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LOCUS XM_044396091 12053 bp mRNA linear INV 09-DEC-2024 (trol), transcript variant X40, mRNA. ACCESSION XM_044396091 VERSION XM_044396091.1 DBLINK BioProject: PRJNA1194641 KEYWORDS RefSeq. SOURCE Drosophila takahashii ORGANISM Drosophila takahashii Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_091683) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_030179915.1-RS_2024_12 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 12/07/2024 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..12053 /organism="Drosophila takahashii" /mol_type="mRNA" /strain="IR98-3 E-12201" /db_xref="taxon:29030" /chromosome="X" /sex="female" /tissue_type="Whole fly" /dev_stage="Adult fly" /collected_by="Originally obtained from EHIME-Fly" gene 1..12053 /gene="trol" /note="terribly reduced optic lobes; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 7 Proteins" /db_xref="GeneID:108055788" CDS 209..11380 /gene="trol" /codon_start=1 /product="basement membrane-specific heparan sulfate proteoglycan core protein isoform X39" /protein_id="XP_044252026.1" /db_xref="GeneID:108055788" /translation="MGSPGSQAPAIAIGISNGRRGHTGSLLLRLLLVAFVLNACHVPP TNAKQITKSKVDDQDFILADTQSLQGSVDLDDDEAFLIPPDSEEKLDKKFTPEGNWWS QGLHRVRRSLNSFFGSDDDDQEKERERQRQRQNNRDAANRQKELRRQQKESQNREKQL RLERQERQRLAKRNNHVVFNRVTDPRKRASDLYDENEASGLNEEETTTYRTYFVVNEP YSDDYKERDSLQFQNLQKLLDEDLRNFFNRNFENNDDEEQEIHSTLERVDQTKDHFKI RVQLRVDLPSSINDFGSKLEQQLNVYKRIDRLGASTDGVFTFTESSEFDEDPIEVALP TDEVEGSGQDSGSCRGDATFQCRRSGKTICDEMRCDGSRDCPDAEDEEGCEVCNELQF KCDNKCLPLNKRCDNRYDCEDQTDEAGCQRYEVEESQPQPQPQPQPEPEPEPEPEPEP EPEPEPEPEEPITDNEQPEQNSECRATEFRCNNGDCIDIRKRCDHISDCSEGEDENEE CRCYADQFRCNNGDCIAESAHCDGNIDCSDQSDELDCGGDSQCLPNQFRCKNGQCVSS TARCNKRSDCLDGSDEQNCANEPNNSGRGTNQLKLKTYPDNQIIKESREVIFRCRDEG PNRAKVKWSRPGGRPLPPGFTDRNGRLEIPNIRVEDAGAYVCEAVGYANYIPGQHVTV NLNVERLNEREIRPDSACTEYQATCMNGECIDKSGICDGHPDCSDGSDEHSCSLGLKC QPNQFMCSNSKCVDRTWRCDGENDCGDNSDETSCDPEPSDAPCRYDEFQCRSGHCIPK SFQCDYMNDCTDGTDEIGCSVPSPMTLPAPSIVVMEYEVLELTCVGTGVPTPTIVWRL NWGHVPEKCESKSYGGTGTLRCPNMRPQDSGAYSCEFINTRGTFYPKTNSIVTVTPVR SDVCKAGFFNMLARKSEECVQCFCFGVSTNCDSANLFTYAIQPPILSHRVVSVELSPF RQIVINEASPGQDLLTLHHGVQFRASNVHYNGRETPFLALPAEYMGNQLKSYGGNLRY EVRYNGNGRPVSGPDVIITGNSFTLTHRVRTHPGQNNRVTIPFLPGGWTKPDGRKGTR EDIMMILANVDNILIRLGYLDSTAREVDLINIALDSAGSADQGLGSASLVEKCTCPPG YVGDSCESCASGYVRQARGPWLGHCVPFTPEPCPAGTYGNPRLGVPCQECPCPHAGAN NFASGCQQSPDGDVICRCNEGYAGKRCEHCAQGYQGNPLAPGGVCRKIPDSSCNVDGT YNIYSNGTCQCKDSVIGEQCDTCAPKSFHLNSFTYTGCIECFCSGVGLDCDSSSWYRN QVTSTFGRTRVNHGFALISDYMRNTPVTVPVSMSTQANALSFVGSAEQAGNTLYWSLP AAFLGNKLTSYGGKLSYTLSYSPLPSGIMSRNSAPDVVIKSGEDLRLIHYRKSQVSPS VANTYAVEIKESAWQRGDELVPNREHVLMALSNITAIYIKATYTTSTKEASLRSVTLD TATATNLGTARAVEVEQCRCPEGYLGLSCEQCAPGYTRDPEAGIYLGLCRPCECNGHS KYCNSETGECESCSDNTEGFNCDRCAAGYVGDATRGTSYDCQYDDGGYPTSRPPAPGN QTAECLVNCQQEGTAGCRGYQCECKRNVAGDRCDQCRPGTYGLSAQNPDGCKECYCSG LTNQCRSASLYRQLIPVDFISTPPLITDEFGDIMDRDNLVPDVPRNVYTYKHTSYTPK YWSLRGSVLGNQLLSYGGRLEYSLIVESVGRDHRGKDVVLIGNGLKLIWSRPDGHDNE QEYHVRLHEDEQWTVEDRGSARQATRADFMTVLSDLQHILILATPKVPTVSTSISNVI LESSITTRAPGATHASDIELCQCPSGYTGTSCESCAPLHYRDASGRCSQCPCDASNTE SCGLVSGGNVECQCRPRWRGDRCREIETNEPTPEPDTSTDDPVRTQIIVSIARPEITI LPVGGSLTLSCTGRMRWTNSPVFVNWYKQGSHLPEGVEVQGGNLQLFNLQISDSGIYI CQAVSNETGHSFTDHVSITVSQEDQRSPAHIVDLPNDVTFEEYVSNEIVCEVEGNPPP TVTWTRVDGHADAQSTRTDNNRLVFDSPRKSDEGRYRCQAENSLSREEKYVVVYVRSN PPQPPPQQDRLYITPQEVNGVAGDSFQLSCQFTSAASLRYDWSHDGRSLSASSPRNVV VRGNVLEVRDANVRDSGTYTCVAFDLRTRRNFTESARVYIEQPNEPGILGDKPHILTL EQNIIIVQGEDLSITCEASGTPYPSIKWTKVQENLAENVRISGNVLTIYGGRSENRGL YSCIAENSHGSDQSSTSIDIEPRERPSLTIDTATQKVSVGSQASLYCAAQGIPEPTVE WVRTDGQPLSPRHKVQAPGYVVIDDIVLDDSGTYECRASNIAGQVSGLATINVQEPTL VRIEPDRQHHIVTQGDELSLSCVGSGVPTPSVFWSFEGRDVDRMGVPEGAVFAQPFRT NTADVKIFRVSKENEGIYVCHGSNDAGEDQQYIRVEVQPRRGDVGAGGDDNGDVDTRQ PPNRPQIQPNPLSNERLTTELGNNVTLICNVDNVNTEWERVDGTPLPHNAYTVRNTLV IVFVEPQNLGQYRCNGIGRDGRVEAHVVRELVLLPLPRITFYPNIPLTVELGQNLDVY CQVENVRPEDVHWTTDNNRPLPSSVRIEGNVLRFASITQAAAGEYRCSATNQYGSRSK NARVVVKQPSGFQPVPHSQVQQRQVGDSIQLRCRLTTQYGDEVRGNIQFNWYREDGSP LPRGVRPDSQVLQLVKLQPEDEGRYICNSYDLGSGQQLPPVSIDLQVLTVPAAPQNPI YLPPVAPPRSPERILEPQLSLSVQSSNLPAGDGTTVECFSSDDSYPDVVWERADGAPL SENVQQVGNNLVISNVASTDAGNYVCKCKTDEGDLYTTSYKLEVEEQPHELKSSKIVY AKVGGNADLQCGADEDRQPSYRWSRQYGQLQAGRSLQNEKLSLDRVQANDAGTYVCSA QYSDGETVDFPNILVVTGAIPQFRQEPRSYMSFPTLSNSSFKFNFELTFRPENADGLL LFNGQTRGSGDYIALSLKDRYAEFRFDFGGKPLLVRAEEPLALDEWHTVRVSRFKRDG YIQVDDQHPVAFPTSQHQQIPQLELIEDLYIGGVPNWEFLPAEAVGQQSGFVGCISRL TLQGRTVELIREAKFKEGITDCRPCAQGPCQNKGVCLESQTEQAYTCVCQPGWTGRDC AIEGTQCTAGVCGSGRCENTENDMECLCPLNRAGDRCQYNEILNEQSLNFKSNSFAAY GTPKVTKVNITLSVRPASLEDSVILYTAESTLPSGDYLALVLRGGHAELLINTAARLD PVVVRSAEPLPLNRWTRIEIRRRLGEGILKVGDGPERKAKAPGSDRILSLKTHLFVGG VDRSTVKINRDVNITKGFDGCISKLYNSQKSVNLLGDIRDAANVQNCGEANEIDDDEY EMPVALPSPKVAENERQLMAPCASDPCENGGSCSEQEDMAICSCPFGFSGKHCQNHLQ LSFNASFRGDGYVELNRSHFQPALEQTYSHIGIVFTTNKPNGLLFWWGQEAGEEYTGQ DFIAAAVVDGYVEYSMRLDGEEAVIRNSDIRVDNGERHIVIAKRDENTAMLELDQILD TGDTRPTINKAMKLPGNVFVGGAPDVAAFTGFRYKDNFNGCIVVVEGETVGQINLSSA AINGVNANVCPANDEPLGGTEPPVV" misc_feature 458..>715 /gene="trol" /note="Coiled-coil domain-containing protein 66; Region: CCDC66; pfam15236" /db_xref="CDD:434558" misc_feature 1250..1360 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1268..1270,1295..1297,1328..1333) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1307..1309,1316..1318,1328..1330,1346..1351) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1337..1351 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1367..1468 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1382..1384,1403..1405,1436..1441) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1415..1417,1424..1426,1436..1438,1454..1459) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1445..1459 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1625..1723 /gene="trol" /note="Low-density lipoprotein receptor domain class A; Region: LDLa; smart00192" /db_xref="CDD:197566" misc_feature order(1643..1645,1667..1669,1700..1705) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1679..1681,1688..1690,1700..1702,1718..1723) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1709..1723 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1739..1843 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1754..1756,1778..1780,1811..1816) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1790..1792,1799..1801,1811..1813,1829..1834) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1820..1834 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 1859..1963 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(1874..1876,1898..1900,1931..1936) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(1910..1912,1919..1921,1931..1933,1949..1954) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 1940..1954 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2006..2212 /gene="trol" /note="Immunoglobulin domain; Region: Ig_3; pfam13927" /db_xref="CDD:464046" misc_feature 2306..2410 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2321..2323,2345..2347,2378..2383) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2357..2359,2366..2368,2378..2380,2396..2401) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2387..2401 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2426..2530 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2441..2443,2465..2467,2498..2503) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2477..2479,2486..2488,2498..2500,2516..2521) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2507..2521 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2555..2659 /gene="trol" /note="Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about...; Region: LDLa; cd00112" /db_xref="CDD:238060" misc_feature order(2570..2572,2594..2596,2627..2632) /gene="trol" /note="putative binding surface [active]" /db_xref="CDD:238060" misc_feature order(2606..2608,2615..2617,2627..2629,2645..2650) /gene="trol" /note="calcium-binding site [ion binding]; other site" /db_xref="CDD:238060" misc_feature 2636..2650 /gene="trol" /note="D-X-S-D-E motif; other site" /db_xref="CDD:238060" misc_feature 2711..2938 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 2720..2734 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:143220" misc_feature 2759..2773 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:143220" misc_feature 2828..2842 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:143220" misc_feature 2870..2887 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:143220" misc_feature 2912..2923 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:143220" misc_feature 3233..3625 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature 3794..3955 /gene="trol" /note="Laminin EGF domain; Region: Laminin_EGF; pfam00053" /db_xref="CDD:395007" misc_feature order(3794..3796,3800..3802,3836..3838,3866..3868, 3872..3874,3899..3901) /gene="trol" /note="EGF-like motif [active]" /db_xref="CDD:238012" misc_feature 3974..4108 /gene="trol" /note="Laminin-type epidermal growth factor-like domai; Region: EGF_Lam; smart00180" /db_xref="CDD:214543" misc_feature 4328..4738 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature <4739..4819 /gene="trol" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; Region: EGF_Lam; cd00055" /db_xref="CDD:238012" misc_feature 4841..4990 /gene="trol" /note="Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in...; Region: EGF_Lam; cd00055" /db_xref="CDD:238012" misc_feature order(4844..4846,4850..4852,4871..4873,4892..4894, 4901..4903,4928..4930) /gene="trol" /note="EGF-like motif [active]" /db_xref="CDD:238012" misc_feature <5099..5191 /gene="trol" /note="Laminin EGF domain; Region: Laminin_EGF; pfam00053" /db_xref="CDD:395007" misc_feature 5387..5791 /gene="trol" /note="Laminin B (Domain IV); Region: Laminin_B; pfam00052" /db_xref="CDD:459652" misc_feature 6068..6316 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 6101..6115 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409353" misc_feature 6149..6163 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409353" misc_feature 6206..6220 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409353" misc_feature 6248..6265 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409353" misc_feature 6293..6304 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409353" misc_feature <6395..6556 /gene="trol" /note="Immunoglobulin domain; Region: Ig_3; pfam13927" /db_xref="CDD:464046" misc_feature 6647..6898 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 6680..6694 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409544" misc_feature 6719..6733 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409544" misc_feature 6788..6802 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409544" misc_feature 6830..6847 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409544" misc_feature 6935..7177 /gene="trol" /note="Immunoglobulin domain; Region: Ig; cl11960" /db_xref="CDD:472250" misc_feature 6986..7000 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409570" misc_feature 7025..7039 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409570" misc_feature 7082..7096 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409570" misc_feature 7124..7141 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409570" misc_feature 7163..7174 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409570" misc_feature 7229..7459 /gene="trol" /note="Immunoglobulin I-set domain; Region: I-set; pfam07679" /db_xref="CDD:400151" misc_feature 7253..7267 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409543" misc_feature 7292..7306 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409543" misc_feature 7397..7414 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409543" misc_feature 7436..7447 /gene="trol" /note="Ig strand G [structural motif]; Region: Ig strand G" /db_xref="CDD:409543" misc_feature 7496..7759 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 7526..7540 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409548" misc_feature 7565..7579 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409548" misc_feature 7697..7714 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409548" misc_feature 8132..8362 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 8159..8173 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409541" misc_feature 8198..8212 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409541" misc_feature 8258..8272 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409541" misc_feature 8300..8317 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409541" misc_feature 8396..>8599 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 8429..8443 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409390" misc_feature 8477..8500 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409390" misc_feature 8546..8560 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409390" misc_feature 8741..8947 /gene="trol" /note="Immunoglobulin domain; Region: Ig_3; pfam13927" /db_xref="CDD:464046" misc_feature 9035..9235 /gene="trol" /note="Immunoglobulin like; Region: IG_like; smart00410" /db_xref="CDD:214653" misc_feature 9059..9073 /gene="trol" /note="Ig strand B [structural motif]; Region: Ig strand B" /db_xref="CDD:409390" misc_feature 9098..9112 /gene="trol" /note="Ig strand C [structural motif]; Region: Ig strand C" /db_xref="CDD:409390" misc_feature 9155..9169 /gene="trol" /note="Ig strand E [structural motif]; Region: Ig strand E" /db_xref="CDD:409390" misc_feature 9197..9214 /gene="trol" /note="Ig strand F [structural motif]; Region: Ig strand F" /db_xref="CDD:409390" misc_feature 9299..9742 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" misc_feature 9809..9907 /gene="trol" /note="EGF-like domain; Region: EGF; pfam00008" /db_xref="CDD:394967" misc_feature 10049..10510 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" misc_feature 10670..10768 /gene="trol" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054" /db_xref="CDD:238011" misc_feature 10793..11254 /gene="trol" /note="Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110" /db_xref="CDD:238058" polyA_site 12053 /gene="trol" /experiment="COORDINATES: polyA evidence [ECO:0006239]" ORIGIN 1 attaggttgc gcgccatcgt tccaggcggt cgcacattcc acgtgccata gccgtaacaa 61 caacctgcca accgcttaaa accaaactca aatacgaacc gaaactgcct tcacacacac 121 aagtacctaa accaaatcta aatagctgcc aaaagaaacc aaaaattcca gagacgtcgt 181 agcatccgtt ccccggaaga agaagaagat gggatcgccg ggatcccaag cgcccgcgat 241 cgcgatcggg atcagtaacg ggcggagagg tcacacgggg tcgctgctcc tgcgcctcct 301 tctcgtggcc ttcgtcctca acgcctgcca cgtacccccg accaatgcca agcaaattac 361 gaaaagtaaa gttgatgacc aggactttat actggccgac acacaatcgc tgcagggcag 421 cgttgacctt gacgatgacg aagcgttcct gattcctccg gattccgaag agaagttgga 481 taagaagttc acgccggagg gcaactggtg gagccagggg ctccatcgtg ttcgccgctc 541 cctaaatagc ttcttcggct ccgacgacga tgatcaggaa aaggaacgtg agcgtcagag 601 gcaaaggcaa aataatcgcg atgccgccaa ccggcaaaag gaacttcggc gccagcaaaa 661 ggagagccag aaccgcgaga agcagctgcg attggagcgc caggagaggc agcgccttgc 721 caagcggaac aatcacgtgg tcttcaatcg cgtcaccgat ccccgcaagc gggcatccga 781 cctttacgac gagaacgagg catctggcct aaacgaggag gaaaccacca cctatcgcac 841 ctactttgtt gttaatgagc catattcaga cgactacaag gagcgggaca gcctccagtt 901 ccagaatctg caaaaacttc ttgacgagga cctgcgcaac ttcttcaatc gcaatttcga 961 aaataacgat gatgaagagc aggaaatcca tagcacccta gagcgagtcg atcaaaccaa 1021 ggaccatttt aaaattcgcg tgcaacttag ggtagatctg cccagttcaa tcaacgactt 1081 tggaagtaag ttggagcaac aactgaatgt ctacaagcga atcgatcgtt tgggtgccag 1141 taccgatggc gtcttcacct ttaccgaatc gagcgaattc gatgaggatc ctatcgaagt 1201 tgcattgccc acggatgagg tggagggctc cggccaagat tccggtagct gtcgcggcga 1261 tgccaccttc cagtgtcgaa ggagtggaaa gactatttgc gatgaaatgc gatgcgatgg 1321 atctcgcgat tgtcccgatg ccgaggacga ggaaggctgc gaggtttgca acgaacttca 1381 gttcaagtgc gataacaagt gtctgccgct caataagcgc tgcgataatc gatacgattg 1441 tgaggatcag acggacgagg ctggttgtca acggtacgaa gtagaagagt ctcagcctca 1501 gccgcagccg caacctcagc ctgaaccgga acctgaacct gaacctgagc ctgagcctga 1561 acctgaacca gaaccagaac ctgaagagcc tataacagac aatgaacagc ctgagcaaaa 1621 ctcagaatgc cgggccaccg agttcagatg caacaatggg gactgcatcg atattagaaa 1681 gcgttgcgat cacatttcgg actgtagcga aggcgaggac gagaacgagg agtgccgctg 1741 ttacgcggat caattccgct gcaataatgg tgactgcatt gcggaatcgg ctcattgcga 1801 tggaaatatc gattgtagcg accagtccga tgaactcgac tgcggaggag actcgcagtg 1861 tctgcccaac caattccgct gcaagaatgg ccaatgtgtg agctctacag cgcgttgcaa 1921 caagcgttcc gattgtttgg atggctccga tgagcagaat tgtgccaatg aacctaacaa 1981 ctccggacgt ggaacgaacc aattgaaact caagacctat cccgacaacc aaatcattaa 2041 ggagagtcgt gaggtcatct tccgttgccg tgacgaaggt cccaaccgcg ccaaggtcaa 2101 gtggtcgcga cccggcggac gtcccctgcc ccccggtttc accgatcgca atggccgcct 2161 ggagatcccc aacatcaggg tggaggatgc tggcgcctat gtctgcgagg ccgtgggcta 2221 tgccaactat attcccggtc agcacgtcac cgtaaacctc aacgtcgagc gcttaaacga 2281 acgcgaaatc cgtccggact cagcctgtac ggagtaccag gccacctgca tgaacggcga 2341 gtgtatcgat aagtcgggca tctgcgatgg acatccggac tgttcggatg gctccgatga 2401 gcacagctgc agtttgggtt tgaagtgtca gcccaaccag ttcatgtgct ccaattccaa 2461 gtgtgtggat cgcacctggc gctgtgatgg cgagaacgac tgcggcgata actccgatga 2521 gacctcttgc gatccggaac caagtgatgc tccgtgccga tacgacgaat tccagtgccg 2581 cagcggtcat tgcattccca agagcttcca gtgcgactat atgaacgatt gtaccgatgg 2641 taccgatgaa attggatgct cggtgccctc tccaatgacc ctacccgcac cctcgattgt 2701 cgtgatggag tacgaggtcc tcgagctgac ctgcgtgggc accggcgtcc cgacgccgac 2761 gatcgtgtgg cgtctcaact ggggccatgt gcccgagaag tgtgaatcga agagctacgg 2821 cggaaccgga accctgcgct gtccgaacat gaggccccag gacagtggtg cctactcgtg 2881 cgagttcatc aacacacgcg gcaccttcta tccgaaaacg aactcgattg tcaccgttac 2941 gccggtgcgc tcggatgtct gcaaggccgg attcttcaat atgctggccc gcaagtcgga 3001 ggaatgcgtc cagtgcttct gctttggcgt ttcgaccaac tgtgacagtg ccaatttgtt 3061 cacctacgcc attcagccac cgatcctttc gcaccgcgtg gtcagcgttg aactcagtcc 3121 gttccgtcaa attgtcatca atgaggctag tccgggtcag gatctgctca ccttgcacca 3181 tggtgttcag ttcagggcat cgaacgtaca ctacaacggc cgggagacac cattcttggc 3241 cctgcccgct gagtatatgg gcaaccagct gaagtcctat ggcggcaatc tgcgctacga 3301 ggtcaggtac aatggcaacg gtagaccggt cagcggaccc gatgtcatca tcaccggcaa 3361 cagtttcacg ctaacccatc gcgttcgcac tcatccgggt cagaacaaca gggtgactat 3421 tcccttcctg ccgggaggct ggacgaagcc ggatggtcgc aagggaacgc gagaggacat 3481 catgatgata ctggccaatg tggacaatat tctgattcga ctgggctacc tggatagcac 3541 agctcgcgaa gtggatctga taaatatcgc cttggattcg gccggaagtg ccgatcaggg 3601 attgggcagt gcctcgctcg tggagaagtg cacctgtccg cccggctatg ttggtgattc 3661 gtgcgagtcc tgtgcctcgg gctatgttcg ccaggcccgc ggaccttggc tgggtcattg 3721 tgtgcccttc accccggaac cgtgcccagc gggaacctac ggcaatcccc gacttggtgt 3781 tccctgccag gagtgtccgt gcccccacgc gggcgccaat aactttgcca gcggctgcca 3841 acagagtccc gatggcgatg tgatttgccg ctgcaacgaa ggctatgccg gcaagaggtg 3901 cgagcactgc gcccagggtt accagggtaa tccgttggca ccgggaggag tctgtcgcaa 3961 gatacccgat agttcgtgca atgtcgacgg cacctacaac atctacagca atggaacgtg 4021 ccagtgcaag gatagcgtga ttggcgaaca gtgcgacacc tgcgcgccga agagtttcca 4081 cctcaattcg ttcacctaca ccggttgcat cgagtgcttc tgcagtggag tgggcttgga 4141 ttgtgacagt agttcgtggt atcgcaacca ggtcaccagc acctttggac gaacgcgcgt 4201 caatcatgga ttcgccctga ttagcgacta tatgcgcaat accccggtaa cggtgcccgt 4261 ttccatgtcc acccaggcca atgccttgag cttcgtggga tccgccgagc aggccggtaa 4321 tacgctctac tggagtcttc ccgccgcctt cctgggcaac aagctgacct cgtacggagg 4381 caagttgagc tacacgctca gctacagtcc cctgcccagc ggcattatgt cgcgcaacag 4441 tgcccccgat gtggtgatca agagcggcga ggatctgagg ctcatccatt acaggaagtc 4501 gcaggtcagt cccagtgtgg ccaacaccta tgccgtggag atcaaggaga gcgcatggca 4561 gcgcggcgat gaactggtgc ctaaccgtga acacgtcctg atggccctca gcaatattac 4621 ggccatctat atcaaggcca cgtacacgac tagcaccaag gaggcctcgc tgcgatcggt 4681 cacattggat acggccacgg ccaccaatct gggcaccgca cgtgccgtcg aagtggagca 4741 gtgccgctgt cccgagggct atttgggtct ctcctgcgag cagtgtgctc ctggctatac 4801 gcgcgatccg gaggcaggaa tctatctggg tctctgcagg ccctgcgagt gcaatggaca 4861 ttccaagtat tgcaacagtg agacaggcga atgcgaaagc tgttccgaca acaccgaagg 4921 attcaattgt gaccgatgcg ccgccggcta tgtgggtgat gccacccgag gaacttcgta 4981 cgactgtcaa tacgatgacg gcggctatcc gacgtcgcgt ccaccggcac cgggcaatca 5041 gacggccgaa tgcctggtga attgccaaca ggagggaacc gccggttgcc gcggctacca 5101 gtgcgagtgc aagaggaatg tggctggcga tcgatgcgat cagtgccgcc ccggaaccta 5161 tggactgtcg gcccaaaatc cggacggttg caaggagtgc tactgctccg gactgaccaa 5221 ccagtgccgc tcggcgtctc tctaccgcca gctgataccc gtggacttca tttcgacgcc 5281 accattgata acagacgaat tcggcgacat catggatagg gataaccttg tgcccgacgt 5341 gcccaggaat gtgtatacct acaagcacac ctcctacacg cccaagtact ggagcctgag 5401 gggtagtgtg ctgggcaacc agctgttgtc gtacggcggc cgcttggagt acagcctgat 5461 tgtggagtcc gttggccggg accatcgtgg caaggatgtg gtcctaattg gcaacggact 5521 caagctgatc tggtcgcgac ccgatggcca tgacaacgag caggaatacc atgtgcgttt 5581 gcatgaggac gagcagtgga cggttgagga tcgtggatcg gcacgacagg ccacgcgggc 5641 cgacttcatg actgtgctgt cggatctgca gcacatcctg atcctggcca cacccaaggt 5701 gcccacggtc agcacctcga ttagcaatgt catcctggag agttcgataa ccacgagagc 5761 gcctggagct acgcatgcct ccgatatcga gttgtgccag tgtccatccg gttatacggg 5821 cacttcctgt gagtcctgcg caccactgca ctaccgcgac gcctctggac gctgcagtca 5881 gtgtccttgc gacgcttcca acacggaatc ctgcggcttg gtcagcggcg gtaacgtcga 5941 atgccagtgc aggccacgct ggaggggtga tcgctgccgg gaaattgaaa ctaacgaacc 6001 gactccggaa ccggatacca gtaccgatga tcccgtgcgc acccagatca tagtgtcgat 6061 tgccaggcca gagattacca ttctgcccgt gggtggatcg ctgaccctca gctgtaccgg 6121 tcgaatgcgc tggaccaata gcccagtgtt tgtgaactgg tacaagcagg gcagtcacct 6181 gcccgaggga gtcgaggtgc aaggcggtaa tctgcagctg ttcaacctgc agatcagcga 6241 ttctggaatc tacatctgcc aggccgtaag caacgagacc ggccacagct ttacggacca 6301 cgtctccatc accgtttccc aggaggacca acgctcgccg gctcacattg tggatttgcc 6361 caacgacgtg accttcgagg agtacgtaag caatgagatc gtctgcgagg tggagggcaa 6421 cccaccaccc actgtcacct ggactcgcgt ggatggccat gcggacgccc aaagtacgcg 6481 aacggacaac aatcggctgg tcttcgattc gccgaggaaa tcggacgagg gtcgctatcg 6541 ctgccaggca gagaatagcc tgagtcggga ggagaagtac gtagtcgtgt atgtccggag 6601 caatcctccc cagccgccgc cgcagcagga tcgtttgtac atcacaccgc aggaggtgaa 6661 cggtgtggcc ggtgactcct tccagttgtc ctgccaattc accagcgctg cctctctgcg 6721 ctacgattgg tcccacgatg gtcgctccct gtccgcgtcg tcaccccgaa atgttgtggt 6781 ccgcggaaat gtcctggaag tccgcgatgc caacgttcgc gactccggca cctacacctg 6841 tgtggccttc gacctgcgca cccgacgcaa cttcaccgag agcgcacggg tctacatcga 6901 gcagcccaac gagccgggaa tccttggcga caagccgcat atcttgacct tggagcagaa 6961 catcataatt gtgcaaggcg aggacttgag catcacatgt gaggcaagtg gaacgcccta 7021 tccctcgatt aagtggacca aggtgcagga gaatctggcc gaaaatgtcc gcatcagtgg 7081 caatgtgctc accatctacg gaggccgcag tgagaatcgt ggtctttact cctgcatcgc 7141 cgagaactct cacggcagcg atcagtccag cacaagcatc gatattgaac cccgggagcg 7201 gccgagtctt acgattgata cggccaccca aaaggtttcg gttggctccc aggcgtccct 7261 ttactgtgcc gcccagggca ttcccgaacc gaccgtcgag tgggttcgaa cggatggtca 7321 gccactgtcg ccgcgtcaca aggtccaggc acccggctat gttgtgatcg atgacattgt 7381 gctcgatgat agcggtacct acgagtgccg ggcgagcaac atagctggcc aggtgagcgg 7441 cttggccacc attaacgtcc aggagccaac tcttgtgcgg atcgaaccag ataggcaaca 7501 ccatatcgtc acccagggcg acgaactctc gctcagctgc gtgggcagtg gcgtccctac 7561 tccttcggtc ttttggagtt tcgagggaag agacgttgac aggatgggag taccggaagg 7621 tgctgttttt gcgcaacctt tccgaaccaa cactgccgac gtgaaaatct tccgggtgag 7681 caaggagaac gaaggcatct acgtctgtca cggatccaat gacgcgggtg aagatcaaca 7741 atacattcgc gtggaggtac aacccagacg gggtgacgtc ggtgcaggag gagatgacaa 7801 tggtgatgtc gatacccgac agccccccaa tcggccccaa atccaaccga atccattgag 7861 caacgaacgc ctgaccaccg aattgggcaa caatgtgacc ctcatctgca acgtggacaa 7921 cgtgaacacg gaatgggaac gcgtcgatgg cacacccctg ccgcacaatg cctacacggt 7981 gagaaatacg ctggtgattg tcttcgtgga gccgcagaat ctgggtcagt accgctgcaa 8041 tggaatcggt cgcgatggac gtgtggaggc ccatgtggtg agggagctgg ttctcctgcc 8101 cctgcccagg atcaccttct atcccaacat cccgctgacc gtggagctgg gccagaactt 8161 ggatgtctac tgccaggtgg agaacgtgcg tccggaggac gtgcattgga ccaccgacaa 8221 caatcgacca ctgcccagtt ccgtacgcat cgagggcaat gtcctcaggt tcgcgtccat 8281 cactcaggct gctgccggtg aataccgctg ctcggccacc aatcaatatg gaagccgatc 8341 gaagaacgcc agggtggtgg tgaaacagcc cagtggcttc cagcccgttc cccactcgca 8401 ggtgcaacag cgtcaggtgg gcgactccat ccagttgcga tgccgcctga ccacccagta 8461 cggcgacgag gttcgcggca atatccagtt caactggtac cgtgaggacg gcagcccctt 8521 gccccgcggt gtccgtccgg atagccaggt gctgcagctg gttaaattgc agcccgagga 8581 cgagggccgc tacatctgca actcgtacga tttgggcagc gggcagcaac tgccccccgt 8641 ctccatcgac ttgcaagtac taacggtacc agcggctccc cagaacccca tctacctgcc 8701 gccagtggcg ccaccacgtt cgcccgaaag gatcctcgag ccccaactga gcctgagtgt 8761 acaatcctcg aacctgccag ccggcgacgg caccaccgtc gagtgcttct cctccgatga 8821 ctcctaccca gatgtcgtgt gggaacgcgc cgatggagct ccactcagcg aaaatgtcca 8881 gcaagtgggc aataacctgg tgattagtaa cgtggcctcc accgatgccg gtaactatgt 8941 gtgcaagtgc aagacggacg agggagatct gtataccacc agctacaaac tggaggtcga 9001 ggagcagccc catgaactga agagctccaa gatagtctac gccaaggttg gcggaaatgc 9061 cgacttgcag tgcggagccg atgaagatcg acagcccagc taccgttggt ctcgccaata 9121 cggacaactt caggcgggac gcagtctgca gaatgagaaa ctttcgttgg atcgcgttca 9181 ggccaacgat gccggaactt atgtttgttc ggcccaatac agcgatggcg agacggttga 9241 cttccccaac attctggttg tgaccggggc gattccccag ttccgccagg agccccgcag 9301 ctacatgagc ttccccacgc tctcgaactc ctcgttcaag ttcaacttcg agctgacctt 9361 ccggccggaa aacgccgacg gactgctgct cttcaatgga cagacccgcg gaagcggtga 9421 ctatatcgca ctctcgctga aggatcgcta tgcggagttc cggttcgatt ttggcggtaa 9481 accgttgctg gtgcgagcgg aggagccact ggctttggat gaatggcaca cggtgcgcgt 9541 gagtcgcttc aagcgggatg gctacatcca ggtggacgac cagcatccgg tggccttccc 9601 cacctcccag catcagcaga taccccagtt ggaactgatt gaggatctgt acattggcgg 9661 cgtgcccaac tgggagttcc tgcccgccga ggcggtgggt cagcaatcag gcttcgtggg 9721 ctgcattagc cggctgaccc tgcagggacg caccgtggag ctgatccggg aggccaagtt 9781 caaggagggc atcaccgatt gccggccctg cgcccaggga ccctgccaga acaagggcgt 9841 ctgcctggag agccagacgg agcaggccta cacctgcgtc tgccagccgg gctggactgg 9901 ccgggattgt gccatcgagg gcacccagtg caccgcagga gtttgcggct cgggacgctg 9961 cgagaatacg gagaacgaca tggagtgcct gtgcccgctg aacagggcag gcgatcgatg 10021 ccagtacaat gagattctaa atgaacagag cttgaatttc aagagcaaca gctttgcggc 10081 ctacggaact cccaaggtca ccaaagtaaa catcacactc tccgttcgtc ccgcgagcct 10141 ggaggactct gtgatcctgt acacggcgga atccactctg cccagcggcg attacctggc 10201 tttggtcctt cgcggtggcc acgcggagct gctgatcaac acggccgccc gcttggatcc 10261 cgtggtggtg cgttcggcgg aaccgctgcc cctcaatcgc tggaccagaa tcgagatcag 10321 gcgtcgcctg ggcgagggaa tcctcaaggt gggcgatgga cccgagcgaa aggccaaggc 10381 accgggatcc gatcgcattc tgtcgctcaa gacccacctc tttgtgggcg gcgtcgatcg 10441 gtcgaccgta aagatcaacc gtgatgtgaa catcaccaag ggcttcgatg gctgcatctc 10501 gaagctgtac aactcgcaga aatccgtcaa tctgctgggt gacatcaggg atgcggcgaa 10561 tgtccagaac tgtggggagg cgaatgagat agatgacgat gagtatgaga tgccagtagc 10621 gctgccatcg cctaaggtcg ccgagaatga acgtcagctg atggcgccgt gtgccagtga 10681 tccctgcgag aacgggggaa gctgcagcga gcaggaggac atggccatct gctcctgtcc 10741 cttcggcttc agcggcaaac actgccagaa tcacctccag ctgagcttca atgcctcgtt 10801 ccgcggcgat ggctacgtgg agctgaaccg cagccacttc caacccgccc tggagcagac 10861 gtactcccac attggcattg tgttcaccac caacaagccg aatggcctgc ttttctggtg 10921 gggccaggag gccggggagg agtacaccgg acaggacttc attgccgccg ccgtggtcga 10981 tggctatgtg gagtactcga tgaggctcga tggcgaggag gcggtcattc ggaacagcga 11041 tatccgcgtg gacaatggcg agcggcacat tgtgatcgcc aagcgggatg agaacaccgc 11101 catgctggaa ctcgatcaga tcctggacac gggcgatacg cgacccacca tcaacaaggc 11161 aatgaagctg ccgggcaatg tgtttgtcgg tggcgctcct gatgtcgcgg cattcacggg 11221 cttccgctac aaggacaatt tcaacggctg cattgtggtc gtcgagggcg aaaccgtggg 11281 ccaaattaac cttagttcag ctgccatcaa tggagtgaat gccaacgtgt gtcccgctaa 11341 cgacgaacct ctgggaggaa ccgaaccgcc agtcgtctga ggacacaacc agcaaccgaa 11401 attagctttt taattaaaca ttaacaaatg aaacaaaaag aaaaacaatt tttatatata 11461 caacatatga ataagcccca agcaaaccta caaaaaattg aatattatac gacgaacaga 11521 taatataaaa acaaaaaaag agagaaacga tcacttctac tacaattgct tcttcgatcc 11581 ttaagtctag gttaaagatt gtagcaagaa aacaagcgaa tatcacaaac atttatttaa 11641 caagaacgcc atgcgagaag tgaaacgaaa cagaaacaat aatgcaatta atgcagataa 11701 tacagataaa gcctagaacc ctaagaacta actaactaac tcgaacaaga acaacaacgc 11761 atactagcca actgcaacca caacaaccac aatagtgaag gcattttaat tataatttta 11821 gtctctagct tataactatg actacgactc gttttttttg tgagcccagt gtaaaatgtt 11881 ggaaatcgga aattggccct acacacaaac acacacaagt tattaattaa ataccaattg 11941 ataccatata atgataaatg aaatactatg aatgcaacta ttgtgaacga acgaaaaccg 12001 ttgagtggat aaaaagcata agcagaagat atattaaaat gaaatcaaca aca