PREDICTED: Drosophila obscura neprilysin-1 (LOC111077453),


LOCUS       XM_022371736            3592 bp    mRNA    linear   INV 14-MAY-2021
            transcript variant X4, mRNA.
ACCESSION   XM_022371736
VERSION     XM_022371736.2
DBLINK      BioProject: PRJNA728747
KEYWORDS    RefSeq.
SOURCE      Drosophila obscura
  ORGANISM  Drosophila obscura
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_024542752.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On May 14, 2021 this sequence version replaced XM_022371736.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Drosophila obscura Annotation
                                           Release 101
            Annotation Version          :: 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.6
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3592
                     /organism="Drosophila obscura"
                     /mol_type="mRNA"
                     /isolate="BZ-5 IFL"
                     /db_xref="taxon:7282"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="whole fly"
                     /dev_stage="Adult fly"
                     /geo_loc_name="Serbia: Babin Zub"
                     /collection_date="2017"
     gene            1..3592
                     /gene="LOC111077453"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 Protein, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 11 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:111077453"
     CDS             605..3253
                     /gene="LOC111077453"
                     /codon_start=1
                     /product="neprilysin-1"
                     /protein_id="XP_022227428.2"
                     /db_xref="GeneID:111077453"
                     /translation="MLATPSGGAAPANVLATAPAPGPVSVSAVSVPPAVAASLASPEK
                     PLNNGYLQANAMDELNATVVSPLLGQQQQQQQAQLQPQLQHQQQQQNKLPTVVFLSPD
                     GSGGVGIGSALQRNPISGASIPPATAWSRTSDWLLKESQQRRRLLILAIAFTVLGAAI
                     GALAIYFASVHQRCQLYPRSVDAAESAAGNARWGLGKAHEEQDNICMTQECVRTAASL
                     LSAMDMTADPCEDFFQYACGTWNKVHPIPEDRSSISTFEVLSDQQQVILRGVLEEPID
                     ERDNQATIKAKTFFKSCMDIPQIRKIGSGRLKQVLKALGGWPVIERNWQPPADLSVEK
                     LMGHLRLNYSEPVLIELYVGADDKNSSVNILQMDQLQYALPSRDYYLKESSANDRKAY
                     HRYMTQVSVLLGANPATAAAELEQVVLFETQLVNVSLAEADRHDTSAVYRKMTLPELQ
                     QLVPEVKWEEYLQTALGPGIPLQADEPLVTYGLRYLTDMGKILRRTDRRVVHNYMLWR
                     LVMSLMTHMIDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKKLGVAVGALFIRDNF
                     NQESKEVALEMIHTIRVAFNELLAENDWMDDETRAVAKEKADSMNERIGYPEVLTNAT
                     ELEQEYVNLTVVPDNFIDNVLSILQWESEKVLHLLRQPVDKEKWTTEPAVVNAFYNPN
                     KNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWW
                     NNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWE
                     KLHGRELQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSSVHSPGFVRVLGPLS
                     NSRDFAHAYSCPLGCNMNPEEKCSVW"
     misc_feature    1280..3244
                     /gene="LOC111077453"
                     /note="Peptidase family M13 includes neprilysin and
                     endothelin-converting enzyme I; Region: M13; cd08662"
                     /db_xref="CDD:341056"
     misc_feature    order(1370..1372,2612..2614,2627..2638,2693..2695,
                     2741..2746,2753..2758,2765..2767,2939..2941,3068..3070,
                     3077..3082,3131..3136,3152..3154)
                     /gene="LOC111077453"
                     /note="active site"
                     /db_xref="CDD:341056"
ORIGIN      
        1 agtcgcgcag cccaatgagc actcaacgcg catccgagaa tagtagagca tcgagaggaa
       61 atcaattgca cactcgcacc ggaagccacg tttttacgct gttttcaccc ctcccatttc
      121 ggtttcgatt cggttcggtt cgaattttgt tttgttcatg tcccgccaca gtttcggtgg
      181 gctcctttag cgcatttctg gctgccatat ggagccggtg tcggccaatg tcaaccgcag
      241 cagcagcagc aacagcaaca gcagcagtaa aaacaggagc cgcatcacgc acgtgtcgat
      301 gaccaaaagt tttgcgccaa aactgaggct gaagtgccat cgacgctgat gtcgcagtca
      361 cagccagcgt cgctgccgtt gtgaaccgtg cgtggagcta ccaagtcaaa gccagcggcc
      421 gacagctttc catcaacata atcggagatt actaaccgtg agccgtgaaa caccacaggc
      481 acaaagccat aaatcaatag ggctcgtacg gtcccgtccc gtcggtgtat cagcccccag
      541 cagataagga gctggaagcg acgccagagc cgggcagtat ttggcagtgt cgccgccgac
      601 cgatatgttg gccacgccga gcggcggcgc agcgcccgct aatgttctcg caaccgctcc
      661 agcccccggt cccgtatccg tatccgccgt atcggtgccc ccagcagtcg ccgcatccct
      721 ggccagtccg gagaagcccc tgaacaatgg ctacctgcag gcgaatgcta tggacgagct
      781 aaatgccacc gtggtgtcgc ctctgctcgg ccagcagcag cagcagcagc aggctcagtt
      841 gcagccacag ttacaacatc agcagcaaca gcagaacaag ctgccaacgg tagttttcct
      901 cagtccggat ggaagcggtg gcgtgggcat tggcagcgcc ctgcaacgga atcccatctc
      961 aggtgcaagc atacccccgg ccaccgcctg gagccgcacc agcgactggc tgctgaagga
     1021 atcacagcag cgacgccgcc tcctgatcct ggccatcgcc ttcaccgttt tgggagctgc
     1081 catcggtgcg ctggctatct actttgccag cgtccatcag cgctgccagc tgtatccccg
     1141 ctccgtggac gccgccgagt ctgcagcagg caatgccaga tggggcctgg gcaaggccca
     1201 cgaggagcag gacaacattt gcatgactca ggaatgcgtg cgaacagcgg cttccctgct
     1261 ctcggccatg gacatgacgg ccgatccctg cgaggacttt ttccagtatg catgcggcac
     1321 ctggaacaag gtacatccca tacccgaaga tcgtagctcc atcagcacat ttgaggtact
     1381 ctccgaccag cagcaggtga tcctgcgggg tgtgctcgag gagccaatcg acgagcgcga
     1441 taaccaggcc accatcaagg ccaagacctt ctttaagagc tgcatggaca ttcctcagat
     1501 aagaaagatc ggctcggggc ggctcaagca ggtgctgaag gctctcggcg gatggccggt
     1561 gatcgagcgt aattggcagc caccggccga tctttcggtg gagaaactga tgggccatct
     1621 gcggctgaac tacagcgaac cggtgctgat tgagctgtat gtgggggcgg atgacaagaa
     1681 cagttcggtg aacattctgc agatggatca gctgcagtat gctctgccct cgcgggacta
     1741 ctacctgaag gagagcagcg ccaatgaccg gaaggcctat catcgctaca tgacgcaggt
     1801 gtcggtgctg ctgggtgcca atccggccac agccgctgcc gaactggaac aggtggtgct
     1861 gttcgagacg cagctggtga atgtctcgct ggccgaggcg gatcggcatg acacgagcgc
     1921 cgtataccgg aagatgacgc tgccggagct gcagcaactg gtgccggagg tcaagtggga
     1981 ggagtacctc cagacggccc tggggccggg cattcccctg caggcggacg agccgctggt
     2041 cacctacggc ctgcgctatc tcaccgatat gggcaagata ttgcggcgca ccgaccgccg
     2101 cgttgtccac aactatatgc tgtggcgcct ggtcatgtcg ctgatgaccc acatgatcga
     2161 cgagtatcag cgggagcggg tggagttccg caagatcctc atgggcattc agtcggagcg
     2221 gacgcgctgg tctcaatgcg tcgagtggac caacaagaag cttggcgtgg ccgtcggtgc
     2281 cctcttcata cgcgacaact ttaaccagga gagcaaggag gtggccctcg agatgataca
     2341 caccatccgg gtggcattca acgagctgct ggccgagaac gactggatgg acgacgagac
     2401 gcgtgcggtg gccaaggaga aggctgactc tatgaacgag aggattggct atcccgaggt
     2461 cctcaccaat gccaccgaac tggagcagga gtatgtgaat ctgactgttg tgccggacaa
     2521 tttcattgac aacgtgctga gcatcttgca gtgggagtcg gagaaggtgc tgcatctgct
     2581 gcgccaaccg gtggacaaag agaagtggac cacagagccg gcggtagtga atgctttcta
     2641 caatcccaac aagaacgata tagtatttcc ggcgggcatt ctgcagcctt tgttctacag
     2701 tcagcacttc cccaagtcgc tcaactatgg tggcattggc gtggtgattg ggcacgagat
     2761 cacccacgga ttcgatgaca aggggcggca gttcgacaag gagggcaaca tgatgcagtg
     2821 gtggaacaat gccaccatcg aggcattccg cgagcgcacc cagtgcgtca tcgatcaata
     2881 ttcgcgctac aagatcaacg aggtggacat gttcatggac ggtcggatga cgcagggcga
     2941 gaacattgcc gacaacggcg gcctcaagca ggccttcagg gcctacaaga aatgggagaa
     3001 gctgcatggt cgcgagctgc agctgcccgg cctcaatatg acccacgatc agcttttctt
     3061 tctcaactat gcccagatat ggtgcggctc gatgcggccg gaggatgcac tgaccaagat
     3121 ccgctcctcc gtccattcgc cgggctttgt tcgtgtcctg gggccgctct cgaattcgcg
     3181 cgactttgca cacgcctaca gctgcccctt gggttgcaac atgaatcccg aggagaagtg
     3241 cagcgtctgg tagatacaca cacacagaag ggaacgttga tgtttttttt ttatatattt
     3301 atatctcata ctaaatatag tacgagtaga taccatatac aattaataca gtacgctaga
     3361 cgacggaaca ccacggagga tggaccacat ctgattcgta tctctattgt gtttttattt
     3421 atatatattt ttttttatct cgatctgtgc tctttttgct gtattttttg ttgttgttgt
     3481 tatagcagtt attatgtaat gtaatgtaat gtaatgcgta gtaacgatga tccatgtata
     3541 ccctgcacat acatatgtat atgcacagag cccacaagcc gcacttccca ca