PREDICTED: Drosophila obscura amyloid-beta-like protein


LOCUS       XM_022354669            3311 bp    mRNA    linear   INV 14-MAY-2021
            (LOC111066230), transcript variant X1, mRNA.
ACCESSION   XM_022354669
VERSION     XM_022354669.2
DBLINK      BioProject: PRJNA728747
KEYWORDS    RefSeq.
SOURCE      Drosophila obscura
  ORGANISM  Drosophila obscura
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_024542752.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On May 14, 2021 this sequence version replaced XM_022354669.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Drosophila obscura Annotation
                                           Release 101
            Annotation Version          :: 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.6
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3311
                     /organism="Drosophila obscura"
                     /mol_type="mRNA"
                     /isolate="BZ-5 IFL"
                     /db_xref="taxon:7282"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="whole fly"
                     /dev_stage="Adult fly"
                     /geo_loc_name="Serbia: Babin Zub"
                     /collection_date="2017"
     gene            1..3311
                     /gene="LOC111066230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 Protein, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 10 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:111066230"
     CDS             305..3175
                     /gene="LOC111066230"
                     /codon_start=1
                     /product="amyloid-beta-like protein isoform X1"
                     /protein_id="XP_022210361.2"
                     /db_xref="GeneID:111066230"
                     /translation="MCAALRQRNLWLRSLWAIAVAILATGTVQGASPRWEPQIAVLCE
                     AGQIYQPQYLSEEGRWVTDLSKKTTGATCLRDKMDLLDYCKKAYPNRDITNIVESSHY
                     QKIGGWCRQGALNAAKCKGSHRWIKPFRCLEGPFQSDALLVPEGCLFDHIHNASRCWP
                     FVRWNQTGAAACQERGMQMRSFAMLLPCGISLFSGVEFVCCPKHFKTDEIHVKKTDLP
                     VMPPAQISSANDELNDNEEDDSNESNYSKDANDDELDDEDDLMADDEEDEMVADEAAA
                     AGGTGSSSGSAGDASSGSLDDINAEYDSGEDGDNYEEDGAGSEGDNDSDTWDQNGSSS
                     GAKPVGLKVPILSMASSSPSSLPVGPDGSSGKAPLKPDQVTRIPIYSPAQAAAREAAI
                     SNANRINRLAAAAAAAAAAAAAAAATGSGAAAGAGAGTGAGAPPPSTAQPTSDPYFTH
                     FDPHYEHQSYKVSQKEAQQRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQSFK
                     QRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQPPN
                     AHHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDIDRA
                     VNQSMTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRIEI
                     ERKVAEKERLRLAEKQRKEQRAAEREKLREEKLRMEAKKVDDMLKSQAAEQQSQSPSQ
                     SSSQSQPPAQSQAQQQQQQQQQQQQQSQQQDKSINSKELGIDGGLVTAANLNLDTTKS
                     EKDLADAEYAEATVSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFMTHDL
                     GHRESSFSLRREFAHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQ
                     GFIEVDQNVTTHHPIVQEDKIVPNMQINGYENPTYKYFEVKE"
     misc_feature    389..910
                     /gene="LOC111066230"
                     /note="amyloid A4; Region: A4_EXTRA; smart00006"
                     /db_xref="CDD:128326"
     misc_feature    1607..2200
                     /gene="LOC111066230"
                     /note="E2 domain of amyloid precursor protein; Region:
                     APP_E2; pfam12925"
                     /db_xref="CDD:463752"
     misc_feature    2354..>2500
                     /gene="LOC111066230"
                     /note="DDRGK domain; Region: DDRGK; pfam09756"
                     /db_xref="CDD:370664"
     misc_feature    3014..3163
                     /gene="LOC111066230"
                     /note="Beta-amyloid precursor protein C-terminus; Region:
                     APP_amyloid; pfam10515"
                     /db_xref="CDD:463129"
ORIGIN      
        1 gagccactgg gcgcccactg aaggcaacga gttgctcatg tggtcggtgc cactcgcagt
       61 cgtttgtgag cgttcgcagc gcaagttgca gcaatactta gtgttaaaca aataagccac
      121 caaagcaaat actcgtacaa ttaagcccga gcagcccgag acacccgtcc agagacagag
      181 acagccggat tcccttggag aaggagctgt tcgtggagag cagagacaga gacaaagaca
      241 aagacaaaag acaagcggag aagcggagaa cagttcagcc aaaggccgaa aaagagtgcg
      301 aacaatgtgc gccgcgctgc gtcaacgcaa tttgtggctg cggagcctct gggccatcgc
      361 cgtagccatc ctggccactg gcactgtaca gggcgcctcg ccacgctggg agccgcaaat
      421 agccgtactc tgcgaagccg gacaaatcta tcagccgcaa tatctgtccg aggagggacg
      481 ctgggtgacg gacctcagca agaagacaac tggcgccaca tgtttgcgtg ataaaatgga
      541 tttgcttgat tactgcaaga aggcctatcc caatcgagac attaccaaca ttgtggagtc
      601 gtcgcactac cagaagatcg gcggctggtg ccgccagggt gctctgaacg cggccaagtg
      661 caagggatcc caccgctgga ttaagccgtt ccgttgtctg gaaggaccat tccaatcgga
      721 cgccttgctg gtgccagagg gctgcctctt cgatcacatc cacaatgcgt cccgctgctg
      781 gccattcgtc agatggaacc agacgggcgc cgccgcctgc caggaacggg gcatgcagat
      841 gcgcagcttc gccatgctgc tgccctgcgg catatcgctc ttctccggcg tggaattcgt
      901 gtgctgcccc aagcacttca agaccgatga gattcatgtg aagaagaccg atctgccggt
      961 gatgcccccg gcacagatca gcagtgccaa cgatgagctg aacgacaacg aggaggatga
     1021 cagcaacgag tccaactact cgaaggacgc caacgatgat gagctggacg acgaggatga
     1081 tctgatggcc gacgacgagg aggacgaaat ggtggccgac gaggcggctg cggctggcgg
     1141 cactgggtcc agctctggct cggctggcga tgccagcagc ggctccctgg atgacattaa
     1201 tgcggaatat gatagcggcg aggatggcga caactacgag gaggatggcg ctggctccga
     1261 gggcgacaat gactccgata cctgggacca gaacggcagc tccagtggcg ccaagcccgt
     1321 gggcctcaag gtacccattt tgtcgatggc ctcctcgtcc ccgtccagcc tgcccgtggg
     1381 tcccgatggc agctccggca aggcacccct gaagcccgac caggttacac gcattcccat
     1441 ttactcgccg gcccaggctg ccgccagaga ggctgccatc agtaatgcca atcgtatcaa
     1501 tcgacttgct gccgcagctg ccgctgctgc tgccgccgct gctgctgctg ccgctactgg
     1561 gtctggagct gcagctggag ctggggctgg gactggagct ggggcaccac caccgtcgac
     1621 ggcacagccc acctctgatc cgtacttcac ccactttgat ccgcactacg agcaccagag
     1681 ctacaaagta agtcagaaag aagcccaaca gcgccttgag gaatcgcatc gcgagaaggt
     1741 cacccgtgtg atgaaggact ggtccgatct ggaggagaag taccaggaca tgcggctggc
     1801 cgatcccaag gctgcccaat catttaagca gcgcatgacc gcccgcttcc agacttctgt
     1861 tcaggcactc gaggaagaag gcaacgccga gaagcaccag ctggccgcca tgcaccagca
     1921 acgcgtgctc gcccacatca accagaggaa gcgcgaggcc atgacctgct acacccaggc
     1981 ccttaccgag cagccaccca atgcccatca tgtggagaag tgtctgcaga agctgctgcg
     2041 ggccctgcac aaggaccgag cccatgccct ggcacactac cgacacctgt tgaactccgg
     2101 cggaccgggc ggcctggagg cggctgcctc agagcgaccc cgcaccctgg agcgtctgat
     2161 cgacatcgat cgggctgtca accagtcgat gaccatgcta aagcgctacc cagagctgtc
     2221 cgccaaaatt gcccagctga tgaacgacta cattctggca ctgcgcagca aggacgacat
     2281 tcccggctcg tcgctcggca tgagcgagga ggcagaggcg ggcatcctgg acaagtaccg
     2341 catcgagatc gagcgcaagg tggccgagaa ggagcgattg cgtctggccg agaagcagcg
     2401 taaggagcag cgtgccgccg agcgtgagaa gctgcgcgag gaaaagctac gcatggaggc
     2461 caagaaggtt gacgacatgc tcaagtcgca ggcggccgag cagcagtccc aatccccatc
     2521 ccagtcctcc tcccagtccc agcccccagc tcagtcgcag gcacagcagc aacagcaaca
     2581 gcaacagcag cagcaacagc agtcgcagca acaagacaag agtattaaca gcaaggagct
     2641 gggcatcgac gggggcctag taaccgctgc caacctgaat ctcgacacca ccaagagcga
     2701 gaaggacctg gccgatgccg agtacgctga ggccactgtc agcaccaagg tgcagactgt
     2761 gttgccaacg gttgacgatg atgccgttca acgggcggtg gaggatgtgg ctgctgccgt
     2821 ggcccaccaa gaggccgagc cgcaggtgca gcacttcatg acccacgatc tgggccaccg
     2881 cgaatcgagc ttctcgctgc gccgcgaatt tgcgcacgcg cacgcggcca aggagggacg
     2941 caacgtctac ttcactctct cctttgccgg catcgccctc atggcggctg tctttgtggg
     3001 tgtggccgtt gccaagtggc gaacatcgcg ctcgccgcac gcccagggct tcattgaggt
     3061 ggatcagaac gtgaccacac accatcccat cgtacaggag gacaagatcg tgcccaatat
     3121 gcagatcaat gggtacgaga atccgaccta caagtacttt gaggtgaaag agtaagcgtc
     3181 ccagcggcag cggtagagca agcgagcagg cgagagcacg gcacatcaac agcaaaaaac
     3241 gcaaaaagca gcagcagcaa aaaaaacaac aacaacaatt tcaaaatgga aaaaaactta
     3301 aacataatat t