Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]
LOCUS XM_070218423 14195 bp mRNA linear INV 09-DEC-2024 (trol), transcript variant X6, mRNA. ACCESSION XM_070218423 VERSION XM_070218423.1 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..14195 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..14195 /gene="trol" /note="terribly reduced optic lobes; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 9 Proteins" /db_xref="GeneID:108055788" CDS 209..13522 /gene="trol" /codon_start=1 /product="basement membrane-specific heparan sulfate proteoglycan core protein isoform X6" /protein_id="XP_070074524.1" /db_xref="GeneID:108055788" /translation="MGSPGSQAPAIAIGISNGRRGHTGSLLLRLLLVAFVLNACHVPP TNAKQITKSKVDDQDFILADTQSLQGSVDLDDDEAFLIPPDSEEKLDKKFTPEGNWWS QGLHRVRRSLNSFFGSDDDDQEKERERQRQRQNNRDAANRQKELRRQQKESQNREKQL RLERQERQRLAKRNNHVVFNRVTDPRKRASDLYDENEASGLNEEETTTYRTYFVVNEP YSDDYKERDSLQFQNLQKLLDEDLRNFFNRNFENNDDEEQEIHSTLERVDQTKDHFKI RVQLRVDLPSSINDFGSKLEQQLNVYKRIDRLGASTDGVFTFTESSVYKYEHQYDIVT PRVIVSGQPITEKPVEAPQEFDEDPIEVALPTDEVEGSGQDSGSCRGDATFQCRRSGK TICDEMRCDGSRDCPDAEDEEGCEVCNELQFKCDNKCLPLNKRCDNRYDCEDQTDEAG CQRYEVEESQPQPQPQPQPEPEPEPEPEPEPEPEPEPEPEEPITDNEQPEQNSECRAT EFRCNNGDCIDIRKRCDHISDCSEGEDENEECPAACSGMEYQCRDGTRCISLSQQCDG HSDCSDADDEEHCDGSGNDGEDCRFDEFRCGTGECIPMRQVCDNIYDCNDYSDEVSCA EEEEDSVGIPIGRPPQRPAPKHDWLDELDANEYHVYHPSNVYELANSKNPCASNQFRC ATTNVCIPLHLRCDNFYHCNDMSDEKDCEQYQRRTTTTTRRPSTSARPSFTFTFTTQG PGLLERRNSTTSRTTAGSTTRATEAPQWPWATRPTETTTTNPITTVGVASSSPQSSCL ENIEFACHNRDCIPIESVCDGTPDCGRSEDEDDALCKCTADKYKCQHGGGCIPKTQVC DGKPQCRDRSDESACHLNGRLNKTRLGVQCQENQYQCGDGSCISGYKRCNGINDCADD ADEYNCIYTYNEDYVDPDDNPLNECDILEFECDYSLCLPLEKKCDGYADCEDLSDEFE CQSYTENCLLSEFECDGYCLPRDQLCNGIINCQDGSDERNCTFCREDAYLCTTGECVA VNQRCNGIVECADGSDERHCATTRLKPSDCGPDQFFCDDLCYNRSIRCNGHMDCSDGS DEIACSSLSVLPCPQHQCPSGRCYSESERCDRHRHCEDGSDEANCCYADQFRCNNGDC IAESAHCDGNIDCSDQSDELDCGGDSQCLPNQFRCKNGQCVSSTARCNKRSDCLDGSD EQNCANEPNNSGRGTNQLKLKTYPDNQIIKESREVIFRCRDEGPNRAKVKWSRPGGRP LPPGFTDRNGRLEIPNIRVEDAGAYVCEAVGYANYIPGQHVTVNLNVERLNEREIRPD SACTEYQATCMNGECIDKSGICDGHPDCSDGSDEHSCSLGLKCQPNQFMCSNSKCVDR TWRCDGENDCGDNSDETSCDPEPSDAPCRYDEFQCRSGHCIPKSFQCDYMNDCTDGTD EIGCSVPSPMTLPAPSIVVMEYEVLELTCVGTGVPTPTIVWRLNWGHVPEKCESKSYG GTGTLRCPNMRPQDSGAYSCEFINTRGTFYPKTNSIVTVTPVRSDVCKAGFFNMLARK SEECVQCFCFGVSTNCDSANLFTYAIQPPILSHRVVSVELSPFRQIVINEASPGQDLL TLHHGVQFRASNVHYNGRETPFLALPAEYMGNQLKSYGGNLRYEVRYNGNGRPVSGPD VIITGNSFTLTHRVRTHPGQNNRVTIPFLPGGWTKPDGRKGTREDIMMILANVDNILI RLGYLDSTAREVDLINIALDSAGSADQGLGSASLVEKCTCPPGYVGDSCESCASGYVR QARGPWLGHCVPFTPEPCPAGTYGNPRLGVPCQECPCPHAGANNFASGCQQSPDGDVI CRCNEGYAGKRCEHCAQGYQGNPLAPGGVCRKIPDSSCNVDGTYNIYSNGTCQCKDSV IGEQCDTCAPKSFHLNSFTYTGCIECFCSGVGLDCDSSSWYRNQVTSTFGRTRVNHGF ALISDYMRNTPVTVPVSMSTQANALSFVGSAEQAGNTLYWSLPAAFLGNKLTSYGGKL SYTLSYSPLPSGIMSRNSAPDVVIKSGEDLRLIHYRKSQVSPSVANTYAVEIKESAWQ RGDELVPNREHVLMALSNITAIYIKATYTTSTKEASLRSVTLDTATATNLGTARAVEV EQCRCPEGYLGLSCEQCAPGYTRDPEAGIYLGLCRPCECNGHSKYCNSETGECESCSD NTEGFNCDRCAAGYVGDATRGTSYDCQYDDGGYPTSRPPAPGNQTAECLVNCQQEGTA GCRGYQCECKRNVAGDRCDQCRPGTYGLSAQNPDGCKECYCSGLTNQCRSASLYRQLI PVDFISTPPLITDEFGDIMDRDNLVPDVPRNVYTYKHTSYTPKYWSLRGSVLGNQLLS YGGRLEYSLIVESVGRDHRGKDVVLIGNGLKLIWSRPDGHDNEQEYHVRLHEDEQWTV EDRGSARQATRADFMTVLSDLQHILILATPKVPTVSTSISNVILESSITTRAPGATHA SDIELCQCPSGYTGTSCESCAPLHYRDASGRCSQCPCDASNTESCGLVSGGNVECQCR PRWRGDRCREIDTSPIIEEPPQICDLSRGFCCSGFQFDIAPNETISFNDTLQIYKGNR IIGNMTKLRYGCPSRETNEPTPEPDTSTDDPVRTQIIVSIARPEITILPVGGSLTLSC TGRMRWTNSPVFVNWYKQGSHLPEGVEVQGGNLQLFNLQISDSGIYICQAVSNETGHS FTDHVSITVSQEDQRSPAHIVDLPNDVTFEEYVSNEIVCEVEGNPPPTVTWTRVDGHA DAQSTRTDNNRLVFDSPRKSDEGRYRCQAENSLSREEKYVVVYVRSNPPQPPPQQDRL YITPQEVNGVAGDSFQLSCQFTSAASLRYDWSHDGRSLSASSPRNVVVRGNVLEVRDA NVRDSGTYTCVAFDLRTRRNFTESARVYIEQPNEPGILGDKPHILTLEQNIIIVQGED LSITCEASGTPYPSIKWTKVQENLAENVRISGNVLTIYGGRSENRGLYSCIAENSHGS DQSSTSIDIEPRERPSLTIDTATQKVSVGSQASLYCAAQGIPEPTVEWVRTDGQPLSP RHKVQAPGYVVIDDIVLDDSGTYECRASNIAGQVSGLATINVQEPTLVRIEPDRQHHI VTQGDELSLSCVGSGVPTPSVFWSFEGRDVDRMGVPEGAVFAQPFRTNTADVKIFRVS KENEGIYVCHGSNDAGEDQQYIRVEVQPRRGDVGAGGDDNGDVDTRQPPNRPQIQPNP LSNERLTTELGNNVTLICNVDNVNTEWERVDGTPLPHNAYTVRNTLVIVFVEPQNLGQ YRCNGIGRDGRVEAHVVRELVLLPLPRITFYPNIPLTVELGQNLDVYCQVENVRPEDV HWTTDNNRPLPSSVRIEGNVLRFASITQAAAGEYRCSATNQYGSRSKNARVVVKQPSG FQPVPHSQVQQRQVGDSIQLRCRLTTQYGDEVRGNIQFNWYREDGSPLPRGVRPDSQV LQLVKLQPEDEGRYICNSYDLGSGQQLPPVSIDLQVLRTTTQYPFNRFKGGVSLKDTP CMVLYICAAVPAAPQNPIYLPPVAPPRSPERILEPQLSLSVQSSNLPAGDGTTVECFS SDDSYPDVVWERADGAPLSENVQQVGNNLVISNVASTDAGNYVCKCKTDEGDLYTTSY KLEVEEQPHELKSSKIVYAKVGGNADLQCGADEDRQPSYRWSRQYGQLQAGRSLQNEK LSLDRVQANDAGTYVCSAQYSDGETVDFPNILVVTGAIPQFRQEPRSYMSFPTLSNSS FKFNFELTFRPENADGLLLFNGQTRGSGDYIALSLKDRYAEFRFDFGGKPLLVRAEEP LALDEWHTVRVSRFKRDGYIQVDDQHPVAFPTSQHQQIPQLELIEDLYIGGVPNWEFL PAEAVGQQSGFVGCISRLTLQGRTVELIREAKFKEGITDCRPCAQGPCQNKGVCLESQ TEQAYTCVCQPGWTGRDCAIEGTQCTAGVCGSGRCENTENDMECLCPLNRAGDRCQYN EILNEQSLNFKSNSFAAYGTPKVTKVNITLSVRPASLEDSVILYTAESTLPSGDYLAL VLRGGHAELLINTAARLDPVVVRSAEPLPLNRWTRIEIRRRLGEGILKVGDGPERKAK APGSDRILSLKTHLFVGGVDRSTVKINRDVNITKGFDGCISKLYNSQKSVNLLGDIRD AANVQNCGEANEIDDDEYEMPVALPSPKVAENERQLMAPCASDPCENGGSCSEQEDMA ICSCPFGFSGKHCQNHLQLSFNASFRGDGYVELNRSHFQPALEQTYSHIGIVFTTNKP NGLLFWWGQEAGEEYTGQDFIAAAVVDGYVEYSMRLDGEEAVIRNSDIRVDNGERHIV IAKRDENTAMLELDQILDTGDTRPTINKAMKLPGNVFVGGAPDVAAFTGFRYKDNFNG CIVVVEGETVGQINLSSAAINGVNANVCPANDEPLGGTEPPVV" misc_feature 458..>715 /gene="trol" /note="Coiled-coil domain-containing protein 66; Region: CCDC66; pfam15236" /db_xref="CDD:434558" misc_feature 1460..1561 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1475..1477,1496..1498,1529..1534) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1508..1510,1517..1519,1529..1531,1547..1552) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1538..1552 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1718..1816 /gene="trol" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(1736..1738,1760..1762,1793..1798) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1772..1774,1781..1783,1793..1795,1811..1816) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1802..1816 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1838..1945 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1853..1855,1880..1882,1913..1918) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1892..1894,1901..1903,1913..1915,1931..1936) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1922..1936 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1973..2077 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1988..1990,2012..2014,2045..2050) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2024..2026,2033..2035,2045..2047,2063..2068) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2054..2068 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2231..2338 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2246..2248,2273..2275,2306..2311) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2285..2287,2294..2296,2306..2308,2324..2329) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2315..2329 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2597..2701 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2615..2617,2639..2641,2672..2677) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2651..2653,2660..2662,2672..2674,2690..2695) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2681..2695 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2714..2821 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2729..2731,2756..2758,2789..2794) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2768..2770,2777..2779,2789..2791,2807..2812) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2798..2812 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2864..2968 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2879..2881,2903..2905,2936..2941) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2915..2917,2924..2926,2936..2938,2954..2959) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2945..2959 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3023..3127 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3038..3040,3062..3064,3095..3100) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3074..3076,3083..3085,3095..3097,3113..3118) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3104..3118 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3146..3247 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3161..3163,3182..3184,3215..3220) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3194..3196,3203..3205,3215..3217,3233..3238) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3224..3238 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3254..3358 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3269..3271,3293..3295,3326..3331) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3305..3307,3314..3316,3326..3328,3344..3349) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3335..3349 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3386..3487 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3401..3403,3422..3424,3455..3460) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3434..3436,3443..3445,3455..3457,3473..3478) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3464..3478 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3515..3607 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3518..3520,3542..3544,3575..3580) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3554..3556,3563..3565,3575..3577,3593..3598) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3584..3598 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3608..3712 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3623..3625,3647..3649,3680..3685) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3659..3661,3668..3670,3680..3682,3698..3703) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3689..3703 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3728..3832 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3743..3745,3767..3769,3800..3805) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3779..3781,3788..3790,3800..3802,3818..3823) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3809..3823 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3875..4081 /gene="trol" /note="Immunoglobulin domain; Region: Ig_3; pfam13927" /db_xref="CDD:464046" misc_feature 4175..4279 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4190..4192,4214..4216,4247..4252) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4226..4228,4235..4237,4247..4249,4265..4270) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4256..4270 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4295..4399 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4310..4312,4334..4336,4367..4372) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4346..4348,4355..4357,4367..4369,4385..4390) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4376..4390 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4424..4528 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4439..4441,4463..4465,4496..4501) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4475..4477,4484..4486,4496..4498,4514..4519) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4505..4519 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4580..4807 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 4589..4603 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 4628..4642 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 4697..4711 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 4739..4756 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 4781..4792 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature 5102..5494 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature 5663..5824 /gene="trol" /note="Laminin EGF domain; Region: Laminin_EGF; pfam00053" /db_xref="CDD:395007" misc_feature order(5663..5665,5669..5671,5705..5707,5735..5737, 5741..5743,5768..5770) /gene="trol" /note="EGF-like motif [active]" /db_xref="CDD:238012" misc_feature 6197..6607 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature <6608..6688 /gene="trol" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; Region: EGF_Lam; cd00055" /db_xref="CDD:238012" misc_feature 6710..6859 /gene="trol" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; Region: EGF_Lam; cd00055" /db_xref="CDD:238012" misc_feature order(6713..6715,6719..6721,6740..6742,6761..6763, 6770..6772,6797..6799) /gene="trol" /note="EGF-like motif [active]" /db_xref="CDD:238012" misc_feature <6968..7060 /gene="trol" /note="Laminin EGF domain; Region: Laminin_EGF; pfam00053" /db_xref="CDD:395007" misc_feature 7256..7660 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature 8123..8371 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 8156..8170 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 8204..8218 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 8261..8275 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 8303..8320 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 8348..8359 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature <8450..8611 /gene="trol" /note="Immunoglobulin domain; Region: Ig_3; pfam13927" /db_xref="CDD:464046" misc_feature 8702..8953 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 8735..8749 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 8774..8788 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 8843..8857 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 8885..8902 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 8990..9232 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 9041..9055 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409570" misc_feature 9080..9094 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409570" misc_feature 9137..9151 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409570" misc_feature 9179..9196 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409570" misc_feature 9218..9229 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409570" misc_feature 9284..9514 /gene="trol" /note="Immunoglobulin I-set domain; Region: I-set; pfam07679" /db_xref="CDD:400151" misc_feature 9308..9322 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 9347..9361 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 9410..9424 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 9452..9469 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 9491..9502 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature 9551..9814 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 9581..9595 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 9620..9634 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 9752..9769 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 10187..10417 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 10214..10228 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 10253..10267 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 10313..10327 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 10355..10372 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 10451..>10654 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 10484..10498 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 10532..10555 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 10601..10615 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 10883..11089 /gene="trol" /note="Immunoglobulin domain; Region: Ig_3; pfam13927" /db_xref="CDD:464046" misc_feature 11177..11377 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 11201..11215 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 11240..11254 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 11297..11311 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 11339..11356 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 11441..11884 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" misc_feature 11951..12049 /gene="trol" /note="EGF-like domain; Region: EGF; pfam00008" /db_xref="CDD:394967" misc_feature 12191..12652 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" misc_feature 12812..12910 /gene="trol" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054" /db_xref="CDD:238011" misc_feature 12935..13396 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" polyA_site 14195 /gene="trol" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN 1 attaggttgc gcgccatcgt tccaggcggt cgcacattcc acgtgccata gccgtaacaa 61 caacctgcca accgcttaaa accaaactca aatacgaacc gaaactgcct tcacacacac 121 aagtacctaa accaaatcta aatagctgcc aaaagaaacc aaaaattcca gagacgtcgt 181 agcatccgtt ccccggaaga agaagaagat gggatcgccg ggatcccaag cgcccgcgat 241 cgcgatcggg atcagtaacg ggcggagagg tcacacgggg tcgctgctcc tgcgcctcct 301 tctcgtggcc ttcgtcctca acgcctgcca cgtacccccg accaatgcca agcaaattac 361 gaaaagtaaa gttgatgacc aggactttat actggccgac acacaatcgc tgcagggcag 421 cgttgacctt gacgatgacg aagcgttcct gattcctccg gattccgaag agaagttgga 481 taagaagttc acgccggagg gcaactggtg gagccagggg ctccatcgtg ttcgccgctc 541 cctaaatagc ttcttcggct ccgacgacga tgatcaggaa aaggaacgtg agcgtcagag 601 gcaaaggcaa aataatcgcg atgccgccaa ccggcaaaag gaacttcggc gccagcaaaa 661 ggagagccag aaccgcgaga agcagctgcg attggagcgc caggagaggc agcgccttgc 721 caagcggaac aatcacgtgg tcttcaatcg cgtcaccgat ccccgcaagc gggcatccga 781 cctttacgac gagaacgagg catctggcct aaacgaggag gaaaccacca cctatcgcac 841 ctactttgtt gttaatgagc catattcaga cgactacaag gagcgggaca gcctccagtt 901 ccagaatctg caaaaacttc ttgacgagga cctgcgcaac ttcttcaatc gcaatttcga 961 aaataacgat gatgaagagc aggaaatcca tagcacccta gagcgagtcg atcaaaccaa 1021 ggaccatttt aaaattcgcg tgcaacttag ggtagatctg cccagttcaa tcaacgactt 1081 tggaagtaag ttggagcaac aactgaatgt ctacaagcga atcgatcgtt tgggtgccag 1141 taccgatggc gtcttcacct ttaccgaatc gagcgtctac aaatacgaac accaatacga 1201 tattgtgaca ccgagagtaa ttgtatctgg acaaccgata actgaaaaac cagtcgaagc 1261 accccaagaa ttcgatgagg atcctatcga agttgcattg cccacggatg aggtggaggg 1321 ctccggccaa gattccggta gctgtcgcgg cgatgccacc ttccagtgtc gaaggagtgg 1381 aaagactatt tgcgatgaaa tgcgatgcga tggatctcgc gattgtcccg atgccgagga 1441 cgaggaaggc tgcgaggttt gcaacgaact tcagttcaag tgcgataaca agtgtctgcc 1501 gctcaataag cgctgcgata atcgatacga ttgtgaggat cagacggacg aggctggttg 1561 tcaacggtac gaagtagaag agtctcagcc tcagccgcag ccgcaacctc agcctgaacc 1621 ggaacctgaa cctgaacctg agcctgagcc tgaacctgaa ccagaaccag aacctgaaga 1681 gcctataaca gacaatgaac agcctgagca aaactcagaa tgccgggcca ccgagttcag 1741 atgcaacaat ggggactgca tcgatattag aaagcgttgc gatcacattt cggactgtag 1801 cgaaggcgag gacgagaacg aggagtgccc cgccgcctgc agcggaatgg agtatcaatg 1861 tcgcgacggc acgcgctgca taagtttgag tcagcagtgc gacggtcatt ccgattgcag 1921 cgacgccgac gacgaggagc attgcgacgg aagtggtaac gatggtgagg attgtcggtt 1981 cgatgagttc cgttgcggaa ctggtgagtg cataccgatg cgtcaggtgt gcgataacat 2041 ctacgattgc aacgattatt ccgatgaggt cagctgcgcc gaggaggagg aagatagtgt 2101 gggcataccc attggccgtc caccgcagag gccagcgccc aaacacgact ggctggacga 2161 attggacgcc aatgagtacc acgtctatca tccaagtaat gtctatgagt tggccaattc 2221 caagaatccc tgtgccagca atcaatttcg ctgcgccacc acgaatgtgt gcatccccct 2281 gcatttgcgt tgcgataatt tctatcactg caacgatatg agcgatgaga aggactgcga 2341 gcagtatcaa cgacgcacca ccaccaccac ccgacgacct tcgacctcgg cccggccctc 2401 cttcaccttc accttcacga cccaggggcc aggcttgctg gagcgtcgca atagcaccac 2461 cagtagaacc accgcaggca gcaccaccag agccaccgaa gcaccacaat ggccatgggc 2521 aaccagaccc accgagacca cgaccactaa cccaataaca acagttggcg tagcgagcag 2581 ctcacctcag tcctcctgtc tcgaaaacat cgaattcgcg tgtcacaatc gcgattgcat 2641 tccgattgag agcgtctgcg atggcacccc cgactgcgga cgcagtgaag acgaggacga 2701 cgctctttgc aagtgcaccg ccgacaagta caaatgccaa cacggcggag gctgcattcc 2761 gaaaacccag gtgtgcgatg gcaaacctca gtgccgcgac cgcagcgacg agagcgcctg 2821 ccatctcaat ggaagattaa ataagactcg tttgggggtc cagtgccagg aaaaccagta 2881 tcaatgtggc gatggaagct gcatctccgg ctacaaacgc tgcaatggca tcaacgattg 2941 cgccgatgac gccgacgaat ataactgcat ctacacctac aacgaagact acgtagaccc 3001 ggacgacaat ccattgaatg aatgtgatat ccttgagttt gaatgtgact acagtctgtg 3061 tttaccgcta gagaagaaat gcgatggcta tgcagactgt gaagacttga gcgacgagtt 3121 cgagtgtcag tcgtacacag agaattgtct attgtctgag ttcgaatgcg atggctactg 3181 cctgccccgc gatcagttat gcaacggaat aatcaattgc caagatggca gcgacgagcg 3241 caactgtacc ttttgccggg aagatgccta cctctgcacc accggcgagt gtgtggccgt 3301 aaatcagaga tgcaacggca tcgtcgaatg cgccgatggc agcgacgagc gtcactgcgc 3361 caccacacga ctaaagccca gcgactgcgg tccggatcag ttcttctgcg atgatttatg 3421 ctataatcgc tctattcgat gcaatggcca tatggattgc tcagatggca gtgatgagat 3481 cgcttgtagc tcgctgtcag tgcttccatg tccacagcac cagtgtccca gtggcaggtg 3541 ttattcggaa agtgagcgat gcgatcgcca caggcactgc gaggatggct ccgatgaggc 3601 caactgctgt tacgcggatc aattccgctg caataatggt gactgcattg cggaatcggc 3661 tcattgcgat ggaaatatcg attgtagcga ccagtccgat gaactcgact gcggaggaga 3721 ctcgcagtgt ctgcccaacc aattccgctg caagaatggc caatgtgtga gctctacagc 3781 gcgttgcaac aagcgttccg attgtttgga tggctccgat gagcagaatt gtgccaatga 3841 acctaacaac tccggacgtg gaacgaacca attgaaactc aagacctatc ccgacaacca 3901 aatcattaag gagagtcgtg aggtcatctt ccgttgccgt gacgaaggtc ccaaccgcgc 3961 caaggtcaag tggtcgcgac ccggcggacg tcccctgccc cccggtttca ccgatcgcaa 4021 tggccgcctg gagatcccca acatcagggt ggaggatgct ggcgcctatg tctgcgaggc 4081 cgtgggctat gccaactata ttcccggtca gcacgtcacc gtaaacctca acgtcgagcg 4141 cttaaacgaa cgcgaaatcc gtccggactc agcctgtacg gagtaccagg ccacctgcat 4201 gaacggcgag tgtatcgata agtcgggcat ctgcgatgga catccggact gttcggatgg 4261 ctccgatgag cacagctgca gtttgggttt gaagtgtcag cccaaccagt tcatgtgctc 4321 caattccaag tgtgtggatc gcacctggcg ctgtgatggc gagaacgact gcggcgataa 4381 ctccgatgag acctcttgcg atccggaacc aagtgatgct ccgtgccgat acgacgaatt 4441 ccagtgccgc agcggtcatt gcattcccaa gagcttccag tgcgactata tgaacgattg 4501 taccgatggt accgatgaaa ttggatgctc ggtgccctct ccaatgaccc tacccgcacc 4561 ctcgattgtc gtgatggagt acgaggtcct cgagctgacc tgcgtgggca ccggcgtccc 4621 gacgccgacg atcgtgtggc gtctcaactg gggccatgtg cccgagaagt gtgaatcgaa 4681 gagctacggc ggaaccggaa ccctgcgctg tccgaacatg aggccccagg acagtggtgc 4741 ctactcgtgc gagttcatca acacacgcgg caccttctat ccgaaaacga actcgattgt 4801 caccgttacg ccggtgcgct cggatgtctg caaggccgga ttcttcaata tgctggcccg 4861 caagtcggag gaatgcgtcc agtgcttctg ctttggcgtt tcgaccaact gtgacagtgc 4921 caatttgttc acctacgcca ttcagccacc gatcctttcg caccgcgtgg tcagcgttga 4981 actcagtccg ttccgtcaaa ttgtcatcaa tgaggctagt ccgggtcagg atctgctcac 5041 cttgcaccat ggtgttcagt tcagggcatc gaacgtacac tacaacggcc gggagacacc 5101 attcttggcc ctgcccgctg agtatatggg caaccagctg aagtcctatg gcggcaatct 5161 gcgctacgag gtcaggtaca atggcaacgg tagaccggtc agcggacccg atgtcatcat 5221 caccggcaac agtttcacgc taacccatcg cgttcgcact catccgggtc agaacaacag 5281 ggtgactatt cccttcctgc cgggaggctg gacgaagccg gatggtcgca agggaacgcg 5341 agaggacatc atgatgatac tggccaatgt ggacaatatt ctgattcgac tgggctacct 5401 ggatagcaca gctcgcgaag tggatctgat aaatatcgcc ttggattcgg ccggaagtgc 5461 cgatcaggga ttgggcagtg cctcgctcgt ggagaagtgc acctgtccgc ccggctatgt 5521 tggtgattcg tgcgagtcct gtgcctcggg ctatgttcgc caggcccgcg gaccttggct 5581 gggtcattgt gtgcccttca ccccggaacc gtgcccagcg ggaacctacg gcaatccccg 5641 acttggtgtt ccctgccagg agtgtccgtg cccccacgcg ggcgccaata actttgccag 5701 cggctgccaa cagagtcccg atggcgatgt gatttgccgc tgcaacgaag gctatgccgg 5761 caagaggtgc gagcactgcg cccagggtta ccagggtaat ccgttggcac cgggaggagt 5821 ctgtcgcaag atacccgata gttcgtgcaa tgtcgacggc acctacaaca tctacagcaa 5881 tggaacgtgc cagtgcaagg atagcgtgat tggcgaacag tgcgacacct gcgcgccgaa 5941 gagtttccac ctcaattcgt tcacctacac cggttgcatc gagtgcttct gcagtggagt 6001 gggcttggat tgtgacagta gttcgtggta tcgcaaccag gtcaccagca cctttggacg 6061 aacgcgcgtc aatcatggat tcgccctgat tagcgactat atgcgcaata ccccggtaac 6121 ggtgcccgtt tccatgtcca cccaggccaa tgccttgagc ttcgtgggat ccgccgagca 6181 ggccggtaat acgctctact ggagtcttcc cgccgccttc ctgggcaaca agctgacctc 6241 gtacggaggc aagttgagct acacgctcag ctacagtccc ctgcccagcg gcattatgtc 6301 gcgcaacagt gcccccgatg tggtgatcaa gagcggcgag gatctgaggc tcatccatta 6361 caggaagtcg caggtcagtc ccagtgtggc caacacctat gccgtggaga tcaaggagag 6421 cgcatggcag cgcggcgatg aactggtgcc taaccgtgaa cacgtcctga tggccctcag 6481 caatattacg gccatctata tcaaggccac gtacacgact agcaccaagg aggcctcgct 6541 gcgatcggtc acattggata cggccacggc caccaatctg ggcaccgcac gtgccgtcga 6601 agtggagcag tgccgctgtc ccgagggcta tttgggtctc tcctgcgagc agtgtgctcc 6661 tggctatacg cgcgatccgg aggcaggaat ctatctgggt ctctgcaggc cctgcgagtg 6721 caatggacat tccaagtatt gcaacagtga gacaggcgaa tgcgaaagct gttccgacaa 6781 caccgaagga ttcaattgtg accgatgcgc cgccggctat gtgggtgatg ccacccgagg 6841 aacttcgtac gactgtcaat acgatgacgg cggctatccg acgtcgcgtc caccggcacc 6901 gggcaatcag acggccgaat gcctggtgaa ttgccaacag gagggaaccg ccggttgccg 6961 cggctaccag tgcgagtgca agaggaatgt ggctggcgat cgatgcgatc agtgccgccc 7021 cggaacctat ggactgtcgg cccaaaatcc ggacggttgc aaggagtgct actgctccgg 7081 actgaccaac cagtgccgct cggcgtctct ctaccgccag ctgatacccg tggacttcat 7141 ttcgacgcca ccattgataa cagacgaatt cggcgacatc atggataggg ataaccttgt 7201 gcccgacgtg cccaggaatg tgtataccta caagcacacc tcctacacgc ccaagtactg 7261 gagcctgagg ggtagtgtgc tgggcaacca gctgttgtcg tacggcggcc gcttggagta 7321 cagcctgatt gtggagtccg ttggccggga ccatcgtggc aaggatgtgg tcctaattgg 7381 caacggactc aagctgatct ggtcgcgacc cgatggccat gacaacgagc aggaatacca 7441 tgtgcgtttg catgaggacg agcagtggac ggttgaggat cgtggatcgg cacgacaggc 7501 cacgcgggcc gacttcatga ctgtgctgtc ggatctgcag cacatcctga tcctggccac 7561 acccaaggtg cccacggtca gcacctcgat tagcaatgtc atcctggaga gttcgataac 7621 cacgagagcg cctggagcta cgcatgcctc cgatatcgag ttgtgccagt gtccatccgg 7681 ttatacgggc acttcctgtg agtcctgcgc accactgcac taccgcgacg cctctggacg 7741 ctgcagtcag tgtccttgcg acgcttccaa cacggaatcc tgcggcttgg tcagcggcgg 7801 taacgtcgaa tgccagtgca ggccacgctg gaggggtgat cgctgccggg aaattgacac 7861 atcgcccatt atcgaagaac cgccccagat atgtgattta agcaggggat tctgttgcag 7921 cggctttcag ttcgatatcg caccgaacga gacaatctcg tttaatgaca ccctgcagat 7981 atataagggc aacagaatca taggaaatat gaccaagctg cgctacggct gtccatcgcg 8041 agaaactaac gaaccgactc cggaaccgga taccagtacc gatgatcccg tgcgcaccca 8101 gatcatagtg tcgattgcca ggccagagat taccattctg cccgtgggtg gatcgctgac 8161 cctcagctgt accggtcgaa tgcgctggac caatagccca gtgtttgtga actggtacaa 8221 gcagggcagt cacctgcccg agggagtcga ggtgcaaggc ggtaatctgc agctgttcaa 8281 cctgcagatc agcgattctg gaatctacat ctgccaggcc gtaagcaacg agaccggcca 8341 cagctttacg gaccacgtct ccatcaccgt ttcccaggag gaccaacgct cgccggctca 8401 cattgtggat ttgcccaacg acgtgacctt cgaggagtac gtaagcaatg agatcgtctg 8461 cgaggtggag ggcaacccac cacccactgt cacctggact cgcgtggatg gccatgcgga 8521 cgcccaaagt acgcgaacgg acaacaatcg gctggtcttc gattcgccga ggaaatcgga 8581 cgagggtcgc tatcgctgcc aggcagagaa tagcctgagt cgggaggaga agtacgtagt 8641 cgtgtatgtc cggagcaatc ctccccagcc gccgccgcag caggatcgtt tgtacatcac 8701 accgcaggag gtgaacggtg tggccggtga ctccttccag ttgtcctgcc aattcaccag 8761 cgctgcctct ctgcgctacg attggtccca cgatggtcgc tccctgtccg cgtcgtcacc 8821 ccgaaatgtt gtggtccgcg gaaatgtcct ggaagtccgc gatgccaacg ttcgcgactc 8881 cggcacctac acctgtgtgg ccttcgacct gcgcacccga cgcaacttca ccgagagcgc 8941 acgggtctac atcgagcagc ccaacgagcc gggaatcctt ggcgacaagc cgcatatctt 9001 gaccttggag cagaacatca taattgtgca aggcgaggac ttgagcatca catgtgaggc 9061 aagtggaacg ccctatccct cgattaagtg gaccaaggtg caggagaatc tggccgaaaa 9121 tgtccgcatc agtggcaatg tgctcaccat ctacggaggc cgcagtgaga atcgtggtct 9181 ttactcctgc atcgccgaga actctcacgg cagcgatcag tccagcacaa gcatcgatat 9241 tgaaccccgg gagcggccga gtcttacgat tgatacggcc acccaaaagg tttcggttgg 9301 ctcccaggcg tccctttact gtgccgccca gggcattccc gaaccgaccg tcgagtgggt 9361 tcgaacggat ggtcagccac tgtcgccgcg tcacaaggtc caggcacccg gctatgttgt 9421 gatcgatgac attgtgctcg atgatagcgg tacctacgag tgccgggcga gcaacatagc 9481 tggccaggtg agcggcttgg ccaccattaa cgtccaggag ccaactcttg tgcggatcga 9541 accagatagg caacaccata tcgtcaccca gggcgacgaa ctctcgctca gctgcgtggg 9601 cagtggcgtc cctactcctt cggtcttttg gagtttcgag ggaagagacg ttgacaggat 9661 gggagtaccg gaaggtgctg tttttgcgca acctttccga accaacactg ccgacgtgaa 9721 aatcttccgg gtgagcaagg agaacgaagg catctacgtc tgtcacggat ccaatgacgc 9781 gggtgaagat caacaataca ttcgcgtgga ggtacaaccc agacggggtg acgtcggtgc 9841 aggaggagat gacaatggtg atgtcgatac ccgacagccc cccaatcggc cccaaatcca 9901 accgaatcca ttgagcaacg aacgcctgac caccgaattg ggcaacaatg tgaccctcat 9961 ctgcaacgtg gacaacgtga acacggaatg ggaacgcgtc gatggcacac ccctgccgca 10021 caatgcctac acggtgagaa atacgctggt gattgtcttc gtggagccgc agaatctggg 10081 tcagtaccgc tgcaatggaa tcggtcgcga tggacgtgtg gaggcccatg tggtgaggga 10141 gctggttctc ctgcccctgc ccaggatcac cttctatccc aacatcccgc tgaccgtgga 10201 gctgggccag aacttggatg tctactgcca ggtggagaac gtgcgtccgg aggacgtgca 10261 ttggaccacc gacaacaatc gaccactgcc cagttccgta cgcatcgagg gcaatgtcct 10321 caggttcgcg tccatcactc aggctgctgc cggtgaatac cgctgctcgg ccaccaatca 10381 atatggaagc cgatcgaaga acgccagggt ggtggtgaaa cagcccagtg gcttccagcc 10441 cgttccccac tcgcaggtgc aacagcgtca ggtgggcgac tccatccagt tgcgatgccg 10501 cctgaccacc cagtacggcg acgaggttcg cggcaatatc cagttcaact ggtaccgtga 10561 ggacggcagc cccttgcccc gcggtgtccg tccggatagc caggtgctgc agctggttaa 10621 attgcagccc gaggacgagg gccgctacat ctgcaactcg tacgatttgg gcagcgggca 10681 gcaactgccc cccgtctcca tcgacttgca agtactaaga actactaccc agtatccttt 10741 caatcggttt aagggcggtg tctccctgaa agacacgccc tgcatggttc tgtatatttg 10801 tgcagcggta ccagcggctc cccagaaccc catctacctg ccgccagtgg cgccaccacg 10861 ttcgcccgaa aggatcctcg agccccaact gagcctgagt gtacaatcct cgaacctgcc 10921 agccggcgac ggcaccaccg tcgagtgctt ctcctccgat gactcctacc cagatgtcgt 10981 gtgggaacgc gccgatggag ctccactcag cgaaaatgtc cagcaagtgg gcaataacct 11041 ggtgattagt aacgtggcct ccaccgatgc cggtaactat gtgtgcaagt gcaagacgga 11101 cgagggagat ctgtatacca ccagctacaa actggaggtc gaggagcagc cccatgaact 11161 gaagagctcc aagatagtct acgccaaggt tggcggaaat gccgacttgc agtgcggagc 11221 cgatgaagat cgacagccca gctaccgttg gtctcgccaa tacggacaac ttcaggcggg 11281 acgcagtctg cagaatgaga aactttcgtt ggatcgcgtt caggccaacg atgccggaac 11341 ttatgtttgt tcggcccaat acagcgatgg cgagacggtt gacttcccca acattctggt 11401 tgtgaccggg gcgattcccc agttccgcca ggagccccgc agctacatga gcttccccac 11461 gctctcgaac tcctcgttca agttcaactt cgagctgacc ttccggccgg aaaacgccga 11521 cggactgctg ctcttcaatg gacagacccg cggaagcggt gactatatcg cactctcgct 11581 gaaggatcgc tatgcggagt tccggttcga ttttggcggt aaaccgttgc tggtgcgagc 11641 ggaggagcca ctggctttgg atgaatggca cacggtgcgc gtgagtcgct tcaagcggga 11701 tggctacatc caggtggacg accagcatcc ggtggccttc cccacctccc agcatcagca 11761 gataccccag ttggaactga ttgaggatct gtacattggc ggcgtgccca actgggagtt 11821 cctgcccgcc gaggcggtgg gtcagcaatc aggcttcgtg ggctgcatta gccggctgac 11881 cctgcaggga cgcaccgtgg agctgatccg ggaggccaag ttcaaggagg gcatcaccga 11941 ttgccggccc tgcgcccagg gaccctgcca gaacaagggc gtctgcctgg agagccagac 12001 ggagcaggcc tacacctgcg tctgccagcc gggctggact ggccgggatt gtgccatcga 12061 gggcacccag tgcaccgcag gagtttgcgg ctcgggacgc tgcgagaata cggagaacga 12121 catggagtgc ctgtgcccgc tgaacagggc aggcgatcga tgccagtaca atgagattct 12181 aaatgaacag agcttgaatt tcaagagcaa cagctttgcg gcctacggaa ctcccaaggt 12241 caccaaagta aacatcacac tctccgttcg tcccgcgagc ctggaggact ctgtgatcct 12301 gtacacggcg gaatccactc tgcccagcgg cgattacctg gctttggtcc ttcgcggtgg 12361 ccacgcggag ctgctgatca acacggccgc ccgcttggat cccgtggtgg tgcgttcggc 12421 ggaaccgctg cccctcaatc gctggaccag aatcgagatc aggcgtcgcc tgggcgaggg 12481 aatcctcaag gtgggcgatg gacccgagcg aaaggccaag gcaccgggat ccgatcgcat 12541 tctgtcgctc aagacccacc tctttgtggg cggcgtcgat cggtcgaccg taaagatcaa 12601 ccgtgatgtg aacatcacca agggcttcga tggctgcatc tcgaagctgt acaactcgca 12661 gaaatccgtc aatctgctgg gtgacatcag ggatgcggcg aatgtccaga actgtgggga 12721 ggcgaatgag atagatgacg atgagtatga gatgccagta gcgctgccat cgcctaaggt 12781 cgccgagaat gaacgtcagc tgatggcgcc gtgtgccagt gatccctgcg agaacggggg 12841 aagctgcagc gagcaggagg acatggccat ctgctcctgt cccttcggct tcagcggcaa 12901 acactgccag aatcacctcc agctgagctt caatgcctcg ttccgcggcg atggctacgt 12961 ggagctgaac cgcagccact tccaacccgc cctggagcag acgtactccc acattggcat 13021 tgtgttcacc accaacaagc cgaatggcct gcttttctgg tggggccagg aggccgggga 13081 ggagtacacc ggacaggact tcattgccgc cgccgtggtc gatggctatg tggagtactc 13141 gatgaggctc gatggcgagg aggcggtcat tcggaacagc gatatccgcg tggacaatgg 13201 cgagcggcac attgtgatcg ccaagcggga tgagaacacc gccatgctgg aactcgatca 13261 gatcctggac acgggcgata cgcgacccac catcaacaag gcaatgaagc tgccgggcaa 13321 tgtgtttgtc ggtggcgctc ctgatgtcgc ggcattcacg ggcttccgct acaaggacaa 13381 tttcaacggc tgcattgtgg tcgtcgaggg cgaaaccgtg ggccaaatta accttagttc 13441 agctgccatc aatggagtga atgccaacgt gtgtcccgct aacgacgaac ctctgggagg 13501 aaccgaaccg ccagtcgtct gaggacacaa ccagcaaccg aaattagctt tttaattaaa 13561 cattaacaaa tgaaacaaaa agaaaaacaa tttttatata tacaacatat gaataagccc 13621 caagcaaacc tacaaaaaat tgaatattat acgacgaaca gataatataa aaacaaaaaa 13681 agagagaaac gatcacttct actacaattg cttcttcgat ccttaagtct aggttaaaga 13741 ttgtagcaag aaaacaagcg aatatcacaa acatttattt aacaagaacg ccatgcgaga 13801 agtgaaacga aacagaaaca ataatgcaat taatgcagat aatacagata aagcctagaa 13861 ccctaagaac taactaacta actcgaacaa gaacaacaac gcatactagc caactgcaac 13921 cacaacaacc acaatagtga aggcatttta attataattt tagtctctag cttataacta 13981 tgactacgac tcgttttttt tgtgagccca gtgtaaaatg ttggaaatcg gaaattggcc 14041 ctacacacaa acacacacaa gttattaatt aaataccaat tgataccata taatgataaa 14101 tgaaatacta tgaatgcaac tattgtgaac gaacgaaaac cgttgagtgg ataaaaagca 14161 taagcagaag atatattaaa atgaaatcaa caaca