PREDICTED: Drosophila obscura amyloid-beta-like protein


LOCUS       XM_022354671            3308 bp    mRNA    linear   INV 14-MAY-2021
            (LOC111066230), transcript variant X2, mRNA.
ACCESSION   XM_022354671
VERSION     XM_022354671.2
DBLINK      BioProject: PRJNA728747
KEYWORDS    RefSeq.
SOURCE      Drosophila obscura
  ORGANISM  Drosophila obscura
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_024542752.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On May 14, 2021 this sequence version replaced XM_022354671.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Drosophila obscura Annotation
                                           Release 101
            Annotation Version          :: 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.6
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3308
                     /organism="Drosophila obscura"
                     /mol_type="mRNA"
                     /isolate="BZ-5 IFL"
                     /db_xref="taxon:7282"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="whole fly"
                     /dev_stage="Adult fly"
                     /geo_loc_name="Serbia: Babin Zub"
                     /collection_date="2017"
     gene            1..3308
                     /gene="LOC111066230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 2 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 9 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:111066230"
     CDS             305..3172
                     /gene="LOC111066230"
                     /codon_start=1
                     /product="amyloid-beta-like protein isoform X2"
                     /protein_id="XP_022210363.2"
                     /db_xref="GeneID:111066230"
                     /translation="MCAALRQRNLWLRSLWAIAVAILATGTVQGASPRWEPQIAVLCE
                     AGQIYQPQYLSEEGRWVTDLSKKTTGATCLRDKMDLLDYCKKAYPNRDITNIVESSHY
                     QKIGGWCRQGALNAAKCKGSHRWIKPFRCLGPFQSDALLVPEGCLFDHIHNASRCWPF
                     VRWNQTGAAACQERGMQMRSFAMLLPCGISLFSGVEFVCCPKHFKTDEIHVKKTDLPV
                     MPPAQISSANDELNDNEEDDSNESNYSKDANDDELDDEDDLMADDEEDEMVADEAAAA
                     GGTGSSSGSAGDASSGSLDDINAEYDSGEDGDNYEEDGAGSEGDNDSDTWDQNGSSSG
                     AKPVGLKVPILSMASSSPSSLPVGPDGSSGKAPLKPDQVTRIPIYSPAQAAAREAAIS
                     NANRINRLAAAAAAAAAAAAAAAATGSGAAAGAGAGTGAGAPPPSTAQPTSDPYFTHF
                     DPHYEHQSYKVSQKEAQQRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSFKQ
                     RMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQPPNA
                     HHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRAV
                     NQSMTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRIEIE
                     RKVAEKERLRLAEKQRKEQRAAEREKLREEKLRMEAKKVDDMLKSQAAEQQSQSPSQS
                     SSQSQPPAQSQAQQQQQQQQQQQQQSQQQDKSINSKELGIDGGLVTAANLNLDTTKSE
                     KDLADAEYAEATVSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFMTHDLG
                     HRESSFSLRREFAHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQG
                     FIEVDQNVTTHHPIVQEDKIVPNMQINGYENPTYKYFEVKE"
     misc_feature    389..907
                     /gene="LOC111066230"
                     /note="amyloid A4; Region: A4_EXTRA; smart00006"
                     /db_xref="CDD:128326"
     misc_feature    1604..2197
                     /gene="LOC111066230"
                     /note="E2 domain of amyloid precursor protein; Region:
                     APP_E2; pfam12925"
                     /db_xref="CDD:463752"
     misc_feature    2351..>2497
                     /gene="LOC111066230"
                     /note="DDRGK domain; Region: DDRGK; pfam09756"
                     /db_xref="CDD:370664"
     misc_feature    3011..3160
                     /gene="LOC111066230"
                     /note="Beta-amyloid precursor protein C-terminus; Region:
                     APP_amyloid; pfam10515"
                     /db_xref="CDD:463129"
ORIGIN      
        1 gagccactgg gcgcccactg aaggcaacga gttgctcatg tggtcggtgc cactcgcagt
       61 cgtttgtgag cgttcgcagc gcaagttgca gcaatactta gtgttaaaca aataagccac
      121 caaagcaaat actcgtacaa ttaagcccga gcagcccgag acacccgtcc agagacagag
      181 acagccggat tcccttggag aaggagctgt tcgtggagag cagagacaga gacaaagaca
      241 aagacaaaag acaagcggag aagcggagaa cagttcagcc aaaggccgaa aaagagtgcg
      301 aacaatgtgc gccgcgctgc gtcaacgcaa tttgtggctg cggagcctct gggccatcgc
      361 cgtagccatc ctggccactg gcactgtaca gggcgcctcg ccacgctggg agccgcaaat
      421 agccgtactc tgcgaagccg gacaaatcta tcagccgcaa tatctgtccg aggagggacg
      481 ctgggtgacg gacctcagca agaagacaac tggcgccaca tgtttgcgtg ataaaatgga
      541 tttgcttgat tactgcaaga aggcctatcc caatcgagac attaccaaca ttgtggagtc
      601 gtcgcactac cagaagatcg gcggctggtg ccgccagggt gctctgaacg cggccaagtg
      661 caagggatcc caccgctgga ttaagccgtt ccgttgtctg ggaccattcc aatcggacgc
      721 cttgctggtg ccagagggct gcctcttcga tcacatccac aatgcgtccc gctgctggcc
      781 attcgtcaga tggaaccaga cgggcgccgc cgcctgccag gaacggggca tgcagatgcg
      841 cagcttcgcc atgctgctgc cctgcggcat atcgctcttc tccggcgtgg aattcgtgtg
      901 ctgccccaag cacttcaaga ccgatgagat tcatgtgaag aagaccgatc tgccggtgat
      961 gcccccggca cagatcagca gtgccaacga tgagctgaac gacaacgagg aggatgacag
     1021 caacgagtcc aactactcga aggacgccaa cgatgatgag ctggacgacg aggatgatct
     1081 gatggccgac gacgaggagg acgaaatggt ggccgacgag gcggctgcgg ctggcggcac
     1141 tgggtccagc tctggctcgg ctggcgatgc cagcagcggc tccctggatg acattaatgc
     1201 ggaatatgat agcggcgagg atggcgacaa ctacgaggag gatggcgctg gctccgaggg
     1261 cgacaatgac tccgatacct gggaccagaa cggcagctcc agtggcgcca agcccgtggg
     1321 cctcaaggta cccattttgt cgatggcctc ctcgtccccg tccagcctgc ccgtgggtcc
     1381 cgatggcagc tccggcaagg cacccctgaa gcccgaccag gttacacgca ttcccattta
     1441 ctcgccggcc caggctgccg ccagagaggc tgccatcagt aatgccaatc gtatcaatcg
     1501 acttgctgcc gcagctgccg ctgctgctgc cgccgctgct gctgctgccg ctactgggtc
     1561 tggagctgca gctggagctg gggctgggac tggagctggg gcaccaccac cgtcgacggc
     1621 acagcccacc tctgatccgt acttcaccca ctttgatccg cactacgagc accagagcta
     1681 caaagtaagt cagaaagaag cccaacagcg ccttgaggaa tcgcatcgcg agaaggtcac
     1741 ccgtgtgatg aaggactggt ccgatctgga ggagaagtac caggacatgc ggctggccga
     1801 tcccaaggct gcccaatcat ttaagcagcg catgaccgcc cgcttccaga cttctgttca
     1861 ggcactcgag gaagaaggca acgccgagaa gcaccagctg gccgccatgc accagcaacg
     1921 cgtgctcgcc cacatcaacc agaggaagcg cgaggccatg acctgctaca cccaggccct
     1981 taccgagcag ccacccaatg cccatcatgt ggagaagtgt ctgcagaagc tgctgcgggc
     2041 cctgcacaag gaccgagccc atgccctggc acactaccga cacctgttga actccggcgg
     2101 accgggcggc ctggaggcgg ctgcctcaga gcgaccccgc accctggagc gtctgatcga
     2161 catcgatcgg gctgtcaacc agtcgatgac catgctaaag cgctacccag agctgtccgc
     2221 caaaattgcc cagctgatga acgactacat tctggcactg cgcagcaagg acgacattcc
     2281 cggctcgtcg ctcggcatga gcgaggaggc agaggcgggc atcctggaca agtaccgcat
     2341 cgagatcgag cgcaaggtgg ccgagaagga gcgattgcgt ctggccgaga agcagcgtaa
     2401 ggagcagcgt gccgccgagc gtgagaagct gcgcgaggaa aagctacgca tggaggccaa
     2461 gaaggttgac gacatgctca agtcgcaggc ggccgagcag cagtcccaat ccccatccca
     2521 gtcctcctcc cagtcccagc ccccagctca gtcgcaggca cagcagcaac agcaacagca
     2581 acagcagcag caacagcagt cgcagcaaca agacaagagt attaacagca aggagctggg
     2641 catcgacggg ggcctagtaa ccgctgccaa cctgaatctc gacaccacca agagcgagaa
     2701 ggacctggcc gatgccgagt acgctgaggc cactgtcagc accaaggtgc agactgtgtt
     2761 gccaacggtt gacgatgatg ccgttcaacg ggcggtggag gatgtggctg ctgccgtggc
     2821 ccaccaagag gccgagccgc aggtgcagca cttcatgacc cacgatctgg gccaccgcga
     2881 atcgagcttc tcgctgcgcc gcgaatttgc gcacgcgcac gcggccaagg agggacgcaa
     2941 cgtctacttc actctctcct ttgccggcat cgccctcatg gcggctgtct ttgtgggtgt
     3001 ggccgttgcc aagtggcgaa catcgcgctc gccgcacgcc cagggcttca ttgaggtgga
     3061 tcagaacgtg accacacacc atcccatcgt acaggaggac aagatcgtgc ccaatatgca
     3121 gatcaatggg tacgagaatc cgacctacaa gtactttgag gtgaaagagt aagcgtccca
     3181 gcggcagcgg tagagcaagc gagcaggcga gagcacggca catcaacagc aaaaaacgca
     3241 aaaagcagca gcagcaaaaa aaacaacaac aacaatttca aaatggaaaa aaacttaaac
     3301 ataatatt