacgaatt 4621 ccagtgccgc agcggtcatt gcattcccaa gagcttccag tgcgactata tgaacgattg 4681 taccgatggt accgatgaaa ttggatgctc ggtgccctct ccaatgaccc tacccgcacc 4741 ctcgattgtc gtgatggagt acgaggtcct cgagctgacc tgcgtgggca ccggcgtccc 4801 gacgccgacg atcgtgtggc gtctcaactg gggccatgtg cccgagaagt gtgaatcgaa 4861 gagctacggc ggaaccggaa ccctgcgctg tccgaacatg aggccccagg acagtggtgc 4921 ctactcgtgc gagttcatca acacacgcgg caccttctat ccgaaaacga actcgattgt 4981 caccgttacg ccggtgcgct cggatgtctg caaggccgga ttcttcaata tgctggcccg 5041 caagtcggag gaatgcgtcc agtgcttctg ctttggcgtt tcgaccaact gtgacagtgc 5101 caatttgttc acctacgcca ttcagccacc gatcctttcg caccgcgtgg tcagcgttga 5161 actcagtccg ttccgtcaaa ttgtcatcaa tgaggctagt ccgggtcagg atctgctcac 5221 cttgcaccat ggtgttcagt tcagggcatc gaacgtacac tacaacggcc gggagacacc 5281 attcttggcc ctgcccgctg agtatatggg caaccagctg aagtcctatg gcggcaatct 5341 gcgctacgag gtcaggtaca atggcaacgg tagaccggtc agcggacccg atgtcatcat 5401 caccggcaac agtttcacgc taacccatcg cgttcgcact catccgggtc agaacaacag 5461 ggtgactatt cccttcctgc cgggaggctg gacgaagccg gatggtcgca agggaacgcg 5521 agaggacatc atgatgatac tggccaatgt ggacaatatt ctgattcgac tgggctacct 5581 ggatagcaca gctcgcgaag tggatctgat aaatatcgcc ttggattcgg ccggaagtgc 5641 cgatcaggga ttgggcagtg cctcgctcgt ggagaagtgc acctgtccgc ccggctatgt 5701 tggtgattcg tgcgagtcct gtgcctcggg ctatgttcgc caggcccgcg gaccttggct 5761 gggtcattgt gtgcccttca ccccggaacc gtgcccagcg ggaacctacg gcaatccccg 5821 acttggtgtt ccctgccagg agtgtccgtg cccccacgcg ggcgccaata actttgccag 5881 cggctgccaa cagagtcccg atggcgatgt gatttgccgc tgcaacgaag gctatgccgg 5941 caagaggtgc gagcactgcg cccagggtta ccagggtaat ccgttggcac cgggaggagt 6001 ctgtcgcaag atacccgata gttcgtgcaa tgtcgacggc acctacaaca tctacagcaa 6061 tggaacgtgc cagtgcaagg atagcgtgat tggcgaacag tgcgacacct gcgcgccgaa 6121 gagtttccac ctcaattcgt tcacctacac cggttgcatc gagtgcttct gcagtggagt 6181 gggcttggat tgtgacagta gttcgtggta tcgcaaccag gtcaccagca cctttggacg 6241 aacgcgcgtc aatcatggat tcgccctgat tagcgactat atgcgcaata ccccggtaac 6301 ggtgcccgtt tccatgtcca cccaggccaa tgccttgagc ttcgtgggat ccgccgagca 6361 ggccggtaat acgctctact ggagtcttcc cgccgccttc ctgggcaaca agctgacctc 6421 gtacggaggc aagttgagct acacgctcag ctacagtccc ctgcccagcg gcattatgtc 6481 gcgcaacagt gcccccgatg tggtgatcaa gagcggcgag gatctgaggc tcatccatta 6541 caggaagtcg caggtcagtc ccagtgtggc caacacctat gccgtggaga tcaaggagag 6601 cgcatggcag cgcggcgatg aactggtgcc taaccgtgaa cacgtcctga tggccctcag 6661 caatattacg gccatctata tcaaggccac gtacacgact agcaccaagg aggcctcgct 6721 gcgatcggtc acattggata cggccacggc caccaatctg ggcaccgcac gtgccgtcga 6781 agtggagcag tgccgctgtc ccgagggcta tttgggtctc tcctgcgagc agtgtgctcc 6841 tggctatacg cgcgatccgg aggcaggaat ctatctgggt ctctgcaggc cctgcgagtg 6901 caatggacat tccaagtatt gcaacagtga gacaggcgaa tgcgaaagct gttccgacaa 6961 caccgaagga ttcaattgtg accgatgcgc cgccggctat gtgggtgatg ccacccgagg 7021 aacttcgtac gactgtcaat acgatgacgg cggctatccg acgtcgcgtc caccggcacc 7081 gggcaatcag acggccgaat gcctggtgaa ttgccaacag gagggaaccg ccggttgccg 7141 cggctaccag tgcgagtgca agaggaatgt ggctggcgat cgatgcgatc agtgccgccc 7201 cggaacctat ggactgtcgg cccaaaatcc ggacggttgc aaggagtgct actgctccgg 7261 actgaccaac cagtgccgct cggcgtctct ctaccgccag ctgatacccg tggacttcat 7321 ttcgacgcca ccattgataa cagacgaatt cggcgacatc atggataggg ataaccttgt 7381 gcccgacgtg cccaggaatg tgtataccta caagcacacc tcctacacgc ccaagtactg 7441 gagcctgagg ggtagtgtgc tgggcaacca gctgttgtcg tacggcggcc gcttggagta 7501 cagcctgatt gtggagtccg ttggccggga ccatcgtggc aaggatgtgg tcctaattgg 7561 caacggactc aagctgatct ggtcgcgacc cgatggccat gacaacgagc aggaatacca 7621 tgtgcgtttg catgaggacg agcagtggac ggttgaggat cgtggatcgg cacgacaggc 7681 cacgcgggcc gacttcatga ctgtgctgtc ggatctgcag cacatcctga tcctggccac 7741 acccaaggtg cccacggtca gcacctcgat tagcaatgtc atcctggaga gttcgataac 7801 cacgagagcg cctggagcta cgcatgcctc cgatatcgag ttgtgccagt gtccatccgg 7861 ttatacgggc acttcctgtg agtcctgcgc accactgcac taccgcgacg cctctggacg 7921 ctgcagtcag tgtccttgcg acgcttccaa cacggaatcc tgcggcttgg tcagcggcgg 7981 taacgtcgaa tgccagtgca ggccacgctg gaggggtgat cgctgccggg aaattgaaac 8041 taacgaaccg actccggaac cggataccag taccgatgat cccgtgcgca cccagatcat 8101 agtgtcgatt gccaggccag agattaccat tctgcccgtg ggtggatcgc tgaccctcag 8161 ctgtaccggt cgaatgcgct ggaccaatag cccagtgttt gtgaactggt acaagcaggg 8221 cagtcacctg cccgagggag tcgaggtgca aggcggtaat ctgcagctgt tcaacctgca 8281 gatcagcgat tctggaatct acatctgcca ggccgtaagc aacgagaccg gccacagctt 8341 tacggaccac gtctccatca ccgtttccca ggaggaccaa cgctcgccgg ctcacattgt 8401 ggatttgccc aacgacgtga ccttcgagga gtacgtaagc aatgagatcg tctgcgaggt 8461 ggagggcaac ccaccaccca ctgtcacctg gactcgcgtg gatggccatg cggacgccca 8521 aagtacgcga acggacaaca atcggctggt cttcgattcg ccgaggaaat cggacgaggg 8581 tcgctatcgc tgccaggcag agaatagcct gagtcgggag gagaagtacg tagtcgtgta 8641 tgtccggagc aatcctcccc agccgccgcc gcagcaggat cgtttgtaca tcacaccgca 8701 ggaggtgaac ggtgtggccg gtgactcctt ccagttgtcc tgccaattca ccagcgctgc 8761 ctctctgcgc tacgattggt cccacgatgg tcgctccctg tccgcgtcgt caccccgaaa 8821 tgttgtggtc cgcggaaatg tcctggaagt ccgcgatgcc aacgttcgcg actccggcac 8881 ctacacctgt gtggccttcg acctgcgcac ccgacgcaac ttcaccgaga gcgcacgggt 8941 ctacatcgag cagcccaacg agccgggaat ccttggcgac aagccgcata tcttgacctt 9001 ggagcagaac atcataattg tgcaaggcga ggacttgagc atcacatgtg aggcaagtgg 9061 aacgccctat ccctcgatta agtggaccaa ggtgcaggag aatctggccg aaaatgtccg 9121 catcagtggc aatgtgctca ccatctacgg aggccgcagt gagaatcgtg gtctttactc 9181 ctgcatcgcc gagaactctc acggcagcga tcagtccagc acaagcatcg atattgaacc 9241 ccgggagcgg ccgagtctta cgattgatac ggccacccaa aaggtttcgg ttggctccca 9301 ggcgtccctt tactgtgccg cccagggcat tcccgaaccg accgtcgagt gggttcgaac 9361 ggatggtcag ccactgtcgc cgcgtcacaa ggtccaggca cccggctatg ttgtgatcga 9421 tgacattgtg ctcgatgata gcggtaccta cgagtgccgg gcgagcaaca tagctggcca 9481 ggtgagcggc ttggccacca ttaacgtcca ggagccaact cttgtgcgga tcgaaccaga 9541 taggcaacac catatcgtca cccagggcga cgaactctcg ctcagctgcg tgggcagtgg 9601 cgtccctact ccttcggtct tttggagttt cgagggaaga gacgttgaca ggatgggagt 9661 accggaaggt gctgtttttg cgcaaccttt ccgaaccaac actgccgacg tgaaaatctt 9721 ccgggtgagc aaggagaacg aaggcatcta cgtctgtcac ggatccaatg acgcgggtga 9781 agatcaacaa tacattcgcg tggaggtaca acccagacgg ggtgacgtcg gtgcaggagg 9841 agatgacaat ggtgatgtcg atacccgaca gccccccaat cggccccaaa tccaaccgaa 9901 tccattgagc aacgaacgcc tgaccaccga attgggcaac aatgtgaccc tcatctgcaa 9961 cgtggacaac gtgaacacgg aatgggaacg cgtcgatggc acacccctgc cgcacaatgc 10021 ctacacggtg agaaatacgc tggtgattgt cttcgtggag ccgcagaatc tgggtcagta 10081 ccgctgcaat ggaatcggtc gcgatggacg tgtggaggcc catgtggtga gggagctggt 10141 tctcctgccc ctgcccagga tcaccttcta tcccaacatc ccgctgaccg tggagctggg 10201 ccagaacttg gatgtctact gccaggtgga gaacgtgcgt ccggaggacg tgcattggac 10261 caccgacaac aatcgaccac tgcccagttc cgtacgcatc gagggcaatg tcctcaggtt 10321 cgcgtccatc actcaggctg ctgccggtga ataccgctgc tcggccacca atcaatatgg 10381 aagccgatcg aagaacgcca gggtggtggt gaaacagccc agtggcttcc agcccgttcc 10441 ccactcgcag gtgcaacagc gtcaggtggg cgactccatc cagttgcgat gccgcctgac 10501 cacccagtac ggcgacgagg ttcgcggcaa tatccagttc aactggtacc gtgaggacgg 10561 cagccccttg ccccgcggtg tccgtccgga tagccaggtg ctgcagctgg ttaaattgca 10621 gcccgaggac gagggccgct acatctgcaa ctcgtacgat ttgggcagcg ggcagcaact 10681 gccccccgtc tccatcgact tgcaagtact aagaactact acccagtatc ctttcaatcg 10741 gtttaagggc ggtgtctccc tgaaagacac gccctgcatg gttctgtata tttgtgcagc 10801 ggtaccagcg gctccccaga accccatcta cctgccgcca gtggcgccac cacgttcgcc 10861 cgaaaggatc ctcgagcccc aactgagcct gagtgtacaa tcctcgaacc tgccagccgg 10921 cgacggcacc accgtcgagt gcttctcctc cgatgactcc tacccagatg tcgtgtggga 10981 acgcgccgat ggagctccac tcagcgaaaa tgtccagcaa gtgggcaata acctggtgat 11041 tagtaacgtg gcctccaccg atgccggtaa ctatgtgtgc aagtgcaaga cggacgaggg 11101 agatctgtat accaccagct acaaactgga ggtcgaggag cagccccatg aactgaagag 11161 ctccaagata gtctacgcca aggttggcgg aaatgccgac ttgcagtgcg gagccgatga 11221 agatcgacag cccagctacc gttggtctcg ccaatacgga caacttcagg cgggacgcag 11281 tctgcagaat gagaaacttt cgttggatcg cgttcaggcc aacgatgccg gaacttatgt 11341 ttgttcggcc caatacagcg atggcgagac ggttgacttc cccaacattc tggttgtgac 11401 cggggcgatt ccccagttcc gccaggagcc ccgcagctac atgagcttcc ccacgctctc 11461 gaactcctcg ttcaagttca acttcgagct gaccttccgg ccggaaaacg ccgacggact 11521 gctgctcttc aatggacaga cccgcggaag cggtgactat atcgcactct cgctgaagga 11581 tcgctatgcg gagttccggt tcgattttgg cggtaaaccg ttgctggtgc gagcggagga 11641 gccactggct ttggatgaat ggcacacggt gcgcgtgagt cgcttcaagc gggatggcta 11701 catccaggtg gacgaccagc atccggtggc cttccccacc tcccagcatc agcagatacc 11761 ccagttggaa ctgattgagg atctgtacat tggcggcgtg cccaactggg agttcctgcc 11821 cgccgaggcg gtgggtcagc aatcaggctt cgtgggctgc attagccggc tgaccctgca 11881 gggacgcacc gtggagctga tccgggaggc caagttcaag gagggcatca ccgattgccg 11941 gccctgcgcc cagggaccct gccagaacaa gggcgtctgc ctggagagcc agacggagca 12001 ggcctacacc tgcgtctgcc agccgggctg gactggccgg gattgtgcca tcgagggcac 12061 ccagtgcacc gcaggagttt gcggctcggg acgctgcgag aatacggaga acgacatgga 12121 gtgcctgtgc ccgctgaaca gggcaggcga tcgatgccag tacaatgaga ttctaaatga 12181 acagagcttg aatttcaaga gcaacagctt tgcggcctac ggaactccca aggtcaccaa 12241 agtaaacatc acactctccg ttcgtcccgc gagcctggag gactctgtga tcctgtacac 12301 ggcggaatcc actctgccca gcggcgatta cctggctttg gtccttcgcg gtggccacgc 12361 ggagctgctg atcaacacgg ccgcccgctt ggatcccgtg gtggtgcgtt cggcggaacc 12421 gctgcccctc aatcgctgga ccagaatcga gatcaggcgt cgcctgggcg agggaatcct 12481 caaggtgggc gatggacccg agcgaaaggc caaggcaccg ggatccgatc gcattctgtc 12541 gctcaagacc cacctctttg tgggcggcgt cgatcggtcg accgtaaaga tcaaccgtga 12601 tgtgaacatc accaagggct tcgatggctg catctcgaag ctgtacaact cgcagaaatc 12661 cgtcaatctg ctgggtgaca tcagggatgc ggcgaatgtc cagaactgtg gggaggcgaa 12721 tgagatagat gacgatgagt atgagatgcc agtagcgctg ccatcgccta aggtcgccga 12781 gaatgaacgt cagctgatgg cgccgtgtgc cagtgatccc tgcgagaacg ggggaagctg 12841 cagcgagcag gaggacatgg ccatctgctc ctgtcccttc ggcttcagcg gcaaacactg 12901 ccagaatcac ctccagctga gcttcaatgc ctcgttccgc ggcgatggct acgtggagct 12961 gaaccgcagc cacttccaac ccgccctgga gcagacgtac tcccacattg gcattgtgtt 13021 caccaccaac aagccgaatg gcctgctttt ctggtggggc caggaggccg gggaggagta 13081 caccggacag gacttcattg ccgccgccgt ggtcgatggc tatgtggagt actcgatgag 13141 gctcgatggc gaggaggcgg tcattcggaa cagcgatatc cgcgtggaca atggcgagcg 13201 gcacattgtg atcgccaagc gggatgagaa caccgccatg ctggaactcg atcagatcct 13261 ggacacgggc gatacgcgac ccaccatcaa caaggcaatg aagctgccgg gcaatgtgtt 13321 tgtcggtggc gctcctgatg tcgcggcatt cacgggcttc cgctacaagg acaatttcaa 13381 cggctgcatt gtggtcgtcg agggcgaaac cgtgggccaa attaacctta gttcagctgc 13441 catcaatgga gtgaatgcca acgtgtgtcc cgctaacgac gaacctctgg gaggaaccga 13501 accgccagtc gtctgaggac acaaccagca accgaaatta gctttttaat taaacattaa 13561 caaatgaaac aaaaagaaaa acaattttta tatatacaac atatgaataa gccccaagca 13621 aacctacaaa aaattgaata ttatacgacg aacagataat ataaaaacaa aaaaagagag 13681 aaacgatcac ttctactaca attgcttctt cgatccttaa gtctaggtta aagattgtag 13741 caagaaaaca agcgaatatc acaaacattt atttaacaag aacgccatgc gagaagtgaa 13801 acgaaacaga aacaataatg caattaatgc agataataca gataaagcct agaaccctaa 13861 gaactaacta actaactcga acaagaacaa caacgcatac tagccaactg caaccacaac 13921 aaccacaata gtgaaggcat tttaattata attttagtct ctagcttata actatgacta 13981 cgactcgttt tttttgtgag cccagtgtaa aatgttggaa atcggaaatt ggccctacac 14041 acaaacacac acaagttatt aattaaatac caattgatac catataatga taaatgaaat 14101 actatgaatg caactattgt gaacgaacga aaaccgttga gtggataaaa agcataagca 14161 gaagatatat taaaatgaaa tcaacaaca