PREDICTED: Drosophila obscura amyloid-beta-like protein


LOCUS       XM_022354677            3284 bp    mRNA    linear   INV 14-MAY-2021
            (LOC111066230), transcript variant X8, mRNA.
ACCESSION   XM_022354677
VERSION     XM_022354677.2
DBLINK      BioProject: PRJNA728747
KEYWORDS    RefSeq.
SOURCE      Drosophila obscura
  ORGANISM  Drosophila obscura
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_024542752.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On May 14, 2021 this sequence version replaced XM_022354677.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Drosophila obscura Annotation
                                           Release 101
            Annotation Version          :: 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.6
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3284
                     /organism="Drosophila obscura"
                     /mol_type="mRNA"
                     /isolate="BZ-5 IFL"
                     /db_xref="taxon:7282"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="whole fly"
                     /dev_stage="Adult fly"
                     /geo_loc_name="Serbia: Babin Zub"
                     /collection_date="2017"
     gene            1..3284
                     /gene="LOC111066230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 Protein, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 7 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:111066230"
     CDS             305..3148
                     /gene="LOC111066230"
                     /codon_start=1
                     /product="amyloid-beta-like protein isoform X8"
                     /protein_id="XP_022210369.2"
                     /db_xref="GeneID:111066230"
                     /translation="MCAALRQRNLWLRSLWAIAVAILATGTVQGASPRWEPQIAVLCE
                     AGQIYQPQYLSEEGRWVTDLSKKTTGATCLRDKMDLLDYCKKAYPNRDITNIVESSHY
                     QKIGGWCRQGALNAAKCKGSHRWIKPFRCLGPFQSDALLVPEGCLFDHIHNASRCWPF
                     VRWNQTGAAACQERGMQMRSFAMLLPCGISLFSGVEFVCCPKHFKTDEIHVKKTDLPV
                     MPPAQISSANDELNDNEEDDSNESNYSKDANDDELDDEDDLMADDEEDEMVADEAAAA
                     GGTGSSSGSAGDASSGSLDDINAEYDSGEDGDNYEEDGAGSEGDNDSDTWDQNGSSSG
                     AKPVGLKVPILSMASSSPSSLPVGPDGSSGKAPLKPDQVTRIPIYSPAQAAAREAAIS
                     NANRINRLAAAAAAAAAAAAAAAATGSGAAAGAGAGTGAGAPPPSTAQPTSDPYFTHF
                     DPHYEHQSYKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSFKQRMTARFQT
                     SVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQPPNAHHVEKCLQ
                     KLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQSMTMLK
                     RYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRIEIERKVAEKER
                     LRLAEKQRKEQRAAEREKLREEKLRMEAKKVDDMLKSQAAEQQSQSPSQSSSQSQPPA
                     QSQAQQQQQQQQQQQQQSQQQDKSINSKELGIDGGLVTAANLNLDTTKSEKDLADAEY
                     AEATVSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFMTHDLGHRESSFSL
                     RREFAHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGFIEVDQNV
                     TTHHPIVQEDKIVPNMQINGYENPTYKYFEVKE"
     misc_feature    389..907
                     /gene="LOC111066230"
                     /note="amyloid A4; Region: A4_EXTRA; smart00006"
                     /db_xref="CDD:128326"
     misc_feature    1604..2173
                     /gene="LOC111066230"
                     /note="E2 domain of amyloid precursor protein; Region:
                     APP_E2; pfam12925"
                     /db_xref="CDD:463752"
     misc_feature    2327..>2473
                     /gene="LOC111066230"
                     /note="DDRGK domain; Region: DDRGK; pfam09756"
                     /db_xref="CDD:370664"
     misc_feature    2987..3136
                     /gene="LOC111066230"
                     /note="Beta-amyloid precursor protein C-terminus; Region:
                     APP_amyloid; pfam10515"
                     /db_xref="CDD:463129"
ORIGIN      
        1 gagccactgg gcgcccactg aaggcaacga gttgctcatg tggtcggtgc cactcgcagt
       61 cgtttgtgag cgttcgcagc gcaagttgca gcaatactta gtgttaaaca aataagccac
      121 caaagcaaat actcgtacaa ttaagcccga gcagcccgag acacccgtcc agagacagag
      181 acagccggat tcccttggag aaggagctgt tcgtggagag cagagacaga gacaaagaca
      241 aagacaaaag acaagcggag aagcggagaa cagttcagcc aaaggccgaa aaagagtgcg
      301 aacaatgtgc gccgcgctgc gtcaacgcaa tttgtggctg cggagcctct gggccatcgc
      361 cgtagccatc ctggccactg gcactgtaca gggcgcctcg ccacgctggg agccgcaaat
      421 agccgtactc tgcgaagccg gacaaatcta tcagccgcaa tatctgtccg aggagggacg
      481 ctgggtgacg gacctcagca agaagacaac tggcgccaca tgtttgcgtg ataaaatgga
      541 tttgcttgat tactgcaaga aggcctatcc caatcgagac attaccaaca ttgtggagtc
      601 gtcgcactac cagaagatcg gcggctggtg ccgccagggt gctctgaacg cggccaagtg
      661 caagggatcc caccgctgga ttaagccgtt ccgttgtctg ggaccattcc aatcggacgc
      721 cttgctggtg ccagagggct gcctcttcga tcacatccac aatgcgtccc gctgctggcc
      781 attcgtcaga tggaaccaga cgggcgccgc cgcctgccag gaacggggca tgcagatgcg
      841 cagcttcgcc atgctgctgc cctgcggcat atcgctcttc tccggcgtgg aattcgtgtg
      901 ctgccccaag cacttcaaga ccgatgagat tcatgtgaag aagaccgatc tgccggtgat
      961 gcccccggca cagatcagca gtgccaacga tgagctgaac gacaacgagg aggatgacag
     1021 caacgagtcc aactactcga aggacgccaa cgatgatgag ctggacgacg aggatgatct
     1081 gatggccgac gacgaggagg acgaaatggt ggccgacgag gcggctgcgg ctggcggcac
     1141 tgggtccagc tctggctcgg ctggcgatgc cagcagcggc tccctggatg acattaatgc
     1201 ggaatatgat agcggcgagg atggcgacaa ctacgaggag gatggcgctg gctccgaggg
     1261 cgacaatgac tccgatacct gggaccagaa cggcagctcc agtggcgcca agcccgtggg
     1321 cctcaaggta cccattttgt cgatggcctc ctcgtccccg tccagcctgc ccgtgggtcc
     1381 cgatggcagc tccggcaagg cacccctgaa gcccgaccag gttacacgca ttcccattta
     1441 ctcgccggcc caggctgccg ccagagaggc tgccatcagt aatgccaatc gtatcaatcg
     1501 acttgctgcc gcagctgccg ctgctgctgc cgccgctgct gctgctgccg ctactgggtc
     1561 tggagctgca gctggagctg gggctgggac tggagctggg gcaccaccac cgtcgacggc
     1621 acagcccacc tctgatccgt acttcaccca ctttgatccg cactacgagc accagagcta
     1681 caaacgcctt gaggaatcgc atcgcgagaa ggtcacccgt gtgatgaagg actggtccga
     1741 tctggaggag aagtaccagg acatgcggct ggccgatccc aaggctgccc aatcatttaa
     1801 gcagcgcatg accgcccgct tccagacttc tgttcaggca ctcgaggaag aaggcaacgc
     1861 cgagaagcac cagctggccg ccatgcacca gcaacgcgtg ctcgcccaca tcaaccagag
     1921 gaagcgcgag gccatgacct gctacaccca ggcccttacc gagcagccac ccaatgccca
     1981 tcatgtggag aagtgtctgc agaagctgct gcgggccctg cacaaggacc gagcccatgc
     2041 cctggcacac taccgacacc tgttgaactc cggcggaccg ggcggcctgg aggcggctgc
     2101 ctcagagcga ccccgcaccc tggagcgtct gatcgacatc gatcgggctg tcaaccagtc
     2161 gatgaccatg ctaaagcgct acccagagct gtccgccaaa attgcccagc tgatgaacga
     2221 ctacattctg gcactgcgca gcaaggacga cattcccggc tcgtcgctcg gcatgagcga
     2281 ggaggcagag gcgggcatcc tggacaagta ccgcatcgag atcgagcgca aggtggccga
     2341 gaaggagcga ttgcgtctgg ccgagaagca gcgtaaggag cagcgtgccg ccgagcgtga
     2401 gaagctgcgc gaggaaaagc tacgcatgga ggccaagaag gttgacgaca tgctcaagtc
     2461 gcaggcggcc gagcagcagt cccaatcccc atcccagtcc tcctcccagt cccagccccc
     2521 agctcagtcg caggcacagc agcaacagca acagcaacag cagcagcaac agcagtcgca
     2581 gcaacaagac aagagtatta acagcaagga gctgggcatc gacgggggcc tagtaaccgc
     2641 tgccaacctg aatctcgaca ccaccaagag cgagaaggac ctggccgatg ccgagtacgc
     2701 tgaggccact gtcagcacca aggtgcagac tgtgttgcca acggttgacg atgatgccgt
     2761 tcaacgggcg gtggaggatg tggctgctgc cgtggcccac caagaggccg agccgcaggt
     2821 gcagcacttc atgacccacg atctgggcca ccgcgaatcg agcttctcgc tgcgccgcga
     2881 atttgcgcac gcgcacgcgg ccaaggaggg acgcaacgtc tacttcactc tctcctttgc
     2941 cggcatcgcc ctcatggcgg ctgtctttgt gggtgtggcc gttgccaagt ggcgaacatc
     3001 gcgctcgccg cacgcccagg gcttcattga ggtggatcag aacgtgacca cacaccatcc
     3061 catcgtacag gaggacaaga tcgtgcccaa tatgcagatc aatgggtacg agaatccgac
     3121 ctacaagtac tttgaggtga aagagtaagc gtcccagcgg cagcggtaga gcaagcgagc
     3181 aggcgagagc acggcacatc aacagcaaaa aacgcaaaaa gcagcagcag caaaaaaaac
     3241 aacaacaaca atttcaaaat ggaaaaaaac ttaaacataa tatt