PREDICTED: Drosophila obscura amyloid-beta-like protein
LOCUS XM_022354674 3299 bp mRNA linear INV 14-MAY-2021
(LOC111066230), transcript variant X5, mRNA.
ACCESSION XM_022354674
VERSION XM_022354674.2
DBLINK BioProject: PRJNA728747
KEYWORDS RefSeq.
SOURCE Drosophila obscura
ORGANISM Drosophila obscura
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT MODEL REFSEQ: This record is predicted by automated computational
analysis. This record is derived from a genomic sequence
(NW_024542752.1) annotated using gene prediction method: Gnomon.
Also see:
Documentation of NCBI's Annotation Process
On May 14, 2021 this sequence version replaced XM_022354674.1.
##Genome-Annotation-Data-START##
Annotation Provider :: NCBI
Annotation Status :: Full annotation
Annotation Name :: Drosophila obscura Annotation
Release 101
Annotation Version :: 101
Annotation Pipeline :: NCBI eukaryotic genome annotation
pipeline
Annotation Software Version :: 8.6
Annotation Method :: Best-placed RefSeq; Gnomon
Features Annotated :: Gene; mRNA; CDS; ncRNA
##Genome-Annotation-Data-END##
FEATURES Location/Qualifiers
source 1..3299
/organism="Drosophila obscura"
/mol_type="mRNA"
/isolate="BZ-5 IFL"
/db_xref="taxon:7282"
/chromosome="Unknown"
/sex="male"
/tissue_type="whole fly"
/dev_stage="Adult fly"
/geo_loc_name="Serbia: Babin Zub"
/collection_date="2017"
gene 1..3299
/gene="LOC111066230"
/note="Derived by automated computational analysis using
gene prediction method: Gnomon. Supporting evidence
includes similarity to: 2 Proteins, and 100% coverage of
the annotated genomic feature by RNAseq alignments,
including 10 samples with support for all annotated
introns"
/db_xref="GeneID:111066230"
CDS 305..3163
/gene="LOC111066230"
/codon_start=1
/product="amyloid-beta-like protein isoform X5"
/protein_id="XP_022210366.2"
/db_xref="GeneID:111066230"
/translation="MCAALRQRNLWLRSLWAIAVAILATGTVQGASPRWEPQIAVLCE
AGQIYQPQYLSEEGRWVTDLSKKTTGATCLRDKMDLLDYCKKAYPNRDITNIVESSHY
QKIGGWCRQGALNAAKCKGSHRWIKPFRCLEGPFQSDALLVPEGCLFDHIHNASRCWP
FVRWNQTGAAACQERGMQMRSFAMLLPCGISLFSGVEFVCCPKHFKTDEIHVKKTDLP
VMPPAQISSANDELNDNEEDDSNESNYSKDANDDELDDEDDLMADDEEDEMVADEAAA
AGGTGSSSGSAGDASSGSLDDINAEYDSGEDGDNYEEDGAGSEGDNDSDTWDQNGSSS
GAKPVGLKVPILSMASSSPSSLPVGPDGSSGKAPLKPDQVTRIPIYSPAQAAAREAAI
SNANRINRLAAAAAAAAAAAAAAAATGSGAAAGAGAGTGAGAPPPSTAQPTSDPYFTH
FDPHYEHQSYKVSQKEAQQRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSFK
QRMTARFQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQPPNAHHV
EKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAVNQS
MTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRIEIERKV
AEKERLRLAEKQRKEQRAAEREKLREEKLRMEAKKVDDMLKSQAAEQQSQSPSQSSSQ
SQPPAQSQAQQQQQQQQQQQQQSQQQDKSINSKELGIDGGLVTAANLNLDTTKSEKDL
ADAEYAEATVSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFMTHDLGHRE
SSFSLRREFAHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGFIE
VDQNVTTHHPIVQEDKIVPNMQINGYENPTYKYFEVKE"
misc_feature 389..910
/gene="LOC111066230"
/note="amyloid A4; Region: A4_EXTRA; smart00006"
/db_xref="CDD:128326"
misc_feature 1607..2188
/gene="LOC111066230"
/note="E2 domain of amyloid precursor protein; Region:
APP_E2; pfam12925"
/db_xref="CDD:463752"
misc_feature 2342..>2488
/gene="LOC111066230"
/note="DDRGK domain; Region: DDRGK; pfam09756"
/db_xref="CDD:370664"
misc_feature 3002..3151
/gene="LOC111066230"
/note="Beta-amyloid precursor protein C-terminus; Region:
APP_amyloid; pfam10515"
/db_xref="CDD:463129"
ORIGIN
1 gagccactgg gcgcccactg aaggcaacga gttgctcatg tggtcggtgc cactcgcagt
61 cgtttgtgag cgttcgcagc gcaagttgca gcaatactta gtgttaaaca aataagccac
121 caaagcaaat actcgtacaa ttaagcccga gcagcccgag acacccgtcc agagacagag
181 acagccggat tcccttggag aaggagctgt tcgtggagag cagagacaga gacaaagaca
241 aagacaaaag acaagcggag aagcggagaa cagttcagcc aaaggccgaa aaagagtgcg
301 aacaatgtgc gccgcgctgc gtcaacgcaa tttgtggctg cggagcctct gggccatcgc
361 cgtagccatc ctggccactg gcactgtaca gggcgcctcg ccacgctggg agccgcaaat
421 agccgtactc tgcgaagccg gacaaatcta tcagccgcaa tatctgtccg aggagggacg
481 ctgggtgacg gacctcagca agaagacaac tggcgccaca tgtttgcgtg ataaaatgga
541 tttgcttgat tactgcaaga aggcctatcc caatcgagac attaccaaca ttgtggagtc
601 gtcgcactac cagaagatcg gcggctggtg ccgccagggt gctctgaacg cggccaagtg
661 caagggatcc caccgctgga ttaagccgtt ccgttgtctg gaaggaccat tccaatcgga
721 cgccttgctg gtgccagagg gctgcctctt cgatcacatc cacaatgcgt cccgctgctg
781 gccattcgtc agatggaacc agacgggcgc cgccgcctgc caggaacggg gcatgcagat
841 gcgcagcttc gccatgctgc tgccctgcgg catatcgctc ttctccggcg tggaattcgt
901 gtgctgcccc aagcacttca agaccgatga gattcatgtg aagaagaccg atctgccggt
961 gatgcccccg gcacagatca gcagtgccaa cgatgagctg aacgacaacg aggaggatga
1021 cagcaacgag tccaactact cgaaggacgc caacgatgat gagctggacg acgaggatga
1081 tctgatggcc gacgacgagg aggacgaaat ggtggccgac gaggcggctg cggctggcgg
1141 cactgggtcc agctctggct cggctggcga tgccagcagc ggctccctgg atgacattaa
1201 tgcggaatat gatagcggcg aggatggcga caactacgag gaggatggcg ctggctccga
1261 gggcgacaat gactccgata cctgggacca gaacggcagc tccagtggcg ccaagcccgt
1321 gggcctcaag gtacccattt tgtcgatggc ctcctcgtcc ccgtccagcc tgcccgtggg
1381 tcccgatggc agctccggca aggcacccct gaagcccgac caggttacac gcattcccat
1441 ttactcgccg gcccaggctg ccgccagaga ggctgccatc agtaatgcca atcgtatcaa
1501 tcgacttgct gccgcagctg ccgctgctgc tgccgccgct gctgctgctg ccgctactgg
1561 gtctggagct gcagctggag ctggggctgg gactggagct ggggcaccac caccgtcgac
1621 ggcacagccc acctctgatc cgtacttcac ccactttgat ccgcactacg agcaccagag
1681 ctacaaagta agtcagaaag aagcccaaca gcgccttgag gaatcgcatc gcgagaaggt
1741 cacccgtgtg atgaaggact ggtccgatct ggaggagaag taccaggaca tgcggctggc
1801 cgatcccaag gctgcccaat catttaagca gcgcatgacc gcccgcttcc aggcactcga
1861 ggaagaaggc aacgccgaga agcaccagct ggccgccatg caccagcaac gcgtgctcgc
1921 ccacatcaac cagaggaagc gcgaggccat gacctgctac acccaggccc ttaccgagca
1981 gccacccaat gcccatcatg tggagaagtg tctgcagaag ctgctgcggg ccctgcacaa
2041 ggaccgagcc catgccctgg cacactaccg acacctgttg aactccggcg gaccgggcgg
2101 cctggaggcg gctgcctcag agcgaccccg caccctggag cgtctgatcg acatcgatcg
2161 ggctgtcaac cagtcgatga ccatgctaaa gcgctaccca gagctgtccg ccaaaattgc
2221 ccagctgatg aacgactaca ttctggcact gcgcagcaag gacgacattc ccggctcgtc
2281 gctcggcatg agcgaggagg cagaggcggg catcctggac aagtaccgca tcgagatcga
2341 gcgcaaggtg gccgagaagg agcgattgcg tctggccgag aagcagcgta aggagcagcg
2401 tgccgccgag cgtgagaagc tgcgcgagga aaagctacgc atggaggcca agaaggttga
2461 cgacatgctc aagtcgcagg cggccgagca gcagtcccaa tccccatccc agtcctcctc
2521 ccagtcccag cccccagctc agtcgcaggc acagcagcaa cagcaacagc aacagcagca
2581 gcaacagcag tcgcagcaac aagacaagag tattaacagc aaggagctgg gcatcgacgg
2641 gggcctagta accgctgcca acctgaatct cgacaccacc aagagcgaga aggacctggc
2701 cgatgccgag tacgctgagg ccactgtcag caccaaggtg cagactgtgt tgccaacggt
2761 tgacgatgat gccgttcaac gggcggtgga ggatgtggct gctgccgtgg cccaccaaga
2821 ggccgagccg caggtgcagc acttcatgac ccacgatctg ggccaccgcg aatcgagctt
2881 ctcgctgcgc cgcgaatttg cgcacgcgca cgcggccaag gagggacgca acgtctactt
2941 cactctctcc tttgccggca tcgccctcat ggcggctgtc tttgtgggtg tggccgttgc
3001 caagtggcga acatcgcgct cgccgcacgc ccagggcttc attgaggtgg atcagaacgt
3061 gaccacacac catcccatcg tacaggagga caagatcgtg cccaatatgc agatcaatgg
3121 gtacgagaat ccgacctaca agtactttga ggtgaaagag taagcgtccc agcggcagcg
3181 gtagagcaag cgagcaggcg agagcacggc acatcaacag caaaaaacgc aaaaagcagc
3241 agcagcaaaa aaaacaacaa caacaatttc aaaatggaaa aaaacttaaa cataatatt