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LOCUS XM_019475442 453 bp mRNA linear PLN 18-APR-2022 ACCESSION XM_019475442 VERSION XM_019475442.1 DBLINK BioProject: PRJNA14005 BioSample: SAMN02953594 KEYWORDS RefSeq. SOURCE Candida albicans SC5314 ORGANISM Candida albicans SC5314 Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Pichiomycetes; Debaryomycetaceae; Candida/Lodderomyces clade; Candida. REFERENCE 1 (bases 1 to 453) AUTHORS Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G. TITLE Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure JOURNAL Genome Biol. 14 (9), R97 (2013) PUBMED 24025428 REFERENCE 2 (bases 1 to 453) AUTHORS van het Hoog,M., Rast,T.J., Martchenko,M., Grindle,S., Dignard,D., Hogues,H., Cuomo,C., Berriman,M., Scherer,S., Magee,B.B., Whiteway,M., Chibana,H., Nantel,A. and Magee,P.T. TITLE Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes JOURNAL Genome Biol. 8 (4), R52 (2007) PUBMED 17419877 REFERENCE 3 (bases 1 to 453) AUTHORS Jones,T., Federspiel,N.A., Chibana,H., Dungan,J., Kalman,S., Magee,B.B., Newport,G., Thorstenson,Y.R., Agabian,N., Magee,P.T., Davis,R.W. and Scherer,S. TITLE The diploid genome sequence of Candida albicans JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (19), 7329-7334 (2004) PUBMED 15123810 REFERENCE 4 (bases 1 to 453) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (15-APR-2022) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (bases 1 to 453) AUTHORS Muzzey,D., Schwartz,K., Weissman,J.S. and Sherlock,G. TITLE Direct Submission JOURNAL Submitted (04-OCT-2016) Department of Genetics, Candida Genome Database, Stanford University, Mail Stop-5120, Stanford, CA 94305, USA REFERENCE 6 (bases 1 to 453) CONSRTM Candida Genome Database TITLE Direct Submission JOURNAL Submitted (30-SEP-2016) Department of Genetics, Candida Genome Database, Stanford University, Mail Stop-5120, Stanford, CA 94305, USA REMARK Sequence and annotation update by submitter COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. This record is derived from an annotated genomic sequence (NC_032094). ##Genome-Annotation-Data-START## Annotation Provider :: CGD Annotation Status :: Full annotation Annotation Version :: A22-s07-m01-r01 URL :: http://www.candidagenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. FEATURES Location/Qualifiers source 1..453 /organism="Candida albicans SC5314" /mol_type="mRNA" /strain="SC5314" /host="Homo sapiens" /culture_collection="ATCC:MYA-2876" /db_xref="taxon:237561" /chromosome="6" /haplotype="A" /geo_loc_name="USA: New York" /collected_by="Margarita Silva-Hutner" gene <1..>453 /gene="FCA1" /locus_tag="CAALFM_C600620WA" /db_xref="GeneID:30515327" CDS 1..453 /gene="FCA1" /locus_tag="CAALFM_C600620WA" /note="Cytosine deaminase; enzyme of pyrimidine salvage; functional homolog of S. cerevisiae Fcy1p; mutation is associated with resistance to flucytosine (5-FC) in a clinical isolate; hyphal downregulated; gene has intron" /codon_start=1 /transl_table=12 /product="cytosine deaminase" /protein_id="XP_019330987.1" /db_xref="CGD:CAL0000189710" /db_xref="GeneID:30515327" /translation="MTFDDKKGLQVALDQAKKSYSEGGIPIGSCIISSDDTVLGQGHN ERIQKHSAILHGEMSALENAGRLPGKTYKDCTIYTTLSPCSMCTGAILLYGFKRVVMG ENVNFLGNEKLLIENGVEVVNLNDQECIDLMAKFIKEKPQDWNEDIGE" misc_feature 25..348 /gene="FCA1" /locus_tag="CAALFM_C600620WA" /note="Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285" /db_xref="CDD:238612" misc_feature order(79..81,130..132,163..171,250..252,259..261) /gene="FCA1" /locus_tag="CAALFM_C600620WA" /note="nucleoside/Zn binding site [active]" /db_xref="CDD:238612" misc_feature order(157..159,172..174,184..186,253..258,265..270, 277..282) /gene="FCA1" /locus_tag="CAALFM_C600620WA" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:238612" misc_feature order(163..171,247..252,259..261) /gene="FCA1" /locus_tag="CAALFM_C600620WA" /note="catalytic motif [active]" /db_xref="CDD:238612" ORIGIN 1 atgacgtttg acgacaaaaa aggtttacaa gttgctcttg atcaagccaa gaaaagttac 61 tcagaaggtg ggatacctat tggttcatgt attatttcat ctgatgacac agtattaggc 121 caaggtcaca acgaaagaat ccaaaaacat tcagctattt tacatggaga aatgtcagca 181 ttagaaaacg caggaagatt accaggaaaa acttataaag attgtaccat ctatactact 241 ttatcaccat gtagtatgtg tactggggcc attttattat atggattcaa aagagttgtg 301 atgggagaaa atgtcaattt cttgggtaat gaaaagttat tgattgaaaa tggtgtcgaa 361 gttgtgaatt taaatgatca agaatgtatt gatttgatgg ccaaattcat taaagagaaa 421 ccacaagatt ggaatgaaga tattggagaa taa