PREDICTED: Drosophila obscura amyloid-beta-like protein


LOCUS       XM_022354675            3287 bp    mRNA    linear   INV 14-MAY-2021
            (LOC111066230), transcript variant X6, mRNA.
ACCESSION   XM_022354675
VERSION     XM_022354675.2
DBLINK      BioProject: PRJNA728747
KEYWORDS    RefSeq.
SOURCE      Drosophila obscura
  ORGANISM  Drosophila obscura
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_024542752.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On May 14, 2021 this sequence version replaced XM_022354675.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Drosophila obscura Annotation
                                           Release 101
            Annotation Version          :: 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.6
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3287
                     /organism="Drosophila obscura"
                     /mol_type="mRNA"
                     /isolate="BZ-5 IFL"
                     /db_xref="taxon:7282"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="whole fly"
                     /dev_stage="Adult fly"
                     /geo_loc_name="Serbia: Babin Zub"
                     /collection_date="2017"
     gene            1..3287
                     /gene="LOC111066230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 2 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 8 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:111066230"
     CDS             305..3151
                     /gene="LOC111066230"
                     /codon_start=1
                     /product="amyloid-beta-like protein isoform X6"
                     /protein_id="XP_022210367.2"
                     /db_xref="GeneID:111066230"
                     /translation="MCAALRQRNLWLRSLWAIAVAILATGTVQGASPRWEPQIAVLCE
                     AGQIYQPQYLSEEGRWVTDLSKKTTGATCLRDKMDLLDYCKKAYPNRDITNIVESSHY
                     QKIGGWCRQGALNAAKCKGSHRWIKPFRCLEGPFQSDALLVPEGCLFDHIHNASRCWP
                     FVRWNQTGAAACQERGMQMRSFAMLLPCGISLFSGVEFVCCPKHFKTDEIHVKKTDLP
                     VMPPAQISSANDELNDNEEDDSNESNYSKDANDDELDDEDDLMADDEEDEMVADEAAA
                     AGGTGSSSGSAGDASSGSLDDINAEYDSGEDGDNYEEDGAGSEGDNDSDTWDQNGSSS
                     GAKPVGLKVPILSMASSSPSSLPVGPDGSSGKAPLKPDQVTRIPIYSPAQAAAREAAI
                     SNANRINRLAAAAAAAAAAAAAAAATGSGAAAGAGAGTGAGAPPPSTAQPTSDPYFTH
                     FDPHYEHQSYKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSFKQRMTARFQ
                     TSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQPPNAHHVEKCL
                     QKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQSMTML
                     KRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRIEIERKVAEKE
                     RLRLAEKQRKEQRAAEREKLREEKLRMEAKKVDDMLKSQAAEQQSQSPSQSSSQSQPP
                     AQSQAQQQQQQQQQQQQQSQQQDKSINSKELGIDGGLVTAANLNLDTTKSEKDLADAE
                     YAEATVSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFMTHDLGHRESSFS
                     LRREFAHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGFIEVDQN
                     VTTHHPIVQEDKIVPNMQINGYENPTYKYFEVKE"
     misc_feature    389..910
                     /gene="LOC111066230"
                     /note="amyloid A4; Region: A4_EXTRA; smart00006"
                     /db_xref="CDD:128326"
     misc_feature    1607..2176
                     /gene="LOC111066230"
                     /note="E2 domain of amyloid precursor protein; Region:
                     APP_E2; pfam12925"
                     /db_xref="CDD:463752"
     misc_feature    2330..>2476
                     /gene="LOC111066230"
                     /note="DDRGK domain; Region: DDRGK; pfam09756"
                     /db_xref="CDD:370664"
     misc_feature    2990..3139
                     /gene="LOC111066230"
                     /note="Beta-amyloid precursor protein C-terminus; Region:
                     APP_amyloid; pfam10515"
                     /db_xref="CDD:463129"
ORIGIN      
        1 gagccactgg gcgcccactg aaggcaacga gttgctcatg tggtcggtgc cactcgcagt
       61 cgtttgtgag cgttcgcagc gcaagttgca gcaatactta gtgttaaaca aataagccac
      121 caaagcaaat actcgtacaa ttaagcccga gcagcccgag acacccgtcc agagacagag
      181 acagccggat tcccttggag aaggagctgt tcgtggagag cagagacaga gacaaagaca
      241 aagacaaaag acaagcggag aagcggagaa cagttcagcc aaaggccgaa aaagagtgcg
      301 aacaatgtgc gccgcgctgc gtcaacgcaa tttgtggctg cggagcctct gggccatcgc
      361 cgtagccatc ctggccactg gcactgtaca gggcgcctcg ccacgctggg agccgcaaat
      421 agccgtactc tgcgaagccg gacaaatcta tcagccgcaa tatctgtccg aggagggacg
      481 ctgggtgacg gacctcagca agaagacaac tggcgccaca tgtttgcgtg ataaaatgga
      541 tttgcttgat tactgcaaga aggcctatcc caatcgagac attaccaaca ttgtggagtc
      601 gtcgcactac cagaagatcg gcggctggtg ccgccagggt gctctgaacg cggccaagtg
      661 caagggatcc caccgctgga ttaagccgtt ccgttgtctg gaaggaccat tccaatcgga
      721 cgccttgctg gtgccagagg gctgcctctt cgatcacatc cacaatgcgt cccgctgctg
      781 gccattcgtc agatggaacc agacgggcgc cgccgcctgc caggaacggg gcatgcagat
      841 gcgcagcttc gccatgctgc tgccctgcgg catatcgctc ttctccggcg tggaattcgt
      901 gtgctgcccc aagcacttca agaccgatga gattcatgtg aagaagaccg atctgccggt
      961 gatgcccccg gcacagatca gcagtgccaa cgatgagctg aacgacaacg aggaggatga
     1021 cagcaacgag tccaactact cgaaggacgc caacgatgat gagctggacg acgaggatga
     1081 tctgatggcc gacgacgagg aggacgaaat ggtggccgac gaggcggctg cggctggcgg
     1141 cactgggtcc agctctggct cggctggcga tgccagcagc ggctccctgg atgacattaa
     1201 tgcggaatat gatagcggcg aggatggcga caactacgag gaggatggcg ctggctccga
     1261 gggcgacaat gactccgata cctgggacca gaacggcagc tccagtggcg ccaagcccgt
     1321 gggcctcaag gtacccattt tgtcgatggc ctcctcgtcc ccgtccagcc tgcccgtggg
     1381 tcccgatggc agctccggca aggcacccct gaagcccgac caggttacac gcattcccat
     1441 ttactcgccg gcccaggctg ccgccagaga ggctgccatc agtaatgcca atcgtatcaa
     1501 tcgacttgct gccgcagctg ccgctgctgc tgccgccgct gctgctgctg ccgctactgg
     1561 gtctggagct gcagctggag ctggggctgg gactggagct ggggcaccac caccgtcgac
     1621 ggcacagccc acctctgatc cgtacttcac ccactttgat ccgcactacg agcaccagag
     1681 ctacaaacgc cttgaggaat cgcatcgcga gaaggtcacc cgtgtgatga aggactggtc
     1741 cgatctggag gagaagtacc aggacatgcg gctggccgat cccaaggctg cccaatcatt
     1801 taagcagcgc atgaccgccc gcttccagac ttctgttcag gcactcgagg aagaaggcaa
     1861 cgccgagaag caccagctgg ccgccatgca ccagcaacgc gtgctcgccc acatcaacca
     1921 gaggaagcgc gaggccatga cctgctacac ccaggccctt accgagcagc cacccaatgc
     1981 ccatcatgtg gagaagtgtc tgcagaagct gctgcgggcc ctgcacaagg accgagccca
     2041 tgccctggca cactaccgac acctgttgaa ctccggcgga ccgggcggcc tggaggcggc
     2101 tgcctcagag cgaccccgca ccctggagcg tctgatcgac atcgatcggg ctgtcaacca
     2161 gtcgatgacc atgctaaagc gctacccaga gctgtccgcc aaaattgccc agctgatgaa
     2221 cgactacatt ctggcactgc gcagcaagga cgacattccc ggctcgtcgc tcggcatgag
     2281 cgaggaggca gaggcgggca tcctggacaa gtaccgcatc gagatcgagc gcaaggtggc
     2341 cgagaaggag cgattgcgtc tggccgagaa gcagcgtaag gagcagcgtg ccgccgagcg
     2401 tgagaagctg cgcgaggaaa agctacgcat ggaggccaag aaggttgacg acatgctcaa
     2461 gtcgcaggcg gccgagcagc agtcccaatc cccatcccag tcctcctccc agtcccagcc
     2521 cccagctcag tcgcaggcac agcagcaaca gcaacagcaa cagcagcagc aacagcagtc
     2581 gcagcaacaa gacaagagta ttaacagcaa ggagctgggc atcgacgggg gcctagtaac
     2641 cgctgccaac ctgaatctcg acaccaccaa gagcgagaag gacctggccg atgccgagta
     2701 cgctgaggcc actgtcagca ccaaggtgca gactgtgttg ccaacggttg acgatgatgc
     2761 cgttcaacgg gcggtggagg atgtggctgc tgccgtggcc caccaagagg ccgagccgca
     2821 ggtgcagcac ttcatgaccc acgatctggg ccaccgcgaa tcgagcttct cgctgcgccg
     2881 cgaatttgcg cacgcgcacg cggccaagga gggacgcaac gtctacttca ctctctcctt
     2941 tgccggcatc gccctcatgg cggctgtctt tgtgggtgtg gccgttgcca agtggcgaac
     3001 atcgcgctcg ccgcacgccc agggcttcat tgaggtggat cagaacgtga ccacacacca
     3061 tcccatcgta caggaggaca agatcgtgcc caatatgcag atcaatgggt acgagaatcc
     3121 gacctacaag tactttgagg tgaaagagta agcgtcccag cggcagcggt agagcaagcg
     3181 agcaggcgag agcacggcac atcaacagca aaaaacgcaa aaagcagcag cagcaaaaaa
     3241 aacaacaaca acaatttcaa aatggaaaaa aacttaaaca taatatt