PREDICTED: Drosophila obscura dynein heavy chain 6, axonemal


LOCUS       XM_022364328           12835 bp    mRNA    linear   INV 14-MAY-2021
            (LOC111072450), mRNA.
ACCESSION   XM_022364328
VERSION     XM_022364328.2
DBLINK      BioProject: PRJNA728747
KEYWORDS    RefSeq; corrected model.
SOURCE      Drosophila obscura
  ORGANISM  Drosophila obscura
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_024542752.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On May 14, 2021 this sequence version replaced XM_022364328.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Drosophila obscura Annotation
                                           Release 101
            Annotation Version          :: 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.6
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            frameshifts :: corrected 2 indels
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAECWW010000165.1  1611016-1611060
            46-1268             JAECWW010000165.1  1611140-1612362
            1269-1413           JAECWW010000165.1  1612436-1612580
            1414-1764           JAECWW010000165.1  1612648-1612998
            1765-1860           JAECWW010000165.1  1613061-1613156
            1861-1991           JAECWW010000165.1  1613226-1613356
            1992-2566           JAECWW010000165.1  1613424-1613998
            2567-2977           JAECWW010000165.1  1614081-1614491
            2978-3368           JAECWW010000165.1  1614562-1614952
            3369-3645           JAECWW010000165.1  1615034-1615310
            3646-4234           JAECWW010000165.1  1615377-1615965
            4235-4235           "N"                1-1
            4236-4260           JAECWW010000165.1  1615966-1615990
            4261-4713           JAECWW010000165.1  1616061-1616513
            4714-5167           JAECWW010000165.1  1616595-1617048
            5168-5537           JAECWW010000165.1  1617050-1617419
            5538-6132           JAECWW010000165.1  1617514-1618108
            6133-6282           JAECWW010000165.1  1618168-1618317
            6283-7522           JAECWW010000165.1  1618381-1619620
            7523-7702           JAECWW010000165.1  1619694-1619873
            7703-7969           JAECWW010000165.1  1619947-1620213
            7970-8155           JAECWW010000165.1  1620283-1620468
            8156-8505           JAECWW010000165.1  1620539-1620888
            8506-8647           JAECWW010000165.1  1620974-1621115
            8648-9651           JAECWW010000165.1  1621339-1622342
            9652-9832           JAECWW010000165.1  1622430-1622610
            9833-10587          JAECWW010000165.1  1623388-1624142
            10588-11656         JAECWW010000165.1  1624221-1625289
            11657-12127         JAECWW010000165.1  1625345-1625815
            12128-12835         JAECWW010000165.1  1625888-1626595
FEATURES             Location/Qualifiers
     source          1..12835
                     /organism="Drosophila obscura"
                     /mol_type="mRNA"
                     /isolate="BZ-5 IFL"
                     /db_xref="taxon:7282"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="whole fly"
                     /dev_stage="Adult fly"
                     /geo_loc_name="Serbia: Babin Zub"
                     /collection_date="2017"
     gene            1..12835
                     /gene="LOC111072450"
                     /note="The sequence of the model RefSeq transcript was
                     modified relative to its source genomic sequence to
                     represent the inferred CDS: inserted 1 base in 1 codon;
                     deleted 1 base in 1 codon; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 3
                     Proteins, and 99% coverage of the annotated genomic
                     feature by RNAseq alignments, including 2 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:111072450"
     CDS             314..12484
                     /gene="LOC111072450"
                     /note="The sequence of the model RefSeq protein was
                     modified relative to its source genomic sequence to
                     represent the inferred CDS: inserted 1 base in 1 codon;
                     deleted 1 base in 1 codon"
                     /codon_start=1
                     /product="LOW QUALITY PROTEIN: dynein heavy chain 6,
                     axonemal"
                     /protein_id="XP_022220020.2"
                     /db_xref="GeneID:111072450"
                     /translation="MSRSSGKGKSSETTLVRWSNSRQNRAPGTGIASAASSELNVTMS
                     AMPPDSNADGDAAAATGTGTGGHVQLLDGKSSVATSSITSPRDTAVSRARKQRLNFQR
                     KGSTVGSVGARSRSPSTTKITTGASLIPNLNLVINRMRARQDDAFVYMDYMLPHDSEY
                     FTPYSLREVEYEDLNPYEPFFTVTRHGVTFWHCSENFFTPLDQWQQEFVQFLSIIQIR
                     SFSIFRLWKGFKVWEKTIKWRKLNEARDYLHNNLFIVIPQLAKAILRMRAEIVQMERL
                     NFVNISNIENWHPFYFLETHMRIYEQLHKIFHDFRTQFGVSIFRACTDAIQARGFYPD
                     DEVNYYPSMKKMREAHSFMDRARKRAFCKTLTNFLTYSDMMVFQMLYRITTKSFEDLA
                     HAFEEHDAVGPTDADISRHSRTDKRVERQRPADKPQHPFFLAMLRLLPDRIDIEPSEE
                     VIKIIFQRITGLILETVLDIRPFTTDPYFKQYTEPSIMGRQEEVLYDGAPDLHWLLRA
                     DSTFQFNRKNIFYLLRKAYDRARTYTERFHAIRENFEIDTHTDPETLSSERDLTTLRN
                     YCDRYCNNVRALDGILEFVYLGLLKLTQTNFKDAVTPVCQRLQNVLATYLPKLAEEET
                     TRLYEEAQDFFGRICFEPQETLDIVNHIRFLDTCSAELDIIFEGIDYVHDLLLIIKDF
                     AIPIDDDRKEDYMDTEDYVNRTKDTLLEIQEKRQEFINRLEEAMMDDIFTLKEEIHVI
                     AVEALEPWLLNAKSERISVTNKLDALMDQLSGCKERAEEFLGYQKEFRIDLTMYEEMD
                     QAFYDIRMRQNLYKTMIDWEQALTDWQAADFNTLIVADMLELNSKTIKNCLQFQKYLP
                     ENNIVPVLQKSAEEFKEKLPVIGYLRNPNLRARHWSEIEELLSHKFFQEKDIVLATYE
                     EVHAFDDEAIGESLMQISSQATGEMQLENMLKAIETIWKETELAIVSHHDQKDVFILA
                     GTEELQAVLDDANVNINTIAASKFVGPIKGKVDEWITDMDQFGKTFEAWMDCQGAWIY
                     LEAIFASADIQRQLPNEAKMFFQVDKCFKEIVRQAKKVALALPTMSSVEVYDALVENN
                     RLLDLISRGLEAYLEVKRVVFPRFYFLSNDELLEILAQTRIPQAVQPHLRKCFDAIYR
                     LEFGSKDSGDDKVVATNDIIAYLSPEGEKLQFGKGLKARGAVEEWLSKVEEAMFVSVK
                     RYMRFGYQCYLAKEREEWFQDHPNQVVLTVSQVQWAADIHRIFDNKEKNPANIMEKMG
                     KFEVKCLKDLGALAALTRRSITSLLRKILCALITIDVHAKDSVRMXIEKEVCKPNDFN
                     WLKMLRFYWADETETVYSRMAAANIPYYYEYLGAGGVLVLTPLTDRCYLCLMGAFQMD
                     LGGAPAGPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKMMGRFFSGLAQCGAWCCF
                     DEFNRIDIEVLSVIAQQLITIRTAKAMRAKRFVFEGREIKINRSCCVFITMNPGYAGR
                     TELPDNLKALFRPISMMVPDYALISEVILYSEGFEDPKILARKMVQMYQLCSQQLSQQ
                     NHYDFGMRAVKSVLVMAGALKRASPDQREDITLIAALRDSNIPKFLADDAVLFRGILS
                     DLFPGVELPDSQHPNLEASLLLGLRQKNLQPVATTIRKCLQLYETMCVRWGVMLVGPT
                     GGGKSVVLHALEFALAHLFEIEVQDPNFRPVVIQTMNPKAVSMNELYGYVDPKTLEWQ
                     DGLLGLAVRTATNVEDEIHQWIMCDGPVDAVWIENLNTVLDDNKMLCLANSERIKLTA
                     WIHMLFEVQDLLQASPATVSRCGMVYVDPTDLGWLPLIDTWREVEMRQKLSPALTEFL
                     YQLFTGYFEKALKIERKRAVYTIHQVTNAKVRLCCALTSSQLEAVKWSPLTDEQAKEL
                     ITKIFSWSVLWSIASNLKDAEKVAYEEQWSRIVAQHPNMDLPKHTMWNYRVDLETREW
                     GKWLDIMPKFKFSSEISYYDMQVPTVDTTKYGYVADLLFKRNIPVMFTGETGVGKTVL
                     AISCMKRLSEGKVIPVILNFSAQTSSIRTQEMIEGPLEKRKRTQLGAPVGKTVIIFID
                     DVNMPKLDTYGSQAAIELLRQFLDFKGFYDREKLFWKEVLDVVLGCACAPPGGGRNPL
                     TPRFVRHFALFSLPKPNEETLTQIFNGILLGFLGSFSGAIRSLSEPMVNACVDVYMRV
                     ANVMLPTPDRSHYIFNLRDLSKCIQGILQATNLHYNQENQILRLFYHETTRVFHDRLI
                     NQEDKDLFKSLMKSVCQLHFKRDVVGDDEPAILFGDFMIFGKPKNERIYDEIKDHAKL
                     ESVLNDYIVDYNSMAVGKRMKLILFQDAMEHTVRLARLLRSDRGNGLLVGVAGMGKQS
                     LTRLASHVNEYNCWQIEMRRNYDLNAFHEDLRVLYRIAGIDNHPVTFLMIDSQIVEEE
                     FLEDINNILNSGEVPNLFESDEFEKIILDARDACNEQQKNEPCNRDSIYKFFINRVRN
                     NLHVVMSMSPVGDAFRRRCRMFPSLVNCTTIDWFTSWPTEALYSVALGLLTKIAPKME
                     DRVALASVTVFMHKTVEDASVRFYKEMKRHYYTTPSSYLELLKLYQNLLKAKNQEIIA
                     KRKRIANGLNKLLETNEVIAVMQKELEVMVPQLDEKSALMKSLLANLTTETKQADTVK
                     QGVMEDEANAKEKAAVAQAISEDAGKDLEIAMPALREAEDALKGLTKADINELKSFTT
                     PPALVQFCMEAVCILLGAKPTWASAKAIMADINFIKRLFEYDKEHMKDDVLKKVKKYI
                     DHKDFTPAKFEKVSKVAKSVSMWVIAMDKFSKVYKVVEPKIKRKEAAEAELKEVMVVL
                     RQKQKELAAVEAKIQTLRDSLDEKQREFQVIQDNVDLTYGRINRAGRLTSALSDEQVR
                     WRETVKSLTADLACVPGDVLVAAACVAYMGAFSHLYRRDMGALWVSKCRENKIPSSGE
                     FNLLKVLGDAYEMRQWNVDGLPKDNISIENGIYATRALRWALMIDPQEQANRWIRNME
                     KENNLQVVKMTDASMMRILENSVRQGYPVLLEEIDETIDPALRPILQRETYKYEGRIY
                     LKLGDQVIDYDENFKLYMTTKLPNPHYLPEVCINVTLVNFLVTESGLEDQLLADIVAI
                     ELPAMEAQRNDLVVKINADKQQLLSLEDKVLKLLFNSEGNILDDEELVETLNDAKETS
                     LIIAARLIDTEETEKIITASRERYRILASRGAILYFVVAGLAEIDPMYQYSLKYFTQV
                     FCNVLRQEHPVQAVEVRISALMVDELKAIYDNISRGLFENHKIIFSFLLALSVERQEK
                     RVSDEEFSFLTRGAVGNIRPKQQPSSTKLSQMEWDACIYLEDNFPDTFAGFSSEIDRP
                     FFLQLQDNSEIFDFARTKQPPTDKWNKRLRIFHKLMFIAIFRKPRFLLNVVSYLHGTV
                     GRYFTEVSATGTQLSTVFLDTSEVTPLIFVLSTGSDPMSGFLKFTTQMQYTEKYYSIS
                     LGQGQGPVAENLIDKSLRLGHWVFLQNCHLATSWMRTLETIVRNLSLGITKSHPEFRL
                     FLSSMPIREFPISVLQNSVKITNEPPKGIKANVIGALADLKRDFFEHHIQNGNWRAIV
                     FGLCMFHAVLLERRKFGPLGWNIMYEFNESDRECGLKTLDFFIDREVMDDIPWEAILY
                     INGEITWGGRVTDYWDLRCLRTVLMIFSSKRIIQPEYKYCRGDAYYRDPRKKTLAEYS
                     TFVQGFPVLEDPEIFGMNQNANIVFQTKETEFFISTLLLGQPRSAADEGQAAENDICQ
                     QIIARIQEALVNKIKREPLHDTLSTLDSKGQVPSLTTVLVQEIDRFNIALGIIHDSLT
                     NLAKAIKGLVVMSEELENVFKALLANLVPASWAKRSFLSIKPLPNYITDFQRRIDFIQ
                     HWAENGAPRSYWISGFFFPQSFLTGVLQTYARRRVLPIDSLKIDFDIVERELVQQDFF
                     EAHNAGKSDERLYGNLLECTDAVINVHGIFIEAARWDLSRGGLCDAKFGELYTRLPIV
                     RFMPCLEISPQVRYEAPLYKTQQRSGVLSTTGHSTNFVLSVLLFSQNDPEFWVMRGTA
                     LVSGVVENVS"
     misc_feature    2702..3937
                     /gene="LOC111072450"
                     /note="Dynein heavy chain, N-terminal region 2; Region:
                     DHC_N2; pfam08393"
                     /db_xref="CDD:462462"
     misc_feature    3374..11350
                     /gene="LOC111072450"
                     /note="Dynein, heavy chain [Cytoskeleton]; Region: DYN1;
                     COG5245"
                     /db_xref="CDD:227570"
     misc_feature    4352..5332
                     /gene="LOC111072450"
                     /note="Hydrolytic ATP binding site of dynein motor region;
                     Region: AAA_6; pfam12774"
                     /db_xref="CDD:463697"
     misc_feature    11486..12457
                     /gene="LOC111072450"
                     /note="Dynein heavy chain C-terminal domain; Region:
                     Dynein_C; pfam18199"
                     /db_xref="CDD:465677"
ORIGIN      
        1 cccaaaggcg gaaggggaag ggactgcaag cgagacaaac ttttggaata tttccaaaac
       61 gcctcaataa agcacacaga atggaacgaa aagctcagca acgaaaagct ctgctgccaa
      121 aggcttttcc atggcaacga aggaaacggg gaagcggaga aaccgttacc cagaacggat
      181 aacaaaaaca gtaaagcagg cacgaataac tgtcagtaca tatataataa atgagtacat
      241 actcatgtaa atataaacat atagccagca tattcagtat atagagacag agtcccccca
      301 acgatattcc aagatgtcca gatcgtcggg gaagggtaaa tcatcagaaa cgacgctggt
      361 gcgatggagc aacagtcggc aaaatcgtgc cccgggcacg gggatagcct ccgctgctag
      421 cagcgaacta aacgtcacca tgtccgccat gccacccgac agcaacgccg atggcgacgc
      481 tgccgccgcc accggcaccg gcaccggcgg tcatgtgcag ctgctggacg gcaagagctc
      541 ggtagccacg agcagcatta catcaccgag ggatacagcg gtatccaggg cgcgaaaaca
      601 gcgactcaac ttccagcgaa agggctcgac ggtgggcagc gttggggcca ggtctcgcag
      661 ccccagcacc accaagataa cgacgggcgc ctcgctgata ccgaatctca atctggtgat
      721 caatcggatg cgggccaggc aggacgatgc attcgtctac atggactaca tgctgccgca
      781 cgacagcgaa tactttacgc cgtacagcct gcgggaggtg gaatacgagg atctgaatcc
      841 atacgagcca ttctttacgg tgacgcgtca cggtgtcacc ttttggcact gctcggagaa
      901 cttcttcacg ccgctcgatc agtggcagca ggaatttgtg cagttcctca gcatcatcca
      961 gatacgttca ttctccattt tccggctctg gaagggcttc aaggtgtggg agaagacaat
     1021 caaatggcgc aagctgaacg aggcgcgcga ctatctgcac aacaatctgt tcattgtgat
     1081 accacagctg gccaaggcca ttttgcgcat gcgcgccgaa atcgttcaaa tggagcgtct
     1141 gaatttcgtg aatatcagca acatcgagaa ctggcatccg ttctactttc tcgagaccca
     1201 tatgcgcatc tacgagcagc tgcacaagat ctttcacgat tttcgtacac aatttggcgt
     1261 ttcgatattt cgtgcctgca cggatgccat acaggcgcgc ggcttctatc cggacgatga
     1321 ggtcaactac tatccatcga tgaagaagat gcgcgaggcg cacagcttta tggatcgggc
     1381 acgcaagcga gccttctgca agaccctaac aaactttctc acgtactccg acatgatggt
     1441 ctttcaaatg ctttaccgca tcaccaccaa aagctttgag gatctggccc atgccttcga
     1501 ggagcacgat gccgtggggc caacggacgc ggacatttcc aggcacagtc gaacggataa
     1561 gcgggtcgag aggcagcggc cggccgacaa gccacagcat ccattctttc tggcaatgct
     1621 gcgactgttg cccgatcgca tcgatatcga gccatcggag gaggtcatca agatcatttt
     1681 tcagcgcatc accggactga tactcgagac ggtgctggac attcgaccat ttacaacgga
     1741 cccgtacttc aagcagtaca cagagccatc gatcatggga cgtcaggagg aggtgctgta
     1801 tgatggcgcg cccgatctgc actggctgct acgtgccgat agcactttcc agtttaatcg
     1861 gaaaaatatc ttctatctgc tgcgcaaagc ctacgatcgg gctcgcacct atacggaacg
     1921 tttccatgca attcgcgaga actttgagat cgacacccac acagatcccg aaactttgag
     1981 cagcgaaagg gatctgacca cgctgcgcaa ctactgcgat cgctattgca acaatgtgcg
     2041 tgccctggat ggtatcttgg agtttgttta tctgggattg ctgaagctga cgcagacgaa
     2101 cttcaaggat gctgtgacgc cggtgtgcca gcgtctgcag aacgtcctgg ccacatatct
     2161 gcccaagctg gccgaggagg agacgacgcg actgtacgag gaggcgcagg atttctttgg
     2221 ccgcatctgc ttcgagccgc aggagacgct cgatattgtg aatcacatac gattcctgga
     2281 cacatgcagc gcggagctcg atatcatatt cgagggtatc gactatgtgc acgatctgct
     2341 gctgattatc aaggactttg ccataccgat cgatgacgat cgcaaagagg actacatgga
     2401 caccgaggac tatgtgaatc gcaccaagga cacgctgctc gagatccagg agaagcggca
     2461 ggagttcatc aatcgcctcg aggaggccat gatggatgac atatttacgc tcaaagagga
     2521 gatacacgtg atcgctgtgg aggccctcga gccatggctc ttgaatgcca aatccgaacg
     2581 gatttcggtt acaaacaagc tggacgcgct gatggatcag ctgagtggtt gcaaggagcg
     2641 tgccgaggag ttcctgggct accagaagga attccgcatc gatctaacca tgtacgagga
     2701 gatggaccag gccttctacg acatacgcat gcgccagaat ctctacaaga cgatgatcga
     2761 ctgggagcag gcactcaccg actggcaggc ggccgatttc aacactttga ttgtcgccga
     2821 tatgctcgaa cttaattcga agacgatcaa aaactgtctg cagttccaga agtatctgcc
     2881 agagaataac attgtgccag tgctgcagaa atcggccgag gagttcaagg agaagctgcc
     2941 cgtcattgga tatctgcgca atcccaatct tcgagctcgc cactggtcag agatcgaaga
     3001 gctgttgagc cataaattct ttcaggagaa ggacatcgtg ctggccacct acgaggaggt
     3061 gcatgccttc gatgacgagg ccattggcga gtccctcatg cagatctcat cacaagccac
     3121 cggcgaaatg cagctcgaga atatgctgaa agccatcgaa acgatctgga aggagaccga
     3181 actggccatt gtctcgcatc acgatcagaa ggatgtcttc atactggccg gcaccgagga
     3241 gctgcaggcg gtgctcgatg atgccaatgt gaatatcaat acgatagccg cctccaaatt
     3301 tgtgggtccc atcaagggca aggtggatga gtggatcacc gatatggatc aatttggcaa
     3361 gactttcgag gcctggatgg actgtcaggg tgcatggata tatttggagg ccatattcgc
     3421 atcggcggat atacagcgcc agctgcccaa cgaggccaaa atgttctttc aggtggacaa
     3481 atgcttcaag gagattgtcc gccaggccaa gaaagtggca ctggccctgc ccacaatgtc
     3541 cagtgtggag gtgtacgatg cccttgtgga gaacaatcga ttgctcgatc taatctcacg
     3601 cggcctggag gcctatctgg aggtgaagcg tgtggtattt cccagattct acttcctgtc
     3661 gaacgatgaa cttctggaga ttctggccca gacgcgcata ccacaggccg tgcagccgca
     3721 tttgcgcaag tgcttcgatg ccatctaccg tctggagttc ggctccaagg acagtggcga
     3781 tgacaaggtg gtggccacca atgacattat cgcctatcta tcgccggagg gcgagaagct
     3841 gcagtttggc aaaggactga aggcgcgcgg cgccgtcgag gagtggctca gcaaggtgga
     3901 ggaggcgatg tttgtctccg tgaagcgcta catgcgcttc ggctatcagt gctatctggc
     3961 caaggagcgc gaggagtggt tccaggatca tcccaatcag gtggtgctca ccgtctccca
     4021 ggtgcagtgg gccgccgaca ttcatcgcat attcgacaac aaggagaaga acccagcgaa
     4081 cataatggaa aagatgggca aatttgaggt gaaatgcctc aaggatctgg gcgcactggc
     4141 ggccctcaca cggcgcagca tcacttcgct gctgcgcaag atcctttgtg cgctgatcac
     4201 catcgatgtc catgccaagg actcggtgcg catgnctatc gagaaggagg tctgcaagcc
     4261 caacgacttc aattggctga aaatgttgcg attctattgg gcggatgaaa cggagaccgt
     4321 gtactcccgt atggcggccg ccaatattcc ctactactat gaatatctgg gcgctggcgg
     4381 tgtcctggtg ctcaccccgc tcacagatcg ctgctacctg tgtctgatgg gcgcctttca
     4441 aatggatttg ggtggagcgc ctgctgggcc ggcgggcacc ggcaaaaccg agacgaccaa
     4501 ggatctggcc aaggccctgg ccaagcagtg tgtcgtcttt aactgctccg atggcctcga
     4561 ctacaagatg atgggccgct tcttttcggg tctggcccag tgcggtgcct ggtgctgctt
     4621 cgacgagttc aatcgcatcg atatcgaggt gctgtccgtg attgcccagc agttgatcac
     4681 catacgaacg gccaaggcca tgagggcaaa gcgattcgtc tttgagggtc gcgagatcaa
     4741 gattaatcgc tcatgctgcg tcttcattac aatgaatccg ggctatgcgg gccgcacaga
     4801 gctgcccgac aatctgaagg ccctgttccg gcccatctca atgatggtgc ccgactatgc
     4861 tttgatctcc gaggtgatcc tatactcgga gggcttcgag gatcccaaaa tcctcgcccg
     4921 caagatggtg cagatgtacc agctgtgcag ccagcagctc agccaacaga atcactacga
     4981 cttcggcatg cgagccgtca agtcggtgct ggtcatggcc ggtgccctga agcgtgcctc
     5041 gcccgatcag cgtgaggata tcacactgat tgccgcactg cgcgactcca atatacccaa
     5101 gttcttggcc gacgatgctg tgctcttccg tggcatcctc agcgatctgt ttccgggcgt
     5161 ggaactgccg gactcacagc atccgaatct ggaggccagt ctgctgctgg gactgcgcca
     5221 gaagaacctg cagccggtgg ccaccaccat acgcaagtgc ctgcagctgt acgagacgat
     5281 gtgtgtgcgg tggggcgtta tgctggtggg tccaacgggc ggcggcaagt ccgtggtgct
     5341 gcatgccctc gagtttgcgc tggcccatct ctttgagatt gaggtgcagg atccgaactt
     5401 tcggcccgtt gtcatacaga caatgaaccc caaggcggtg tccatgaacg agctgtacgg
     5461 ctatgtggat cccaagacgc tggaatggca ggacggtctc cttggtctgg ccgtgcgcac
     5521 agccaccaat gtggaggatg agatccatca gtggatcatg tgcgatggcc cagtggatgc
     5581 tgtttggatt gagaacttga acaccgtgct ggacgacaac aagatgctgt gtctggcgaa
     5641 ttcggaacgc atcaagctca ccgcctggat acacatgctg ttcgaggtgc aggatctgct
     5701 gcaggcctca cccgccactg tctcacggtg cggcatggtc tacgtggatc ccaccgatct
     5761 tggctggctg ccgctgatcg atacctggcg tgaggtggag atgcgccaga agctgtcacc
     5821 cgcactcacc gaattcctgt atcaactgtt cacgggctac tttgagaagg cattgaagat
     5881 cgagcgtaag cgtgcggtgt acaccatcca tcaggtgacc aatgccaagg tgcgtctgtg
     5941 ctgtgccctc acctcatcgc agctggaggc cgtcaagtgg tcgccattga cagacgaaca
     6001 ggccaaggag ctcatcacaa agatcttctc atggagcgta ctctggtcga ttgcctccaa
     6061 tctgaaggat gccgaaaaag ttgcctacga ggagcagtgg agccgcatcg ttgcccagca
     6121 tccgaatatg gacctgccaa agcatacaat gtggaactat cgcgtggatc tggagacacg
     6181 cgaatggggc aaatggctgg acataatgcc caagttcaag ttcagctcgg agatctccta
     6241 ctatgacatg caggtgccca cagtggatac caccaaatac ggctatgttg ctgatcttct
     6301 gttcaagcgc aatatacccg tcatgtttac gggtgagacg ggcgtgggca aaacggtgct
     6361 ggccatcagt tgcatgaagc gtctgtccga gggcaaggtc ataccagtaa tcctcaactt
     6421 ttcggcacag acgagcagca tacgcaccca ggagatgatc gaggggccgc tggagaagcg
     6481 aaagcgcacc caattgggtg cgccagtggg caagacggtg atcatattta tagacgatgt
     6541 gaatatgccc aagctggaca cgtacggcag ccaggcggcc attgagctgt tgcgtcagtt
     6601 tctcgacttc aagggcttct acgaccggga gaagctcttc tggaaggagg tgctcgatgt
     6661 ggtgctgggc tgtgcctgtg caccgcctgg tggcggtcgc aatccgctaa caccgcgctt
     6721 tgtgcgacac tttgcattgt tctcgctgcc caagcccaat gaggagaccc tcacgcagat
     6781 ctttaatggc attctgttag gctttttggg ctcattttcg ggtgcgatac gctccctctc
     6841 cgagccgatg gtgaatgcct gcgtggatgt ctatatgcgg gtggccaatg tgatgctgcc
     6901 gacgcccgat cgctctcatt atatattcaa tttgcgagat ctgtccaagt gcattcaggg
     6961 catactgcag gcgaccaatc tgcactacaa tcaggagaat cagatactgc gtctgttcta
     7021 ccatgagacg acgcgcgtct ttcacgatcg cctgatcaat caggaggaca aggatctgtt
     7081 caagagcctc atgaagagcg tctgccagct gcactttaag cgcgacgttg tcggcgatga
     7141 cgagccggcg attctgttcg gtgactttat gatatttggc aagccgaaaa acgaacgcat
     7201 ctacgacgag atcaaggatc atgccaagct ggagagcgtc ctcaatgact acatcgtcga
     7261 ctacaactca atggccgtgg gcaagcgcat gaagctgata ctcttccagg acgccatgga
     7321 gcatacggtc cggctggccc gcctgctgcg cagcgatcgt ggcaatggcc tactggtggg
     7381 cgtcgccggc atgggcaaac agtcgcttac acgcctggcc tcccatgtca atgagtacaa
     7441 ttgctggcag atcgagatgc ggcgcaatta cgatctgaat gcgttccacg aggatttgcg
     7501 tgtcctttac cgcatcgcag ggattgataa ccatccggtg accttcctga tgatcgacag
     7561 ccagattgtc gaggaggagt tcctggagga catcaacaac atcctcaact cgggcgaggt
     7621 gcccaatctc tttgaaagcg atgaattcga gaagatcata ctggatgccc gcgacgcctg
     7681 caacgagcaa caaaagaatg aaccctgcaa tcgtgacagc atctacaagt tctttatcaa
     7741 tcgagtgcgc aacaatctgc atgtggtgat gtcaatgagt cccgtgggcg atgcctttcg
     7801 tcgccgttgc cgcatgttcc cctcgctggt caactgcacg acaatcgatt ggttcaccag
     7861 ctggcccacg gaggccctct attcggtggc ccttggactg ctcaccaaga ttgcacccaa
     7921 aatggaagat cgcgtcgcgc tggccagcgt cacagtgttt atgcataaga ctgtggagga
     7981 tgcatcggtg cgtttctaca aggagatgaa gcgccactat tacaccacgc ccagcagcta
     8041 cctggagctg ctgaagctct atcagaatct gctgaaggcc aagaaccagg agatcattgc
     8101 caagcgcaag cgcattgcca atggcctcaa caagctgctg gagaccaacg aagtgattgc
     8161 tgtgatgcaa aaggaactgg aggtgatggt gccccagctg gatgagaaat cggcgctgat
     8221 gaagtcgctg ctggcgaatc tcacaacgga aacgaagcag gcggacaccg tcaagcaggg
     8281 cgtcatggag gacgaggcca atgccaaaga gaaggcggcc gtggctcagg ccatatccga
     8341 ggatgctggc aaggatctag agattgcaat gccggcgctg cgcgaggccg aggatgcctt
     8401 gaagggcctc accaaggcgg acatcaatga gctaaaatca ttcacaacgc ccccagcgct
     8461 ggtgcagttc tgcatggagg ccgtttgcat tctactgggc gccaaaccca cttgggcttc
     8521 agctaaggct attatggcgg acataaactt catcaagcgg ctgttcgagt acgacaagga
     8581 gcacatgaag gacgatgtgc tgaagaaggt caagaagtac atcgatcaca aggattttac
     8641 cccagccaaa ttcgaaaagg tctcgaaggt ggccaaatcg gtgagcatgt gggtgattgc
     8701 catggacaag ttctcgaaag tgtacaaggt ggtggagccg aaaatcaagc gcaaggaggc
     8761 cgccgaggcg gagctcaagg aggtgatggt cgtgctgcgg cagaagcaaa aggagctggc
     8821 cgccgtcgag gcgaaaattc agacgctgcg cgacagcctc gacgagaagc agcgcgaatt
     8881 tcaggtgatt caggacaatg tcgatctcac ctatggccgc atcaatcgcg ccggccgcct
     8941 cacctccgcc ctgtccgacg agcaggtgcg ctggcgtgag acggtcaaat cgctgaccgc
     9001 cgatctggcc tgtgtgccgg gcgatgttct cgtggcagcc gcttgtgtgg cctatatggg
     9061 tgccttctcg cacctgtatc ggcgcgacat gggcgccctg tgggtgagca agtgtcgcga
     9121 gaataagata ccctccagcg gggagttcaa tctgctgaag gtgctgggcg atgcgtacga
     9181 gatgcgtcag tggaatgtgg acggtctgcc caaggacaac atctccatcg agaatggcat
     9241 ctatgcgacg cgcgccctgc gctgggcctt gatgatcgat ccccaggagc aggccaatcg
     9301 ctggatacgc aacatggaga aggagaacaa tctgcaggtg gtgaaaatga ccgatgcgag
     9361 catgatgcgc atcctggaga atagcgtacg gcagggctat ccggtgctgc tcgaggagat
     9421 cgacgaaaca atcgatccgg cactgcggcc catcctgcaa cgcgagacat acaagtacga
     9481 gggtcgcata tatctcaagc tgggcgatca ggtcattgac tacgatgaga actttaagct
     9541 gtatatgacc acaaagctgc ccaatcccca ctacctgccg gaggtgtgca tcaatgtgac
     9601 gctggtcaat ttcctagtga ccgaaagtgg cctcgaggat cagctactag ccgacattgt
     9661 ggccattgag ctacctgcca tggaggcgca acgcaacgat ctggtggtga agatcaatgc
     9721 cgacaagcag cagctgttga gcctcgagga caaggtgctg aagctgctgt tcaactccga
     9781 gggcaacata ctcgatgacg aggagctggt ggagaccctt aacgatgcca aggaaacgtc
     9841 gctcatcatt gccgctcgcc tcatcgacac cgaggaaacg gagaagatta tcaccgcatc
     9901 gcgtgaacgg tataggattt tggcgtcgcg cggtgccatc ctgtactttg tggtggctgg
     9961 actggccgag atcgatccca tgtatcagta cagcctcaag tactttacgc aggtcttctg
    10021 caatgtcctg cgccaggagc atcccgtgca ggccgtcgag gtgcgcatct ccgccttgat
    10081 ggtggacgaa ctgaaggcca tctatgacaa catatcgcgt ggcctgtttg aaaatcacaa
    10141 gatcatcttt agcttcctgc tggccctgtc cgtggagcgg caggagaagc gcgtctccga
    10201 cgaggagttc agtttcctaa cacgcggcgc cgtcggcaat atacgtccca agcagcagcc
    10261 atccagcaca aagctcagcc aaatggagtg ggatgcgtgc atctacttgg aggacaactt
    10321 tccggacaca ttcgcgggct tcagcagcga gatagacagg ccgttcttcc tgcagctgca
    10381 ggacaacagc gagatctttg actttgcccg caccaagcag ccgcccacgg acaagtggaa
    10441 caagcggctg cgcatctttc acaagctcat gttcatcgct atcttccgca agccgcgctt
    10501 cctgctgaat gttgtcagct atctgcatgg caccgttggc cgctacttca ccgaggtctc
    10561 tgccacgggc acacaattga gcaccgtctt cctggacacc tccgaggtga cgcctctgat
    10621 ctttgtgctg tcaacgggct ccgatccgat gtcgggcttc ctgaagttca ccacccaaat
    10681 gcaatatacg gaaaagtact attcgatatc gctgggccag ggccagggac cggtggccga
    10741 gaatctgatt gacaagagcc tgcggctggg acactgggtc tttctgcaga attgccattt
    10801 ggccacctca tggatgcgca ccctagagac aattgtgcgc aatctgtcgc tgggcattac
    10861 caagtcgcat cccgaatttc ggctcttcct ctcatcgatg cccatcaggg agttcccaat
    10921 cagtgtgctg cagaattcgg tgaagatcac caatgagccg cccaagggta tcaaggcgaa
    10981 tgtgattggc gccctggcgg atctcaagcg ggacttcttc gagcatcaca tccagaacgg
    11041 caactggcgg gccattgtct ttgggctgtg catgttccat gcggtgctgc tggagcgtcg
    11101 caaattcggt ccccttggct ggaacatcat gtacgagttc aatgagagcg atcgcgagtg
    11161 cggcctcaag acgctcgatt tctttatcga tcgcgaggta atggacgata taccctggga
    11221 ggcgatactc tatattaacg gtgagatcac ctggggcggt cgcgtcaccg actactggga
    11281 tctgcgttgc ctgcgcacgg tgctgatgat cttctcgtcg aagcggatca tacagccgga
    11341 gtataagtat tgtcggggcg atgcctacta tagggatccg cgcaagaaga cgctcgccga
    11401 gtactcgacc tttgtgcagg gctttccggt gctcgaggat ccggagatat ttggcatgaa
    11461 tcagaacgcc aatattgtgt ttcagaccaa ggaaacggaa ttctttatca gcaccctgct
    11521 gctgggccag ccacgatcag ccgccgacga gggtcaggcg gcggagaatg acatctgtca
    11581 gcagattatt gcccgcatcc aggaggcgct ggtcaacaag atcaagcgtg agcccctcca
    11641 tgacaccctc tcgacgctgg acagcaaggg acaggtgccg tcgctgacaa cggtgctggt
    11701 gcaggagatc gatcgcttca acattgcgct gggcatcata cacgacagcc tgacgaatct
    11761 ggccaaggcc atcaagggtc tggtggtgat gtccgaggag ctggagaatg tattcaaggc
    11821 gctgctggcc aatctggtgc ccgcttcctg ggccaagcgg agtttcctct ccattaagcc
    11881 gctgcccaac tacataacgg actttcagcg acgcatcgac ttcattcagc actgggcgga
    11941 gaatggggcg ccgcgctcct actggatcag tggcttcttc tttccgcagt ccttcctcac
    12001 gggcgtgctg cagacgtacg cgcgccgtcg cgtgctgccc atcgattcgc tgaagatcga
    12061 ctttgacatt gtcgagcggg agctggtgca gcaggatttc tttgaggccc acaatgcggg
    12121 taaaagtgac gaacgtttgt atggcaatct gctggagtgc accgatgccg tcatcaatgt
    12181 ccatggcata ttcatcgaag cggcccgctg ggacctcagc cggggcggcc tctgcgatgc
    12241 caaattcggt gagctgtaca cgcgcctgcc catcgttcgg ttcatgccct gcctggagat
    12301 ttcaccgcag gtgcgttacg aggcgccact ctacaagacc cagcagcgat ccggcgtcct
    12361 ctccaccacc ggccattcca cgaatttcgt cttgtccgtc ctgctgttta gccaaaatga
    12421 tcccgaattt tgggtgatgc gtggcacagc tctcgtttcg ggtgtcgttg agaatgtgtc
    12481 ctaaaaaaca aaaaaaaaac ggagcagtat agggagttat ctctgagttg tctcgtaatg
    12541 tactgatatt ttctctgttt attttctgca tattttcctt acggcatttc gtttattttg
    12601 ttactctgtt ctcatgctct ctctcatgct gttttgtcgt gtgcgtgtgt atgtgtgtgt
    12661 gtgtactgtt attatataca aataaatgtt cttaagatta agatctaggg tttttttttc
    12721 tggggtagga ggctggctat ataccacatc tctagcacat ttagatatat cctttttggt
    12781 tcgatttttt ttagtttttt tttttttgtt cgattctaca tgtttacagc tacga