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LOCUS XM_070218422 14282 bp mRNA linear INV 09-DEC-2024 (trol), transcript variant X5, mRNA. ACCESSION XM_070218422 VERSION XM_070218422.1 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..14282 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..14282 /gene="trol" /note="terribly reduced optic lobes; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 9 Proteins" /db_xref="GeneID:108055788" CDS 209..13609 /gene="trol" /codon_start=1 /product="basement membrane-specific heparan sulfate proteoglycan core protein isoform X5" /protein_id="XP_070074523.1" /db_xref="GeneID:108055788" /translation="MGSPGSQAPAIAIGISNGRRGHTGSLLLRLLLVAFVLNACHVPP TNAKQITKSKVDDQDFILADTQSLQGSVDLDDDEAFLIPPDSEEKLDKKFTPEGNWWS QGLHRVRRSLNSFFGSDDDDQEKERERQRQRQNNRDAANRQKELRRQQKESQNREKQL RLERQERQRLAKRNNHVVFNRVTDPRKRASDLYDENEASGLNEEETTTYRTYFVVNEP YSDDYKERDSLQFQNLQKLLDEDLRNFFNRNFENNDDEEQEIHSTLERVDQTKDHFKI RVQLRVDLPSSINDFGSKLEQQLNVYKRIDRLGASTDGVFTFTESSEFDEDPIEVALP TDEVEGSGQDSGSCRGDATFQCRRSGKTICDEMRCDGSRDCPDAEDEEGCEVCNELQF KCDNKCLPLNKRCDNRYDCEDQTDEAGCQRYEVEESQPQPQPQPQPEPEPEPEPEPEP EPEPEPEPEEPITDNEQPEQNSECRATEFRCNNGDCIDIRKRCDHISDCSEGEDENEE CPAACSGMEYQCRDGTRCISLSQQCDGHSDCSDADDEEHCDGSGNDGEDCRFDEFRCG TGECIPMRQVCDNIYDCNDYSDEVSCAEEEEDSVGIPIGRPPQRPAPKHDWLDELDAN EYHVYHPSNVYELANSKNPCASNQFRCATTNVCIPLHLRCDNFYHCNDMSDEKDCEQY QRRTTTTTRRPSTSARPSFTFTFTTQGPGLLERRNSTTSRTTAGSTTRATEAPQWPWA TRPTETTTTNPITTVGVASSSPQSSCLENIEFACHNRDCIPIESVCDGTPDCGRSEDE DDALCKCTADKYKCQHGGGCIPKTQVCDGKPQCRDRSDESACHLNGRLNKTRLGVQCQ ENQYQCGDGSCISGYKRCNGINDCADDADEYNCIYTYNEDYVDPDDNPLNECDILEFE CDYSLCLPLEKKCDGYADCEDLSDEFECQSYTENCLLSEFECDGYCLPRDQLCNGIIN CQDGSDERNCTFCREDAYLCTTGECVAVNQRCNGIVECADGSDERHCVVNTTETNYHY PTHNPKPKTCRTHEWQCTNLECIEMRLKCDDVPDCSDGSDEDLSICFGTATTRLKPSD CGPDQFFCDDLCYNRSIRCNGHMDCSDGSDEIACSSLSVLPCPQHQCPSGRCYSESER CDRHRHCEDGSDEANCCYADQFRCNNGDCIAESAHCDGNIDCSDQSDELDCGGDSQCL PNQFRCKNGQCVSSTARCNKRSDCLDGSDEQNCANEPNNSGRGTNQLKLKTYPDNQII KESREVIFRCRDEGPNRAKVKWSRPGGRPLPPGFTDRNGRLEIPNIRVEDAGAYVCEA VGYANYIPGQHVTVNLNVERLNEREIRPDSACTEYQATCMNGECIDKSGICDGHPDCS DGSDEHSCSLGLKCQPNQFMCSNSKCVDRTWRCDGENDCGDNSDETSCDPEPSDAPCR YDEFQCRSGHCIPKSFQCDYMNDCTDGTDEIGCSVPSPMTLPAPSIVVMEYEVLELTC VGTGVPTPTIVWRLNWGHVPEKCESKSYGGTGTLRCPNMRPQDSGAYSCEFINTRGTF YPKTNSIVTVTPVRSDVCKAGFFNMLARKSEECVQCFCFGVSTNCDSANLFTYAIQPP ILSHRVVSVELSPFRQIVINEASPGQDLLTLHHGVQFRASNVHYNGRETPFLALPAEY MGNQLKSYGGNLRYEVRYNGNGRPVSGPDVIITGNSFTLTHRVRTHPGQNNRVTIPFL PGGWTKPDGRKGTREDIMMILANVDNILIRLGYLDSTAREVDLINIALDSAGSADQGL GSASLVEKCTCPPGYVGDSCESCASGYVRQARGPWLGHCVPFTPEPCPAGTYGNPRLG VPCQECPCPHAGANNFASGCQQSPDGDVICRCNEGYAGKRCEHCAQGYQGNPLAPGGV CRKIPDSSCNVDGTYNIYSNGTCQCKDSVIGEQCDTCAPKSFHLNSFTYTGCIECFCS GVGLDCDSSSWYRNQVTSTFGRTRVNHGFALISDYMRNTPVTVPVSMSTQANALSFVG SAEQAGNTLYWSLPAAFLGNKLTSYGGKLSYTLSYSPLPSGIMSRNSAPDVVIKSGED LRLIHYRKSQVSPSVANTYAVEIKESAWQRGDELVPNREHVLMALSNITAIYIKATYT TSTKEASLRSVTLDTATATNLGTARAVEVEQCRCPEGYLGLSCEQCAPGYTRDPEAGI YLGLCRPCECNGHSKYCNSETGECESCSDNTEGFNCDRCAAGYVGDATRGTSYDCQYD DGGYPTSRPPAPGNQTAECLVNCQQEGTAGCRGYQCECKRNVAGDRCDQCRPGTYGLS AQNPDGCKECYCSGLTNQCRSASLYRQLIPVDFISTPPLITDEFGDIMDRDNLVPDVP RNVYTYKHTSYTPKYWSLRGSVLGNQLLSYGGRLEYSLIVESVGRDHRGKDVVLIGNG LKLIWSRPDGHDNEQEYHVRLHEDEQWTVEDRGSARQATRADFMTVLSDLQHILILAT PKVPTVSTSISNVILESSITTRAPGATHASDIELCQCPSGYTGTSCESCAPLHYRDAS GRCSQCPCDASNTESCGLVSGGNVECQCRPRWRGDRCREIDTSPIIEEPPQICDLSRG FCCSGFQFDIAPNETISFNDTLQIYKGNRIIGNMTKLRYGCPSRETNEPTPEPDTSTD DPVRTQIIVSIARPEITILPVGGSLTLSCTGRMRWTNSPVFVNWYKQGSHLPEGVEVQ GGNLQLFNLQISDSGIYICQAVSNETGHSFTDHVSITVSQEDQRSPAHIVDLPNDVTF EEYVSNEIVCEVEGNPPPTVTWTRVDGHADAQSTRTDNNRLVFDSPRKSDEGRYRCQA ENSLSREEKYVVVYVRSNPPQPPPQQDRLYITPQEVNGVAGDSFQLSCQFTSAASLRY DWSHDGRSLSASSPRNVVVRGNVLEVRDANVRDSGTYTCVAFDLRTRRNFTESARVYI EQPNEPGILGDKPHILTLEQNIIIVQGEDLSITCEASGTPYPSIKWTKVQENLAENVR ISGNVLTIYGGRSENRGLYSCIAENSHGSDQSSTSIDIEPRERPSLTIDTATQKVSVG SQASLYCAAQGIPEPTVEWVRTDGQPLSPRHKVQAPGYVVIDDIVLDDSGTYECRASN IAGQVSGLATINVQEPTLVRIEPDRQHHIVTQGDELSLSCVGSGVPTPSVFWSFEGRD VDRMGVPEGAVFAQPFRTNTADVKIFRVSKENEGIYVCHGSNDAGEDQQYIRVEVQPR RGDVGAGGDDNGDVDTRQPPNRPQIQPNPLSNERLTTELGNNVTLICNVDNVNTEWER VDGTPLPHNAYTVRNTLVIVFVEPQNLGQYRCNGIGRDGRVEAHVVRELVLLPLPRIT FYPNIPLTVELGQNLDVYCQVENVRPEDVHWTTDNNRPLPSSVRIEGNVLRFASITQA AAGEYRCSATNQYGSRSKNARVVVKQPSGFQPVPHSQVQQRQVGDSIQLRCRLTTQYG DEVRGNIQFNWYREDGSPLPRGVRPDSQVLQLVKLQPEDEGRYICNSYDLGSGQQLPP VSIDLQVLRTTTQYPFNRFKGGVSLKDTPCMVLYICAAVPAAPQNPIYLPPVAPPRSP ERILEPQLSLSVQSSNLPAGDGTTVECFSSDDSYPDVVWERADGAPLSENVQQVGNNL VISNVASTDAGNYVCKCKTDEGDLYTTSYKLEVEEQPHELKSSKIVYAKVGGNADLQC GADEDRQPSYRWSRQYGQLQAGRSLQNEKLSLDRVQANDAGTYVCSAQYSDGETVDFP NILVVTGAIPQFRQEPRSYMSFPTLSNSSFKFNFELTFRPENADGLLLFNGQTRGSGD YIALSLKDRYAEFRFDFGGKPLLVRAEEPLALDEWHTVRVSRFKRDGYIQVDDQHPVA FPTSQHQQIPQLELIEDLYIGGVPNWEFLPAEAVGQQSGFVGCISRLTLQGRTVELIR EAKFKEGITDCRPCAQGPCQNKGVCLESQTEQAYTCVCQPGWTGRDCAIEGTQCTAGV CGSGRCENTENDMECLCPLNRAGDRCQYNEILNEQSLNFKSNSFAAYGTPKVTKVNIT LSVRPASLEDSVILYTAESTLPSGDYLALVLRGGHAELLINTAARLDPVVVRSAEPLP LNRWTRIEIRRRLGEGILKVGDGPERKAKAPGSDRILSLKTHLFVGGVDRSTVKINRD VNITKGFDGCISKLYNSQKSVNLLGDIRDAANVQNCGEANEIDDDEYEMPVALPSPKV AENERQLMAPCASDPCENGGSCSEQEDMAICSCPFGFSGKHCQNHLQLSFNASFRGDG YVELNRSHFQPALEQTYSHIGIVFTTNKPNGLLFWWGQEAGEEYTGQDFIAAAVVDGY VEYSMRLDGEEAVIRNSDIRVDNGERHIVIAKRDENTAMLELDQILDTGDTRPTINKA MKLPGNVFVGGAPDVAAFTGFRYKDNFNGCIVVVEGETVGQINLSSAAINGVNANVCP ANDEPLGGTEPPVV" misc_feature 458..>715 /gene="trol" /note="Coiled-coil domain-containing protein 66; Region: CCDC66; pfam15236" /db_xref="CDD:434558" misc_feature 1367..1468 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1382..1384,1403..1405,1436..1441) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1415..1417,1424..1426,1436..1438,1454..1459) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1445..1459 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1625..1723 /gene="trol" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(1643..1645,1667..1669,1700..1705) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1679..1681,1688..1690,1700..1702,1718..1723) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1709..1723 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1745..1852 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1760..1762,1787..1789,1820..1825) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1799..1801,1808..1810,1820..1822,1838..1843) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1829..1843 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1880..1984 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1895..1897,1919..1921,1952..1957) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1931..1933,1940..1942,1952..1954,1970..1975) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1961..1975 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2138..2245 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2153..2155,2180..2182,2213..2218) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2192..2194,2201..2203,2213..2215,2231..2236) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2222..2236 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2504..2608 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2522..2524,2546..2548,2579..2584) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2558..2560,2567..2569,2579..2581,2597..2602) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2588..2602 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2621..2728 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2636..2638,2663..2665,2696..2701) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2675..2677,2684..2686,2696..2698,2714..2719) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2705..2719 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2771..2875 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2786..2788,2810..2812,2843..2848) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2822..2824,2831..2833,2843..2845,2861..2866) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2852..2866 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2930..3034 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2945..2947,2969..2971,3002..3007) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2981..2983,2990..2992,3002..3004,3020..3025) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3011..3025 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3053..3154 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3068..3070,3089..3091,3122..3127) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3101..3103,3110..3112,3122..3124,3140..3145) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3131..3145 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3161..3265 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3176..3178,3200..3202,3233..3238) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3212..3214,3221..3223,3233..3235,3251..3256) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3242..3256 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3323..3421 /gene="trol" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(3341..3343,3365..3367,3398..3403) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3377..3379,3386..3388,3398..3400,3416..3421) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3407..3421 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3473..3574 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3488..3490,3509..3511,3542..3547) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3521..3523,3530..3532,3542..3544,3560..3565) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3551..3565 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3602..3694 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3605..3607,3629..3631,3662..3667) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3641..3643,3650..3652,3662..3664,3680..3685) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3671..3685 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3695..3799 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3710..3712,3734..3736,3767..3772) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3746..3748,3755..3757,3767..3769,3785..3790) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3776..3790 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3815..3919 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(3830..3832,3854..3856,3887..3892) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(3866..3868,3875..3877,3887..3889,3905..3910) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 3896..3910 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 3962..4168 /gene="trol" /note="Immunoglobulin domain; Region: Ig_3; pfam13927" /db_xref="CDD:464046" misc_feature 4262..4366 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4277..4279,4301..4303,4334..4339) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4313..4315,4322..4324,4334..4336,4352..4357) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4343..4357 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4382..4486 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4397..4399,4421..4423,4454..4459) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4433..4435,4442..4444,4454..4456,4472..4477) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4463..4477 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4511..4615 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4526..4528,4550..4552,4583..4588) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4562..4564,4571..4573,4583..4585,4601..4606) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4592..4606 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4667..4894 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 4676..4690 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 4715..4729 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 4784..4798 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 4826..4843 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 4868..4879 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature 5189..5581 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature 5750..5911 /gene="trol" /note="Laminin EGF domain; Region: Laminin_EGF; pfam00053" /db_xref="CDD:395007" misc_feature order(5750..5752,5756..5758,5792..5794,5822..5824, 5828..5830,5855..5857) /gene="trol" /note="EGF-like motif [active]" /db_xref="CDD:238012" misc_feature 6284..6694 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature <6695..6775 /gene="trol" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; Region: EGF_Lam; cd00055" /db_xref="CDD:238012" misc_feature 6797..6946 /gene="trol" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; Region: EGF_Lam; cd00055" /db_xref="CDD:238012" misc_feature order(6800..6802,6806..6808,6827..6829,6848..6850, 6857..6859,6884..6886) /gene="trol" /note="EGF-like motif [active]" /db_xref="CDD:238012" misc_feature <7055..7147 /gene="trol" /note="Laminin EGF domain; Region: Laminin_EGF; pfam00053" /db_xref="CDD:395007" misc_feature 7343..7747 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature 8210..8458 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 8243..8257 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 8291..8305 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 8348..8362 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 8390..8407 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 8435..8446 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature <8537..8698 /gene="trol" /note="Immunoglobulin domain; Region: Ig_3; pfam13927" /db_xref="CDD:464046" misc_feature 8789..9040 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 8822..8836 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 8861..8875 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 8930..8944 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 8972..8989 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 9077..9319 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 9128..9142 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409570" misc_feature 9167..9181 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409570" misc_feature 9224..9238 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409570" misc_feature 9266..9283 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409570" misc_feature 9305..9316 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409570" misc_feature 9371..9601 /gene="trol" /note="Immunoglobulin I-set domain; Region: I-set; pfam07679" /db_xref="CDD:400151" misc_feature 9395..9409 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 9434..9448 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 9497..9511 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 9539..9556 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 9578..9589 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature 9638..9901 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 9668..9682 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 9707..9721 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 9839..9856 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 10274..10504 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 10301..10315 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 10340..10354 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 10400..10414 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 10442..10459 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 10538..>10741 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 10571..10585 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 10619..10642 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 10688..10702 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 10988..11194 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 11060..11074 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 11123..11134 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 11162..11179 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 11264..11464 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 11288..11302 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 11327..11341 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 11384..11398 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 11426..11443 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 11528..11971 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" misc_feature 12038..12136 /gene="trol" /note="EGF-like domain; Region: EGF; pfam00008" /db_xref="CDD:394967" misc_feature 12278..12739 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" misc_feature 12899..12997 /gene="trol" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054" /db_xref="CDD:238011" misc_feature 13022..13483 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" polyA_site 14282 /gene="trol" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN 1 attaggttgc gcgccatcgt tccaggcggt cgcacattcc acgtgccata gccgtaacaa 61 caacctgcca accgcttaaa accaaactca aatacgaacc gaaactgcct tcacacacac 121 aagtacctaa accaaatcta aatagctgcc aaaagaaacc aaaaattcca gagacgtcgt 181 agcatccgtt ccccggaaga agaagaagat gggatcgccg ggatcccaag cgcccgcgat 241 cgcgatcggg atcagtaacg ggcggagagg tcacacgggg tcgctgctcc tgcgcctcct 301 tctcgtggcc ttcgtcctca acgcctgcca cgtacccccg accaatgcca agcaaattac 361 gaaaagtaaa gttgatgacc aggactttat actggccgac acacaatcgc tgcagggcag 421 cgttgacctt gacgatgacg aagcgttcct gattcctccg gattccgaag agaagttgga 481 taagaagttc acgccggagg gcaactggtg gagccagggg ctccatcgtg ttcgccgctc 541 cctaaatagc ttcttcggct ccgacgacga tgatcaggaa aaggaacgtg agcgtcagag 601 gcaaaggcaa aataatcgcg atgccgccaa ccggcaaaag gaacttcggc gccagcaaaa 661 ggagagccag aaccgcgaga agcagctgcg attggagcgc caggagaggc agcgccttgc 721 caagcggaac aatcacgtgg tcttcaatcg cgtcaccgat ccccgcaagc gggcatccga 781 cctttacgac gagaacgagg catctggcct aaacgaggag gaaaccacca cctatcgcac 841 ctactttgtt gttaatgagc catattcaga cgactacaag gagcgggaca gcctccagtt 901 ccagaatctg caaaaacttc ttgacgagga cctgcgcaac ttcttcaatc gcaatttcga 961 aaataacgat gatgaagagc aggaaatcca tagcacccta gagcgagtcg atcaaaccaa 1021 ggaccatttt aaaattcgcg tgcaacttag ggtagatctg cccagttcaa tcaacgactt 1081 tggaagtaag ttggagcaac aactgaatgt ctacaagcga atcgatcgtt tgggtgccag 1141 taccgatggc gtcttcacct ttaccgaatc gagcgaattc gatgaggatc ctatcgaagt 1201 tgcattgccc acggatgagg tggagggctc cggccaagat tccggtagct gtcgcggcga 1261 tgccaccttc cagtgtcgaa ggagtggaaa gactatttgc gatgaaatgc gatgcgatgg 1321 atctcgcgat tgtcccgatg ccgaggacga ggaaggctgc gaggtttgca acgaacttca 1381 gttcaagtgc gataacaagt gtctgccgct caataagcgc tgcgataatc gatacgattg 1441 tgaggatcag acggacgagg ctggttgtca acggtacgaa gtagaagagt ctcagcctca 1501 gccgcagccg caacctcagc ctgaaccgga acctgaacct gaacctgagc ctgagcctga 1561 acctgaacca gaaccagaac ctgaagagcc tataacagac aatgaacagc ctgagcaaaa 1621 ctcagaatgc cgggccaccg agttcagatg caacaatggg gactgcatcg atattagaaa 1681 gcgttgcgat cacatttcgg actgtagcga aggcgaggac gagaacgagg agtgccccgc 1741 cgcctgcagc ggaatggagt atcaatgtcg cgacggcacg cgctgcataa gtttgagtca 1801 gcagtgcgac ggtcattccg attgcagcga cgccgacgac gaggagcatt gcgacggaag 1861 tggtaacgat ggtgaggatt gtcggttcga tgagttccgt tgcggaactg gtgagtgcat 1921 accgatgcgt caggtgtgcg ataacatcta cgattgcaac gattattccg atgaggtcag 1981 ctgcgccgag gaggaggaag atagtgtggg catacccatt ggccgtccac cgcagaggcc 2041 agcgcccaaa cacgactggc tggacgaatt ggacgccaat gagtaccacg tctatcatcc 2101 aagtaatgtc tatgagttgg ccaattccaa gaatccctgt gccagcaatc aatttcgctg 2161 cgccaccacg aatgtgtgca tccccctgca tttgcgttgc gataatttct atcactgcaa 2221 cgatatgagc gatgagaagg actgcgagca gtatcaacga cgcaccacca ccaccacccg 2281 acgaccttcg acctcggccc ggccctcctt caccttcacc ttcacgaccc aggggccagg 2341 cttgctggag cgtcgcaata gcaccaccag tagaaccacc gcaggcagca ccaccagagc 2401 caccgaagca ccacaatggc catgggcaac cagacccacc gagaccacga ccactaaccc 2461 aataacaaca gttggcgtag cgagcagctc acctcagtcc tcctgtctcg aaaacatcga 2521 attcgcgtgt cacaatcgcg attgcattcc gattgagagc gtctgcgatg gcacccccga 2581 ctgcggacgc agtgaagacg aggacgacgc tctttgcaag tgcaccgccg acaagtacaa 2641 atgccaacac ggcggaggct gcattccgaa aacccaggtg tgcgatggca aacctcagtg 2701 ccgcgaccgc agcgacgaga gcgcctgcca tctcaatgga agattaaata agactcgttt 2761 gggggtccag tgccaggaaa accagtatca atgtggcgat ggaagctgca tctccggcta 2821 caaacgctgc aatggcatca acgattgcgc cgatgacgcc gacgaatata actgcatcta 2881 cacctacaac gaagactacg tagacccgga cgacaatcca ttgaatgaat gtgatatcct 2941 tgagtttgaa tgtgactaca gtctgtgttt accgctagag aagaaatgcg atggctatgc 3001 agactgtgaa gacttgagcg acgagttcga gtgtcagtcg tacacagaga attgtctatt 3061 gtctgagttc gaatgcgatg gctactgcct gccccgcgat cagttatgca acggaataat 3121 caattgccaa gatggcagcg acgagcgcaa ctgtaccttt tgccgggaag atgcctacct 3181 ctgcaccacc ggcgagtgtg tggccgtaaa tcagagatgc aacggcatcg tcgaatgcgc 3241 cgatggcagc gacgagcgtc actgcgtagt caacaccaca gagaccaact accattatcc 3301 cacacacaat cctaaaccaa aaacctgccg aacccacgag tggcagtgta cgaatctcga 3361 gtgcatcgag atgagattga agtgcgatga tgttccggat tgctcggatg gatccgatga 3421 ggacctcagc atttgcttcg gcacggccac cacacgacta aagcccagcg actgcggtcc 3481 ggatcagttc ttctgcgatg atttatgcta taatcgctct attcgatgca atggccatat 3541 ggattgctca gatggcagtg atgagatcgc ttgtagctcg ctgtcagtgc ttccatgtcc 3601 acagcaccag tgtcccagtg gcaggtgtta ttcggaaagt gagcgatgcg atcgccacag 3661 gcactgcgag gatggctccg atgaggccaa ctgctgttac gcggatcaat tccgctgcaa 3721 taatggtgac tgcattgcgg aatcggctca ttgcgatgga aatatcgatt gtagcgacca 3781 gtccgatgaa ctcgactgcg gaggagactc gcagtgtctg cccaaccaat tccgctgcaa 3841 gaatggccaa tgtgtgagct ctacagcgcg ttgcaacaag cgttccgatt gtttggatgg 3901 ctccgatgag cagaattgtg ccaatgaacc taacaactcc ggacgtggaa cgaaccaatt 3961 gaaactcaag acctatcccg acaaccaaat cattaaggag agtcgtgagg tcatcttccg 4021 ttgccgtgac gaaggtccca accgcgccaa ggtcaagtgg tcgcgacccg gcggacgtcc 4081 cctgcccccc ggtttcaccg atcgcaatgg ccgcctggag atccccaaca tcagggtgga 4141 ggatgctggc gcctatgtct gcgaggccgt gggctatgcc aactatattc ccggtcagca 4201 cgtcaccgta aacctcaacg tcgagcgctt aaacgaacgc gaaatccgtc cggactcagc 4261 ctgtacggag taccaggcca cctgcatgaa cggcgagtgt atcgataagt cgggcatctg 4321 cgatggacat ccggactgtt cggatggctc cgatgagcac agctgcagtt tgggtttgaa 4381 gtgtcagccc aaccagttca tgtgctccaa ttccaagtgt gtggatcgca cctggcgctg 4441 tgatggcgag aacgactgcg gcgataactc cgatgagacc tcttgcgatc cggaaccaag 4501 tgatgctccg tgccgatacg acgaattcca gtgccgcagc ggtcattgca ttcccaagag 4561 cttccagtgc gactatatga acgattgtac cgatggtacc gatgaaattg gatgctcggt 4621 gccctctcca atgaccctac ccgcaccctc gattgtcgtg atggagtacg aggtcctcga 4681 gctgacctgc gtgggcaccg gcgtcccgac gccgacgatc gtgtggcgtc tcaactgggg 4741 ccatgtgccc gagaagtgtg aatcgaagag ctacggcgga accggaaccc tgcgctgtcc 4801 gaacatgagg ccccaggaca gtggtgccta ctcgtgcgag ttcatcaaca cacgcggcac 4861 cttctatccg aaaacgaact cgattgtcac cgttacgccg gtgcgctcgg atgtctgcaa 4921 ggccggattc ttcaatatgc tggcccgcaa gtcggaggaa tgcgtccagt gcttctgctt 4981 tggcgtttcg accaactgtg acagtgccaa tttgttcacc tacgccattc agccaccgat 5041 cctttcgcac cgcgtggtca gcgttgaact cagtccgttc cgtcaaattg tcatcaatga 5101 ggctagtccg ggtcaggatc tgctcacctt gcaccatggt gttcagttca gggcatcgaa 5161 cgtacactac aacggccggg agacaccatt cttggccctg cccgctgagt atatgggcaa 5221 ccagctgaag tcctatggcg gcaatctgcg ctacgaggtc aggtacaatg gcaacggtag 5281 accggtcagc ggacccgatg tcatcatcac cggcaacagt ttcacgctaa cccatcgcgt 5341 tcgcactcat ccgggtcaga acaacagggt gactattccc ttcctgccgg gaggctggac 5401 gaagccggat ggtcgcaagg gaacgcgaga ggacatcatg atgatactgg ccaatgtgga 5461 caatattctg attcgactgg gctacctgga tagcacagct cgcgaagtgg atctgataaa 5521 tatcgccttg gattcggccg gaagtgccga tcagggattg ggcagtgcct cgctcgtgga 5581 gaagtgcacc tgtccgcccg gctatgttgg tgattcgtgc gagtcctgtg cctcgggcta 5641 tgttcgccag gcccgcggac cttggctggg tcattgtgtg cccttcaccc cggaaccgtg 5701 cccagcggga acctacggca atccccgact tggtgttccc tgccaggagt gtccgtgccc 5761 ccacgcgggc gccaataact ttgccagcgg ctgccaacag agtcccgatg gcgatgtgat 5821 ttgccgctgc aacgaaggct atgccggcaa gaggtgcgag cactgcgccc agggttacca 5881 gggtaatccg ttggcaccgg gaggagtctg tcgcaagata cccgatagtt cgtgcaatgt 5941 cgacggcacc tacaacatct acagcaatgg aacgtgccag tgcaaggata gcgtgattgg 6001 cgaacagtgc gacacctgcg cgccgaagag tttccacctc aattcgttca cctacaccgg 6061 ttgcatcgag tgcttctgca gtggagtggg cttggattgt gacagtagtt cgtggtatcg 6121 caaccaggtc accagcacct ttggacgaac gcgcgtcaat catggattcg ccctgattag 6181 cgactatatg cgcaataccc cggtaacggt gcccgtttcc atgtccaccc aggccaatgc 6241 cttgagcttc gtgggatccg ccgagcaggc cggtaatacg ctctactgga gtcttcccgc 6301 cgccttcctg ggcaacaagc tgacctcgta cggaggcaag ttgagctaca cgctcagcta 6361 cagtcccctg cccagcggca ttatgtcgcg caacagtgcc cccgatgtgg tgatcaagag 6421 cggcgaggat ctgaggctca tccattacag gaagtcgcag gtcagtccca gtgtggccaa 6481 cacctatgcc gtggagatca aggagagcgc atggcagcgc ggcgatgaac tggtgcctaa 6541 ccgtgaacac gtcctgatgg ccctcagcaa tattacggcc atctatatca aggccacgta 6601 cacgactagc accaaggagg cctcgctgcg atcggtcaca ttggatacgg ccacggccac 6661 caatctgggc accgcacgtg ccgtcgaagt ggagcagtgc cgctgtcccg agggctattt 6721 gggtctctcc tgcgagcagt gtgctcctgg ctatacgcgc gatccggagg caggaatcta 6781 tctgggtctc tgcaggccct gcgagtgcaa tggacattcc aagtattgca acagtgagac 6841 aggcgaatgc gaaagctgtt ccgacaacac cgaaggattc aattgtgacc gatgcgccgc 6901 cggctatgtg ggtgatgcca cccgaggaac ttcgtacgac tgtcaatacg atgacggcgg 6961 ctatccgacg tcgcgtccac cggcaccggg caatcagacg gccgaatgcc tggtgaattg 7021 ccaacaggag ggaaccgccg gttgccgcgg ctaccagtgc gagtgcaaga ggaatgtggc 7081 tggcgatcga tgcgatcagt gccgccccgg aacctatgga ctgtcggccc aaaatccgga 7141 cggttgcaag gagtgctact gctccggact gaccaaccag tgccgctcgg cgtctctcta 7201 ccgccagctg atacccgtgg acttcatttc gacgccacca ttgataacag acgaattcgg 7261 cgacatcatg gatagggata accttgtgcc cgacgtgccc aggaatgtgt atacctacaa 7321 gcacacctcc tacacgccca agtactggag cctgaggggt agtgtgctgg gcaaccagct 7381 gttgtcgtac ggcggccgct tggagtacag cctgattgtg gagtccgttg gccgggacca 7441 tcgtggcaag gatgtggtcc taattggcaa cggactcaag ctgatctggt cgcgacccga 7501 tggccatgac aacgagcagg aataccatgt gcgtttgcat gaggacgagc agtggacggt 7561 tgaggatcgt ggatcggcac gacaggccac gcgggccgac ttcatgactg tgctgtcgga 7621 tctgcagcac atcctgatcc tggccacacc caaggtgccc acggtcagca cctcgattag 7681 caatgtcatc ctggagagtt cgataaccac gagagcgcct ggagctacgc atgcctccga 7741 tatcgagttg tgccagtgtc catccggtta tacgggcact tcctgtgagt cctgcgcacc 7801 actgcactac cgcgacgcct ctggacgctg cagtcagtgt ccttgcgacg cttccaacac 7861 ggaatcctgc ggcttggtca gcggcggtaa cgtcgaatgc cagtgcaggc cacgctggag 7921 gggtgatcgc tgccgggaaa ttgacacatc gcccattatc gaagaaccgc cccagatatg 7981 tgatttaagc aggggattct gttgcagcgg ctttcagttc gatatcgcac cgaacgagac 8041 aatctcgttt aatgacaccc tgcagatata taagggcaac agaatcatag gaaatatgac 8101 caagctgcgc tacggctgtc catcgcgaga aactaacgaa ccgactccgg aaccggatac 8161 cagtaccgat gatcccgtgc gcacccagat catagtgtcg attgccaggc cagagattac 8221 cattctgccc gtgggtggat cgctgaccct cagctgtacc ggtcgaatgc gctggaccaa 8281 tagcccagtg tttgtgaact ggtacaagca gggcagtcac ctgcccgagg gagtcgaggt 8341 gcaaggcggt aatctgcagc tgttcaacct gcagatcagc gattctggaa tctacatctg 8401 ccaggccgta agcaacgaga ccggccacag ctttacggac cacgtctcca tcaccgtttc 8461 ccaggaggac caacgctcgc cggctcacat tgtggatttg cccaacgacg tgaccttcga 8521 ggagtacgta agcaatgaga tcgtctgcga ggtggagggc aacccaccac ccactgtcac 8581 ctggactcgc gtggatggcc atgcggacgc ccaaagtacg cgaacggaca acaatcggct 8641 ggtcttcgat tcgccgagga aatcggacga gggtcgctat cgctgccagg cagagaatag 8701 cctgagtcgg gaggagaagt acgtagtcgt gtatgtccgg agcaatcctc cccagccgcc 8761 gccgcagcag gatcgtttgt acatcacacc gcaggaggtg aacggtgtgg ccggtgactc 8821 cttccagttg tcctgccaat tcaccagcgc tgcctctctg cgctacgatt ggtcccacga 8881 tggtcgctcc ctgtccgcgt cgtcaccccg aaatgttgtg gtccgcggaa atgtcctgga 8941 agtccgcgat gccaacgttc gcgactccgg cacctacacc tgtgtggcct tcgacctgcg 9001 cacccgacgc aacttcaccg agagcgcacg ggtctacatc gagcagccca acgagccggg 9061 aatccttggc gacaagccgc atatcttgac cttggagcag aacatcataa ttgtgcaagg 9121 cgaggacttg agcatcacat gtgaggcaag tggaacgccc tatccctcga ttaagtggac 9181 caaggtgcag gagaatctgg ccgaaaatgt ccgcatcagt ggcaatgtgc tcaccatcta 9241 cggaggccgc agtgagaatc gtggtcttta ctcctgcatc gccgagaact ctcacggcag 9301 cgatcagtcc agcacaagca tcgatattga accccgggag cggccgagtc ttacgattga 9361 tacggccacc caaaaggttt cggttggctc ccaggcgtcc ctttactgtg ccgcccaggg 9421 cattcccgaa ccgaccgtcg agtgggttcg aacggatggt cagccactgt cgccgcgtca 9481 caaggtccag gcacccggct atgttgtgat cgatgacatt gtgctcgatg atagcggtac 9541 ctacgagtgc cgggcgagca acatagctgg ccaggtgagc ggcttggcca ccattaacgt 9601 ccaggagcca actcttgtgc ggatcgaacc agataggcaa caccatatcg tcacccaggg 9661 cgacgaactc tcgctcagct gcgtgggcag tggcgtccct actccttcgg tcttttggag 9721 tttcgaggga agagacgttg acaggatggg agtaccggaa ggtgctgttt ttgcgcaacc 9781 tttccgaacc aacactgccg acgtgaaaat cttccgggtg agcaaggaga acgaaggcat 9841 ctacgtctgt cacggatcca atgacgcggg tgaagatcaa caatacattc gcgtggaggt 9901 acaacccaga cggggtgacg tcggtgcagg aggagatgac aatggtgatg tcgatacccg 9961 acagcccccc aatcggcccc aaatccaacc gaatccattg agcaacgaac gcctgaccac 10021 cgaattgggc aacaatgtga ccctcatctg caacgtggac aacgtgaaca cggaatggga 10081 acgcgtcgat ggcacacccc tgccgcacaa tgcctacacg gtgagaaata cgctggtgat 10141 tgtcttcgtg gagccgcaga atctgggtca gtaccgctgc aatggaatcg gtcgcgatgg 10201 acgtgtggag gcccatgtgg tgagggagct ggttctcctg cccctgccca ggatcacctt 10261 ctatcccaac atcccgctga ccgtggagct gggccagaac ttggatgtct actgccaggt 10321 ggagaacgtg cgtccggagg acgtgcattg gaccaccgac aacaatcgac cactgcccag 10381 ttccgtacgc atcgagggca atgtcctcag gttcgcgtcc atcactcagg ctgctgccgg 10441 tgaataccgc tgctcggcca ccaatcaata tggaagccga tcgaagaacg ccagggtggt 10501 ggtgaaacag cccagtggct tccagcccgt tccccactcg caggtgcaac agcgtcaggt 10561 gggcgactcc atccagttgc gatgccgcct gaccacccag tacggcgacg aggttcgcgg 10621 caatatccag ttcaactggt accgtgagga cggcagcccc ttgccccgcg gtgtccgtcc 10681 ggatagccag gtgctgcagc tggttaaatt gcagcccgag gacgagggcc gctacatctg 10741 caactcgtac gatttgggca gcgggcagca actgcccccc gtctccatcg acttgcaagt 10801 actaagaact actacccagt atcctttcaa tcggtttaag ggcggtgtct ccctgaaaga 10861 cacgccctgc atggttctgt atatttgtgc agcggtacca gcggctcccc agaaccccat 10921 ctacctgccg ccagtggcgc caccacgttc gcccgaaagg atcctcgagc cccaactgag 10981 cctgagtgta caatcctcga acctgccagc cggcgacggc accaccgtcg agtgcttctc 11041 ctccgatgac tcctacccag atgtcgtgtg ggaacgcgcc gatggagctc cactcagcga 11101 aaatgtccag caagtgggca ataacctggt gattagtaac gtggcctcca ccgatgccgg 11161 taactatgtg tgcaagtgca agacggacga gggagatctg tataccacca gctacaaact 11221 ggaggtcgag gagcagcccc atgaactgaa gagctccaag atagtctacg ccaaggttgg 11281 cggaaatgcc gacttgcagt gcggagccga tgaagatcga cagcccagct accgttggtc 11341 tcgccaatac ggacaacttc aggcgggacg cagtctgcag aatgagaaac tttcgttgga 11401 tcgcgttcag gccaacgatg ccggaactta tgtttgttcg gcccaataca gcgatggcga 11461 gacggttgac ttccccaaca ttctggttgt gaccggggcg attccccagt tccgccagga 11521 gccccgcagc tacatgagct tccccacgct ctcgaactcc tcgttcaagt tcaacttcga 11581 gctgaccttc cggccggaaa acgccgacgg actgctgctc ttcaatggac agacccgcgg 11641 aagcggtgac tatatcgcac tctcgctgaa ggatcgctat gcggagttcc ggttcgattt 11701 tggcggtaaa ccgttgctgg tgcgagcgga ggagccactg gctttggatg aatggcacac 11761 ggtgcgcgtg agtcgcttca agcgggatgg ctacatccag gtggacgacc agcatccggt 11821 ggccttcccc acctcccagc atcagcagat accccagttg gaactgattg aggatctgta 11881 cattggcggc gtgcccaact gggagttcct gcccgccgag gcggtgggtc agcaatcagg 11941 cttcgtgggc tgcattagcc ggctgaccct gcagggacgc accgtggagc tgatccggga 12001 ggccaagttc aaggagggca tcaccgattg ccggccctgc gcccagggac cctgccagaa 12061 caagggcgtc tgcctggaga gccagacgga gcaggcctac acctgcgtct gccagccggg 12121 ctggactggc cgggattgtg ccatcgaggg cacccagtgc accgcaggag tttgcggctc 12181 gggacgctgc gagaatacgg agaacgacat ggagtgcctg tgcccgctga acagggcagg 12241 cgatcgatgc cagtacaatg agattctaaa tgaacagagc ttgaatttca agagcaacag 12301 ctttgcggcc tacggaactc ccaaggtcac caaagtaaac atcacactct ccgttcgtcc 12361 cgcgagcctg gaggactctg tgatcctgta cacggcggaa tccactctgc ccagcggcga 12421 ttacctggct ttggtccttc gcggtggcca cgcggagctg ctgatcaaca cggccgcccg 12481 cttggatccc gtggtggtgc gttcggcgga accgctgccc ctcaatcgct ggaccagaat 12541 cgagatcagg cgtcgcctgg gcgagggaat cctcaaggtg ggcgatggac ccgagcgaaa 12601 ggccaaggca ccgggatccg atcgcattct gtcgctcaag acccacctct ttgtgggcgg 12661 cgtcgatcgg tcgaccgtaa agatcaaccg tgatgtgaac atcaccaagg gcttcgatgg 12721 ctgcatctcg aagctgtaca actcgcagaa atccgtcaat ctgctgggtg acatcaggga 12781 tgcggcgaat gtccagaact gtggggaggc gaatgagata gatgacgatg agtatgagat 12841 gccagtagcg ctgccatcgc ctaaggtcgc cgagaatgaa cgtcagctga tggcgccgtg 12901 tgccagtgat ccctgcgaga acgggggaag ctgcagcgag caggaggaca tggccatctg 12961 ctcctgtccc ttcggcttca gcggcaaaca ctgccagaat cacctccagc tgagcttcaa 13021 tgcctcgttc cgcggcgatg gctacgtgga gctgaaccgc agccacttcc aacccgccct 13081 ggagcagacg tactcccaca ttggcattgt gttcaccacc aacaagccga atggcctgct 13141 tttctggtgg ggccaggagg ccggggagga gtacaccgga caggacttca ttgccgccgc 13201 cgtggtcgat ggctatgtgg agtactcgat gaggctcgat ggcgaggagg cggtcattcg 13261 gaacagcgat atccgcgtgg acaatggcga gcggcacatt gtgatcgcca agcgggatga 13321 gaacaccgcc atgctggaac tcgatcagat cctggacacg ggcgatacgc gacccaccat 13381 caacaaggca atgaagctgc cgggcaatgt gtttgtcggt ggcgctcctg atgtcgcggc 13441 attcacgggc ttccgctaca aggacaattt caacggctgc attgtggtcg tcgagggcga 13501 aaccgtgggc caaattaacc ttagttcagc tgccatcaat ggagtgaatg ccaacgtgtg 13561 tcccgctaac gacgaacctc tgggaggaac cgaaccgcca gtcgtctgag gacacaacca 13621 gcaaccgaaa ttagcttttt aattaaacat taacaaatga aacaaaaaga aaaacaattt 13681 ttatatatac aacatatgaa taagccccaa gcaaacctac aaaaaattga atattatacg 13741 acgaacagat aatataaaaa caaaaaaaga gagaaacgat cacttctact acaattgctt 13801 cttcgatcct taagtctagg ttaaagattg tagcaagaaa acaagcgaat atcacaaaca 13861 tttatttaac aagaacgcca tgcgagaagt gaaacgaaac agaaacaata atgcaattaa 13921 tgcagataat acagataaag cctagaaccc taagaactaa ctaactaact cgaacaagaa 13981 caacaacgca tactagccaa ctgcaaccac aacaaccaca atagtgaagg cattttaatt 14041 ataattttag tctctagctt ataactatga ctacgactcg ttttttttgt gagcccagtg 14101 taaaatgttg gaaatcggaa attggcccta cacacaaaca cacacaagtt attaattaaa 14161 taccaattga taccatataa tgataaatga aatactatga atgcaactat tgtgaacgaa 14221 cgaaaaccgt tgagtggata aaaagcataa gcagaagata tattaaaatg aaatcaacaa 14281 ca