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LOCUS XM_044396282 15440 bp mRNA linear INV 09-DEC-2024 receptor-related protein megalin (mgl), transcript variant X1, mRNA. ACCESSION XM_044396282 VERSION XM_044396282.2 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Dec 9, 2024 this sequence version replaced XM_044396282.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..15440 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..15440 /gene="mgl" /note="low-density lipoprotein receptor-related protein megalin; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 20 Proteins" /db_xref="GeneID:108054711" CDS 1015..15297 /gene="mgl" /codon_start=1 /product="low-density lipoprotein receptor-related protein 2" /protein_id="XP_044252217.1" /db_xref="GeneID:108054711" /translation="MNPTPMGIGFGFGRKPPNKARMRSRWRPPPPATTLLTPDPAEGD NPAADPLQVTEASASASAPSSPIGDHRHPQLDSSRAAEPRLQHQQQEAQHYRQHRGQL TTLALLLLALVALSNLETLLAVRTEGPRNRHGSPGGSLGSTGGINTECPTDSFRCNNG KCISHHWVCNYQKDCDDGEDEMQSCPPPECETPQLNCGQYVFNKTYCIPPHYRCDMIE DCEDKSDEAQCTYRKCQHTDVFCNAPNGAAPAEGARLAGPCVPKEKRCDGYLDCRTGK DEEGCSGVSCRLDQFRCANGHKCIDAALKCNHRDDCGDNSDEQGCNFPPCHHAQFRCS NALCIPYNFHCDGYHDCADKSDEANCTAIACPDNKHLCPRGGASGTPKCILKSQLCDG KRDCEDGSDEETNCSIASCPALSCEFKCGPSLTGGVCYCKPGQSLAPDNRTCVDLDEC AEWGHCDQLCTNTLGSYTCQCAQGYTLINDSKCIAPDANNLQLIFAHDRAIMQMKPHG SEPMVLANATAAAGVTFHYARNTLYWSDIKTRKVQSLPLDAQNKAVSPFDQTLPGTWA PVALAVDWVGDKIYVADLVGQKIDVFELSGQWHAVVLGSNLTSPADLALDPTAGLMFV ADGGQVLRAHMDGTHARSIVSEAAYKASGVTVDIIAKRVFWCDSLLDYIESVDYEGGH RVMVLRGQQVPSPSRLALFENRIYWTDATKQGIMSVDKFEGPTSIQVTHKSKDIREPK GIIAVHALSQPRVSNPCGNNNGGCNHMCIVTAVKGAPTGLGFRCACSTGYQLETDLKL CKPVSEFLMYSQQRFIKGKVLEPVIEGFSDAIMPVVSRRARFVGLDFDARDEFIYYSD VLQDVIYRVHRNGTGREIVLASQNEGVEGLAVDWASKNLYYIDSRKGTLNVLSTRNVT HRRTLLKNLKRPRAIVVHPNRGFIFFSEWDRPANITRANTDGSGLLVFKNVTLGWPNG LSIDFKEDRVYWCDALLDHVQHANLDGTDIKTVNSRLVRHPFSIVIHNDWMYITDWRL DAIIRLHKLTGEQEEMMVREPQTNRLYGVKVYSHEVQRIAETQPCHRNNGGCQKICFA VPIGGGNATTNGGTPSFGRLQSRCSCPYGERLAEDQMSCIPDPSAEPPVQPCPNSWDF TCNNQRCIPKSWVCDGDDDCLDNSDEEQNCTKPTCGSNEFQCRSGRCIPQNFRCDQEN DCGDNSDEQECGNVTCGTSQFACANGRCIPNMWKCDSENDCGDSSDEGDFCAEKTCAY FQFTCPRTGHCIPQSWVCDGDDDCFDKQDEKDCPPISCLANQFKCADLRQCVEESYKC DGIPDCNDGSDEVGCPPMGPNQCNLEKHFRCKSTGFCIPIAWHCDGSNDCSDHSDEQD CGQITCAQNFFKCNNTNCVFKAYICDGKDDCGDNSDEGAEHACVPPPFKCPHGQWQCP GVSERCVNITSVCDDTADCPNGSDEGEGCDLAECEHQAGQCSSFCQKTPNGALCICPP GSEIGEDGYTCIDTNECDPPGLCSQQCTNTKGSYFCSCQEGYILEPNKHTCKAVNHTA AFLIISNRHSILVADLKEQGLERVPIIVENVVATASNMHTGTIFWSDMKLKKISRLDR GMEPQEIINTGLDLVEGLAYDWIAQNLYWLDSKLNTIEVSAENGSNRLVLVRENITQP RGMCIDPSPGARWIFWTDWGENPRVERIGMDGTMRKTIINTKIYWPNGLTLDIATKRV YFADSKLDFIDFCYYNGTGRQQVLASSHYLLHPHSLSLFEDTLYWTDRQLNRVLSANK FRGKNQTVVSHLISQPLSIHVHHASLQPMTPNPCASARCQHLCLLSPSASEGYSCKCK PGFKLLSEGRCIEEENPFLMVVKGTQIVDLPLNGGDARAGALAPVIGIESSTGLDFDR KGETLYWVQGREDDDENCTIYTTPYGGGNKTLFLGTESGIVGAPYTIAFDWLGRNLYI GNRVASNIEAVRVDGKQKYRTIILANDGYANSVSRPKQIVLDPTDGKLFWIDEGVLEV PIKIGRVDMNGQNPIVVFQDFAHPESLAVDTEKKMLYYSASNPAVIGSMDYNGADHTL IVMKDSHPMAKPRSLGILDHRLYYLDPLYERIVRIDLPHGDNPKTIVDNESDLRSMMI YKKRALMQHPCQTNNGGCKHLCIPGSGATRTCSCGIGYRKENEINCVAYKTFAVVSQL DMIRGYSLSDSAEAMVPVSGPGHHILHVDVMYREQWIYWAEYNRGYWNGIFRSRPNGT DLQHVVKDGIGSNGIRGLTIDWVAGNMYFTNVYPHENYVEVCWLDGSNRKVLVKTTTD APRELAVNPVKRLLYWIDYGQHPRIGKALLDGSKWTPLVTSGISLPRDLTIDMQTHDI YWVDSKLDTIQKISFNGANRKVIRRDLPNPMGIAVYLNDVYWVDRNLMTVFKASKHSA NETATRVRTNLEKLRDIAIYNINNQPQDDTNPCAHLGNGGCDQLCFSFPPEGGATGPS GRNFRCECATGKLSADERKCEVVNEYLVFATRTEIRAVNLDPHSTEVPFTPLTNLTNV VGLDFDFADNRMLYTQIRPWAKIAYTKANKPGHDDITVVLNKGINPEGIAYDWTQSKI YWTDSSNNSIYAMNLDGSELVMIARVERPRAIVLDPCNGTLFFTDWGRFGTSGKIFRT TMAGSLKRAIVDKDLSQPSGLAIDYDERRLYWTDAVREKIERSDLDGQNRELLVAATI YPFAITVFRNYIYWTDLQLRGVYRAEKHTGANMVEMVKRLEDSPRDIRIYSADRQKCN VNPCRINNGGCAQSCHPAPNGKAECKCDDNTKVVNEGRMCAPRNNTCEASKFYCKNGR CISRMWSCDGDDDCGDNSDEDPNYCAYHSCSPNEFRCNNGRCIFKSWKCDHENDCKDG SDELGCTYPPCVDGEFTCGNGRCIPQAQVCNGVNDCKDNATSDETHERCPMNTTCPAN HLKCEKTNICVEPYWLCDGDNDCGDNSDEDPLHCGQRTCPTNSFRCPNHRCIPATWYC DGDDDCGDGADEPPDYCKSEGRTCFGDLFTCDNGNCIPRIYICDGDNDCLDNSDEDNR HQCNDRKCDEETEFTCVENKSWQRAQCIPKKWICDGDPDCVDGADENTTLHNCATQQP CGEDMFTCGNGRCINKGWICDHDNDCGDGTDEGKFCNSKYKTCSAQEFTCQNFKCIRN QSRCDGEDDCGDHSDEVGCAKENITCPQGQFACTNGQCIDYNLVCNKYPDCADESDEP AHCNVDECAKVEINQCGHKCVDTLTGYYCDCNEGYKLLADGKACADVDECLEQPGACS QHCSNTPGGFYCKCDETYYERQNDEHTCKRKDKIPPWLIFTNKYYVRNMSVDGHQYNL MHQDLMNVVALDFDIREEYMYFCDVTAKTIFRAKYGEADDEMPPEREAVIRHDSHGLE GIAIDWVGRKLYWLDRHSKNLDVSELDGTKRKTLRSGVVDPRAIVVHPGIGYLYFTSW HLQAYIAKMGMDGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYADLEG RHRHTVLSGSKVPHVFALSLFDDYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRPYD LHINHPLRQLPYTNPCGTNNGGCSHLCLIAPPPESTYLNIEGYIEEGAPIFKCACPNQ FYLARDMKTCVANCTAGQHLCGGRDEKCIPWFWKCDGEKDCKDGSDEPATCAARHCRA GTFQCKNTNCTPSATICDGVDDCGDRSDEQNCDLPCPLSDFKCKSSGRCILDSWRCDG DADCKDGSDEDPAVCFKRTCDPKTEFACKNGRCIPQLWMCDFDNDCGDDSDEPAYMCR QRNCTTGWQRCPGQSNYRCIPKWLFCDGKDDCRDNSDELPENCPKCNPETDFKCGNNR CIPKQWMCDFADDCGDASDENEAVCKGRYRECSESEFRCGNGKCISSRWQCDHEDDCG DNSDEMHCEGYQCKNGTFQCASGHCIASYFRCDGDRDCRDMSDEVGCPPRFPGGRYCP ESRFQCNNNLCVSLSDLCDGTDDCGDGSDEDPSVCSDFNCDTLRRFQCSNHRCVARYQ ICDGVDNCGDGSDENNMTLCASKQKPCDLYTQYQCANKHCIERSQVCDFSDDCGDASD ELGCHHTSSCSEQNRGGCQHHCHNLTDGGYICTCYPGYIIAGDNKKKCSDVDECLTRQ HTCSHQCHNLNGTYSCSCREGFHLTDGSSGVCRAEKEDVILVFANGQEIRGLDLQKRE EFDVIAEEKRIEALDYDAQQQIVFWADSYDKTIKRSYMVNAIDGRAKIGFAQDLNMKG GSKPTAVAVDWLASNLYWTEMDRTGSKPRGRVMVAKTDGRYRRSIVNAGLEVPTSIAV NPQLGRIYWSDAGSAPKIEVSWMDGSKRRPLITEQIRHPAGLTIDYSQDHIIYWVDTK LNAIESMRADGSRRKAIVKGDQLRHPVSLDLFESNMFWMTRDTGELVRQDKFGRGVQV VLHRNLVNPSGLKVYHDKRYNTSLPNPCDNSTCSHLCLLVPGGHRCACPDASGPPPSH RSTAEVICNAAAEHPRPAPRICPCQNGGLCKEDAQGELVCDCLAEFRGEHCETSTTGA FGHGGANVTAVVVPIMVILLVMMAAAGAWYVIRKRPFGKLARMPAMTSSQSVTFRHGS NVEFSESGFPGASAPGAGDVAPIEGYNLQTVNANKARDFANPMYDAVQSGTTADPGMG NGSGIYDVPGEPSAKGKAMGHHAGGSFTEPASAIIAPSSITHKASPQLQLRTRELDPS ADTGKDTQFLVEEDKSEC" misc_feature 1462..1560 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1477..1479,1501..1503,1534..1539) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1513..1515,1522..1524,1534..1536,1552..1557) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1543..1557 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature <1633..1701 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1648..1650,1657..1659,1669..1671,1687..1692) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1678..1692 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1870..1977 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1885..1887,1912..1914,1945..1950) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1924..1926,1933..1935,1945..1947,1963..1968) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1954..1968 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1990..2094 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2005..2007,2029..2031,2062..2067) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2041..2043,2050..2052,2062..2064,2080..2085) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2071..2085 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2107..2232 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2122..2124,2164..2166,2197..2202) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2176..2178,2185..2187,2197..2199,2215..2220) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2206..2220 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature <2335..2460 /gene="mgl" /note="Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057" /db_xref="CDD:469594" misc_feature <2470..2898 /gene="mgl" /note="DNA-binding beta-propeller fold protein YncE [General function prediction only]; Region: YncE; COG3391" /db_xref="CDD:442618" misc_feature 2713..>3144 /gene="mgl" /note="NHL repeat unit of beta-propeller proteins; Region: NHL; cl18310" /db_xref="CDD:302697" misc_feature 2713..2826 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 2842..2958 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 2965..3075 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 3283..3411 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 3556..>3972 /gene="mgl" /note="Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Region: YvrE; COG3386" /db_xref="CDD:442613" misc_feature 3760..3888 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 3913..4017 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 4450..4530 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(4450..4452,4474..4476,4507..4512) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4486..4488,4495..4497,4507..4509,4525..4530) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4516..4530 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4552..4659 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: Ldl_recept_a; pfam00057" /db_xref="CDD:395011" misc_feature order(4570..4572,4594..4596,4627..4632) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4606..4608,4615..4617,4627..4629,4645..4650) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4636..4650 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4669..4767 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(4687..4689,4711..4713,4744..4749) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4723..4725,4732..4734,4744..4746,4762..4767) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4753..4767 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4792..4899 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4807..4809,4834..4836,4867..4872) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4846..4848,4855..4857,4867..4869,4885..4890) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4876..4890 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 4912..5019 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(4927..4929,4954..4956,4987..4992) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(4966..4968,4975..4977,4987..4989,5005..5010) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 4996..5010 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 5056..5151 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(5059..5061,5086..5088,5119..5124) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(5098..5100,5107..5109,5119..5121,5137..5142) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 5128..5142 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 5161..5259 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(5179..5181,5203..5205,5236..5241) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(5215..5217,5224..5226,5236..5238,5254..5259) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 5245..5259 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 5293..5397 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(5311..5313,5341..5343,5374..5379) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(5353..5355,5362..5364,5374..5376,5392..5397) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 5383..5397 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 5554..5649 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 5863..5985 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 5989..6123 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 6058..6177 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 6124..6252 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 7024..7152 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 7441..>7527 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 7765..7905 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 7966..8088 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 8044..8166 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 8722..>9120 /gene="mgl" /note="NHL repeat unit of beta-propeller proteins; Region: NHL; cl18310" /db_xref="CDD:302697" misc_feature 8764..8853 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 8887..9021 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 8998..9126 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 9586..9690 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9601..9603,9625..9627,9658..9663) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9637..9639,9646..9648,9658..9660,9676..9681) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 9667..9681 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9703..9810 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9718..9720,9742..9744,9775..9780) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9754..9756,9763..9765,9775..9777,9799..9804) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature order(9784..9789,9796..9804) /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 9835..9936 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(9850..9852,9877..9879,9910..9915) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(9889..9891,9898..9900,9910..9912,9928..9933) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 9919..9933 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 10087..10185 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(10105..10107,10129..10131,10162..10167) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(10141..10143,10150..10152,10162..10164,10180..10185) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 10171..10185 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 10225..10332 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(10234..10236,10276..10278,10309..10314) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(10288..10290,10297..10299,10309..10311,10327..10332) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 10318..10332 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 10369..10464 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(10384..10386,10408..10410,10441..10446) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(10420..10422,10429..10431,10441..10443,10459..10464) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 10450..10464 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 10495..10599 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(10510..10512,10534..10536,10567..10572) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(10546..10548,10555..10557,10567..10569,10585..10590) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 10576..10590 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 10615..10713 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(10633..10635,10657..10659,10690..10695) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(10669..10671,10678..10680,10690..10692,10708..10713) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 10699..10713 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 10762..10848 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 10864..10974 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 11071..11169 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 11203..11331 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 11389..11520 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 11479..11595 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 11593..11721 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 11806..11964 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 11974..12075 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(11989..11991,12019..12021,12052..12057) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12031..12033,12040..12042,12052..12054,12070..12075) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12061..12075 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12100..12204 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(12115..12117,12139..12141,12172..12177) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12151..12153,12160..12162,12172..12174,12190..12195) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12181..12195 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12214..12312 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(12229..12231,12256..12258,12289..12294) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12268..12270,12277..12279,12289..12291,12307..12312) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12298..12312 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12337..12438 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(12358..12360,12382..12384,12415..12420) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12394..12396,12403..12405,12415..12417,12433..12438) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12424..12438 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12466..12570 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(12481..12483,12514..12516,12547..12552) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12526..12528,12535..12537,12547..12549,12565..12570) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12556..12570 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12598..12690 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(12610..12612,12634..12636,12667..12672) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12646..12648,12655..12657,12667..12669,12685..12690) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12676..12690 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12724..12828 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(12739..12741,12763..12765,12796..12801) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12775..12777,12784..12786,12796..12798,12814..12819) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12805..12819 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12841..12945 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(12856..12858,12880..12882,12913..12918) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(12892..12894,12901..12903,12913..12915,12931..12936) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 12922..12936 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 12973..13068 /gene="mgl" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(12988..12990,13012..13014,13045..13050) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(13024..13026,13033..13035,13045..13047,13063..13068) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 13054..13068 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 13114..13200 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(13114..13116,13138..13140,13171..13176) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(13150..13152,13159..13161,13171..13173,13189..13194) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 13180..13194 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 13243..13338 /gene="mgl" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(13249..13251,13273..13275,13306..13311) /gene="mgl" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(13285..13287,13294..13296,13306..13308,13324..13329) /gene="mgl" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 13315..13329 /gene="mgl" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 13354..13464 /gene="mgl" /note="Coagulation Factor Xa inhibitory site; Region: FXa_inhibition; pfam14670" /db_xref="CDD:464251" misc_feature 13474..13569 /gene="mgl" /note="Calcium-binding EGF-like domain; Region: EGF_CA; smart00179" /db_xref="CDD:214542" misc_feature order(13474..13476,13483..13485,13525..13527) /gene="mgl" /note="Ca2+ binding site [ion binding]; other site" /db_xref="CDD:238011" misc_feature 13813..>14265 /gene="mgl" /note="NHL repeat unit of beta-propeller proteins; Region: NHL; cl18310" /db_xref="CDD:302697" misc_feature 13858..13995 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 14005..14106 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" misc_feature 14035..14160 /gene="mgl" /note="Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058" /db_xref="CDD:459654" misc_feature 14107..14238 /gene="mgl" /note="Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135" /db_xref="CDD:214531" misc_feature 14128..14253 /gene="mgl" /note="NHL repeat [structural motif]; Region: NHL repeat" /db_xref="CDD:271320" ORIGIN 1 cagtcgctcg cggagcgtcg tcgtgaacgg tcagccagcg cggctaataa ctaactaact 61 ttggtgacag tgcgccatac tgactctgat ccgaacccga atcgaggccc acagcagcca 121 gaacatatta ccaacaatat atcagagcgg aaagtaaacg gagctactct gaacgaaaga 181 aagaccttct ctaagataaa tcctgttgag tgtttcgagt tttttttcga gattgcagtg 241 aaaaactcca agggatatgc aatttcctta tcaaacgaaa gagacggcaa caacaacagc 301 aaccaaccga caagatgcca tcgccatctc cctcgcacca tattaatttt tatttttcaa 361 gtgtctgaaa tacaacaacc gacgtaaaaa aaagaggagg aaaaaacgaa aataaaatat 421 aaatacgcaa aggaaaatcg cgggaagaga cgagaaaagt ttaaagacgc cgaaggcaaa 481 agttcacata aagcagccga aaaaagtttt tcaattattg taaaaagtgt taaaaagata 541 gggccaacgc gagcgagcga gcgagagcga gagggggcta gagtgcgaga gtgcgagaac 601 gagacagcca gcaattatct ttcataagca aaaaagttta gcagcaggca aaagagcaaa 661 cggaataaga cgaacggggg ggaatttaat taaatttaat taattgctct ttcaagtgcc 721 cccgcggcaa cgcccacaaa agcaaataaa ttaaaaatat taaacgcgtt aattttccgc 781 ttatttcatt aaagcagcag cccaccaaac aaaaaccaaa caaaaatatt tcgaaaaaga 841 atagagaaat caagccagaa gagagggaat tctcaaaggc agaagacaga agaccggtgg 901 gcagagaaga ggtcaccaga aggtcaccga aaccccaaaa aagaatccaa acctaaaccc 961 acggataaga agcaaaggag cgaaggagcc agcgaagcga ccaacgaacc aaaaatgaat 1021 ccgacgccca tgggcattgg attcggattt ggtcgcaagc cgcccaacaa ggccagaatg 1081 cgttcccgct ggcgaccacc gccgccggcg acaaccctgc tgacccctga ccccgccgag 1141 ggcgacaacc cggcagccga tccgctgcag gtcacagagg cctccgcctc agcttcggcg 1201 ccatcctcgc ccatcggcga ccaccgccat ccgcagctgg acagcagcag agctgccgag 1261 ccgaggctgc agcaccagca acaggaagca cagcactacc gccagcaccg cggccagttg 1321 acaaccctgg cgctgctgct actggccctc gtagccctca gcaacctgga aaccctgctc 1381 gccgtgcgca ccgaaggacc gcgcaaccgc catggatcac caggtggcag cttgggcagc 1441 acaggcggca tcaataccga gtgtccgacg gactccttcc gctgcaacaa cggcaagtgc 1501 atctcgcacc actgggtctg caattaccaa aaggactgcg acgatggcga ggacgagatg 1561 cagtcgtgcc ccccaccgga atgcgaaact ccccagctga actgcgggca gtatgtgttc 1621 aacaagacct attgcatccc tccgcactat cgttgcgata tgatcgagga ttgcgaggac 1681 aaatcggacg aggcccagtg cacttaccgc aagtgccagc acacggacgt cttctgcaac 1741 gcccccaatg gagccgcccc cgcggagggc gcccgcctgg ccggaccctg tgtgccgaag 1801 gagaaacgct gcgacggcta cctggactgc cgcaccggga aggacgagga gggctgcagc 1861 ggcgtctcct gtcgcctcga ccagttccgc tgcgccaatg gacacaagtg catcgatgcc 1921 gctctgaagt gcaaccaccg cgacgactgt ggcgataatt ccgacgaaca gggatgcaac 1981 ttcccgccct gccaccacgc ccagttccgg tgctcgaacg ccctatgcat tccgtacaac 2041 ttccactgcg atggctacca cgactgcgcc gacaagagcg acgaggccaa ctgcacggcc 2101 atcgcctgtc cggacaacaa gcacctctgt ccacgaggag gcgccagcgg aacacccaag 2161 tgcatcctga agtcccaact gtgcgacggc aagcgggact gcgaggatgg tagcgacgag 2221 gagaccaact gttcgattgc ctcttgccca gctctgagtt gtgagttcaa gtgcggaccc 2281 tcgctgaccg gaggcgtgtg ctactgcaaa cctggtcaat cgctggcccc ggacaaccga 2341 acttgtgtgg acctcgacga gtgcgccgag tggggtcact gcgaccagct gtgcacgaac 2401 accctgggct cgtacacctg ccagtgtgcc cagggctaca cgctgatcaa cgactccaag 2461 tgcattgccc cggatgcgaa taacctgcag ctgatcttcg cccacgatcg tgccataatg 2521 caaatgaagc cgcatggcag tgaacctatg gtactggcca atgccaccgc tgcggccgga 2581 gtgaccttcc attatgcgag gaatacgctc tactggtcgg acatcaagac aaggaaggtt 2641 caatctctgc ctctggatgc acagaacaag gctgtctcgc cattcgatca aacgctaccc 2701 ggaacctggg ctcccgtagc tctggccgtc gattgggtgg gcgataagat atatgtggcc 2761 gatttggtgg gtcagaagat cgatgtcttc gagctgagtg gtcaatggca tgccgtggtc 2821 ctaggttcaa acctcacctc gcccgccgac ctcgctttgg atcccacggc tggtctgatg 2881 ttcgtggcgg atggtggtca agtgctccgt gcccacatgg atggaaccca tgcccgttcg 2941 attgtctcgg aggctgccta caaggcgagc ggcgtgacgg tggacatcat tgccaagcgc 3001 gtcttctggt gcgactccct gctggattat attgagtcgg tagactatga gggtggtcat 3061 agggttatgg tccttcgagg acagcaagtg cctagtccct cgcgactcgc tctgttcgaa 3121 aaccgcatct actggacgga tgccaccaag cagggcatca tgtcggtgga caagttcgag 3181 ggtcccacct ccattcaggt gacccacaag tccaaggaca ttcgggagcc caaaggcatc 3241 attgcggtgc atgcactgag tcaaccgagg gtctcgaatc catgtggcaa taacaatggt 3301 ggctgcaatc atatgtgcat cgtcaccgcg gtcaagggag ctcccacggg attgggtttc 3361 cgttgcgcct gctcgacggg ctatcaactg gagacggact tgaagctttg caaaccggtt 3421 agcgagttcc tcatgtactc gcaacagcga tttatcaagg gcaaagtatt agagcccgtg 3481 atcgagggct tcagcgatgc cattatgcca gtggtttccc gccgagctcg tttcgttggc 3541 ctggatttcg atgcccgcga tgagttcatc tactactcgg acgttctgca ggatgtgatc 3601 tatagggtgc atcgaaatgg aacaggtcgc gagattgttt tggcctccca aaatgagggc 3661 gtcgagggac tggctgtcga ttgggcctct aagaatctct actacatcga ttcacgcaag 3721 ggcaccttga atgtcttgtc cacgaggaat gtcactcatc gcaggactct gctgaagaat 3781 ttgaaacgtc caagggccat tgtggtccac cctaatcgcg gcttcatctt cttctccgaa 3841 tgggatcgac cggcgaatat cacgcgggca aacaccgatg gcagtggtct gttggtcttc 3901 aagaacgtca ctttgggatg gcccaatggt ctgtctattg acttcaagga ggatagggtt 3961 tactggtgcg atgccttgct agaccatgtt caacatgcca atttggatgg cacggacatc 4021 aagacagtga actcgcgact ggtgcgacat cccttctcga ttgtcatcca caacgattgg 4081 atgtatatta cggactggcg attggatgcc attatcaggc tgcacaagct gacgggcgag 4141 caggaggaga tgatggtgag ggagccgcag accaacaggc tgtatggggt taaggtgtac 4201 agtcacgagg ttcagaggat cgcggagacg caaccctgtc accggaacaa cgggggatgc 4261 cagaagatct gctttgcggt tccgattgga ggagggaatg ctacaacgaa tggaggtaca 4321 ccctcctttg gtcgcctgca gtcgcggtgc tcgtgtccct atggcgagcg gctggccgag 4381 gatcagatga gctgcatccc cgatccgagt gccgagccgc cggtgcagcc gtgcccgaac 4441 tcctgggact tcacgtgcaa caaccagcgg tgcattccca agtcgtgggt ctgcgatggc 4501 gacgacgact gcctggacaa cagcgatgag gagcagaact gcacgaaacc cacctgcgga 4561 tcgaacgagt tccagtgccg atcgggccgc tgcattccgc agaacttccg ctgcgaccag 4621 gagaacgact gtggcgacaa ctcggacgag caggaatgcg gcaacgtgac ctgcggcacc 4681 tcgcagttcg cctgcgccaa tgggcgatgc attccgaata tgtggaagtg cgacagcgag 4741 aacgattgtg gggatagcag cgatgagggt gacttttgtg ccgagaagac ctgcgcctac 4801 ttccagttca cgtgtccgcg gacgggtcac tgcataccgc agagttgggt gtgcgacggc 4861 gacgacgatt gcttcgacaa gcaggacgag aaggactgtc cgccgatctc ctgtctggcc 4921 aatcagttca agtgcgccga tctgcggcag tgcgtcgagg agtcgtacaa atgcgatggc 4981 ataccggact gcaacgatgg ctccgacgag gtgggctgcc cgcccatggg cccgaatcag 5041 tgtaatctcg agaagcactt ccgctgcaag tctactggct tctgtatacc catcgcctgg 5101 cattgtgatg gctcgaatga ttgctcggat cattcggatg agcaggactg cggtcagatc 5161 acctgtgccc agaacttctt caagtgcaac aacacgaact gtgtgttcaa ggcctacatt 5221 tgcgacggca aggacgattg tggtgataac tcggatgagg gtgccgagca tgcctgtgtt 5281 ccgccgccct tcaagtgtcc ccacggtcag tggcaatgtc ccggggtctc ggagagatgc 5341 gtgaacataa cctccgtttg cgatgacacc gccgattgtc ccaatggttc cgatgagggt 5401 gaaggttgcg acctcgccga gtgcgaacat caggcgggtc agtgctccag tttctgtcag 5461 aagaccccga atggagctct gtgcatctgt ccacctggtt cggagatcgg agaagatggc 5521 tatacctgta tagacactaa tgaatgcgat cccccgggtc tctgttctca acagtgtacg 5581 aacaccaagg gctcgtactt ctgttcctgc caagagggtt acattttgga gcccaataag 5641 cacacctgca aggcagtcaa tcacaccgcc gccttcctga tcatctccaa taggcattct 5701 atcctagtgg ccgatctcaa ggaacaggga ctggaaaggg tgcccattat agtggagaat 5761 gtggtggcca ccgcttcgaa catgcacacg ggcaccattt tctggagcga catgaagctg 5821 aagaagatct cgcgattgga taggggaatg gaaccgcagg agattatcaa cacgggattg 5881 gatctggtgg agggactggc ctacgattgg atagcccaga atctctactg gctggacagc 5941 aagctgaaca cgatcgaggt gtcggcggag aatggttcga atcgattggt tcttgttaga 6001 gagaacatca ctcagcccag aggcatgtgc atcgatccga gtcccggggc aagatggatc 6061 ttctggacgg actggggtga gaatccgcgg gtggagcgga tcggcatgga tggaacgatg 6121 aggaagacga tcatcaatac gaagatctat tggcccaatg gtttgaccct ggacatagcc 6181 accaagcggg tttactttgc ggattccaag ctggacttta tagacttttg ctactacaat 6241 ggaaccggga gacagcaggt tttggccagc agtcactacc tcctgcatcc gcactcgctg 6301 tccctcttcg aggataccct gtactggacg gacaggcaat tgaatcgggt tctctcggcg 6361 aataagttta ggggcaagaa tcagacggtg gtttcgcacc tgattagcca accgctgtcc 6421 atccacgtgc atcatgcctc cctgcagccg atgaccccga atccctgtgc ctcagcacgc 6481 tgccagcatc tgtgtctgct gagtcccagc gcctcggagg gctactcgtg caagtgcaag 6541 ccgggcttca agctgctcag cgagggtcgc tgcatcgagg aggagaatcc cttcctgatg 6601 gtcgtcaagg gcacgcagat agtggatctt ccgctgaatg gtggcgatgc gagggcagga 6661 gccttggctc cggtgattgg aatcgagagc agcactggcc tggactttga tcgcaaggga 6721 gagaccctct attgggtgca gggcagggag gatgatgacg agaattgcac tatctatacg 6781 acaccatacg gaggtggcaa caagaccctc ttcctgggca ccgaaagcgg cattgtcgga 6841 gcaccctaca ccattgcctt cgattggttg ggtcggaatc tctacattgg caaccgggtg 6901 gccagtaata tcgaggcagt gcgagtggat ggaaagcaaa agtaccggac aatcatccta 6961 gccaacgatg gttatgccaa ctcggtgtcg cgacccaagc aaatagtgct cgatcccacc 7021 gacggcaagc tcttctggat cgacgagggc gtgctggagg tgcccatcaa gatcggcagg 7081 gtggacatga atgggcagaa ccccattgtg gtcttccagg actttgccca tcccgaatcg 7141 ctggccgtgg acacggagaa gaagatgctc tactacagtg ccagcaatcc ggcggtgatt 7201 ggttcgatgg attataacgg agctgatcac acgctgattg tgatgaagga ctcgcatccg 7261 atggccaagc cgaggagtct gggcatcctg gatcaccgac tatactattt ggatcccttg 7321 tacgagcgga ttgtgcgaat cgatctgccg catggcgata atcccaagac aattgtggat 7381 aatgaatcgg atttgagatc gatgatgatc tacaagaagc gcgctttgat gcagcatccc 7441 tgccagacga acaacggcgg ctgcaagcat ctctgcattc cgggatcggg agctacgagg 7501 acctgctcct gcggcattgg ttatcgcaag gagaacgaga tcaattgcgt ggcctacaag 7561 accttcgcgg tcgtctccca gctggacatg atcaggggat atagcttaag tgacagtgca 7621 gaggccatgg ttccggtgag cggacctggt catcacatcc tccacgtgga cgtcatgtat 7681 cgggagcaat ggatctactg ggcggaatac aatcggggct actggaatgg catcttcagg 7741 tcgcgaccca atggcaccga tctgcagcat gtggtcaagg atgggatcgg aagcaatggc 7801 atccggggac tgaccatcga ttgggtggcc ggtaatatgt actttaccaa tgtctatccg 7861 catgagaatt acgtggaggt ctgctggctg gacggtagca ataggaaggt gttggtcaag 7921 accaccacgg atgcaccgcg tgaactcgcg gtgaatcccg tgaagaggct gctctactgg 7981 atcgactatg gtcagcatcc gaggattggg aaagctctgc tggacggaag caagtggacg 8041 cctttggtga cgtcggggat ctcgttgcca cgcgatctaa ccatcgatat gcagacgcat 8101 gacatctact gggtggactc gaaactggac accatccaga agatctcctt taatggggcc 8161 aatcgcaagg tcattcggag ggatctgccc aatcccatgg gcatcgctgt ctatctgaac 8221 gacgtgtact gggtggacag gaacctgatg accgtgttca aggcctccaa gcacagtgct 8281 aatgagacgg ccaccagggt gaggacgaat ctggagaagc tgagggacat tgcgatctac 8341 aatatcaaca atcagccgca ggacgatacc aatccttgtg cccacttggg caacggcggc 8401 tgcgatcagt tgtgcttcag tttcccaccc gaagggggag ccaccggtcc atcgggcagg 8461 aatttccgtt gcgagtgtgc gacgggtaag ctgagtgccg acgagcgaaa gtgcgaggtg 8521 gtcaacgagt atctggtctt tgccacacga accgaaattc gagccgttaa cctcgatccc 8581 cattccacgg aggtgccttt taccccgctg actaatctca cgaatgtcgt gggtctggac 8641 tttgatttcg cggacaatcg aatgttgtat acgcagattc gcccatgggc caagatcgcc 8701 tatacgaagg cgaataagcc gggacacgat gacatcacgg tggtgctgaa caagggcatc 8761 aatcccgagg gcattgcgta cgattggacg cagtcgaaga tctattggac ggacagctcg 8821 aacaactcga tctatgcgat gaatctggat ggcagtgaac tggtgatgat tgcccgggtg 8881 gagcgtcccc gagcgattgt cctggatccc tgcaatggaa cgctgttctt cacggattgg 8941 ggaagattcg gaacctctgg caagatattc cgcacgacga tggcgggatc tctgaagaga 9001 gcgatcgtgg ataaggacct gtcgcagccc agtggcctgg ccatcgatta cgatgagagg 9061 aggttgtatt ggacggatgc ggtgagggag aagatcgagc gatccgattt ggatggtcag 9121 aacagggagc tcctggtggc cgccaccata tatcccttcg cgatcaccgt gttccgtaac 9181 tacatctact ggacggatct ccagctgcgc ggtgtctacc gggcggagaa gcacacgggt 9241 gcgaatatgg tggagatggt gaagcgactg gaggattcgc cgcgagacat tcgcatctac 9301 agtgcggatc ggcagaagtg caatgtgaat ccgtgcagga tcaacaatgg gggatgtgcc 9361 cagagttgtc acccggcgcc gaatggcaag gccgagtgca aatgcgatga taatacgaag 9421 gtggtgaacg agggaaggat gtgtgcaccg aggaataata cgtgcgaggc cagcaagttc 9481 tactgcaaga atggcaggtg catttcgagg atgtggtcct gcgatggcga cgacgactgt 9541 ggggataatt ccgatgagga tcccaactac tgtgcctatc actcctgctc gccgaatgag 9601 ttccgttgca acaatggtcg gtgtattttc aagtcttgga agtgcgatca cgagaacgat 9661 tgcaaggatg gctccgatga gctgggctgc acctatccgc cctgcgtcga tggtgagttc 9721 acctgcggca atggcaggtg tattccccag gcccaggtgt gcaatggggt gaacgattgc 9781 aaggacaatg ccacctcgga cgagacgcac gagaggtgtc ccatgaacac cacctgtccg 9841 gcgaatcatc tcaagtgcga gaagacgaat atctgtgtgg agccctattg gctgtgcgat 9901 ggcgacaacg attgcggcga caactccgac gaggatcccc tgcattgtgg tcagagaact 9961 tgtcccacga acagcttccg ctgccccaac caccgatgca ttccggccac ctggtactgc 10021 gatggcgacg atgattgcgg cgatggcgcc gacgagccac cagattactg caagtccgaa 10081 ggacgcactt gcttcgggga tctcttcacc tgcgacaatg gcaactgcat acccagaatc 10141 tacatttgcg acggtgacaa cgattgcctg gacaacagtg acgaggacaa ccggcatcag 10201 tgcaatgacc gaaagtgtga tgaggaaacg gaattcacct gcgtggagaa caagtcctgg 10261 cagcgagccc agtgcatccc caaaaaatgg atctgcgacg gagatccgga ttgtgtagat 10321 ggagccgacg agaacaccac cctgcacaac tgtgctacgc agcaaccctg tggcgaggac 10381 atgttcacct gcggcaacgg acgctgcatc aataagggat ggatctgcga ccatgacaac 10441 gattgcggcg acggcaccga cgagggcaag ttctgcaact ccaagtacaa gacctgctcg 10501 gcccaggagt tcacctgcca gaacttcaag tgcatccgca accagtcgag gtgcgatggc 10561 gaggacgact gcggcgatca ctcggacgag gtgggctgcg ccaaggagaa catcacctgt 10621 ccgcagggac agttcgcctg tacgaatggc cagtgcatcg actacaatct ggtgtgcaac 10681 aagtatcccg actgtgccga cgagtccgat gagccggccc actgcaacgt ggacgagtgc 10741 gccaaggtgg agatcaatca gtgcggccac aagtgcgtgg acacgctgac gggctactac 10801 tgtgactgca atgagggcta caaacttctg gccgacggca aggcatgtgc ggatgtggac 10861 gagtgcctgg agcagccggg cgcctgttcc cagcactgtt cgaacacccc gggtggattc 10921 tactgcaagt gcgatgagac ctactacgag cggcagaacg atgagcacac gtgcaagcga 10981 aaggacaaga taccaccctg gctgatcttc accaacaagt actatgtgcg aaatatgtcg 11041 gtggatggac atcagtacaa tttgatgcac caggatctga tgaatgtggt ggccctggac 11101 tttgacattc gcgaggagta catgtacttc tgcgacgtga cggccaagac gatattccgg 11161 gccaagtatg gggaggcaga tgacgagatg ccgccggagc gggaggctgt gatcaggcac 11221 gattcccatg gactggaggg catcgccatc gattgggtgg gtcgcaagct ctactggttg 11281 gacaggcact ccaagaacct ggatgtttcc gaactggatg gaaccaaacg caagaccctg 11341 aggagtggtg tcgttgatcc gcgtgccatt gtcgtgcatc ctggcatcgg ttatctgtac 11401 ttcacctcct ggcatctgca agcctacatt gccaaaatgg gcatggatgg ttcgaacttc 11461 tcgaggatcc tgaactggaa cgacggtatc gcctggccga atgccctgtc cattgactac 11521 ttcacggatc gtatttactg ggcggacgcc cacttggact acatagccta tgctgatttg 11581 gagggcaggc atcggcatac ggtgctctct ggcagcaagg tgcctcatgt gtttgcactg 11641 agtctcttcg acgactacat ctactggagt gactggaatc tgaaggccat tgtgcgggcc 11701 aacaagttcc atggtgccaa ctacacggtg ctgaggaata ccacccatcg tccctacgac 11761 ctgcacatca atcatccgct gaggcaactg ccctacacca atccctgtgg caccaacaac 11821 ggcggttgct cgcatctctg cctgatagct ccaccgccgg agtccacgta cctgaatatc 11881 gagggctata tcgaggaggg agctccgatc ttcaagtgcg cctgtcccaa tcagttctac 11941 ttggcccggg acatgaagac ttgcgtggcc aattgcacgg ccgggcagca tttgtgcggc 12001 ggtcgggatg agaagtgcat accgtggttc tggaagtgcg acggggagaa ggactgcaag 12061 gatggcagcg atgagccagc cacctgtgcc gcgcgacact gccgggccgg aacgttccag 12121 tgcaagaata ccaactgcac accctcggcg accatttgcg atggcgtgga cgactgcggt 12181 gatcgtagcg acgaacagaa ttgcgatcta ccctgcccgc tgtccgattt caagtgcaaa 12241 tccagtggta ggtgcatcct ggacagctgg cgctgcgatg gcgatgccga ctgcaaggat 12301 ggcagcgacg aggaccccgc cgtgtgcttc aagcgcacct gcgatcccaa gacggagttt 12361 gcctgcaaga atggccgctg cattccgcaa ctgtggatgt gcgatttcga caacgattgc 12421 ggcgatgatt ccgatgagcc ggcgtacatg tgccgccagc gcaactgcac caccggctgg 12481 cagagatgcc ctggtcagtc gaactaccgc tgcattccca agtggctgtt ctgcgacggc 12541 aaggacgatt gtcgggacaa cagcgacgag ctgccagaga actgccccaa gtgtaatccc 12601 gagacggact tcaagtgcgg caacaaccga tgcataccca agcaatggat gtgtgacttt 12661 gcggacgatt gtggcgatgc tagcgatgag aacgaggctg tctgcaaggg tcgctatcgg 12721 gagtgctccg aatcggagtt ccgctgcggc aacggcaagt gcatctcctc ccggtggcag 12781 tgcgatcatg aggacgactg cggcgacaac tcggacgaga tgcactgcga gggctatcag 12841 tgcaaaaacg gcaccttcca gtgcgcttcc ggtcattgca tagcctccta cttccgttgc 12901 gacggcgatc gcgattgccg cgacatgtcc gacgaggtgg gctgtccgcc gcgcttcccg 12961 ggcggtcgct actgtcccga gtcgcgtttc cagtgcaaca acaacctgtg cgtctcgctg 13021 tcggacctct gtgacggcac agatgattgc ggtgatggca gcgacgagga tcccagcgtt 13081 tgcagtgact tcaattgcga taccctgcgg cgattccagt gctccaatca tcgatgcgtg 13141 gctcgctatc aaatctgcga tggtgtggac aactgcggcg atggcagtga tgagaacaac 13201 atgaccctgt gtgccagcaa acagaagccc tgcgatctgt acacccagta ccagtgcgcc 13261 aacaagcact gcatcgaacg ctcgcaggtg tgcgacttct ccgacgattg tggcgatgcc 13321 agcgatgagt tgggctgcca ccacacgagc agctgctccg aacagaatcg cggtgggtgt 13381 cagcatcact gccacaatct caccgacggt gggtacatat gcacctgcta tcccggctac 13441 atcatagccg gcgacaacaa gaagaagtgc tccgacgtgg acgagtgcct cacgcgacag 13501 cacacgtgtt cgcatcagtg tcacaatctc aatggcacct actcgtgcag ttgccgcgag 13561 ggtttccatc tgaccgacgg ctcgagtggc gtttgtcgtg ccgaaaagga ggatgtcatt 13621 ttggtatttg ccaacggtca ggagatccga ggtttggacc tccagaaacg cgaggaattc 13681 gatgtgattg cggaggagaa gcggatcgag gcactggact acgatgccca gcagcagatc 13741 gtcttttggg cggatagcta tgacaagacg atcaagcgtt cgtacatggt gaatgccatc 13801 gatggcaggg ccaagattgg ctttgcccag gatctgaaca tgaagggagg atcgaaaccc 13861 accgccgtgg ccgtcgattg gctggcctcg aatctctact ggacggaaat ggacaggacg 13921 ggctcgaagc cgcgtggtcg agtgatggtg gccaagacgg atggaaggta tcgcaggtcg 13981 attgtgaatg ccggtctgga ggtgcccact tcgatagcgg ttaatccaca gctgggcagg 14041 atctactggt cggatgcggg ctccgcgccc aagatagagg tctcctggat ggatgggtcc 14101 aagcggcgac cgctgatcac cgagcagatt cgtcatcccg ccggcctgac catcgattac 14161 tcgcaggatc acatcatcta ctgggtggac accaagctga atgccattga atcgatgcgg 14221 gccgatggtt cgcgtcgcaa ggccattgtg aagggtgacc agctgaggca tcccgtttcc 14281 ctcgatctct tcgaatccaa catgttctgg atgacacgcg acaccgggga gctggtgcgc 14341 caggataagt tcgggcgcgg agtgcaggtg gtgctgcatc gcaacctcgt caatccgtcc 14401 ggcctgaagg tctaccacga caagcggtac aacacctcgc tgcccaatcc gtgcgacaac 14461 tccacctgct cgcacctctg cctcctggtg cccggcggcc atcggtgcgc ctgtcccgac 14521 gcctccggtc cgccgccctc gcatcgcagc accgccgagg tgatctgtaa tgccgccgcc 14581 gagcatccgc gtccggcgcc gaggatttgt ccctgccaga acggcgggct ctgcaaggag 14641 gatgcccagg gtgagctcgt ctgcgactgt ttggccgagt tccggggcga gcactgcgag 14701 acgagcacca ccggagcctt tggtcatggg ggcgccaatg tcaccgccgt cgtggtgccc 14761 atcatggtca tcctgctggt gatgatggcc gccgccggcg cctggtacgt catccggaag 14821 agaccttttg gcaaattggc tcgcatgccg gcgatgacct cgtcgcagag cgtgaccttc 14881 cgccacgggt cgaatgtgga gttcagcgag agcggcttcc cgggggcatc cgcaccgggg 14941 gccggcgatg tggcgcccat cgagggctac aacctgcaga cggtgaacgc gaacaaggcg 15001 cgcgactttg ccaatccgat gtacgatgca gtgcagtcgg gcaccaccgc cgatccaggc 15061 atgggcaacg gctcgggcat ctacgatgtg cccggcgaac cgtcggccaa gggcaaggcc 15121 atgggccacc atgcgggcgg atccttcacg gagcccgcct cggcgatcat cgcgcccagc 15181 agcatcacgc acaaggcgtc gccgcagctg cagctgcgca ccagggagct ggacccctcg 15241 gcggacaccg gcaaggacac ccagttcctg gtggaggagg acaagtccga gtgctgatat 15301 caagcccgtc aatcggctgc agttgcgatg gccagctgtc gccggcagca gcagcagcag 15361 aagcagcaga agcatccgga gaacagctat ccgctgcaga cataacacag actggtcaag 15421 caaaggaagg agcagcagca