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PREDICTED: Drosophila takahashii GTPase regulator associated with


LOCUS       XM_070218274            3994 bp    mRNA    linear   INV 09-DEC-2024
            FAK (Graf), transcript variant X3, mRNA.
ACCESSION   XM_070218274
VERSION     XM_070218274.1
DBLINK      BioProject: PRJNA1194641
KEYWORDS    RefSeq.
SOURCE      Drosophila takahashii
  ORGANISM  Drosophila takahashii
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091683) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030179915.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/07/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3994
                     /organism="Drosophila takahashii"
                     /mol_type="mRNA"
                     /strain="IR98-3 E-12201"
                     /db_xref="taxon:29030"
                     /chromosome="X"
                     /sex="female"
                     /tissue_type="Whole fly"
                     /dev_stage="Adult fly"
                     /collected_by="Originally obtained from EHIME-Fly"
     gene            1..3994
                     /gene="Graf"
                     /note="GTPase regulator associated with FAK; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 Protein"
                     /db_xref="GeneID:108056722"
     CDS             444..3503
                     /gene="Graf"
                     /codon_start=1
                     /product="rho GTPase-activating protein Graf isoform X1"
                     /protein_id="XP_070074375.1"
                     /db_xref="GeneID:108056722"
                     /translation="MGGGKNIRRGLEPLEFEECIVDSPDFRENLNRHEKELDHTSHQI
                     KRIIKEVKDLMSAAKMLSTRMKQLAILLTDFNFECIGTAQTDDENVICESLKRFGAII
                     GNIEDEREKMLTLADKHIIESLEDFRKKQIGGVKENKKKFDKKTEKFCQSQERFLNMS
                     TKKPENTIQEADASLGMHEREYIQESLSYVLRIQEVQERIKFEFVEILLAFISGWLVF
                     YHTAHEQAEDHRDYLQDLRHKVQKTRENFEEAREKVTELKTKYMEKRTKPEEIFTKRG
                     YLFLMEKSSILKISLLEPFKATWTKYYCTFKKQKREFTMLQFNQMNHNFTRPEARDDE
                     KLTLFSCQRRASEFEKRFCFDLTFKEKPGVVYTFQALSEKDHRYWISAMDGTEPTYLA
                     PGKIKVSEAYHLDEAGFMFIRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLSLGLNQK
                     ETDDVFVDDKYRDLMESNTIASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVN
                     EVHKLVYKLPQPNFQMLDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLLRPREESVA
                     AILDIKFNNIVINILIDNYERIFKNKPSADVKLPVEAAKAPSIMYPARSSPPTRMPRA
                     SQIGKAASTGAMGSTSSTAAAAAAAGNPMFLNQQKIYRVVSKSNCTEPTMSSSLQNIP
                     NGDNYASGGAGCISLSPPMHMLNGILSPTIGSINNLHTISKNETTVGTTTAAGTRRYV
                     PNDTAEVATDYGIIGANNGGVTLQSHHAIPVSSTTNFRHPEYLVTQSGSTNHLYTNSS
                     SSVAGAAATSGNRISLNNVSPPNTAMRKERFLGSTGSGPQQHPPVQRGLHSYGQTKQQ
                     QQQHYSPLMPTSTSSSNDSVCDSLSSNNGQHLGARNSNDYAMLTSQNSSLSPHLGHGS
                     ACDEVVTATTVSCGGSANESSEYPPSKMHRNRDINQIKRDLSTGTARVRTLYACMGES
                     EGELSFEPNQIITNVRYSHEPGWLQGTLNGKTGLIPENYVEHLKPHH"
     misc_feature    522..1142
                     /gene="Graf"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain of
                     Oligophrenin1-like Rho GTPase Activating Proteins; Region:
                     BAR_RhoGAP_OPHN1-like; cd07602"
                     /db_xref="CDD:153286"
     misc_feature    order(549..551,558..563,573..575,579..584,591..596,
                     600..605,612..617,621..626,633..638,642..647,654..656,
                     735..737,744..749,1023..1025,1032..1037,1041..1043,
                     1056..1058,1065..1070,1074..1079,1089..1094,1101..1106,
                     1110..1115,1119..1124,1128..1133)
                     /gene="Graf"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:153286"
     misc_feature    1260..1613
                     /gene="Graf"
                     /note="GTPase Regulator Associated with Focal adhesion and
                     related proteins Pleckstrin homology (PH) domain; Region:
                     BAR-PH_GRAF_family; cd01249"
                     /db_xref="CDD:269953"
     misc_feature    1590..2195
                     /gene="Graf"
                     /note="GTPase-activator protein (GAP) for Rho-like
                     GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases.
                     Small GTPases (G proteins) cluster into distinct families,
                     and all act as molecular switches, active in their
                     GTP-bound form but inactive when bound to...; Region:
                     RhoGAP; cl02570"
                     /db_xref="CDD:470621"
     misc_feature    order(1734..1736,1866..1868,1878..1880,2085..2087,
                     2094..2099,2166..2168)
                     /gene="Graf"
                     /note="GTPase interaction site; other site"
                     /db_xref="CDD:238090"
     misc_feature    1734..1736
                     /gene="Graf"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238090"
     misc_feature    3324..3485
                     /gene="Graf"
                     /note="Src Homology 3 domain of GTPase Regulator
                     Associated with Focal adhesion kinase and similar
                     proteins; Region: SH3_GRAF-like; cd11882"
                     /db_xref="CDD:212815"
     misc_feature    order(3339..3341,3345..3347,3354..3356,3366..3368,
                     3423..3428,3465..3467,3471..3476)
                     /gene="Graf"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212815"
     polyA_site      3994
                     /gene="Graf"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gtgtgcgcgt ttgcgtttgc ggtacgcgaa aaagcgaaaa actaccgacg ggacggtctc
       61 gtaactaaga gcatttattt ttgttttgcc caagtgaatt cggatttgga atcgcaatcg
      121 gaatcggaat aggaattcgg aattccgatg ggctaaagtc attttccccc cgtgcagagt
      181 gtttttgcga ggatgtcgac ccgatgaacg gaatatttca atatgcatcg tccacctact
      241 gaaaaacagt atttacattg aaacgtaaat atttaaaagg agccagagcc actcttcctg
      301 taaatgtttc aaacaccaca gcttcaacgc ctgaatacaa atatacacca tacattagcc
      361 accgcggaag aacgcagcct gaaataacct aaagcagctg ggcccgaaaa tcttcaatat
      421 ttttgaaacc aaaagcaaac acaatgggcg gcggcaaaaa tatacgccgc ggcttggagc
      481 cactggagtt cgaggaatgc atcgtcgaca gtccggactt tcgcgaaaat ctaaaccgac
      541 atgaaaagga gctggaccac actagtcatc aaataaaacg aataatcaaa gaggtcaagg
      601 atctaatgag tgcggcaaag atgctgtcca ctagaatgaa acaattggcc attttactta
      661 ccgactttaa ctttgagtgc ataggcactg ctcagaccga cgacgagaat gtcatttgcg
      721 aaagcctaaa acgctttggt gctatcattg gcaatatcga agatgagcgc gagaaaatgc
      781 taacgctcgc tgacaaacat attattgagt cgctggagga ttttcgaaaa aagcaaattg
      841 gcggcgtcaa agaaaacaaa aagaaattcg ataagaaaac ggagaaattc tgtcagtcgc
      901 aggagcgttt tctcaatatg tcaactaaaa agcccgagaa cacaatacag gaggctgatg
      961 ctagcttggg catgcacgaa cgcgagtata tccaggagtc gctgagctat gtcctgcgga
     1021 tacaggaagt gcaggaacga atcaaattcg agttcgtcga gatactgctc gcatttattt
     1081 ctggctggtt ggtgttctat cacacagccc acgaacaggc ggaagatcat cgcgactacc
     1141 tgcaggattt gaggcacaag gtgcagaaga ctcgcgaaaa tttcgaagag gctcgcgaaa
     1201 aggttactga gttgaaaaca aagtacatgg aaaaacgcac aaagcccgag gagattttca
     1261 caaagcgggg ctacctattt ttaatggaaa aaagttccat tctgaaaatc tcccttttag
     1321 agccattcaa agcgacgtgg acgaaatact attgtacatt caagaagcaa aagcgcgagt
     1381 tcacgatgct gcagttcaat caaatgaatc acaatttcac caggccggag gcacgcgatg
     1441 acgagaagct gacgctcttc tcgtgccagc gaagagcctc ggagttcgag aagcgcttct
     1501 gcttcgattt gaccttcaag gagaagccgg gcgtcgtcta tacctttcag gcgctaagcg
     1561 aaaaggatca tcgctactgg attagcgcta tggatggcac ggagccgact tatctggcgc
     1621 ctggtaaaat caaagtcagc gaggcatacc atctggatga ggccggcttc atgttcatcc
     1681 gccgctgcat tcaagtatta gagatccgtg gtctggagga cgaggggatt taccggaaga
     1741 gcggtgtggg taccaaaatc agcaagctgc tctcgctggg cctgaatcaa aaggaaaccg
     1801 acgacgtctt cgtggacgac aagtaccggg atttaatgga gagcaacacc attgccagtg
     1861 ccctgaaaat gtatctgcga aatctaaatg agcccttgat gacctatcaa taccacagtg
     1921 attttattga ggcagccaag caagaaaccc tgaatcaacg cgtgaacgag gtgcacaagc
     1981 tggtctacaa attgccacag cctaattttc agatgctgga catggttatt tgccatttga
     2041 cagacgtttc acgaaagtac gagaagaaca agatgtccgt attcaatctg ggcgtggttt
     2101 tcggacccac tttgctgcga cctcgcgagg aatcggtggc cgccatactg gatattaaat
     2161 tcaacaatat cgtcattaac attctgattg ataactacga gcggatcttc aagaacaagc
     2221 ccagcgccga tgtaaagctg cctgtggagg ccgccaaggc gccgagcatt atgtatcccg
     2281 cacgcagcag tccacccacg cgaatgccgc gtgcctctca aataggaaag gccgcttcga
     2341 ctggtgccat gggcagtacg agcagcactg cggcggcggc ggcagcggcg gggaatccga
     2401 tgttcctcaa tcagcagaag atctaccgcg tggtcagcaa atccaattgt acagagccca
     2461 ccatgtcgtc cagcctgcag aatattccga atggcgataa ctatgcttcg ggcggtgccg
     2521 gctgcatttc cctgtcgccg cccatgcata tgctgaatgg catactctcg ccgaccatcg
     2581 gcagcatcaa caatctgcac acaatatcga agaacgagac gacggtagga acgacaacgg
     2641 cggcgggcac acggcgatac gttcccaacg acacggctga ggtcgcgacc gattatggta
     2701 ttataggtgc caacaatggc ggcgtgacgc tgcagtcgca tcatgccata cccgtcagca
     2761 gcacgaccaa tttccggcat cccgagtacc tagtgaccca gtcggggtcg actaatcacc
     2821 tatatacgaa cagtagctct agtgtcgctg gtgccgccgc tacctcaggc aatcggatta
     2881 gtctgaacaa cgtttccccg ccaaatacag cgatgcgaaa ggagagattt ctcggtagca
     2941 ccggcagcgg gccgcagcag catccgcccg tccaacgggg cctccactcg tacggccaaa
     3001 cgaagcagca gcagcagcag cactactcac ccctgatgcc cacgtcaacg tcgagctcca
     3061 acgacagcgt atgtgattca ctttcttcca ataacggcca gcatttgggc gcacgcaact
     3121 ctaatgatta tgccatgcta acgtcacaga actcatcgct gtcgccgcat cttggacacg
     3181 gatccgcctg cgatgaggtc gtcacggcca ccaccgtcag ctgcggcggc tccgccaacg
     3241 agagttccga gtatccgccc agcaaaatgc atcgtaatcg tgacattaac caaataaaac
     3301 gtgatttgtc aacgggcaca gctcgagtgc gcacactcta tgcttgcatg ggcgagagcg
     3361 agggggagct ttcgtttgag cccaatcaaa taataaccaa tgttcggtat tcccacgagc
     3421 ccggctggtt gcagggcaca ctaaatggaa aaacaggact cattccggag aactatgtgg
     3481 aacacttgaa gccccaccat tagattacgc tttggttcgg cttgggagtt cgaatgttcc
     3541 ctcgtatttt ttgcattcgt cgttagataa aattaaaaaa aaaacaaaaa caaaacaaaa
     3601 aaatgaaata ttaggaaatc gaaaaatgat cgttgtgtaa aaaaaactaa aactaatttt
     3661 tgagtatgtg cccttggggt tgttttacat gaaatgcatt ttattttatg ctggaaacca
     3721 ggaaaccaca atcttacctt ataactatgt taacctttat aataccatga ccatacaatg
     3781 tacttatttt taattattta ataaggagta taaactcagt gcaactgcaa agatttattt
     3841 actaattgtt acgctcttca tttgttgctt atttatacat aattcacgta atttgtgcaa
     3901 aaatgaatta catcgtatct aatatctact acatatacaa ttgtataaaa ataaatagca
     3961 gtgcttcgaa cacttttaaa atgtaaactt taaa